DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap1 and S-Lap4

DIOPT Version :9

Sequence 1:	NP_648244.1	Gene:	S-Lap1 / 38986	FlyBaseID:	FBgn0035915	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	202/531 - (38%)
Similarity:	305/531 - (57%)	Gaps:	29/531 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RSYASQAVNQML----LLQQMDICA--DQPSRALVIGVYADEEDKNDAGILTPAGWRYNLQKTNG 87
            |:.....|.:.|    |:|....|.  .:.|:.||:|||..|.| ||.. |||||.:.| .:.:|
  Fly     5 RNVLKSVVQRRLPVSHLIQIRTACGGESKSSKGLVVGVYQKEND-NDPK-LTPAGEKVN-DRLHG 66

  Fly    88 RLIEVLRMSGPMPKRGEARLLFAVEPERIPYYSVVAVVGLGKECLGYNPYEVLDEQKEAIRRSVA 152
            :|.|::..|......|..::...::||    :..:||||:|.|.:|:|..|:|||..|.:|.:..
  Fly    67 KLQEMICQSKITGHLGRGKIFNNIDPE----FRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAG 127

  Fly   153 AACRILAELDTDRIEVENCGHAESAAEGAALGIWLYQELRDPKTRIFVPAIDLYATKDEVCDIEG 217
            ...|.|.|:....:.|:...:||.|||||.|.:|.|.::...:....:|.::||    |..|.||
  Fly   128 IGARSLQEIGVSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELY----ESPDYEG 188

  Fly   218 WRIGLQKAAAQNLTRQLQEMPSNLLTPTAFAQNVVEVLCKSGVNVEVKVEGWAESQSMHAFLAVG 282
            |..|:.||.||||.|::.:.|:..:|||.|||..|:.||..|:.||::...|.|.|.:|:||.:.
  Fly   189 WTRGVFKAEAQNLARRMCDTPACCMTPTLFAQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIA 253

  Fly   283 KASCEPPIFLELSYYGTCAEERPIVLVGQGITYDAGGLCLKKKKELFNMRGDMTGAAVVVATCRA 347
            |.|||||:.:|::|.||..|::||:.:|:|||:::|.:.|:|.:.:...|..|:|||..||..|.
  Fly   254 KGSCEPPVLMEITYCGTNPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRC 318

  Fly   348 VAGLRLPVNIRGLIPLCENVVGCNSFRPGDMVKSMNGKTIEVQCTDHEDVLVLADALLYAQN-FC 411
            ||.|.||:|:..:||||||:....:.:|||:|..||.|::.|:..|...|:|:||.|||.|: :.
  Fly   319 VAALALPINVCCIIPLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYK 383

  Fly   412 PKCIIDIGTCSGYMRQSLDEAACGVFTNSEILWQQIKHASMHTGDRVWRFPLWNFYSKAVRAGGR 476
            |:.::|:.|....::::....|.|:|:||..:|:|.:.|...|||||||.||||:|.|.:
  Fly   384 PRLVVDVATLGSGVKKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQI----- 443

  Fly   477 SDVQNYGIGRGGR----PCKAAAFLREFVPCGQWMHID--ATNVMVTNGIDFEYLRRGMAGRPTR 535
            :|...|.:...||    .|.|||.|.|.|||..|.|:|  .|.::...|:......:.|.|||||
  Fly   444 TDEMGYDLSNDGRGLANSCLAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTR 508

  Fly   536 TLIEFIAQTIC 546
            ||.:|:.|..|
  Fly   509 TLAQFLYQMAC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap1	NP_648244.1	PRK00913	44..542	CDD:234863	195/506 (39%)
S-Lap1	NP_648244.1	Peptidase_M17	55..541	CDD:238247	192/492 (39%)
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	193/498 (39%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	193/494 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472698
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	12	11.750