DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rhea and Tln1

DIOPT Version :9

Sequence 1:	NP_001246674.1	Gene:	rhea / 38978	FlyBaseID:	FBgn0260442	Length:	2836	Species:	Drosophila melanogaster
Sequence 2:	XP_038965907.1	Gene:	Tln1 / 313494	RGDID:	1306247	Length:	2559	Species:	Rattus norvegicus

Alignment Length:	2589	Identity:	1215/2589 - (46%)
Similarity:	1706/2589 - (65%)	Gaps:	97/2589 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||||.:  |.|.||:||:|:|.|:|||::||::..||:.|.||::|||:||:..::|:|||
  Rat     1 MVALSLRISI--GNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPSDFGLFLSDDDPKKGIWLE 63

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .|:.|.||:|.|.||:|||:|.|.|::|||||.||||:||||:.|:.:::.||.:||||||:||.
  Rat    64 AGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYS 128

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKR-KIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGID 194
            ||||..|.:.:.      ||.||:: |.:.:| :.|||.|::||.||||:||:|..|||||||::
  Rat   129 LVRELMEEKKDE------GTGTLRKDKTLLRD-EKKMEKLKQKLHTDDELNWLDHGRTLREQGVE 186

  Fly   195 EAETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHN 259
            |.||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||||.|..|||||||
  Rat   187 EHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHN 251

  Fly   260 EAKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLV 324
            |.|||.||||||||||:.||:.|| |:|||..|:....:|||:|||.|.|.||.|.||||:||||
  Rat   252 EQKHKAGFLDLKDFLPKEYVKQKG-ERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLV 315

  Fly   325 KEKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSV 389
            ||||.|||||||||||:||:.|:|:||.|||::..|.||.::||.|||.:||||||||.:.||||
  Rat   316 KEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSV 380

  Fly   390 QTTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVE 454
            ||||.|||.||||||||||||||::|||||:||||.|||:|:||:|.|:|.||.:.||:.:....
  Rat   381 QTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKAEHG 445

  Fly   455 SLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYI 518
            |:|.|.|||. ..|..::....:...|.....||::..|.||           ||..|:||.|.|
  Rat   446 SVALPAIMRSGASGPENFQVGSMPPAQQQVTSGQMHRGHMPP-----------LTSAQQALTGTI 499

  Fly   519 SAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASH 581
            ::....:..|...|.....:..||.|..|..||:|.:|.||..:.|.|..::|.||.::  ||..
  Rat   500 NSSMQAVQAAQAALDDFDALPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGD 564

  Fly   582 PDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMEND-TSGDQLLEAARNLCSAFSDLLKAAEPE 645
            |.|.|..|:..:|:.|:..:.|:::.|:|:|||:|:: .:|..||:||:.|..|.|:||::|:|.
  Rat   565 PAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPA 629

  Fly   646 SKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLH-------------------DMLLALAK 691
            |.||.|:|:.||..||:|:..:|..|.|.:.    |.|                   |:|:.|||
  Rat   630 SAEPRQNLLQAAGNVGQASGELLQQIGESDT----DPHFQMFVPRGAGAPSPPDSPTDILMQLAK 690

  Fly   692 AVANTTAALVLRAKNIAASCDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEA 756
            |||:..|||||:||::|...:|...:.:||.||:||||:|||||||.||||||:.:..|:|||..
  Rat   691 AVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVE 755

  Fly   757 AAKNVARAVNSLCEVCNEASNDPKLKADLLAAARDVSKSLTDMLEHVKLSSR------EHANRTS 815
            |.:.||:||.........|:.|.:|...:.|||..|:::|.::|:|||..:.      .:...|.
  Rat   756 AGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATD 820

  Fly   816 TELSPVENVIIGTDILVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQ 880
            |.|:..||      |..|..|..||||.||.|.|.|:.|:.:||.:|:.:.|.:..|.||||||.
  Rat   821 TILTVTEN------IFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKI 879

  Fly   881 LADATAKLVEAARLCSSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAAS 945
            |||||||:||||:..:::|...:.|..||:|||.||..|..||.. |:|:.|:||||..:||||:
  Rat   880 LADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQN-AIKKKLVQRLEHAAKQAAA 943

  Fly   946 AATQCISAAQNAVQHSQDHQTKETLL-QDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAE 1009
            :|||.|:|||:|....:.....:.|| |.||.||:.||.||..::.::||||.|:|||.||.|::
  Rat   944 SATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQ 1008

  Fly  1010 QFIEPALQVSKSSRALQPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEE 1074
            .|::|..::..:::|..||:.|..||.|||:.|.:||..::||.:.||:|::|||..|::|||..
  Rat  1009 SFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSV 1073

  Fly  1075 VRKLHDVLDDTRQAAIAGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAG 1139
            |:.|...|.:.:.||..|:|:||||:|:|....:|..|.|.|..|:::||..:.....:|||.|.
  Rat  1074 VQNLEKDLQEIKAAAREGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAA 1138

  Fly  1140 RDTALALGDFTRSVHGVAATTQNPA----IIDCADDVVTSSARLIEQAQRTLQGASNPEA---LT 1197
            ||.|..|....::..||||.|.:||    ::|.|.|.:..::.|||:|::......:||:   |.
  Rat  1139 RDVAGGLRSLAQAARGVAALTTDPAVQAIVLDTASDALDKASSLIEEAKKASGHPGDPESQQRLA 1203

  Fly  1198 QAGREVTGALSATVDCIPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSS 1262
            |..:.||.||:..|.|:||||:||.|||.|.:.|:.|.....|||:..:...||.|.:.|..|:.
  Rat  1204 QVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQ 1268

  Fly  1263 AGGEIV-VSYSSPALLAESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLL 1326
            |..|:| .|..:|..||.:|..|..::...|...:|||||...:|.|:.::.:|:.:|..|..||
  Rat  1269 AATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLL 1333

  Fly  1327 STAKSIAADPGQPNAKNLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPH 1391
            ..||:::.||..||.|:.|.||||.||:|||||:....|.||||||||||:|.:|.:|.:|:.|.
  Rat  1334 LAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPV 1398

  Fly  1392 EPINELGYFDCVEQATGKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYL 1456
            :|||::.||.|::.....|:.||.|::.:..|||.....||..::...:.::.|..|:::|||||
  Rat  1399 QPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYL 1463

  Fly  1457 IGVSHPSSVAGRPGIIDQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQ 1521
            :|||.|:|.||:.|:::..|...|.|.|:..|..:.....|:.|::||.|::|||||.||:.||.
  Rat  1464 VGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRL 1528

  Fly  1522 ASMNTSNPVAKNEFIVLAKQVATATSDLVQDIKAIE----EQSAGGSRERLVDPLLEAVKAVRQY 1582
            ||..|:||.||.:|:..||:||.:|::||:.|||::    |::....|.... ||||||..:..:
  Rat  1529 ASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATA-PLLEAVDNLSAF 1592

  Fly  1583 ASSSEFSSVPAKISAEGRKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPV 1647
            ||:.|||||||:||.|||.|.||::.:.:.:::....:::.|::||:.|.:||.|..|:.||..|
  Rat  1593 ASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTV 1657

  Fly  1648 SESVKRLVDNIRDKAPGQAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNS 1712
            |:|:|:|:.::|||||||.:||..:..|.:|.|:||..:||..:|.|:.|...:......|.:.:
  Rat  1658 SDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTA 1722

  Fly  1713 ASELIDKLEPIRMAGKNNAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVE 1777
            ..|:...:||:..|.:..|.||||.|.::::|..|:...|:||.:..:...|||:|:.||:::.|
  Rat  1723 VQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAE 1787

  Fly  1778 SAITLVQSAKESAGNPR-ATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSI 1841
            ||:.|:.:|||:.|||: |.|....|::|:....||:::|..|:.:..:..|:|.|:::.:.::|
  Rat  1788 SALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAI 1852

  Fly  1842 TRLTDKRQSLLNASYSDTFVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQL 1906
            .:|.:........|    ||||||.||..||.||....||..||:..|..|..||..:|.:|.:|
  Rat  1853 NQLDEGPMGEPEGS----FVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRL 1913

  Fly  1907 TQDSVGASTTTSSPDVAMRIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEK 1969
            ...:..|:....:.::...|:..|.:||...|::: :.||..:  |:|...:||:...||.||||
  Rat  1914 ASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALV-TKAGALQCSPSDVYTKKELIECARRVSEK 1977

  Fly  1970 VAQVLAALQAGSRGTQACINAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKA 2034
            |:.||||||||:|||||||.||..|||||.||||||||||||||:.:|..:||||||.||:|||.
  Rat  1978 VSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKV 2042

  Fly  2035 LVEDTKVLVTGAAGTQDQLANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASA 2099
            |||||||||..|||:|::||.|||::|:|||:||:.||.||.|||:..|::||::||||||||.|
  Rat  2043 LVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKA 2107

  Fly  2100 LGDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQ 2164
            |||||:.||.|:||..:||::..||.||:|||.||:||||||||||||.|:||||:|||.|.|.|
  Rat  2108 LGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQ 2172

  Fly  2165 EIRAMHSPPPVGNTQVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVC 2229
            |:....||.|...|.. |||.||:|..:|.|||||||||.|..|.|:::.|||.||||::||..|
  Rat  2173 ELAVFCSPEPPAKTST-PEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRAC 2236

  Fly  2230 RSVAWNCAETEELRSRTLEAGTAVGESYRDLLSGI----LHNCSADDRMHL---SRRVAKCVTDL 2287
            :..|::.....::|.|.|..|......|.:||..:    |...:.:.:..|   |:|||..||:|
  Rat  2237 KEAAFHPEVAPDVRLRALHFGRECANGYLELLDHVLLPTLQKPNPELKQQLTGHSKRVAGSVTEL 2301

  Fly  2288 VAMARLLKGSDWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMI 2352
            :..|..:||::|:||||||||||||||||||:|:||||||..|:||.:..   |.||::.|:|.|
  Rat  2302 IQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPK---EADESLNFEEQI 2363

  Fly  2353 LEAAKGIMGASAALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEA 2417
            |||||.|..|::|||:||:||||||:..|||...|..:.||||||:|||||||:|||||::|.||
  Rat  2364 LEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEA 2428

  Fly  2418 AQNLVRGVGTEEMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKSTDNLVHSAQ 2482
            |...|:|..::|.|||:||||||||||||:|||||::.:|||.:|||||||||.:::||||.:||
  Rat  2429 ANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQ 2493

  Fly  2483 Q--GLEAEEEHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            :  ..|.:|..::.:...||.|:||.|.|:..:||||:||||||:.|..:|..|
  Rat  2494 KAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQ 2547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_001246674.1	FERM_f0	4..85	CDD:293120	43/80 (54%)
		B41	89..322	CDD:214604	146/233 (63%)
		FERM_N	92..147	CDD:286467	29/54 (54%)
		FERM_M	215..322	CDD:278785	75/106 (71%)
		FERM_C_Talin	318..409	CDD:269973	66/90 (73%)
		Talin_middle	510..668	CDD:286254	59/160 (37%)
		I_LWEQ	686..>778	CDD:302998	47/91 (52%)
		Vinculin	<874..>1035	CDD:279395	76/161 (47%)
		talin-RS	1661..1832	CDD:213393	59/171 (35%)
		Tar	<1694..2005	CDD:223910	116/313 (37%)
		VBS	1859..1982	CDD:286057	50/124 (40%)
		I_LWEQ	2392..2534	CDD:279885	84/143 (59%)
Tln1	XP_038965907.1	FERM_F0_TLN1	2..85	CDD:340691	44/84 (52%)
		FERM_F1_TLN1	86..197	CDD:340693	64/117 (55%)
		B41	88..313	CDD:214604	146/232 (63%)
		FERM_C_Talin	309..400	CDD:269973	66/90 (73%)
		Talin_middle	491..652	CDD:401182	59/160 (37%)
		I_LWEQ	839..>935	CDD:418644	48/96 (50%)
		talin-RS	1221..1368	CDD:213393	61/146 (42%)
		talin-RS	1671..1843	CDD:213393	59/171 (35%)
		VBS	1866..1990	CDD:312463	51/128 (40%)
		ILWEQ	2354..2550	CDD:214607	112/194 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345599
Domainoid	1	1.000	854	1.000	Domainoid score	I55
eggNOG	1	0.900	-	-		E1_KOG4261
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2175	1.000	Inparanoid score	I36
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7374at33208
OrthoFinder	1	1.000	-	-		FOG0003071
OrthoInspector	1	1.000	-	-		otm45632
orthoMCL	1	0.900	-	-		OOG6_103395
Panther	1	1.100	-	-	LDO	PTHR19981
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1785
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760