DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rhea and tln2a

DIOPT Version :9

Sequence 1:	NP_001246674.1	Gene:	rhea / 38978	FlyBaseID:	FBgn0260442	Length:	2836	Species:	Drosophila melanogaster
Sequence 2:	XP_009301497.1	Gene:	tln2a / 556842	ZFINID:	ZDB-GENE-040724-263	Length:	2548	Species:	Danio rerio

Alignment Length:	2576	Identity:	1222/2576 - (47%)
Similarity:	1720/2576 - (66%)	Gaps:	83/2576 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||:|||::..||..||.||||||:|||..::|:|||
Zfish     1 MVALSLKICVRQCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASEYGLFLSDEDPRKGIWLE 65

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..:|:|||||||||:||||:.|.:|:|.||::|||||:|||.
Zfish    66 GGRTLDYYMLRNGDILEYKKKQRPQKVKMLDGAVKTIMVDDSKTVGELLVTICSRIGITNYEEYS 130

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGIDE 195
            |::|..|.:.    |...|||...|.::.::|  |||.|:.||.|||::||:|..||.||||::|
Zfish   131 LIQETVEEKK----DEGTGTLKKDRTLLREER--KMEKLKAKLHTDDDLNWLDHGRTFREQGVEE 189

  Fly   196 AETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNE 260
            :||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||.|||..||||||.|
Zfish   190 SETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFGGIQTQIQFGPHIE 254

  Fly   261 AKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVK 325
            .||||||||||:|||:.|::.:|.|||||.||:...:::||:|||.|.|.||.|.||||:|||||
Zfish   255 HKHKTGFLDLKEFLPKEYIKQRGAEKKIFQEHKGCGEMTEIEAKVKYVKLARSLRTYGVSFFLVK 319

  Fly   326 EKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSVQ 390
            |||..|||||||||||||:||:|:||.||:::..||||||:||.|||.:||||||:|...|||||
Zfish   320 EKMKSKNKLVPRLLGVTKESVMRVDEKTKDVVQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQ 384

  Fly   391 TTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVES 455
            |||.|||.|||||||||||||||:||.||:||||.:||:||||:|.|:|.||.:.||:.::...|
Zfish   385 TTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEEATMLEESVSPKKSTILQQQFNRVGRVEHGS 449

  Fly   456 LAHPGIMRPYD-GERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYIS 519
            :|.|||:|... |..:.....:...|.....||::..|.||           |:..|:||:|.|:
Zfish   450 VALPGILRSGSVGAETLNMGTMPAPQQQITTGQMHLGHMPP-----------LSAAQQALVGTIN 503

  Fly   520 AGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASHP 582
            .....:.:|.::|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::  ||..|
Zfish   504 TSMQAVQQAQDDLEEVEELPPLGDDMASKMWIQNKMDESKHDIHSQVDAITAGTASVVNLTAGDP 568

  Fly   583 DEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKAAEPES 646
            .:.|..|:..:::.|:..:.|::|.|:|:|||||::. ||..|:.|||.|..|.||||||.||.|
Zfish   569 TDTDYTAVGCAITTISSNLTEMSKGVKLLAALMEDEVGSGHDLMRAARTLTGAVSDLLKAVEPTS 633

  Fly   647 KEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKNIAASC 711
            .||.|.::.||..:|:|:..:|..|.|.|..|.  ..|:|:.|||||||..|.:||:|||:|...
Zfish   634 GEPRQTVLTAAGSIGQASGDLLRQIGENETDER--FQDVLMNLAKAVANAAAMMVLKAKNVAQVS 696

  Fly   712 DDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNEAS 776
            :|...:||||.||:||||:|||||||||||:||:.:..|:|||..|.|.|.|:|....:.|..|:
Zfish   697 EDSVMQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVEGCVKACLSAT 761

  Fly   777 NDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHANR----------TSTELSPVENVIIGTDIL 831
            :|.:|...:.|||..|:::|:|:|.||    |.:|.|          |.|.::..||      |.
Zfish   762 SDGELLKAVSAAAGIVTQALSDLLTHV----RNYATRGEPIGRYDQATDTIMNVTEN------IF 816

  Fly   832 VSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAARLCS 896
            .|..|..||||.||.|.|.|:.|:.:::.:|:.:.|.:..:.||:|||.||||||::||||:..:
Zfish   817 SSMGDAGEMVRQARVLAQATSDLVNAMRSDAEVEVDVNNSKKLLAAAKLLADATARMVEAAKGAA 881

  Fly   897 SNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAVQHS 961
            :.|.:.|.|..||:|||.|| :.|.||...|:|:.||.|||..:||||:||||.|:|:|||...:
Zfish   882 AYPENEDQQQKLREAAEGLR-VATNAAAQNAIKKKLITRLENAAKQAAAAATQTIAASQNAAASN 945

  Fly   962 QDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSRALQ 1026
            ::....:.|:|.|:.|||.||:||..::.::.||:|.:|||.||.|::.|::|..::..|:::..
Zfish   946 KNTAAHQQLVQSCRAVADHIPQLVQGVRGSQGQPEDGSAQLALIIASKNFLQPGSKMVSSAKSSV 1010

  Fly  1027 PTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQAAIA 1091
            |||||..:|.||.:.|.:|...::||.:.||.|.:|||..|::|||..|:.|.:.|.|.:.||..
Zfish  1011 PTVTDQAAAMQLGQCAKNLATTLAELRTAAQTAHEACGPMEIDSALIAVQTLKNELQDAKMAASE 1075

  Fly  1092 GQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSVHGV 1156
            |||:||||:::|..|.:|..::|.||.:::|||:........|.|.|..:||.||....::..||
Zfish  1076 GQLKPLPGESLEKCAQDLGGTSKAVGSSMAQLLTCAAQGNEHYTGVAASETAQALKTLAQAARGV 1140

  Fly  1157 AATTQNP----AIIDCADDVVTSSARLIEQAQRTLQGASNPE---ALTQAGREVTGALSATVDCI 1214
            ||||.:|    |::|.|.:|:..||:||.:|:..|....:.|   .|.|..:.|:.:|:|.|:|:
Zfish  1141 AATTSDPAGAAAMLDSAREVMEGSAKLISEAKEALVAPGDAEIQQRLAQVAKAVSHSLNACVNCL 1205

  Fly  1215 PGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPALLA 1278
            |||::||:||:::.|.|:.|.:...||.|:.:...||:|.|.|..|:.:.|::| .|..:...||
Zfish  1206 PGQKDVDMALKSIGEASKKLLVETLPPCSKSFQEAQSDLNQTAADLNQSAGDVVHASRGTTTQLA 1270

  Fly  1279 ESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAKN 1343
            ::|..|:.|:.:.|...:||||.|..::.:..:|.:|:::|..|..||..|||::.|||..||||
Zfish  1271 DASGKFSDNFDEFLDAGIEMAGHTPGKDDQLQVIGNLKNISMASSKLLLAAKSLSVDPGAGNAKN 1335

  Fly  1344 LLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQATG 1408
            ||.||||.||:|||||:....|:||||:|||||:|.:||:|.:||.|:||:|:|.||||:|....
Zfish  1336 LLAAAARSVTDSINQLITMCTQNAPGQRECDNALRELEAVRGLLDNPNEPVNDLSYFDCIESVME 1400

  Fly  1409 KSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGIID 1473
            .|:.||.:::.:.:|.|......|...|...:.::.||.|::.||:||:|||.|||.||.||::|
Zfish  1401 NSKVLGESMAGISHNCKTGDVPAFGDCVGGASKALCGLTEAAGQASYLVGVSDPSSQAGHPGLVD 1465

  Fly  1474 QAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIVL 1538
            ..|...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:|||||..|:..
Zfish  1466 PIQFARANQAIQMACQNLVDPDSSPSQVLSAATIVAKHTSALCNACRLASSKTANPVAKRHFVQS 1530

  Fly  1539 AKQVATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKISAEGR 1600
            ||:||.:|::||:.|||::...:..:||:   ...||:|||..:..:||:.||:||||:||.||.
Zfish  1531 AKEVANSTANLVKTIKALDGDFSEENREKCRIATAPLIEAVDNLTIFASNPEFASVPAQISREGS 1595

  Fly  1601 KAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPGQ 1665
            .||||:||:.|.::|....::|.|:||.:.|.:||.|..|:.||..||:|:|.|:..||||||||
Zfish  1596 AAQEPIIQSARSMLDSSTHLLKTARSLVMNPKDPPTWSLLAGHSRTVSDSIKSLITAIRDKAPGQ 1660

  Fly  1666 AQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKNN 1730
            .:|:..:..:..|.|:::..:||..:|.|.:|.:.:......|..:|..|:...:|||..|.|..
Zfish  1661 KECDSAIDNINKCIRDIEQASLAAVSQNLPRRDEVSSEALQEQLTSSVQEVGHLIEPITTAAKGE 1725

  Fly  1731 AEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPRA 1795
            |.||||.|.::..|..|:|:.::|..:..:..||||:|:.||:::.|||:.::.:|||..|||:|
Zfish  1726 AAQLGHKVSQLVSYFTPLVSASMGIASKTLDHQQQMNLLDQTKTLAESALQMLYAAKEGGGNPKA 1790

  Fly  1796 THAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDTF 1860
            :|.|..:.:|....|||:.:|..|:.:..:|.|:|:|:::.:..|:.:|.:........|    |
Zfish  1791 SHTHDAIAEAAQLMREAVDDLLLTLNEAASEVGMVSGMVDSIADSMGKLGEGTPPEPEGS----F 1851

  Fly  1861 VDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAMR 1925
            |:|||.||..:|.||..|.||..||...|..|..||..:|.:|.||......||.|....::..:
Zfish  1852 VEYQTTMVRYSKAIAVSAQEMITKSVSSPEDLCSLASQVTADYSQLAVQGRLASATAEPEEIGFQ 1916

  Fly  1926 IRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQACI 1988
            |:|:|.:||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::||||||
Zfish  1917 IKTSVQELGHGCIVLVQ-KAGALQISPTDSFTKRELIECARAVTEKVSMVLSALQAGNKGTQACI 1980

  Fly  1989 NAAHTVSGIIGDLDTTIMFATAGTLHSDGDG-SFADHREHILQTAKALVEDTKVLVTGAAGTQDQ 2052
            .||..|||||.|||||||||:||||:::.|. |||||||:||:||||||||||.||:|||.:|::
Zfish  1981 TAASAVSGIIADLDTTIMFASAGTLNAENDSDSFADHRENILKTAKALVEDTKNLVSGAASSQEK 2045

  Fly  2053 LANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASALGDLINCTKLASGKSIND 2117
            ||.|||::..|||||.:.||.||.|:|...|::||::||||||||.||.:||:.||.|:||:.:|
Zfish  2046 LAQAAQSSAKTITQLTDVVKLGAASIGPDDPETQVVLINAVKDVAKALAELISATKCAAGKAADD 2110

  Fly  2118 PSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQEIRAMHS--PPPVGNTQV 2180
            |||..||.:|:|||.||:||||||||||||.:|||||:|||:|.|.||:....|  .|...:|
Zfish  2111 PSMFQLKSAAKVMVTNVTSLLKTVKAVEDEASRGTRALEATIECIRQELTMFQSKETPEKSST-- 2173

  Fly  2181 GPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELRSR 2245
             ||:.||:|..:|.|||||||||.|..|.|::|.|||.|:.|::||..|:..|:|...:.|:|||
Zfish  2174 -PEEFIRMTKGITTATAKAVAAGNSARQEDVISTANLSRKVIADMLTSCKQAAFNEEVSVEVRSR 2237

  Fly  2246 TLEAGTAVGESYRDLLS---GILHNCSADDRMHL---SRRVAKCVTDLVAMARLLK-----GSDW 2299
            .|..||.....|.|||.   .:|...:.|.:..|   |::||..||:|:..|..:|     .::|
Zfish  2238 ALLYGTECTNGYIDLLEHVLQVLQKPTGDQKQKLAMFSKKVAAAVTELIQTAEAMKDEGVYSTEW 2302

  Fly  2300 IDPEDPTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILEAAKGIMGASA 2364
            :||||||||||.|||||||||:||||||..|:||.:..   :.||::.|:|.||||||.|..|::
Zfish  2303 VDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPK---QADESLDFEEQILEAAKSIAAATS 2364

  Fly  2365 ALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQNLVRGVGTEE 2429
            |||::|:||||||:..|||...|..:.||||||:|||||||:|||||.:|.|||...|:|..:||
Zfish  2365 ALVKSASAAQRELVAQGKVGAIPANAVDDGQWSQGLISAARMVAAATSNLCEAANASVQGHASEE 2429

  Fly  2430 MLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKSTDNLVHSAQQ-GLEAEEEHSL 2493
            .|||:||||||||||||:|||||::.:|||.||||||||||.:::||||.:||: .....::.::
Zfish  2430 KLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRAAQKAAFNKADDDNV 2494

  Fly  2494 KINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            .:.|..|.|:||.|.|:..:||||:||||||:.|..:|..|
Zfish  2495 VVKTRFVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQ 2535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_001246674.1	FERM_f0	4..85	CDD:293120	47/80 (59%)
		B41	89..322	CDD:214604	142/232 (61%)
		FERM_N	92..147	CDD:286467	31/54 (57%)
		FERM_M	215..322	CDD:278785	73/106 (69%)
		FERM_C_Talin	318..409	CDD:269973	68/90 (76%)
		Talin_middle	510..668	CDD:286254	60/160 (38%)
		I_LWEQ	686..>778	CDD:302998	50/91 (55%)
		Vinculin	<874..>1035	CDD:279395	75/160 (47%)
		talin-RS	1661..1832	CDD:213393	59/170 (35%)
		Tar	<1694..2005	CDD:223910	119/312 (38%)
		VBS	1859..1982	CDD:286057	50/124 (40%)
		I_LWEQ	2392..2534	CDD:279885	84/142 (59%)
tln2a	XP_009301497.1	FERM_f0	4..85	CDD:293120	47/80 (59%)
		B41	90..316	CDD:214604	142/231 (61%)
		FERM_N	92..188	CDD:286467	54/101 (53%)
		FERM_M	206..316	CDD:278785	75/109 (69%)
		FERM_C_Talin	312..403	CDD:269973	68/90 (76%)
		Talin_middle	494..655	CDD:286254	60/160 (38%)
		talin-RS	1045..>1174	CDD:213393	52/128 (41%)
		talin-RS	1656..1827	CDD:213393	59/170 (35%)
		VBS	1850..1974	CDD:286057	51/128 (40%)
		talin-RS	1975..2141	CDD:213393	111/165 (67%)
		ILWEQ	2343..2538	CDD:214607	111/193 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586574
Domainoid	1	1.000	895	1.000	Domainoid score	I50
eggNOG	1	0.900	-	-		E1_KOG4261
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56692
Inparanoid	1	1.050	2225	1.000	Inparanoid score	I36
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7374at33208
OrthoFinder	1	1.000	-	-		FOG0003071
OrthoInspector	1	1.000	-	-		otm24245
orthoMCL	1	0.900	-	-		OOG6_103395
Panther	1	1.100	-	-	O	PTHR19981
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1785
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760