DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap1 and S-Lap3

DIOPT Version :9

Sequence 1:	NP_648244.1	Gene:	S-Lap1 / 38986	FlyBaseID:	FBgn0035915	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001261679.1	Gene:	S-Lap3 / 326187	FlyBaseID:	FBgn0045770	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	202/507 - (39%)
Similarity:	306/507 - (60%)	Gaps:	26/507 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RALVIGVYADEEDKNDAGILTPAGWRYNLQKTNGRLIEVL---RMSGPMPKRGEARLLFAVEPER 115
            :.:|:|:|..|..|...  |||||.::: .:..|:|.|::   :::|   :.|..::...|:.|
  Fly    47 KGIVLGLYEKESGKGPR--LTPAGEKFD-DRVQGKLSELVCETKLTG---RLGRGKVFNNVDSE- 104

  Fly   116 IPYYSVVAVVGLGKECLGYNPYEVLDEQKEAIRRSVAAACRILAELDTDRIEVENCGHAESAAEG 180
               :..:.|||:|.|.:.:|..|:|||..|.:|.:.....|.|..:....:.|:|..:||.||||
  Fly   105 ---FRSICVVGVGLEGIAFNELEMLDEGMENVRIAAGIGARSLQSIGCSEVHVDNMDYAEQAAEG 166

  Fly   181 AALGIWLYQELRDPKTRIFVPAIDLYATKDEVCDIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPT 245
            |||.||.|:|....|.|..:|.::|:.:.    |:|.|..||.||.||||.|:|.:.|:|.:|||
  Fly   167 AALAIWRYEENLAKKYRSTIPKLELHGSP----DVESWTRGLFKAEAQNLARRLCDAPANCMTPT 227

  Fly   246 AFAQNVVEVLCKSGVNVEVKVEGWAESQSMHAFLAVGKASCEPPIFLELSYYGTCAEERPIVLVG 310
            ..||..|:.||..|:.|||:...|.|.|.:::||.:.|.|||||:.||::|.||..|::||:|||
  Fly   228 IVAQAAVDSLCPCGITVEVRTMEWIEQQHLNSFLMIAKGSCEPPVLLEVAYCGTAPEDKPILLVG 292

  Fly   311 QGITYDAGGLCLKKKKELFNMRGDMTGAAVVVATCRAVAGLRLPVNIRGLIPLCENVVGCNSFRP 375
            ||||:::||:.|:..|.:...|||:||||.::|..||.|.|.||:||..:||||||:....|.:|
  Fly   293 QGITFNSGGINLRPCKGMDEFRGDLTGAACILAAMRAAAALSLPINITAVIPLCENLPSGMSCKP 357

  Fly   376 GDMVKSMNGKTIEVQCTDHEDVLVLADALLYAQ-NFCPKCIIDIGT-CSGYMRQSLDEAACGVFT 438
            ||:|..:|.|::.|:......|:|::|.:||.| .:.|:.::|:|: |.| :::::...|.|:::
  Fly   358 GDVVTLLNSKSLAVRNISRTGVVVISDPMLYGQITYKPRLVVDVGSMCKG-VKKAVGGGATGIWS 421

  Fly   439 NSEILWQQIKHASMHTGDRVWRFPLWNFYSKAVRAGGRSDVQNYGIGRGGRPCKAAAFLREFVPC 503
            ||..:|:|.:.|...||||:||||||.:|...|......|:.|.|.|... .|.|||.|.|.|||
  Fly   422 NSHYIWKQFQRAGSLTGDRLWRFPLWRYYKDRVAEHLSFDLLNDGEGYAS-SCLAAAVLHELVPC 485

  Fly   504 GQWMHID--ATNVMVTNGIDFEYLRRG-MAGRPTRTLIEFIAQTICKDTAPK 552
            ..|.|:|  .|.::.|.|: ..||..| |.|||||||::|:.|..|.: .||
  Fly   486 SDWAHLDTYGTGLLSTYGL-IPYLTAGRMTGRPTRTLVQFLYQIACPE-QPK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap1	NP_648244.1	PRK00913	44..542	CDD:234863	198/495 (40%)
S-Lap1	NP_648244.1	Peptidase_M17	55..541	CDD:238247	197/493 (40%)
S-Lap3	NP_001261679.1	Peptidase_M17	47..525	CDD:238247	197/494 (40%)
S-Lap3	NP_001261679.1	PRK00913	49..525	CDD:234863	197/492 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472696
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1683
SonicParanoid	1	1.000	-	-		X713
	13	12.780