DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5989 and MDM38

DIOPT Version :9

Sequence 1:	NP_648242.1	Gene:	CG5989 / 38984	FlyBaseID:	FBgn0017429	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_014615.1	Gene:	MDM38 / 854130	SGDID:	S000005387	Length:	573	Species:	Saccharomyces cerevisiae

Alignment Length:	406	Identity:	76/406 - (18%)
Similarity:	144/406 - (35%)	Gaps:	114/406 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FCSR-NYATKPEAA---VPPQIKRNVAAEITSVGKVIYETGWDANKPIEKPKVR----PSSSSST 96
            |.|| :..|:.:|:   |..|..|.:|:.|.|....:...|...|.|:   .:|    ..|.|.|
Yeast     4 FASRASCVTRRQASLYFVKNQGPRLIASTIPSCHWPLRAQGVQPNYPL---SLRFYSTDKSKSVT 65

  Fly    97 QP-TPSKKPEDEKRKELDTVKSKRDQMRDNMQDYI-FTRYFNY-VKNYDKVLEKNFPKAMQLYRV 158
            :| .|:......|.||...||.|.     .::.|. .|:...| :|...|:|.| |.:..:|.|.
Yeast    66 KPVAPTSTDAPAKPKETLMVKVKH-----ALKHYANGTKLLGYEIKVSTKLLIK-FAQGYELSRR 124

  Fly   159 FFDGVKDFFGDMKRFLKIARIANDSPQGIRALNRQELELYMQMPRDMMKVAPALIGCSLPMVGYA 223
            ..:.::...||:.|.:..:..          |.....||::..   .:|:.|.|:
Yeast   125 ERNQLRRTMGDVFRLIPFSAF----------LIIPFAELFLPF---ALKLFPNLL---------- 166

  Fly   224 FFPLVFYYPRSF------------------LTAHFW----------------TPQQRSEFQSYYM 254
                    |.::                  .|:.|.                ..:::.:|.:::.
Yeast   167 --------PSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQKFLNFFR 223

  Fly   255 KRRLCNNKDVFRCLQDKLKATASHPKHSAFADILGQLGSGTHPTPEMLIDVKDIFAEGPYSLLGM 319
            |........:.....|::.|.|...|:.:..|.|.:        |:               |..|
Yeast   224 KLYSAKEGKIMTFQHDEISAIAQMFKNDSVLDNLSR--------PQ---------------LAAM 265

  Fly   320 SRKHVRNLVNLHGLPSSIFKRHRLHEHAFLVHYMDQAITREGGVHNLTPDALRYSCYLRGLNPDS 384
            |:     .::|....:....|:::......:...|:.|..| ||.:|:.:.|..:|..||:....
Yeast   266 SK-----FMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYE-GVESLSQEELYQACVSRGMKAYG 324

  Fly   385 LSSEAMIEWLRKWVKV 400
            :|.|.:::.|:.|:::
Yeast   325 VSKEDLVDNLKVWLEL 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5989	NP_648242.1	LETM1	150..403	CDD:285063	42/285 (15%)
MDM38	NP_014615.1	LETM1	83..353	CDD:400222	53/324 (16%)
MDM38	NP_014615.1	PspC_subgroup_1	<364..>507	CDD:411407
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14009
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940