DRSC/TRiP Functional Genomics Resources

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Protein Alignment rhea and tln2b

DIOPT Version :9

Sequence 1:NP_001246674.1 Gene:rhea / 38978 FlyBaseID:FBgn0260442 Length:2836 Species:Drosophila melanogaster
Sequence 2:XP_021326415.1 Gene:tln2b / 100333114 ZFINID:ZDB-GENE-130325-1 Length:2580 Species:Danio rerio


Alignment Length:2569 Identity:1208/2569 - (47%)
Similarity:1719/2569 - (66%) Gaps:72/2569 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||::||::..||..||.|:||||:||:..::|:|||
Zfish    36 MVALSLKICVRQCNVVKTMQFEPSTPVYDACRIIRERVPEAQSGQASDYGLFLSDDDPRKGIWLE 100

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..:::||||.:|||:||||:.|.:|:|.||::|||||:|||.
Zfish   101 SGRTLDYYMLRNGDVLEYKKKQRPQKIKMLDGTIKTIMVDDSKTVGELLVTICSRIGITNYEEYS 165

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGIDE 195
            |::|..|.:.|    :..|||...|.::..:|  |||.|:.||.|||::||:|.|||.||||::|
Zfish   166 LIQEQVEEKKE----DGMGTLKKDRTLLRDER--KMEKLKAKLHTDDDLNWLDHSRTFREQGVEE 224

  Fly   196 AETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNE 260
            :|.:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||||||..||||||.|
Zfish   225 SEILLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGIQAQIQFGPHVE 289

  Fly   261 AKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVK 325
            .|||.||||||:|||:.|::.:|.||:||.:|:...:::||:|||.|.|.||.|.||||:|||||
Zfish   290 HKHKPGFLDLKEFLPKEYIKQRGAEKRIFQDHKTCGEMTEIEAKVKYVKLARSLRTYGVSFFLVK 354

  Fly   326 EKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSVQ 390
            |||..||||||||||:||:||:|:||.|||::..||||||:||.|||.:||||||:|...|||||
Zfish   355 EKMKSKNKLVPRLLGITKESVMRVDEKTKEVVQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQ 419

  Fly   391 TTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVES 455
            |||.|||.|||||||||||||||:||.||::|||.|||:||||:|.|:|.||.:.||:.::...|
Zfish   420 TTEGEQISQLIAGYIDIILKKKQSKDRFGLDGDEESTMLEESVSPKKSTILQQQFNRVGRVEHGS 484

  Fly   456 LAHPGIMR--PYDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYI 518
            :|.|||||  ...|..::....:.:.|....:||::..|.||           |:..|:||:|.|
Zfish   485 VALPGIMRSGSIGGPDTFNMGTMPSAQQQITMGQMHRGHMPP-----------LSVAQQALMGTI 538

  Fly   519 SAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASH 581
            :.....:.:|..:|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::  ||..
Zfish   539 NTSMQAVQQAQADLGEVDNLPPLGHDMASRMWVQNKVDESKHEIHSQVDAITAGTASVVNLTAGD 603

  Fly   582 PDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKAAEPE 645
            |.:.|..|:..:::.|:..:.|::|.|:|:|||||::. ||..|:.|||.|..|.||||:|.||.
Zfish   604 PIDTDYTAVGCAITTISSNLTEMSKGVKLLAALMEDEVGSGQNLMGAARTLTGAVSDLLRAVEPT 668

  Fly   646 SKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKNIAAS 710
            |.||.|.::.||..:|:|:..:|..:.|.|. :.| ..|:::.|||||||..|.|||:|||:|..
Zfish   669 SGEPRQTVLTAAGSIGQASGDLLKQMGEGET-DGR-FQDIMMNLAKAVANAAAMLVLKAKNVAQV 731

  Fly   711 CDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNEA 775
            .:|...:||||.||:||||:|||||||.|||:||:.:..|:|||..|.:.|.|:|......|:.|
Zfish   732 AEDTALQNRVITAATQCALSTSQLVACTKVVSPTISSPVCQEQLVEAGRLVERSVEGCLRACHAA 796

  Fly   776 SNDPKLKADLLAAARDVSKSLTDMLEHVK--LSSREHANR----TSTELSPVENVIIGTDILVST 834
            |.:.:|...:..|:..||::|:|:|:||:  .|..|...|    |.|.::..|:      |..|.
Zfish   797 SEEAELLRQVNLASGGVSQALSDLLQHVRHYASCGEPIGRYDQATDTIMTVTES------IFTSM 855

  Fly   835 HDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAARLCSSNP 899
            .|..||||.||.|.|.|:.|:.:::.:|:.:.|.|..:.||:|||.||||||::||||:..::.|
Zfish   856 GDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDVDNSKKLLAAAKLLADATARMVEAAKGAAAYP 920

  Fly   900 HDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAVQHSQDH 964
            .:.|.|..||:|||.|| :.|.||...|:|:.||.|||..:||||:||||.|:|||||...:::.
Zfish   921 ENEDQQQRLREAAEGLR-VATNAAAQNAIKKKLIHRLENAAKQAAAAATQTIAAAQNAAASNKNT 984

  Fly   965 QTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSRALQPTV 1029
            .:.:.|:..||.|||.||.||..::.::|.|:|..|||.||.|::.|::|..::..||:|..|||
Zfish   985 MSHQQLVFSCKAVADHIPHLVQGMRGSQAHPEDLGAQLALIIASQSFLQPGSKMVTSSKAAVPTV 1049

  Fly  1030 TDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQAAIAGQL 1094
            ||..:|.||.:.|.:|..|::||.:.||:|.:|||..|::|||..|:.|...|.|.:.||:..||
Zfish  1050 TDQAAAMQLGQCAKNLATCLAELRTAAQKAHEACGPLEIDSALSAVQTLKSELQDAKMAALDLQL 1114

  Fly  1095 RPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSVHGVAAT 1159
            :||||:::|..|.:|..::|.||.:::|||:........|.|.|.|:||.||....::..||||:
Zfish  1115 KPLPGESLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALRTLAQAARGVAAS 1179

  Fly  1160 TQNP----AIIDCADDVVTSSARLIEQAQRTL---QGASNPEALTQAGREVTGALSATVDCIPGQ 1217
            |..|    |::|.|..|:..||.||.:|.:.|   ..|.:.:.|.|..:.|:.:|:..|:|:|||
Zfish  1180 TVEPQAAAAMLDSAYHVMEGSAMLIHEAHQALVCPGDAESQQRLAQVAKAVSHSLNNCVNCLPGQ 1244

  Fly  1218 REVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPALLAESS 1281
            ::||:|||::.|.|:.|.:...||.|:.:...|::|...|.:|:.:.|::| .|..|.:.||.:|
Zfish  1245 KDVDMALRSIGEASKKLLVENLPPCSKSFQEAQTDLNHTAAELNHSAGDVVQSSRGSSSQLAVAS 1309

  Fly  1282 QNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAKNLLH 1346
            ..|:.::.:.|...:||||.||.::.:..:|.:|:::|..|..||..|||::.|||..||||||.
Zfish  1310 GKFSQDFDEFLDAGIEMAGHTQSKDDQIQVISNLKNISMASSKLLLAAKSLSVDPGAANAKNLLA 1374

  Fly  1347 AAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQATGKSR 1411
            ||||.||||||||:....|.||||||||||:|.:||:|.|||.|:||:::|.||||:|.....|:
Zfish  1375 AAARAVTESINQLITLCTQQAPGQKECDNALRELEAVRGMLDNPNEPVSDLSYFDCIESVMENSK 1439

  Fly  1412 NLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGIIDQAQ 1476
            .||.:::.:..:.|......|...|...:.::.||.|::.||:||:|||.|:|.:|..|::|..|
Zfish  1440 VLGESMAGISQHCKTGNVPAFGDCVGVASKALCGLTEAAGQASYLVGVSDPNSQSGHQGLVDPIQ 1504

  Fly  1477 LTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIVLAKQ 1541
            ...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:||||:..|:..||:
Zfish  1505 FARANQAIQMACQNLVDPASSPSQVLSAATIVAKHTSALCNACRLASSKTANPVARRHFVQSAKE 1569

  Fly  1542 VATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKISAEGRKAQ 1603
            ||..|::||:.|||::...:..:|||   ...||:|||..:..:||:.||:|:||:||.||..||
Zfish  1570 VANTTANLVKTIKALDGDFSDENRERCRVATTPLIEAVDNLSTFASNPEFASIPAQISHEGSAAQ 1634

  Fly  1604 EPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPGQAQC 1668
            ||::::.|.::|....:::.|:||.:.|.:||.|..|:.||..||:|:|.|:.:||||||||.:|
Zfish  1635 EPIVRSARSMLDSSTHLLETARSLIINPKDPPTWSILAGHSRTVSDSIKSLITSIRDKAPGQREC 1699

  Fly  1669 EQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKNNAEQ 1733
            :|.:.::....|:::..:||...|.|.:|.|.:|........::..|:...::||..|.:..|.|
Zfish  1700 DQSIDSINKSIRDIEQVSLAAVGQSLPRRDDISLEALQELLTSAVQEIGHLIDPISTAARGEAAQ 1764

  Fly  1734 LGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPRATHA 1798
            |||.|.:::.|..|::..::|..:.....||||:::.||:::.|||:.::.:|||..|||:|||.
Zfish  1765 LGHKVTQLASYFEPVIVASVGLASKHADHQQQMNILDQTKTLFESALQMLYAAKEGGGNPKATHT 1829

  Fly  1799 HPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDTFVDY 1863
            |..:.:|....:||:.::..|:.:..:|.|:|.|::|.:..||.|:.:...    .....|||||
Zfish  1830 HDAISEAAQLMKEAVDDIMVTLNEAASEGGMVGGMVESIAESIGRMDEGTP----PEPDGTFVDY 1890

  Fly  1864 QTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAMRIRT 1928
            ||.||..:|.||..|.||..||...|..|..||..:|.:|.||.|....|:.|....:|..:|:|
Zfish  1891 QTTMVKFSKAIAITAQEMMTKSVTCPEELGGLASQVTVDYSQLAQQGRLAAATAELEEVGSQIKT 1955

  Fly  1929 TVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQACINAA 1991
            .|.:||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::||||||.||
Zfish  1956 RVQELGHGCIYLVQ-KAGALQMSPTDSFTKRELIECARAVTEKVSMVLSALQAGNKGTQACITAA 2019

  Fly  1992 HTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQDQLANA 2056
            .:|||||.|||||||||:||||:::.:.|||||||:||:||||||||||:||:|||.:||:||.|
Zfish  2020 SSVSGIIADLDTTIMFASAGTLNAENEESFADHRENILKTAKALVEDTKLLVSGAASSQDKLAQA 2084

  Fly  2057 AQNAVSTITQLAEAVKRGACSLGSTQPDSQVMVINAVKDVASALGDLINCTKLASGKSINDPSMQ 2121
            ||::..|||||.:.||.||.|:||..|::||::||||:|||.||.:||:.||.|:||:.:||||.
Zfish  2085 AQSSAKTITQLTDVVKLGAASMGSEDPETQVVLINAVRDVAKALAELISATKCAAGKAADDPSMY 2149

  Fly  2122 DLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEATVEAISQEIRAMHSP--PPVGNTQVGPED 2184
            .||.:|:|||.||:||||||||||||.||||||:|||:|.|.||:....|.  |....|   ||:
Zfish  2150 QLKSAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDNPEKSTT---PEE 2211

  Fly  2185 LIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAISEMLIVCRSVAWNCAETEELRSRTLEA 2249
            .||:|..:|.|||||||||.|..|.|::|.|||.|:|||:||..|:..|::....|::|::.|..
Zfish  2212 FIRMTKGITVATAKAVAAGNSAQQEDVISTANLSRKAISDMLTTCKQAAYHPEVGEDVRNKALLY 2276

  Fly  2250 GTAVGESYRDLLSG---ILHNCSADDRMH---LSRRVAKCVTDLVAMARLLK--GSDWIDPEDPT 2306
            |......|.|||..   :|...:|:.:..   ||::||..||:|:..|..:|  ||:|:||||||
Zfish  2277 GIECTTGYVDLLEHVLLVLQKPTAEQKQQLASLSKKVASSVTELIQTAEAMKDGGSEWVDPEDPT 2341

  Fly  2307 VIAENELLGAAASIDAAAKKLASLRPRRQADVKIELDENMKFDEMILEAAKGIMGASAALVRAAN 2371
            ||||.|||||||||:||||||..|:||.:..   :.||::.|:|.||||||.|..|::|||::|:
Zfish  2342 VIAETELLGAAASIEAAAKKLEQLKPRAKPK---QADESLDFEEQILEAAKSIAAATSALVKSAS 2403

  Fly  2372 AAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAAATHSLVEAAQNLVRGVGTEEMLISTAK 2436
            ||||||:..|||...|..:.||||||:|||||||:|||||.:|.|||...|:|..:||.|||:||
Zfish  2404 AAQRELVAQGKVGSIPANAVDDGQWSQGLISAARMVAAATSNLCEAANASVQGHASEEKLISSAK 2468

  Fly  2437 QVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKSTDNLVHSAQQ-GLEAEEEHSLKINTSMV 2500
            ||||||||||:|||||::.:|||.||||||||||.:::||||.:||: ..:..|:.|:.:.|..|
Zfish  2469 QVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVKAAQKAAFDKAEDDSVVVKTKFV 2533

  Fly  2501 DGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            .|:||.|.|:..:||||:||||||:.|.::|..|
Zfish  2534 GGIAQIIAAQEEMLRKERELEEARKKLAHIRQQQ 2567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rheaNP_001246674.1 FERM_f0 4..85 CDD:293120 44/80 (55%)
B41 89..322 CDD:214604 137/232 (59%)
FERM_N 92..147 CDD:286467 28/54 (52%)
FERM_M 215..322 CDD:278785 71/106 (67%)
FERM_C_Talin 318..409 CDD:269973 68/90 (76%)
Talin_middle 510..668 CDD:286254 59/160 (37%)
I_LWEQ 686..>778 CDD:302998 49/91 (54%)
Vinculin <874..>1035 CDD:279395 78/160 (49%)
talin-RS 1661..1832 CDD:213393 54/170 (32%)
Tar <1694..2005 CDD:223910 118/312 (38%)
VBS 1859..1982 CDD:286057 53/124 (43%)
I_LWEQ 2392..2534 CDD:279885 86/142 (61%)
tln2bXP_021326415.1 FERM_f0 39..120 CDD:318667 44/80 (55%)
B41 125..351 CDD:214604 137/231 (59%)
FERM_C_Talin 347..438 CDD:269973 68/90 (76%)
Talin_middle 530..691 CDD:312608 59/160 (37%)
talin-RS 1081..>1210 CDD:213393 51/128 (40%)
talin-RS 1692..1863 CDD:213393 54/170 (32%)
VBS 1886..2010 CDD:312463 53/124 (43%)
ILWEQ 2375..2570 CDD:214607 113/193 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 426 1.000 Domainoid score I590
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7374at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1785
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.820

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