DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rhea and tln-1

DIOPT Version :9

Sequence 1:	NP_001246674.1	Gene:	rhea / 38978	FlyBaseID:	FBgn0260442	Length:	2836	Species:	Drosophila melanogaster
Sequence 2:	NP_490886.2	Gene:	tln-1 / 171736	WormBaseID:	WBGene00006771	Length:	2553	Species:	Caenorhabditis elegans

Alignment Length:	2622	Identity:	990/2622 - (37%)
Similarity:	1503/2622 - (57%)	Gaps:	152/2622 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||.:......:.||:||:|:|.::||.|:||:||| ......:|||:|..||...:.:|::
Worm     1 MGVLSLTVSSAEKGIKKTMQFEPSTLIYDAAKLIREKFA-MHDVNANEYGIFRLDENPSKSLWMD 64

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .|||..:|::.|:|.:||:||.|.|:|||||||||||.||:||||||||:.:|.||||:|:|||.
Worm    65 NGRTFEHYLVRNKDEIEYKRKIRLLKVRMLDGAVKTISVDESQPVSQLMMTVCNKIGISNYEEYS 129

  Fly   131 LVREDNEAQN-----ENLPDNKFGTLTLKRK----------------IMEKDRDAKMESLRKKLK 174
            |||:|...||     .....|...|..||.|                .|.|..:.|:|.|||||.
Worm   130 LVRDDILMQNGGGGGGGGGQNGGSTWNLKEKESRSKSSDRGGGGIYGTMRKKNEQKLEELRKKLH 194

  Fly   175 TDDEMNWVDVSRTLREQGIDEAETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVT 239
            ||:|:.|:|.::|||||||.|.||::|||::||||.|:||||||||||||||.||.||.|.|||.
Worm   195 TDEELPWLDHTKTLREQGITEEETLILRRKYFFSDSNVDSRDPVQLNLLYVQCRDGILRGLHPVE 259

  Fly   240 QDKACEFAGIQVHIQFG--PHNEAKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEID 302
            ::.|.:.|.:|.|||:|  |:::.|.   .||.:|.||:.|.:.|..|||:.:.:::....||:|
Worm   260 KETAFQLAALQSHIQYGDFPYDKPKF---HLDGRDVLPKEYAKNKENEKKVVAMYKELSGTSELD 321

  Fly   303 AKVLYTKTARELPTYGVTFFLVKEKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRR 367
            ||..|....|.|.|||||||:||||:.||||||||||||.|:||:|:||::|:||..|||..|||
Worm   322 AKSKYVHLCRGLKTYGVTFFVVKEKLPGKNKLVPRLLGVNKESVMRVDENSKQILKEWPLEQVRR 386

  Fly   368 WGASPNTFTLDFGDYANQYYSVQTTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEES 432
            |..|...|:||||||.:.|||||||:.|:|.|||.||:|||||||:|:||.||||||||||:|:.
Worm   387 WVPSAKCFSLDFGDYQDGYYSVQTTDGEKIAQLIQGYVDIILKKKRTQDHQGIEGDEGSTMLEDM 451

  Fly   433 VAPSKATFL--------QHETNRMEQLNVESLAHPGIMRPYDGERSYMENEVQTVQYGAFVGQVN 489
            |||:|||.:        ||.|:.:       :|..|::|...|.:.|   .:...||||..|::
Worm   452 VAPAKATLVAHGQIGSGQHATDGL-------VAVRGVLRTPQGGQGY---GINGAQYGAVSGEI- 505

  Fly   490 HAHQPPTTKEV----RISSVNLTE-PQRALLGYISAGQDVLIRA--DEELRTKA----PIQELGS 543
                  |::|:    |:...::.: |||||:|.|.|    .|||  |.|:..:|    .|.....
Worm   506 ------TSQELARAQRLRYQDMYQHPQRALIGTIEA----TIRAVEDAEIELEAEPQIDIPRFND 560

  Fly   544 DLRSIEWRENTLDTSKQAVSSHVATMSAATAQIITASHPDEVDTEAISASVSQIAQTIPEVTKEV 608
            |.....|.|.....:|:.|:..:|.|.|||||::..:..:|.| :.:..:::.|...:|:|::.|
Worm   561 DYSQNRWMEEQQAVNKENVNERLAAMGAATAQVVQWTAVEEYD-DRVGTAIATIGSNLPDVSRNV 624

  Fly   609 RLIAALMENDTSGDQLLEAARNLCSAFSDLLKAAEPESKEPPQHLINAASRVGEATTHVLSTIAE 673
            |.:.|.||:...|| ||:|.:.||.||...|....||::.....:...|..|||.:.|:::.:
Worm   625 RDLGAFMEHRERGD-LLDATKKLCGAFGKFLNTVNPETEARRNEVFRTAGHVGETSQHLINVM-- 686

  Fly   674 EEVPE--NRDLHDMLLALAKAVANTTAALVLRAKNIAASCDDEQARNRVIGAASQCALATSQLVA 736
             |.|.  .:...:.|:..||.||.:||.|||.||.|:|.||:.|.:.|||.:|::||.|||||||
Worm   687 -EAPNEGQQKFDERLVQSAKNVATSTAQLVLCAKTISAECDEPQVQERVIQSATKCAFATSQLVA 750

  Fly   737 CAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNEASNDPKLKADLLAAARDVSKSLTDMLE 801
            ||:|||||:.|.||::||..||..|.::||:|......|........|:..|||.|:.:|..:||
Worm   751 CARVVAPTIDNNACQQQLSTAATEVTQSVNNLLHDAEHAVYQQSSLTDIHEAARQVTSALDSLLE 815

  Fly   802 HVKLSSREHANRTSTELSPVENVIIGTDILVSTHDPQE-MVRHARTLGQTTAQLIQSIKGEADQQ 865
            |.|.|.:....|...| .....|:..|:.:|....|.| :.|.||.:.:.:..|.:..:.||.|:
Worm   816 HAKCSPKTQTTRREEE-EMYNEVLRRTNRMVVHQGPSEDLTREARKVVRHSQLLTEQFQHEAHQR 879

  Fly   866 QDADMKRHLLSAAKQLADATAKLVEAARLCSSNPHDSDNQNALRKAAEELREITTTAANTPAMKR 930
              .:.:..||.||.::|.||::::.|.....|.|...:.:.|||.|||.|.::|..... ...::
Worm   880 --PEHRERLLDAAAKVAHATSEMILATEQAESQPRQVETEYALRTAAERLGQVTNETTQ-EQQEQ 941

  Fly   931 GLIQRLEFCSKQAASAATQCISAAQNAVQHSQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQP 995
            .::||||..:||.|..|||.||||.:|....:....||.|:.:..:.|..:|.|:||::.::...
Worm   942 HIMQRLEQAAKQTAYDATQTISAANSAKDVIESRSYKENLVYESTQTAGHLPNLITSIRESQKVD 1006

  Fly   996 DDP----NAQLNLIEAAEQFIEPALQVSKSSRALQPTVTDIPSATQLSKGALHLGQCVSELHSVA 1056
            :.|    .||..||..:.:.:|.::::.:::|...|.|:|...|:.|.:.|..||..:::|.:..
Worm  1007 NTPGEKFKAQSRLIRDSYKVLETSVRLFETARTAVPMVSDSHLASSLDQSANRLGTSLADLRTSV 1071

  Fly  1057 QRARDACGGQELESALEEVRKLHDVLDDTRQAAIAGQLRPLPGQTVENTADELRKSAKNVGIALS 1121
            ..|:.....|:|..:.|.:::|.|.|.:|::.|||.:|.|:...|..:.:.:|..:..|||..::
Worm  1072 NDAQQLNFSQQLLYSEELIKELDDQLVNTQKRAIARELPPIQNATSFSVSSKLMATTSNVGSGVA 1136

  Fly  1122 QLL-SSVLHNQRSYAGAAGRDTALALGDFTRSVHGVAAT---TQNPAIIDCADDVVTSSARLIEQ 1182
            ||: ::...|...|.|.:..:.|..|.|||.::..:...   .|...:|..|..||..|.|:.::
Worm  1137 QLITAAATSNDDKYVGTSAVELAQGLRDFTDAITEIVTVRTDIQLDKLIVSARSVVHESGRVFDR 1201

  Fly  1183 AQRTLQGASNPEALTQAGREVTGALSATVDCIPGQREVDVALRNVSELSEILSMSEFPPSSRPYA 1247
            .:.    .|.|..||.|...|:.:|...:.|:|..:.::.|:..:       ..:....:.||
Worm  1202 VRE----KSAPTVLTDAAMNVSTSLKQVISCLPDTKHIEKAIHEI-------QTAHTSANIRP-- 1253

  Fly  1248 TLQSELKQVAEQLSSAGGEIVVSYSSPALLAESSQNFAANYRDLL-SVSMEMAGQTQEEEVRSHM 1311
               .|::|.|.:...|..::||:..||. ..|:...|...|.||. ||..::..|:....|::.:
Worm  1254 ---MEVRQAANKFIEATSQLVVTIGSPD-SREAVDIFVRAYCDLHGSVVAQLQRQSNMNNVKTAI 1314

  Fly  1312 IESLRHVSTQSCSLLSTAKSIAADPGQPNAKNLLHAAARGVTESINQLVDASIQ---SAPGQKEC 1373
            |:.|......|..:|.|.:. |.:|..........:..|.:..::||||:.|..   .:..|:||
Worm  1315 IDRLEEAQRGSIGVLETLRQ-AGNPSDHTLSQQFTSKTRELATTVNQLVELSGMDGGESRWQREC 1378

  Fly  1374 DNAMRNIEALRLMLDYPHEPINELGYFDCVEQATGKSRNLGYAISEMINNAKQSQHVEFSQSVNN 1438
            |.|:|.|:|:..:..:.:.|:|:.|||..::..:..||.||.|::.|..:||.:....|..||.:
Worm  1379 DAALRRIQAVYHVTQHANVPLNDNGYFASLQSVSDGSRRLGEAMTGMARHAKGNDTEGFCTSVRD 1443

  Fly  1439 VNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGIIDQAQLTWAYQGIRQHCDIVSSQQSTKPQMIS 1503
            ..|::..|.||:|.:|||:|:|||:|..||..:||.:::..:.:.|...|..|.|:|..:.:::|
Worm  1444 SADALCSLAESASHSAYLVGISHPASSPGRAALIDSSEVARSVESINASCQRVESRQLNREELMS 1508

  Fly  1504 ALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIVLAKQVATATSDLVQDIKAIEEQSAGGSR-ER 1567
            .::.|.|.:|.|..:||.||..|.||..|...:..|..||:.||.||...|.::......|| ..
Worm  1509 DISSITKQSSSLAQLCRIASEKTQNPNVKKHLVGCAMGVASKTSSLVTAFKDLDRMPDAESRCTS 1573

  Fly  1568 LVDPLLEAVKAVRQYASSSEFSSVPAKISAEGRKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPD 1632
            ....|.:....:..:|...:|:::...||.||..||:|::|:.|.::|...:|::.|||.|..|.
Worm  1574 SASELRQVALQLLHFADKPDFAAIQGSISTEGHSAQQPILQSSREMLDSSAQMIQTAKSWASAPQ 1638

  Fly  1633 NPPVWQQLSMHSTPVSESVKRLVDNIRDKAPGQAQCEQVLHTLGTCTRELDSCALAVNAQGLSQR 1697
            :...||:::::|..||:|:.|||:.|.:.||||.:.|..:..|...:.:::..|:...|.|..|:
Worm  1639 DEATWQRMAVNSRQVSDSIMRLVNAIHEAAPGQMELEAAIGRLSALSGQIERSAMDCYASGNVQK 1703

  Fly  1698 RDNNLHGFSG------QTMNSASELIDKLEPIRMAGKNNAEQLGHAVGEISRYVVPMVNGAIGAC 1756
                 ||.:.      |..:.||:|.||::.:..|...:.|:|...|....:.|..:.:.|..|.
Worm  1704 -----HGANAERQLLQQVQHIASQLEDKVDDLHNAAVEHGERLPKVVQLHCQMVEDLADAACCAA 1763

  Fly  1757 THIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPRATHAHPRLDDAIDGTREAIQELQQTVE 1821
            ...|.|.||..|..:.::|||:.:.::.:::||.|||.|.|||..:.||....:.||.:::||:.
Worm  1764 GMTVDSNQQTELFDKCKTVVEAELAMMVASRESGGNPNAVHAHANVKDAAGQLKHAIGDMRQTIA 1828

  Fly  1822 KINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDTFVDYQTRMVARAKEIASLANEMNAKSS 1886
            |:::|.|.|.|:::.::.||.. ||...|  :|....:|.|.||||.|..::|...|.||...::
Worm  1829 KVSSEQGAVQGMVDTISSSIAH-TDVAVS--SAHPGSSFADAQTRMTAYLEDIRRTAIEMPTLNT 1890

  Fly  1887 VEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAMRIRTTVIDLGRSVSSMIQSSAGG--AR 1949
            .:   |...::::::.|:.:..|...|:......|:..|::..|..||.|....: :.|||  |.
Worm  1891 TD---LGAASLNLSEKYRLVAGDVRQAAGMLPEADIGQRLKLAVQKLGTSCIETV-TVAGGKRAH 1951

  Fly  1950 PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQACINAAHTVSGIIGDLDTTIMFATAGTLH 2014
            |.|...|::::..|..|.|:|.||||||.:.|||||||||||:|||||||||||||||||:|:|:
Worm  1952 PEDERIQRQLSSQAGTVVERVEQVLAALHSASRGTQACINAANTVSGIIGDLDTTIMFATSGSLN 2016

  Fly  2015 SDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQDQLANAAQNAVSTITQLAEAVKRGACSLG 2079
            |..|..|..|:|.|::||||||||||.||.|||..|:|||.||||||.||..|::|||.||.||.
Worm  2017 SSDDRKFPSHKEAIVKTAKALVEDTKALVAGAASNQEQLAVAAQNAVRTIVNLSDAVKTGAVSLS 2081

  Fly  2080 STQPDSQVMVINAVKDVASALGDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAV 2144
            |...::||:||:||:|||:||..||..||.|||.|:..|:|..||::|:|||.||:.|||||..|
Worm  2082 SENSETQVLVIHAVRDVAAALTSLIQATKNASGLSLQHPAMGHLKDAAKVMVSNVARLLKTVATV 2146

  Fly  2145 EDEHTRGTRAMEATVEAISQEIRAMHSPPPVG---NTQVGPEDLIRVTMNVTAATAKAV-AAGTS 2205
            |:::.:||||:||.|:||..|::........|   .|...||.|.:...:|:..|.:.: .|...
Worm  2147 EEKNQQGTRAVEAAVDAIGFEMKQFEHDLNEGAAIPTDFRPEHLQQTAEHVSEITKRVMQGADAP 2211

  Fly  2206 NLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELRSRTLEAGTAVGESYRDLL----SGILH 2266
            ..:.:|:..|||.|.|:..:|.|.|::: |.|:|...|...|::|..|..:.:.||    :.::.
Worm  2212 QSEEEIIGVANLSRSAVRSLLAVVRTIS-NDADTAPQRYAVLDSGRDVANNVKSLLVSLHTQMVR 2275

  Fly  2267 NCSADDRMHL----SRRVAKCVTDLVAMARLLKGSDW-IDPEDPTVIAENELLGAAASIDAAAKK 2326
            |...::...|    |:.|:..::.||.:...:.|... .:.|.....|||||||||:||:||:.|
Worm  2276 NPGQEESRRLLLEASKGVSSALSHLVGLCNEMTGLPHNHEMESAAAQAENELLGAASSIEAASAK 2340

  Fly  2327 LASLRPRRQADVKIELDENMKFDEMILEAAKGIMGASAALVRAANAAQRELIDTGKVARRPLTSS 2391
            ||.||||:......:.....:||:.|:.:||||:.|...|:|:|:.|||||...|:.|     :.
Worm  2341 LAELRPRQIVQENTQEIVETEFDDNIIISAKGILHAVHTLMRSASNAQRELAMQGRAA-----AG 2400

  Fly  2392 DDG--QWSEGLISAARLVAAATHSLVEAAQNLVRGVGTEEMLISTAKQVAASTAQLLIACKVKSN 2454
            ..|  |||||||||||:|.|:.|.|.:||..|::|..|||.|||.||||::||||||:||.|:::
Worm  2401 GTGTYQWSEGLISAARVVVASVHKLCDAANTLMKGQTTEERLISAAKQVSSSTAQLLVACNVRAD 2465

  Fly  2455 PNSEAGRRLQAAGNAVIKSTDNLVHSAQQGLEAEEEHSLKINTSMVDGMAQEINARSAVLRKEKE 2519
            |:|:|.|||||||.||..:.:.||.||||.:.|.::.::.|:..:|:|:||.::|:..|||||:|
Worm  2466 PDSQANRRLQAAGQAVRNAAERLVQSAQQEMIARDDRNIAISDRLVNGIAQVMDAQEEVLRKERE 2530

  Fly  2520 LEEARQLLKNVRHAQRYAKNAQ 2541
            |.|||..|.::..| ||.::.:
Worm  2531 LGEARHKLAHLNKA-RYERDGE 2551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_001246674.1	FERM_f0	4..85	CDD:293120	32/80 (40%)
		B41	89..322	CDD:214604	128/255 (50%)
		FERM_N	92..147	CDD:286467	36/59 (61%)
		FERM_M	215..322	CDD:278785	52/108 (48%)
		FERM_C_Talin	318..409	CDD:269973	61/90 (68%)
		Talin_middle	510..668	CDD:286254	54/163 (33%)
		I_LWEQ	686..>778	CDD:302998	49/91 (54%)
		Vinculin	<874..>1035	CDD:279395	51/164 (31%)
		talin-RS	1661..1832	CDD:213393	52/176 (30%)
		Tar	<1694..2005	CDD:223910	110/318 (35%)
		VBS	1859..1982	CDD:286057	38/124 (31%)
		I_LWEQ	2392..2534	CDD:279885	75/143 (52%)
tln-1	NP_490886.2	FERM_f0	4..84	CDD:293120	32/80 (40%)
		B41	89..341	CDD:214604	128/254 (50%)
		FERM_N	91..>135	CDD:286467	33/43 (77%)
		FERM_M	232..341	CDD:278785	54/111 (49%)
		FERM_C_Talin	337..428	CDD:269973	61/90 (68%)
		Talin_middle	525..683	CDD:286254	54/163 (33%)
		I_LWEQ	698..>783	CDD:302998	47/84 (56%)
		talin-RS	1667..1839	CDD:213393	52/176 (30%)
		VBS	1863..1984	CDD:286057	38/124 (31%)
		talin-RS	1985..2146	CDD:213393	104/160 (65%)
		ILWEQ	2357..2549	CDD:214607	96/197 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159359
Domainoid	1	1.000	547	1.000	Domainoid score	I125
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56692
Inparanoid	1	1.050	1555	1.000	Inparanoid score	I40
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7374at33208
OrthoFinder	1	1.000	-	-		FOG0003071
OrthoInspector	1	1.000	-	-		oto17443
orthoMCL	1	0.900	-	-		OOG6_103395
Panther	1	1.100	-	-	LDO	PTHR19981
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1785
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900