DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rhea and TLN2

DIOPT Version :9

Sequence 1:	NP_001246674.1	Gene:	rhea / 38978	FlyBaseID:	FBgn0260442	Length:	2836	Species:	Drosophila melanogaster
Sequence 2:	XP_005254765.1	Gene:	TLN2 / 83660	HGNCID:	15447	Length:	2557	Species:	Homo sapiens

Alignment Length:	2586	Identity:	1220/2586 - (47%)
Similarity:	1727/2586 - (66%)	Gaps:	94/2586 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||:|||::..||..||.|:||||:|||..::|:|||
Human     1 MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRKGIWLE 65

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..::|||||:|||::||||:.|.:|:|.||::|||||:|||.
Human    66 AGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYS 130

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDR-----DAKMESLRKKLKTDDEMNWVDVSRTLRE 190
            |::|..|.:.|.      ||.|||     |||     :.|||.|:.||.|||::||:|.|||.||
Human   131 LIQETIEEKKEE------GTGTLK-----KDRTLLRDERKMEKLKAKLHTDDDLNWLDHSRTFRE 184

  Fly   191 QGIDEAETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQF 255
            ||:||.||:||||:||:||||:|||||||||||||||||.||:|:|||:.:|||||.|.|..|||
Human   185 QGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEFGGFQAQIQF 249

  Fly   256 GPHNEAKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVT 320
            |||.|.|||.||||||:|||:.|::.:|.||:||.||:...::|||:|||.|.|.||.|.||||:
Human   250 GPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVS 314

  Fly   321 FFLVKEKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQ 385
            ||||||||.|||||||||||:|||||:|:||.|||:|..||||||:||.|||.:||||||:|...
Human   315 FFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQES 379

  Fly   386 YYSVQTTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQ 450
            ||||||||.|||.|||||||||||||||:||.||:||||.|||:||||:|.|:|.||.:.||..:
Human   380 YYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQFNRTGK 444

  Fly   451 LNVESLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRAL 514
            ....|:|.|.:||. ..|..::....:.:.|....|||::..|.||           ||..|:||
Human   445 AEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMVGQMHRGHMPP-----------LTSAQQAL 498

  Fly   515 LGYISAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII-- 577
            :|.|:.....:.:|.::|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::
Human   499 MGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNL 563

  Fly   578 TASHPDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKA 641
            ||..|.:.|..|:..:::.|:..:.|::|.|:|:||||:::. ||:.||.|||.|..|.||||||
Human   564 TAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDLLKA 628

  Fly   642 AEPESKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKN 706
            .:|.|.||.|.::.||..:|:|:..:|..|.|.|..|.  ..|:|::|||||||..|.|||:|||
Human   629 VQPTSGEPRQTVLTAAGSIGQASGDLLRQIGENETDER--FQDVLMSLAKAVANAAAMLVLKAKN 691

  Fly   707 IAASCDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEV 771
            :|...:|...:||||.||:||||:|||||||||||:||:.:..|:|||..|.|.|.|:|.:....
Human   692 VAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRA 756

  Fly   772 CNEASNDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHANRTSTELSPVENVIIGTD------- 829
            |..|:.|.:|...:.|||..||::|.|:|:||    |:.|:|.    .|:......||
Human   757 CQAATTDSELLKQVSAAASVVSQALHDLLQHV----RQFASRG----EPIGRYDQATDTIMCVTE 813

  Fly   830 -ILVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAAR 893
             |..|..|..||||.||.|.|.|:.|:.:::.:|:.:.|.:..:.||:|||.|||:||::||||:
Human   814 SIFSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAK 878

  Fly   894 LCSSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAV 958
            ..::||.:.|.|..||:|||.|| :.|.||...|:|:.::.|||..:||||:||||.|:|:|||.
Human   879 GAAANPENEDQQQRLREAAEGLR-VATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAA 942

  Fly   959 QHSQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSR 1023
            ..:::...::.|:|.||.|||.||:||..::.::||.:|.:|||.||.:::.|::|..::..|::
Human   943 VSNKNPAAQQQLVQSCKAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAK 1007

  Fly  1024 ALQPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQA 1088
            |..|||:|..:|.|||:.|.:|...::||.:.:|:|.:|||..|::|||..|:.|.:.|.|.:.|
Human  1008 AAVPTVSDQAAAMQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMA 1072

  Fly  1089 AIAGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSV 1153
            |:..||:||||:|:|..|.:|..::|.||.:::|||:........|.|.|.|:||.||....::.
Human  1073 AVESQLKPLPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAA 1137

  Fly  1154 HGVAATTQNP----AIIDCADDVVTSSARLIEQAQRTL---QGASNPEALTQAGREVTGALSATV 1211
            .||||:|.:|    |::|.|.||:..||.||::|::.|   ..|...:.|.|..:.|:.:|:..|
Human  1138 RGVAASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNNCV 1202

  Fly  1212 DCIPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPA 1275
            :|:|||::|||||:::.|.|:.|.:...|||::|:...||||.|.|..|:.:.||:| .:.....
Human  1203 NCLPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHATRGQSG 1267

  Fly  1276 LLAESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPN 1340
            .||.:|..|:.::.:.|...:|||||.|.:|.:..:|.:|:::|..|..||..|||::.|||.||
Human  1268 ELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLAAKSLSVDPGAPN 1332

  Fly  1341 AKNLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQ 1405
            |||||.||||.||||||||:....|.||||||||||:|.:|.::.|||.|:||:::|.||||:|.
Human  1333 AKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLDNPNEPVSDLSYFDCIES 1397

  Fly  1406 ATGKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPG 1470
            ....|:.||.:::.:..|||......|.:.|...:.::.||.|:::|||||:|:|.|:|.||..|
Human  1398 VMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTEAAAQAAYLVGISDPNSQAGHQG 1462

  Fly  1471 IIDQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEF 1535
            ::|..|...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:|||||..|
Human  1463 LVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKRHF 1527

  Fly  1536 IVLAKQVATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKISA 1597
            :..||:||.:|::||:.|||::...:..:|.:   ...||:|||:.:..:||:.||.|:||:||:
Human  1528 VQSAKEVANSTANLVKTIKALDGDFSEDNRNKCRIATAPLIEAVENLTAFASNPEFVSIPAQISS 1592

  Fly  1598 EGRKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKA 1662
            ||.:||||::.:.:.:::....:::.|:|||:.|.:||.|..|:.||..||:|:|.|:.:|||||
Human  1593 EGSQAQEPILVSAKTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKA 1657

  Fly  1663 PGQAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAG 1727
            |||.:|:..:..:..|.|:::..:||..:|.|:.|.|.::.....|..:...|:...::||..|.
Human  1658 PGQRECDYSIDGINRCIRDIEQASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAA 1722

  Fly  1728 KNNAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGN 1792
            :..|.||||.|.:::.|..|::..|:|..:.|:..||||:::.||:::.|||:.::.:|||..||
Human  1723 RGEAAQLGHKVTQLASYFEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGN 1787

  Fly  1793 PRATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYS 1857
            |:|.|.|..:.:|....:||:.::..|:.:..:|.|:|.|:::.:..::::|.:...    ....
Human  1788 PKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTP----PEPK 1848

  Fly  1858 DTFVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDV 1922
            .|||||||.:|..:|.||..|.||..||...|..|..||..||.:|..|......|:.|....::
Human  1849 GTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEI 1913

  Fly  1923 AMRIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQ 1985
            ..:|||.|.|||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::|||
Human  1914 GFQIRTRVQDLGHGCIFLVQ-KAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQ 1977

  Fly  1986 ACINAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQ 2050
            |||.||..|||||.||||||||||||||:::...:||||||:||:||||||||||:||:|||.|.
Human  1978 ACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTP 2042

  Fly  2051 DQLANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASALGDLINCTKLASGKSI 2115
            |:||.|||::.:|||||||.||.||.||||..|::||::|||:||||.||.|||:.||.|:.|.:
Human  2043 DKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPV 2107

  Fly  2116 NDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQEIRAMHSPPPVGNTQV 2180
            :||||..||.:|:|||.||:||||||||||||.||||||:|||:|.|.||:....|......|.
Human  2108 DDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTS- 2171

  Fly  2181 GPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELRSR 2245
            .||:.||:|..:|.|||||||||.|..|.|:::.|||.|:|:|:||..|:..:::...::|:|:|
Human  2172 SPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTR 2236

  Fly  2246 TLEAGTAVGESYRDLLSG---ILHNCSADDRMHL---SRRVAKCVTDLVAMARLLKGSDWIDPED 2304
            .|..||.....|.|||..   ||...:.:.:..|   |:|||..||:|:..|..:||::|:||||
Human  2237 ALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQAAEAMKGTEWVDPED 2301

  Fly  2305 PTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILEAAKGIMGASAALVRA 2369
            ||||||.|||||||||:||||||..|:||.:..   :.||.:.|:|.||||||.|..|::|||::
Human  2302 PTVIAETELLGAAASIEAAAKKLEQLKPRAKPK---QADETLDFEEQILEAAKSIAAATSALVKS 2363

  Fly  2370 ANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQNLVRGVGTEEMLIST 2434
            |:||||||:..|||...|..::||||||:|||||||:|||||.||.|||...|:|..:||.|||:
Human  2364 ASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHASEEKLISS 2428

  Fly  2435 AKQVAASTAQLLIACKVKSNPNSEAGRRLQ---------------AAGNAVIKSTDNLVHSAQQG 2484
            ||||||||||||:|||||::.:|||.||||               ||||||.:::||||.:||:.
Human  2429 AKQVAASTAQLLVACKVKADQDSEAMRRLQVMVTDAGGKILLLERAAGNAVKRASDNLVRAAQKA 2493

  Fly  2485 LEAE-EEHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            ...: ::..:.:.|..|.|:||.|.|:..:|:||:||||||:.|..:|..|
Human  2494 AFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQ 2544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_001246674.1	FERM_f0	4..85	CDD:293120	46/80 (58%)
		B41	89..322	CDD:214604	142/237 (60%)
		FERM_N	92..147	CDD:286467	29/54 (54%)
		FERM_M	215..322	CDD:278785	70/106 (66%)
		FERM_C_Talin	318..409	CDD:269973	71/90 (79%)
		Talin_middle	510..668	CDD:286254	59/160 (37%)
		I_LWEQ	686..>778	CDD:302998	51/91 (56%)
		Vinculin	<874..>1035	CDD:279395	73/160 (46%)
		talin-RS	1661..1832	CDD:213393	55/170 (32%)
		Tar	<1694..2005	CDD:223910	115/312 (37%)
		VBS	1859..1982	CDD:286057	52/124 (42%)
		I_LWEQ	2392..2534	CDD:279885	84/157 (54%)
TLN2	XP_005254765.1	FERM_f0	4..85	CDD:318667	46/80 (58%)
		B41	90..316	CDD:214604	142/236 (60%)
		FERM_C_Talin	312..403	CDD:269973	71/90 (79%)
		Talin_middle	494..655	CDD:312608	59/160 (37%)
		I_LWEQ	706..842	CDD:327626	62/143 (43%)
		talin-RS	1045..>1174	CDD:213393	53/128 (41%)
		talin-RS	1656..1827	CDD:213393	55/170 (32%)
		VBS	1850..1974	CDD:312463	52/124 (42%)
		ILWEQ	2337..2547	CDD:214607	111/208 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152094
Domainoid	1	1.000	863	1.000	Domainoid score	I56
eggNOG	1	0.900	-	-		E1_KOG4261
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56692
Inparanoid	1	1.050	2215	1.000	Inparanoid score	I41
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7374at33208
OrthoFinder	1	1.000	-	-		FOG0003071
OrthoInspector	1	1.000	-	-		otm41512
orthoMCL	1	0.900	-	-		OOG6_103395
Panther	1	1.100	-	-	O	PTHR19981
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4187
SonicParanoid	1	1.000	-	-		X1785
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790