DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rhea and tln1

DIOPT Version :9

Sequence 1:NP_001246674.1 Gene:rhea / 38978 FlyBaseID:FBgn0260442 Length:2836 Species:Drosophila melanogaster
Sequence 2:XP_031750909.1 Gene:tln1 / 733752 XenbaseID:XB-GENE-6039297 Length:2558 Species:Xenopus tropicalis


Alignment Length:2586 Identity:1227/2586 - (47%)
Similarity:1729/2586 - (66%) Gaps:93/2586 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:  |.|.||:||:|:|.::|||::||::..||..|||:::|||:|||..::|:|||
 Frog     1 MVALSLKISI--GNVVKTMQFEPSTMIYDACRIIRERVPEAQIGQPNDFGLFLSDEDPKKGIWLE 63

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .|:.|.||:|.|.||||||:|.|.|::|||||.|||::||||:.:|.|::.||.:|||||::||.
 Frog    64 AGKALDYYMLRNGDTLEYRKKQRPLKIRMLDGTVKTVMVDDSKTMSDLLMTICARIGITNYDEYS 128

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKR-KIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGID 194
            ||||..|.:.|.:      |.|||| |.:.:| |.|||.|::||.||||:||:|..|||||||:|
 Frog   129 LVREIMEEKKEEI------TGTLKRDKTLLRD-DKKMEKLKQKLHTDDELNWLDPGRTLREQGVD 186

  Fly   195 EAETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHN 259
            |.||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||||.|..:||||||
 Frog   187 ENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGYQCQVQFGPHN 251

  Fly   260 EAKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLV 324
            |.|||.|||:||||||:.|::.|| |:|||..||:..::|||:||..|.|.||.|.||||:||||
 Frog   252 EVKHKPGFLELKDFLPKEYIKQKG-ERKIFLAHRQCGNMSEIEAKARYVKLARSLKTYGVSFFLV 315

  Fly   325 KEKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSV 389
            ||||.|||||||||||:||:.|:|:||.|||::..|.||.::||.|||.:||||||||.:.||||
 Frog   316 KEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSV 380

  Fly   390 QTTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVE 454
            ||||.|||.||||||||||||||::|||||:||||.|||:|:||:|.|:|.||.:.|::.::...
 Frog   381 QTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTLLQQQFNQVGKVEHG 445

  Fly   455 SLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYI 518
            |:|.|.|||. ..|..::....:...|.....||::..|.||           ||..|:||.|.|
 Frog   446 SVALPAIMRSGASGPENFQVGSMPQAQQQTVSGQMHLGHMPP-----------LTSAQQALTGTI 499

  Fly   519 SAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASH 581
            ::....:..|...|.....:..||.|..|..||:|.:|.||..:.|.|..::|.||.::  ||.:
 Frog   500 NSSMQAINAAQATLDDFDTLPPLGDDAASKAWRKNKMDNSKHEIHSQVDAITAGTASVVNLTAGN 564

  Fly   582 PDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMEND-TSGDQLLEAARNLCSAFSDLLKAAEPE 645
            |.:.|..|:..:|:.|:..:.|:::.|:|:|||||:: .:|.|||.||:||..|.|||||.|:|.
 Frog   565 PADTDYTAVGCAVTTISSNLTEMSRGVKLLAALMEDEGGNGRQLLHAAKNLAGAVSDLLKTAQPA 629

  Fly   646 SKEPPQHLINAASRVGEATTHVLSTIAEEE----------------VPENRDLHDMLLALAKAVA 694
            |.||.|.|:.||..||.|:..:|..|.|.:                .|......|||:.||||||
 Frog   630 STEPRQVLMQAAGNVGMASGELLKQIGECDTDSQFQISAARATRGLTPLAEQKTDMLVQLAKAVA 694

  Fly   695 NTTAALVLRAKNIAASCDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAK 759
            :..|||||:|||:|...||...:.:||.||:||||:|||||||.||||||:.:..|:|||..|.|
 Frog   695 SAAAALVLKAKNVAERTDDGAQQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLLEAGK 759

  Fly   760 NVARAVNSLCEVCNEASNDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHAN----------RT 814
            .||::|....|....|..||:|...:..||..|:::|.|:|:|:|    :||:          .|
 Frog   760 QVAKSVEGCVEASEAAVQDPELLKAVGVAASAVTQALNDLLQHIK----KHASGGPPTGRYDQAT 820

  Fly   815 STELSPVENVIIGTDILVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAK 879
            .|.|:..||      |..|..|..||||.||.|.|.|:.|:.:||.:|:::.|.:..|.||||||
 Frog   821 DTILNVTEN------IFSSMGDAGEMVRQARILAQATSDLVGAIKADAERESDLENSRKLLSAAK 879

  Fly   880 QLADATAKLVEAARLCSSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAA 944
            .||||||::||||:..:::|...:.|..||:|||.||..|..||.. |:|:.|:.:||..:||||
 Frog   880 LLADATARMVEAAKGAAAHPDSEEQQQKLREAAEGLRMATNAAAQN-AIKKKLVHKLEQAAKQAA 943

  Fly   945 SAATQCISAAQNAVQHSQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAE 1009
            ::|||.|:|||||...:::...::.|:|.||.|||.||.||..::.:::|||.|:|||:||.|::
 Frog   944 ASATQTIAAAQNAASSNKNPAAQQQLVQSCKVVADQIPMLVQGVRGSQSQPDSPSAQLSLISASQ 1008

  Fly  1010 QFIEPALQVSKSSRALQPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEE 1074
            .|::|..::..:.:|..|||:|..||.||.:...:|...::||.:.||:|.:|||..|::|||..
 Frog  1009 NFLQPGAKLVAAGKAAVPTVSDPASAMQLGQCTKNLASALAELRTAAQKAHEACGPLEIDSALNL 1073

  Fly  1075 VRKLHDVLDDTRQAAIAGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAG 1139
            ||.|...|.:.|.||..|:|:||||:|:|..|.:|..|.|.|..:::|||..::|...:|.|.|.
 Frog  1074 VRSLEQDLQEARAAAREGKLQPLPGETMEKCAQDLGSSTKAVSSSIAQLLGEIVHGNENYTGRAA 1138

  Fly  1140 RDTALALGDFTRSVHGVAATTQNPAI----IDCADDVVTSSARLIEQAQRTLQGASNPEA---LT 1197
            ||.|.||....::..||||.:.:||:    ::||:||:..:..|||:|:|.:...::||.   |.
 Frog  1139 RDVAQALRSLAQASRGVAANSTDPAVQNAMLECAEDVMDKAGNLIEEAKRAVGKPTDPEGQQRLA 1203

  Fly  1198 QAGREVTGALSATVDCIPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSS 1262
            |..:.|:.|||..|:|:||||:||.|::::.|.|:||..|.|||.::.:...|.:|.|.|..|:.
 Frog  1204 QVAKAVSQALSRCVNCLPGQRDVDAAIKSIGEASKILLASSFPPGTKNFQEAQGQLNQAAAGLNQ 1268

  Fly  1263 AGGEIV-VSYSSPALLAESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLL 1326
            :..|:| .|..:|..||::|..::.::.:.|...:|||||:|.:|.::.::.:|:.:|..|..||
 Frog  1269 SANELVQASRGTPQDLAKASGKYSHDFNEFLQAGVEMAGQSQNKEDQAQVVSNLKSISLSSSKLL 1333

  Fly  1327 STAKSIAADPGQPNAKNLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPH 1391
            ..||:::|||..||.|:.|.||||.||:|||||:....|.||||||||||:|.:|.:|.:|..|.
 Frog  1334 LAAKALSADPAAPNLKSQLAAAARAVTDSINQLITVCTQQAPGQKECDNALRELETVRELLQNPT 1398

  Fly  1392 EPINELGYFDCVEQATGKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYL 1456
            ||:|:..||.|::.....|:.||.:::.:..|||.....||.:||:..:.::.||.|:::|||||
 Frog  1399 EPVNDQSYFHCLDSVMENSKVLGESMAGISQNAKTCNLPEFGESVSAASKALCGLTEAAAQAAYL 1463

  Fly  1457 IGVSHPSSVAGRPGIIDQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQ 1521
            :|||.|:|.||:.|::|..|...|.|.|:..|..:.....|:.|::||.|::|||||.||:.||.
 Frog  1464 VGVSDPNSHAGQQGLVDPTQFARANQAIQMACQNLGDPACTQSQVLSAATIVAKHTSALCNACRV 1528

  Fly  1522 ASMNTSNPVAKNEFIVLAKQVATATSDLVQDIKAIEEQSAGGSRERLVD---PLLEAVKAVRQYA 1583
            ||.:|||||||.:|:..||:||.:|::||:.|||::......:|.:..:   ||::||:.:..:|
 Frog  1529 ASTHTSNPVAKRQFVQSAKEVANSTANLVKTIKALDGAFNDDNRVKCRNATVPLIQAVENLTAFA 1593

  Fly  1584 SSSEFSSVPAKISAEGRKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVS 1648
            |:.||:||||:||.||.:|.||::.|.:.:::....:::.|:|||..|.:||.|..|:.||..||
 Frog  1594 SNPEFASVPAQISPEGLRAMEPIVTAAKLMLESSSGLIQTARSLAANPKDPPQWSVLAGHSRTVS 1658

  Fly  1649 ESVKRLVDNIRDKAPGQAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSA 1713
            :|:|:|:.|:|||||||.:|:|.:..|....|:||..:|...:|.|:.|...:......|...|.
 Frog  1659 DSIKKLITNMRDKAPGQRECDQAIELLNQSVRDLDQASLEAISQQLAPREGISQEALHTQMQTSV 1723

  Fly  1714 SELIDKLEPIRMAGKNNAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVES 1778
            .|:.:.:||:..|.:.::.||||.|.::::|..|:.:.||||.:..::.||||:|:.||:::.||
 Frog  1724 QEISNLIEPMAAAARADSSQLGHKVSQMAQYFEPLTHAAIGAASKTINHQQQMNLLDQTKTLAES 1788

  Fly  1779 AITLVQSAKESAGNPR-ATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSIT 1842
            |:.::.::||:.|||: |.|....||:|.....||:::|..|:.:..:..|.|.|:::.:.::|.
 Frog  1789 ALQMLYTSKEAGGNPKVAAHTQEALDEAAQMMHEAVEDLTVTLNEAASAAGAVGGMVDSITQAIN 1853

  Fly  1843 RLTDKRQSLLNASYSDTFVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLT 1907
            :|.::.......|    ||||||.||..||.||....||..||:..|..|..||..:|..|.||.
 Frog  1854 KLDEEPAGEPEGS----FVDYQTTMVKTAKAIAVTVQEMVTKSTTNPDELGTLANQLTNEYGQLA 1914

  Fly  1908 QDSVGASTTTSSPDVAMRIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKV 1970
            |::..|:.|..:.::...|:..|.:||.:.|.:: :.||..:  |||:..:||:..|||.|||||
 Frog  1915 QEAKPAAMTAENEEIGSHIKQRVQELGHNCSLLV-TKAGALQCSPNDSYTKKELIESARRVSEKV 1978

  Fly  1971 AQVLAALQAGSRGTQACINAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKAL 2035
            :.||||||||:|||||||.||..|||||.||||||||||||||:.:...:||||||.||:|||||
 Frog  1979 SHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNRENAETFADHREGILKTAKAL 2043

  Fly  2036 VEDTKVLVTGAAGTQDQLANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASAL 2100
            ||||||||..|..:|::||.|||::|:|||:|||.||.||.|||:..|::||::||||||||.||
 Frog  2044 VEDTKVLVQNATSSQEKLAQAAQSSVTTITRLAETVKLGAASLGAEDPETQVVLINAVKDVAKAL 2108

  Fly  2101 GDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQE 2165
            ||||:.||.|:|||.:|||:..||.||:|||.||:||||||||||||.|:||||:|||:|.|.||
 Frog  2109 GDLISATKAAAGKSSDDPSVYQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATIEHIRQE 2173

  Fly  2166 IRAMHSPPPVGNTQVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCR 2230
            :....||.|...|.. |||.||:|..:|.|||||||||.|..|.|:::.|||.||||::||..|:
 Frog  2174 LAVFSSPEPPPQTST-PEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRSCK 2237

  Fly  2231 SVAWNCAETEELRSRTLEAGTAVGESYRDLLSG---ILHNCSADDRMHL---SRRVAKCVTDLVA 2289
            ...::.....::|.|....|......|..||..   ||...|.:.:..|   |::||..||:|:.
 Frog  2238 EAVYHPEVNADVRMRATRFGKECAIGYLQLLEHVLLILQKPSPELKQQLATHSKQVAGSVTELIQ 2302

  Fly  2290 MARLLKGSDWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILE 2354
            .|..:||::|:||||||||||||||||||:|:||||||..|:||.:..   :.||::.|:|.|||
 Frog  2303 AAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPK---QADESLNFEEQILE 2364

  Fly  2355 AAKGIMGASAALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQ 2419
            |||.|..|::|||:||:||||||:..|||...|..:.||||||:|||||||:|||||.:|.|||.
 Frog  2365 AAKSIAAATSALVKAASAAQRELVAQGKVGAIPANADDDGQWSQGLISAARMVAAATSNLCEAAN 2429

  Fly  2420 NLVRGVGTEEMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKSTDNLVHSAQQG 2484
            :.|:|..:||.|||:||||||||||||:|||||::.:|||.||||.|||||.:::||||.:||:.
 Frog  2430 SAVQGHASEEKLISSAKQVAASTAQLLVACKVKADHDSEAMRRLQVAGNAVKRASDNLVKAAQKA 2494

  Fly  2485 LEAEE-EHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            ...:: :.::.:...||.|:||.|.|:..:||||:||||||:.|..:|..|
 Frog  2495 AAFQDHDETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAMIRQQQ 2545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rheaNP_001246674.1 FERM_f0 4..85 CDD:293120 43/80 (54%)
B41 89..322 CDD:214604 146/233 (63%)
FERM_N 92..147 CDD:286467 29/54 (54%)
FERM_M 215..322 CDD:278785 72/106 (68%)
FERM_C_Talin 318..409 CDD:269973 66/90 (73%)
Talin_middle 510..668 CDD:286254 63/160 (39%)
I_LWEQ 686..>778 CDD:302998 50/91 (55%)
Vinculin <874..>1035 CDD:279395 74/160 (46%)
talin-RS 1661..1832 CDD:213393 58/171 (34%)
Tar <1694..2005 CDD:223910 122/313 (39%)
VBS 1859..1982 CDD:286057 55/124 (44%)
I_LWEQ 2392..2534 CDD:279885 83/142 (58%)
tln1XP_031750909.1 FERM_F0_TLN1 2..85 CDD:340691 44/84 (52%)
FERM_F1_TLN1 86..197 CDD:340693 67/117 (57%)
FERM_M 207..313 CDD:395297 72/106 (68%)
FERM_C_Talin 309..400 CDD:269973 66/90 (73%)
Talin_middle 491..652 CDD:401182 63/160 (39%)
I_LWEQ 607..>775 CDD:418644 80/167 (48%)
talin-RS 1671..1833 CDD:213393 56/161 (35%)
VBS 1866..1990 CDD:312463 56/128 (44%)
ILWEQ 2353..2548 CDD:214607 111/193 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 423 1.000 Domainoid score I624
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2210 1.000 Inparanoid score I41
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7374at33208
OrthoFinder 1 1.000 - - FOG0003071
OrthoInspector 1 1.000 - - otm48725
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1785
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
66.060

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