DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rhea and Tln2

DIOPT Version :9

Sequence 1:NP_001246674.1 Gene:rhea / 38978 FlyBaseID:FBgn0260442 Length:2836 Species:Drosophila melanogaster
Sequence 2:XP_006511496.1 Gene:Tln2 / 70549 MGIID:1917799 Length:2559 Species:Mus musculus


Alignment Length:2593 Identity:1220/2593 - (47%)
Similarity:1727/2593 - (66%) Gaps:108/2593 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||:|||::..||..||.|:||||:|||..::|:|||
Mouse     3 MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRKGIWLE 67

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..::|||||:|||::||||:.|.:|:|.||::|||||:|||.
Mouse    68 AGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYS 132

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDR-----DAKMESLRKKLKTDDEMNWVDVSRTLRE 190
            |::|..|.:.|.      ||.|||     |||     :.|||.|:.||.|||::||:|.|||.||
Mouse   133 LIQETIEEKKEE------GTGTLK-----KDRTLLRDERKMEKLKAKLHTDDDLNWLDHSRTFRE 186

  Fly   191 QGIDEAETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQF 255
            ||:||.||:||||:||:||||:|||||||||||||||||.||:|:|||:.:|||||.|.|..|||
Mouse   187 QGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEFGGFQAQIQF 251

  Fly   256 GPHNEAKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVT 320
            |||.|.|||.||||||:|||:.|::.:|.||:||.||:...::|||:|||.|.|.||.|.||||:
Mouse   252 GPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVS 316

  Fly   321 FFLVKEKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQ 385
            ||||||||.|||||||||||:|||||:|:||.|||:|..||||||:||.|||.:||||||:|...
Mouse   317 FFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQES 381

  Fly   386 YYSVQTTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQ 450
            ||||||||.|||.|||||||||||||||:||.||:||||.|||:||||:|.|:|.||.:.||..:
Mouse   382 YYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQFNRTGK 446

  Fly   451 LNVESLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRAL 514
            ....|:|.|.:||. ..|..::....:.:.|....|||::..|.||           ||..|:||
Mouse   447 AEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMVGQMHRGHMPP-----------LTSAQQAL 500

  Fly   515 LGYISAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII-- 577
            :|.|:.....:.:|.::|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::  
Mouse   501 MGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNL 565

  Fly   578 TASHPDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKA 641
            ||..|.:.|..|:..:::.|:..:.|::|.|:|:||||::|. ||:.||.|||.|..|.||||||
Mouse   566 TAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDDVGSGEDLLRAARTLAGAVSDLLKA 630

  Fly   642 AEPESKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKN 706
            .:|.|.||.|.::.||..:|:|:..:|..|.|.|..|.  ..|:|::|||||||..|.|||:|||
Mouse   631 VQPTSGEPRQTVLTAAGSIGQASGDLLRQIGENETDER--FQDVLMSLAKAVANAAAMLVLKAKN 693

  Fly   707 IAASCDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEV 771
            :|...:|...:||||.||:||||:|||||||||||:||:.:..|:|||..|.|.|.|:|.:....
Mouse   694 VAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRA 758

  Fly   772 CNEASNDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHANR----------TSTELSPVENVII 826
            |..|::|.:|...:.|||..||::|.|:|:||    |:.|:|          |.|.:...|:   
Mouse   759 CQAATSDSELLKQVSAAASVVSQALHDLLQHV----RQFASRGEPIGRYDQATDTIMCVTES--- 816

  Fly   827 GTDILVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEA 891
               |..|..|..||||.||.|.|.|:.|:.:::.:|:.:.|.:..:.||:|||.|||:||::|||
Mouse   817 ---IFSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEA 878

  Fly   892 ARLCSSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQN 956
            |:..::||.:.|.|..||:|||.|| :.|.||...|:|:.::.|||..:||||:||||.|:|:||
Mouse   879 AKGAAANPENEDQQQRLREAAEGLR-VATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQN 942

  Fly   957 AVQHSQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKS 1021
            |...:::...::.|:|.||.|||.||:||..::.::||.:|.:|||.||.:::.|::|..::..|
Mouse   943 AAISNKNPSAQQQLVQSCKAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSS 1007

  Fly  1022 SRALQPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTR 1086
            ::|..|||:|..:|.|||:.|.:|...::||.:.:|:|.:|||..|::|||..|:.|.:.|.|.:
Mouse  1008 AKAAVPTVSDQAAAMQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAK 1072

  Fly  1087 QAAIAGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTR 1151
            .||...||:||||:|:|..|.:|..::|.||.:::|||:........|.|.|.|:||.||....:
Mouse  1073 MAAAESQLKPLPGETLEKCAQDLGSTSKGVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQ 1137

  Fly  1152 SVHGVAATTQNP----AIIDCADDVVTSSARLIEQAQRTLQGASNPEA---LTQAGREVTGALSA 1209
            :..||||:|.:|    |::|.|.||:..||.||::|::.|....:.|:   |.|..:.|:.:|:.
Mouse  1138 AARGVAASTNDPEAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDTESQQRLAQVAKAVSHSLNN 1202

  Fly  1210 TVDCIPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSS 1273
            .|:|:|||::|||||:::.|.|:.|.:...|||::|:...||||.|.|..|:.:.||:| .:...
Mouse  1203 CVNCLPGQKDVDVALKSIGEASKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVHATRGQ 1267

  Fly  1274 PALLAESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQ 1338
            ...||.:|..|:.::.:.|...:|||||.|.:|.:..:|.:|:::|..|..||..|||::.|||.
Mouse  1268 SGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQMQVIGNLKNISMASSKLLLAAKSLSVDPGA 1332

  Fly  1339 PNAKNLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCV 1403
            |||||||.||||.||||||||:....|.||||||||||:|.:|.::.||:.|:||:::|.||||:
Mouse  1333 PNAKNLLAAAARAVTESINQLIMLCTQQAPGQKECDNALRELETVKGMLENPNEPVSDLSYFDCI 1397

  Fly  1404 EQATGKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGR 1468
            |.....|:.||.:::.:..|||......|.:.|...:.::.||.|:::|||||:|:|.|:|.||.
Mouse  1398 ESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTEAAAQAAYLVGISDPNSQAGH 1462

  Fly  1469 PGIIDQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKN 1533
            .|::|..|...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:|||||.
Mouse  1463 QGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKR 1527

  Fly  1534 EFIVLAKQVATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKI 1595
            .|:..||:||.:|::||:.|||::...:..:|.:   ...||:|||:.:..:||:.||:|:||:|
Mouse  1528 HFVQSAKEVANSTANLVKTIKALDGDFSEDNRNKCRIATTPLIEAVENLTAFASNPEFASIPAQI 1592

  Fly  1596 SAEGRKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRD 1660
            |:||.:||||::.:.:.:::....:::.|:|||:.|.:||.|..|:.||..||:|:|.|:.:|||
Mouse  1593 SSEGSQAQEPILVSAKTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRD 1657

  Fly  1661 KAPGQAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRM 1725
            |||||.:|:..:..:..|.|:::..:||..:|.|:.|.|.::.....|..:...|:...::||..
Mouse  1658 KAPGQRECDYSIDGINRCIRDIEQASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIAT 1722

  Fly  1726 AGKNNAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESA 1790
            |.:..|.||||.|.:::.|..|::..|:|..:.::..||||:::.||:::.|||:.::.:|||..
Mouse  1723 AARGEAAQLGHKVTQLASYFEPLILAAVGVASKMLDHQQQMTVLDQTKTLAESALQMLYAAKEGG 1787

  Fly  1791 GNPRATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNAS 1855
            |||:|.|.|..:.:|....:||:.::..|:.:..:|.|:|.|:::.:..::::|.:...    ..
Mouse  1788 GNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTP----PE 1848

  Fly  1856 YSDTFVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSP 1920
            ...|||||||.:|..:|.||..|.||..||...|..|..||..||.:|..|......|:.|....
Mouse  1849 PKGTFVDYQTTVVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTTDYGHLALQGQMAAATAEPE 1913

  Fly  1921 DVAMRIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRG 1983
            ::..:|||.|.|||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::|
Mouse  1914 EIGFQIRTRVQDLGHGCIFLVQ-KAGALQVCPTDSYTKRELIECARSVTEKVSLVLSALQAGNKG 1977

  Fly  1984 TQACINAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAG 2048
            |||||.||..|||||.||||||||||||||:::...:||||||:||:||||||||||:||:|||.
Mouse  1978 TQACITAATAVSGIIADLDTTIMFATAGTLNAENGETFADHRENILKTAKALVEDTKLLVSGAAS 2042

  Fly  2049 TQDQLANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASALGDLINCTKLASGK 2113
            |.|:||.|||::.:|||||||.||.||.||||..|::||::|||:||||.||.|||..||.|:.|
Mouse  2043 TPDKLAQAAQSSAATITQLAEVVKLGAASLGSNDPETQVVLINAIKDVAKALSDLIGATKGAASK 2107

  Fly  2114 SINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQEIRAMHSPPPVGNT 2178
            ..:||||..||.:|:|||.||:||||||||||||.||||||:|||:|.|.||:....|......|
Mouse  2108 PADDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIEYIKQELTVFQSKDIPEKT 2172

  Fly  2179 QVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELR 2243
            . .||:.||:|..:|.|||||||||.|..|.|:::.|||.|:|:|:|||.|:..::....:||:|
Mouse  2173 S-SPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLIACKQASFYPDVSEEVR 2236

  Fly  2244 SRTLEAGTAVGESYRDLLSGIL-----------HNCSADDRMHLSRRVAKCVTDLVAMARLLKGS 2297
            :|.|..||.....|.|||..:|           |..:|     .|:|||..||:|:..|..:||:
Mouse  2237 TRALRYGTECTLGYLDLLEHVLVILQKPTPELKHQLAA-----FSKRVAGAVTELIQAAEAMKGT 2296

  Fly  2298 DWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILEAAKGIMGA 2362
            :|:||||||||||.|||||||||:||||||..|:||.:..   :.||.:.|:|.||||||.|..|
Mouse  2297 EWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPK---QADETLDFEEQILEAAKSIAAA 2358

  Fly  2363 SAALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQNLVRGVGT 2427
            ::|||::|:||||||:..|||...|..::||||||:|||||||:|||||.||.|||...|:|..:
Mouse  2359 TSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAATSSLCEAANASVQGHAS 2423

  Fly  2428 EEMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQ---------------AAGNAVIKSTDNL 2477
            ||.|||:||||||||||||:|||||::.:|||.:|||               ||||||.:::|||
Mouse  2424 EEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQVMVTDAGGKILLLERAAGNAVKRASDNL 2488

  Fly  2478 VHSAQQGLEAE-EEHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            |.:||:....: ::..:.:.|..|.|:||.|.|:..:|:||:||||||:.|..:|..|
Mouse  2489 VRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQ 2546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rheaNP_001246674.1 FERM_f0 4..85 CDD:293120 46/80 (58%)
B41 89..322 CDD:214604 142/237 (60%)
FERM_N 92..147 CDD:286467 29/54 (54%)
FERM_M 215..322 CDD:278785 70/106 (66%)
FERM_C_Talin 318..409 CDD:269973 71/90 (79%)
Talin_middle 510..668 CDD:286254 60/160 (38%)
I_LWEQ 686..>778 CDD:302998 51/91 (56%)
Vinculin <874..>1035 CDD:279395 73/160 (46%)
talin-RS 1661..1832 CDD:213393 54/170 (32%)
Tar <1694..2005 CDD:223910 114/312 (37%)
VBS 1859..1982 CDD:286057 52/124 (42%)
I_LWEQ 2392..2534 CDD:279885 83/157 (53%)
Tln2XP_006511496.1 FERM_F0_TLN2 6..89 CDD:340692 46/82 (56%)
FERM_F1_TLN2 90..201 CDD:340694 65/121 (54%)
FERM_M 211..318 CDD:395297 70/106 (66%)
FERM_C_Talin 314..405 CDD:269973 71/90 (79%)
Talin_middle 496..657 CDD:401182 60/160 (38%)
I_LWEQ 691..>767 CDD:418644 40/75 (53%)
talin-RS 1047..>1176 CDD:213393 53/128 (41%)
talin-RS 1658..1829 CDD:213393 54/170 (32%)
VBS 1852..1976 CDD:312463 52/124 (42%)
ILWEQ 2339..2549 CDD:214607 110/208 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167842171
Domainoid 1 1.000 861 1.000 Domainoid score I56
eggNOG 1 0.900 - - E1_KOG4261
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56692
Inparanoid 1 1.050 2178 1.000 Inparanoid score I40
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7374at33208
OrthoFinder 1 1.000 - - FOG0003071
OrthoInspector 1 1.000 - - otm43564
orthoMCL 1 0.900 - - OOG6_103395
Panther 1 1.100 - - O PTHR19981
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4187
SonicParanoid 1 1.000 - - X1785
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.790

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