DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap1 and S-Lap8

DIOPT Version :9

Sequence 1:	NP_648244.1	Gene:	S-Lap1 / 38986	FlyBaseID:	FBgn0035915	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	203/498 - (40%)
Similarity:	308/498 - (61%)	Gaps:	17/498 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RALVIGVYADEEDKNDAGI-LTPAGWRYNLQKTNGRLIEVLRMSGPMPKRGEARLLFAVEPERIP 117
            :.:|:|:||.:.||   |: |:|.|.::: .:..|::.|:::.||...:.|..||...::.|
  Fly    50 QGVVVGLYAKDGDK---GLKLSPGGEKFD-DRVGGKITELIKESGLNGELGVGRLYQNIDKE--- 107

  Fly   118 YYSVVAVVGLGKECLGYNPYEVLDEQKEAIRRSVAAACRILAELDTDRIEVENCGHAESAAEGAA 182
             |..|||||||||..|:|..||:||..|.:|...|...|.|.........|:...:.|.||||||
  Fly   108 -YWAVAVVGLGKEGAGFNAEEVIDEGMENVRVCAAVGARALQLQGCTTCHVDGMEYPEQAAEGAA 171

  Fly   183 LGIWLYQELRDPKTRIFVPAIDLYATKDEVCDIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPTAF 247
            :.:|.|...:..|.||.:|.::||.:.|:    :.|..||.||.:|||.|:|.:.|:|.:||:.|
  Fly   172 MAVWRYNVNKRKKNRIAIPKLELYGSTDQ----DAWTRGLFKAESQNLARRLSDTPANQMTPSIF 232

  Fly   248 AQNVVEVLCKSGVNVEVKVEGWAESQSMHAFLAVGKASCEPPIFLELSYYGTCAEERPIVLVGQG 312
            ||..|:.||..||:|||:...|.|:|::::||.|.|.||||||.||:||.||..|||||:::|:|
  Fly   233 AQATVDALCPCGVSVEVRSMDWIETQNLNSFLMVAKGSCEPPIILEVSYCGTSPEERPILMLGKG 297

  Fly   313 ITYDAGGLCLKKKKELFNMRGDMTGAAVVVATCRAVAGLRLPVNIRGLIPLCENVVGCNSFRPGD 377
            :|:::|||||..|:.:...||.::||||.||..||.|.|.||:|:..::|||||:....:.:|||
  Fly   298 LTFNSGGLCLHPKRGMDEYRGAVSGAAVCVAAIRAAAALSLPINVSAVLPLCENMPSGMATKPGD 362

  Fly   378 MVKSMNGKTIEVQCTDHEDVLVLADALLYAQN-FCPKCIIDIGTCSGYMRQSLDEAACGVFTNSE 441
            :|..:||||:.::.......::|||.|||||: |.||.::::|:.:..:|:.|..:|.|::||:.
  Fly   363 VVTLLNGKTMRIKDISLAGTVLLADPLLYAQSTFKPKLVVEVGSMASGIRKGLGASATGLWTNNS 427

  Fly   442 ILWQQIKHASMHTGDRVWRFPLWNFYSKAVRAGGRSDVQNYGIGRGGRPCKAAAFLREFVPCGQW 506
            .||:..:.|...||||:||.|||.::.|.|......|:.:.|.|... .|.|||.|.|.|||..|
  Fly   428 FLWKNFQKAGALTGDRLWRMPLWRYFRKLVAPRASYDICSTGEGHAS-SCLAAAILYELVPCSDW 491

  Fly   507 MHID--ATNVMVTNGIDFEYLRRGMAGRPTRTLIEFIAQTICK 547
            :|:|  .|.::..:|:....|:..|.|||||::|:|:.|..||
  Fly   492 VHLDTHGTGMLAKHGVPPYLLKDCMTGRPTRSIIQFLYQMACK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap1	NP_648244.1	PRK00913	44..542	CDD:234863	200/491 (41%)
S-Lap1	NP_648244.1	Peptidase_M17	55..541	CDD:238247	199/489 (41%)
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	199/489 (41%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	194/475 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472700
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1683
SonicParanoid	1	1.000	-	-		X713
	13	12.780