DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rhea and tln2

DIOPT Version :9

Sequence 1:NP_001246674.1 Gene:rhea / 38978 FlyBaseID:FBgn0260442 Length:2836 Species:Drosophila melanogaster
Sequence 2:XP_012822328.1 Gene:tln2 / 100144637 XenbaseID:XB-GENE-481871 Length:2567 Species:Xenopus tropicalis


Alignment Length:2596 Identity:1212/2596 - (46%)
Similarity:1719/2596 - (66%) Gaps:104/2596 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||::||::.:||..||..::|||:|||..::|:|||
 Frog     1 MVALSLKICVRQCNVVKTMQFEPSTAVYDACRIIRERVSEAQSGQALDFGLFLSDEDPRKGIWLE 65

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..::||||||.|.||||||:.|.:|:|.||::|||||:|||.
 Frog    66 AGRTLDYYMLRNGDVLEYKKKHRPQKIRMLDGAAKMILVDDSKTVGELLVTICSRIGITNYEEYS 130

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGIDE 195
            |:||..|.:.|    .:.|||...|.::..::  |||.|:.||.|:||:||:|.|||.||||:||
 Frog   131 LIRETMEEKKE----EQTGTLKKDRTLLRDEK--KMEKLKAKLHTEDELNWLDHSRTFREQGVDE 189

  Fly   196 AETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNE 260
            .||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||.|||..||||||.|
 Frog   190 NETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFGGIQAQIQFGPHVE 254

  Fly   261 AKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVK 325
            :|||.|||:||:|||:.|::.:|.|||||.||:...:::||:|||.|.|.||.|.||||:|||||
 Frog   255 SKHKPGFLELKEFLPKEYMKQRGAEKKIFQEHKNCGEMTEIEAKVKYVKLARSLRTYGVSFFLVK 319

  Fly   326 EKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSVQ 390
            |||.|||||||||||:|||||:|:||.|||:|..||||||:||.|||.:||||||:|...|||||
 Frog   320 EKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQ 384

  Fly   391 TTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFL-QHETNRMEQLNVE 454
            |||.|||.|||||||||||||||:||.||:||||.|||:||||:|.|:|.| |.:..|..:..:.
 Frog   385 TTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQQITRPGKPELG 449

  Fly   455 SLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYI 518
            ::|.|.|:|. ..|..::....:.:.|.....||::..|.||           ||..|:||:|.|
 Frog   450 TVALPAIIRSGSSGPETFNVGSMPSAQQQLTTGQMHRGHMPP-----------LTSAQQALMGTI 503

  Fly   519 SAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASH 581
            :.....:.:|..:|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::  ||..
 Frog   504 NTSMHAVQQAHSDLSQVDNLPPLGHDMASRVWIQNKVDESKHEIHSQVDAITAGTASVVNLTAGD 568

  Fly   582 PDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKAAEPE 645
            |.|.|..|:..:::.|:..:.|::|.|:|:|||||::. ||::||.|||.|..|.||||.|.:|.
 Frog   569 PTETDYTAVGCAITTISSNLTEMSKGVKLLAALMEDEVGSGEKLLGAARTLAGAVSDLLTAVQPS 633

  Fly   646 SKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKNIAAS 710
            |.||.|.::.||..:|:|:..:|..|.|.|..|.  ..|:|:.|||||||..|.|||:|||:|..
 Frog   634 SGEPRQTVLTAAGSIGQASGELLRQIGENEADER--FQDVLMNLAKAVANAAAMLVLKAKNVAQV 696

  Fly   711 CDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNEA 775
            .:|...:||||.||:||||:|||||||||||:||:.:..|:|||..|.|.|.|:|.:....|:.|
 Frog   697 TEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVHACHSA 761

  Fly   776 SNDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHANR----------TSTELSPVENVIIGTDI 830
            :.|.:|...:.|||..||::|.|:|:||    |:.|:|          |.|.:|..|:      |
 Frog   762 TEDIELLKQVSAAASVVSQALNDLLQHV----RQFASRGEPIGRYDQATDTIMSVTES------I 816

  Fly   831 LVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAARLC 895
            ..|..|..||||.||.|.|.|:.|:.:::.:|:.:.|.|..:.||:|||.|||:||::||||:..
 Frog   817 FSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMDNSKKLLAAAKLLADSTARMVEAAKGA 881

  Fly   896 SSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAVQH 960
            ::||.:.|.|..||:|||.|| :.|.||...|:|:.::.|||..:||||:||||.|:|:|||...
 Frog   882 AANPENEDQQQRLREAAEGLR-VATNAAAQNAIKKKIVNRLEAAAKQAAAAATQTIAASQNASLS 945

  Fly   961 SQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSRAL 1025
            :::....:.|:|.||.|||.||:||..:::::||.:|.:|||.||.:::.|::|..::..|::|.
 Frog   946 NKNTAAHQQLVQSCKTVADHIPQLVQGVRSSQAQAEDLSAQLTLIVSSQNFLQPGSKMVASAKAA 1010

  Fly  1026 QPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQAAI 1090
            .|||||..:|.|||:.|.:|...::||.:.||:|.:|||..|::|||..|:.|.:.|.|.:.||.
 Frog  1011 VPTVTDQAAAMQLSQCAKNLATSLAELRTAAQKAHEACGPMEIDSALNAVQTLKNELQDAKMAAS 1075

  Fly  1091 AGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSVHG 1155
            ..||:||||:|:|..|.:|..::|.||.:::|||:........|.|.|.|:||.||....::..|
 Frog  1076 DRQLKPLPGETLEKCAQDLGSTSKTVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARG 1140

  Fly  1156 VAATTQNPA----IIDCADDVVTSSARLIEQAQRTLQGASNPE---ALTQAGREVTGALSATVDC 1213
            |||:|.:|.    ::|.|.||:..||.||::|::.|....:.|   .|.|..:.|:.:|:..|:|
 Frog  1141 VAASTSDPQAASDMLDSARDVMEGSANLIQEAKQALVAPGDAEIQQRLAQVAKAVSHSLNNCVNC 1205

  Fly  1214 IPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPALL 1277
            :|||::||:||:::.|.|:.|.:...|||::.:...||||.|.||.|:.:.||:| .|......|
 Frog  1206 LPGQKDVDMALKSIGESSKKLLVDSLPPSTKSFQEAQSELNQAAEDLNQSAGEVVHASRGQSGEL 1270

  Fly  1278 AESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAK 1342
            |.:|..|:.::.:.|...:|||||||.::.:..:|.||:.:|..|..||..|||::.|.|.|:||
 Frog  1271 AAASGKFSQDFDEFLDAGIEMAGQTQNKDDQMQVIGSLKTISMASSKLLLAAKSLSVDSGAPSAK 1335

  Fly  1343 NLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQAT 1407
            |||.||||.||||||||:....|.||||||||||:|.:|.::.||:.|:||.::|.||||:|...
 Frog  1336 NLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLENPNEPASDLSYFDCIESVM 1400

  Fly  1408 GKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGII 1472
            ..|:.||.:::.:..|||......|.:.|:..:.::.||.|::.|||||:|:|.|:|.||:.|::
 Frog  1401 ENSKVLGESMAGISQNAKTGDLPAFGECVSVASKALCGLTEAAVQAAYLVGISDPNSQAGQQGLV 1465

  Fly  1473 DQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIV 1537
            |..|...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:|||||..|:.
 Frog  1466 DPIQFARANQAIQMACQNLVDPASSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKRHFVQ 1530

  Fly  1538 LAKQVATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKISAEG 1599
            .||:||.:|::||:.||.::...:..:|.:   ...||:.||:.:..:||:.||:|:||:||:||
 Frog  1531 SAKEVANSTANLVKTIKTLDGDFSEENRNKCSIATSPLISAVENLTAFASNPEFASIPAQISSEG 1595

  Fly  1600 RKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPG 1664
            .:||||::.:...:::....::|.|:|||:.|.:||.|..|:.||..||:|:|.|:.:|||||||
 Frog  1596 ARAQEPILVSAVTMLESSSSLIKTARSLAINPKDPPTWSSLAGHSRIVSDSIKSLITSIRDKAPG 1660

  Fly  1665 QAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKN 1729
            |.:|:|.:.::....|:::..:||..:|.|:.|.|.:|.....|..:...|:...::||..|.:.
 Frog  1661 QRECDQSIDSINRFIRDIEQASLASVSQDLAMRDDISLEALQEQLTSVVQEIGHLIDPITTAARG 1725

  Fly  1730 NAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPR 1794
            .|.||||.|.:::||..|:|..|:|..:.::..||||:::.||:::.|||:.::.:|||..|||:
 Frog  1726 EAAQLGHKVTQLARYFEPLVLAAVGLVSKVLDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPK 1790

  Fly  1795 ATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDT 1859
            |.|.|..:.:|....:||:.:|..|:.:..:|.|:|.|:::.:..::::|.:...    ...:.|
 Frog  1791 AFHTHDAIAEAAQLMKEAVDDLMITLNEAASEVGMVGGMVDSIAEAMSKLDEGTP----PEPTGT 1851

  Fly  1860 FVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAM 1924
            ||||||..|..:|.||..|.||..||...|..|..||..:|.:|..|......|:.|....:|..
 Frog  1852 FVDYQTTGVKYSKAIAVTAQEMMTKSVTNPEELGGLASQVTSDYGNLAVQGRMAAATAEPKEVGF 1916

  Fly  1925 RIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQAC 1987
            :|::.:.|||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::|||||
 Frog  1917 QIKSRIQDLGHGCIFLVQ-KAGALQICPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQAC 1980

  Fly  1988 INAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQDQ 2052
            |.|:..|||||.||||||||||||||:::...|||||||:||:||||||||||:||:|||.:|::
 Frog  1981 ITASSAVSGIIADLDTTIMFATAGTLNAENKESFADHRENILKTAKALVEDTKLLVSGAASSQEK 2045

  Fly  2053 LANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQ------------------------VMVINAV 2093
            ||.|||::.:|||||||.||.||.||||..|::|                        |::|||:
 Frog  2046 LAQAAQSSANTITQLAEVVKLGAASLGSDDPETQLFIFLQIRRPGPETVFQMNTEQCGVVLINAI 2110

  Fly  2094 KDVASALGDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEAT 2158
            ||||.||||||..||.|:||:.:||||..||.:|:|||.||:||||||||||||.||||||:|||
 Frog  2111 KDVAKALGDLIEATKCAAGKAADDPSMYQLKSAAKVMVTNVTSLLKTVKAVEDEATRGTRALEAT 2175

  Fly  2159 VEAISQEIRAMHSPPPVGNTQVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAIS 2223
            :|.|.||:....|......|. .||:.||:|..:|.|||||||||.|..|.|:::.|||.|:|:|
 Frog  2176 IEHIKQELTVFQSKDIPEKTS-SPEESIRMTKGITTATAKAVAAGNSCRQEDVIATANLSRKAVS 2239

  Fly  2224 EMLIVCRSVAWNCAETEELRSRTLEAGTAVGESYRDLLS---GILHNCSADDRMHL---SRRVAK 2282
            |||..|:...::.....:.|.|....||....:|.::|.   .||...|.:.:..|   |:|:|.
 Frog  2240 EMLTACKQAVYHPDVNADTRQRAFRYGTECTFAYLEMLEHVLSILQKPSLETKQQLSIFSKRIAA 2304

  Fly  2283 CVTDLVAMARLLKGSDWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPR---RQADVKIELDE 2344
            .||:|:.....:||::|:||:|||||||.|||||||||:||||||..|:||   |||      ||
 Frog  2305 AVTELIQTTETMKGTEWVDPQDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPRQA------DE 2363

  Fly  2345 NMKFDEMILEAAKGIMGASAALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAA 2409
            .:.|:|.||||||.|..|::|||::|:||||||:..|||......::||||||:|||||||:|||
 Frog  2364 TLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGAIAANAADDGQWSQGLISAARMVAA 2428

  Fly  2410 ATHSLVEAAQNLVRGVGTEEMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKST 2474
            ||.:|.|:|...|:|..:||.|||:||||||||||||:|||||::.:|||.||||||||||.:::
 Frog  2429 ATSNLCESANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRAS 2493

  Fly  2475 DNLVHSAQQ-GLEAEEEHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            ||||.:||: .....||..:.:.|..|.|:||.|.|:..:|:||:||||||:.|..:|..|
 Frog  2494 DNLVRAAQKAAFSKAEEDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQ 2554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rheaNP_001246674.1 FERM_f0 4..85 CDD:293120 43/80 (54%)
B41 89..322 CDD:214604 141/232 (61%)
FERM_N 92..147 CDD:286467 31/54 (57%)
FERM_M 215..322 CDD:278785 71/106 (67%)
FERM_C_Talin 318..409 CDD:269973 71/90 (79%)
Talin_middle 510..668 CDD:286254 60/160 (38%)
I_LWEQ 686..>778 CDD:302998 51/91 (56%)
Vinculin <874..>1035 CDD:279395 74/160 (46%)
talin-RS 1661..1832 CDD:213393 58/170 (34%)
Tar <1694..2005 CDD:223910 114/312 (37%)
VBS 1859..1982 CDD:286057 49/124 (40%)
I_LWEQ 2392..2534 CDD:279885 84/142 (59%)
tln2XP_012822328.1 FERM_f0 4..85 CDD:293120 43/80 (54%)
B41 90..316 CDD:214604 141/231 (61%)
FERM_N 92..188 CDD:286467 54/101 (53%)
FERM_M 206..316 CDD:278785 73/109 (67%)
FERM_C_Talin 312..403 CDD:269973 71/90 (79%)
Talin_middle 495..656 CDD:286254 60/160 (38%)
talin-RS 1046..>1175 CDD:213393 52/128 (41%)
talin-RS 1207..1354 CDD:213393 67/146 (46%)
talin-RS 1657..1828 CDD:213393 58/170 (34%)
VBS 1851..1975 CDD:286057 49/124 (40%)
ILWEQ 2362..2557 CDD:214607 110/193 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 793 1.000 Domainoid score I80
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H56692
Inparanoid 1 1.050 2210 1.000 Inparanoid score I41
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7374at33208
OrthoFinder 1 1.000 - - FOG0003071
OrthoInspector 1 1.000 - - otm48725
Panther 1 1.100 - - O PTHR19981
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1785
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.160

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