Protein Alignment rhea and tln2

DIOPT Version :10

• Sequence 1: NP_648238.1
• Gene: rhea / 38978
• FlyBaseID: FBgn0260442
• Length: 2836
• Species: Drosophila melanogaster
• Sequence 2: XP_012822328.1
• Gene: tln2 / 100144637
• XenbaseID: XB-GENE-481871
• Length: 2567
• Species: Xenopus tropicalis
• Alignment Length: 2596
• Identity: 1212/2596 - (46%)
• Similarity: 1719/2596 - (66%)
• Gaps: 104/2596 - (4%)

  Fly     1 MSTLSLRIQLEGGRVTKTIQFQPNTTVFDACKVIRDKFAEAVQGQPSEYGLFISDEQNQQGVWLE 65
            |..|||:|.:....|.||:||:|:|.|:|||::||::.:||..||..::|||:|||..::|:|||
 Frog     1 MVALSLKICVRQCNVVKTMQFEPSTAVYDACRIIRERVSEAQSGQALDFGLFLSDEDPRKGIWLE 65

  Fly    66 PGRTLGYYILHNQDTLEYRRKTRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYG 130
            .||||.||:|.|.|.|||::|.|..::||||||.|.||||||:.|.:|:|.||::|||||:|||.
 Frog    66 AGRTLDYYMLRNGDVLEYKKKHRPQKIRMLDGAAKMILVDDSKTVGELLVTICSRIGITNYEEYS 130

  Fly   131 LVREDNEAQNENLPDNKFGTLTLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQGIDE 195
            |:||..|.:.|    .:.|||...|.::..::  |||.|:.||.|:||:||:|.|||.||||:||
 Frog   131 LIRETMEEKKE----EQTGTLKKDRTLLRDEK--KMEKLKAKLHTEDELNWLDHSRTFREQGVDE 189

  Fly   196 AETVLLRRRFFFSDQNIDSRDPVQLNLLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNE 260
            .||:||||:||:||||:|||||||||||||||||.||:|:|||:.||||||.|||..||||||.|
 Frog   190 NETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFGGIQAQIQFGPHVE 254

  Fly   261 AKHKTGFLDLKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVK 325
            :|||.|||:||:|||:.|::.:|.|||||.||:...:::||:|||.|.|.||.|.||||:|||||
 Frog   255 SKHKPGFLELKEFLPKEYMKQRGAEKKIFQEHKNCGEMTEIEAKVKYVKLARSLRTYGVSFFLVK 319

  Fly   326 EKMNGKNKLVPRLLGVTKDSVLRLDEHTKEILISWPLTTVRRWGASPNTFTLDFGDYANQYYSVQ 390
            |||.|||||||||||:|||||:|:||.|||:|..||||||:||.|||.:||||||:|...|||||
 Frog   320 EKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLDFGEYQESYYSVQ 384

  Fly   391 TTEAEQIVQLIAGYIDIILKKKQTKDHFGIEGDEGSTMVEESVAPSKATFL-QHETNRMEQLNVE 454
            |||.|||.|||||||||||||||:||.||:||||.|||:||||:|.|:|.| |.:..|..:..:.
 Frog   385 TTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSPKKSTILQQQQITRPGKPELG 449

  Fly   455 SLAHPGIMRP-YDGERSYMENEVQTVQYGAFVGQVNHAHQPPTTKEVRISSVNLTEPQRALLGYI 518
            ::|.|.|:|. ..|..::....:.:.|.....||::..|.||           ||..|:||:|.|
 Frog   450 TVALPAIIRSGSSGPETFNVGSMPSAQQQLTTGQMHRGHMPP-----------LTSAQQALMGTI 503

  Fly   519 SAGQDVLIRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSAATAQII--TASH 581
            :.....:.:|..:|.....:..||.|:.|..|.:|.:|.||..:.|.|..::|.||.::  ||..
 Frog   504 NTSMHAVQQAHSDLSQVDNLPPLGHDMASRVWIQNKVDESKHEIHSQVDAITAGTASVVNLTAGD 568

  Fly   582 PDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMENDT-SGDQLLEAARNLCSAFSDLLKAAEPE 645
            |.|.|..|:..:::.|:..:.|::|.|:|:|||||::. ||::||.|||.|..|.||||.|.:|.
 Frog   569 PTETDYTAVGCAITTISSNLTEMSKGVKLLAALMEDEVGSGEKLLGAARTLAGAVSDLLTAVQPS 633

  Fly   646 SKEPPQHLINAASRVGEATTHVLSTIAEEEVPENRDLHDMLLALAKAVANTTAALVLRAKNIAAS 710
            |.||.|.::.||..:|:|:..:|..|.|.|..|.  ..|:|:.|||||||..|.|||:|||:|..
 Frog   634 SGEPRQTVLTAAGSIGQASGELLRQIGENEADER--FQDVLMNLAKAVANAAAMLVLKAKNVAQV 696

  Fly   711 CDDEQARNRVIGAASQCALATSQLVACAKVVAPTLHNAACREQLEAAAKNVARAVNSLCEVCNEA 775
            .:|...:||||.||:||||:|||||||||||:||:.:..|:|||..|.|.|.|:|.:....|:.|
 Frog   697 TEDTVLQNRVIAAATQCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVHACHSA 761

  Fly   776 SNDPKLKADLLAAARDVSKSLTDMLEHVKLSSREHANR----------TSTELSPVENVIIGTDI 830
            :.|.:|...:.|||..||::|.|:|:||    |:.|:|          |.|.:|..|:      |
 Frog   762 TEDIELLKQVSAAASVVSQALNDLLQHV----RQFASRGEPIGRYDQATDTIMSVTES------I 816

  Fly   831 LVSTHDPQEMVRHARTLGQTTAQLIQSIKGEADQQQDADMKRHLLSAAKQLADATAKLVEAARLC 895
            ..|..|..||||.||.|.|.|:.|:.:::.:|:.:.|.|..:.||:|||.|||:||::||||:..
 Frog   817 FSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMDNSKKLLAAAKLLADSTARMVEAAKGA 881

  Fly   896 SSNPHDSDNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAATQCISAAQNAVQH 960
            ::||.:.|.|..||:|||.|| :.|.||...|:|:.::.|||..:||||:||||.|:|:|||...
 Frog   882 AANPENEDQQQRLREAAEGLR-VATNAAAQNAIKKKIVNRLEAAAKQAAAAATQTIAASQNASLS 945

  Fly   961 SQDHQTKETLLQDCKRVADTIPRLVTSLKTTRAQPDDPNAQLNLIEAAEQFIEPALQVSKSSRAL 1025
            :::....:.|:|.||.|||.||:||..:::::||.:|.:|||.||.:::.|::|..::..|::|.
 Frog   946 NKNTAAHQQLVQSCKTVADHIPQLVQGVRSSQAQAEDLSAQLTLIVSSQNFLQPGSKMVASAKAA 1010

  Fly  1026 QPTVTDIPSATQLSKGALHLGQCVSELHSVAQRARDACGGQELESALEEVRKLHDVLDDTRQAAI 1090
            .|||||..:|.|||:.|.:|...::||.:.||:|.:|||..|::|||..|:.|.:.|.|.:.||.
 Frog  1011 VPTVTDQAAAMQLSQCAKNLATSLAELRTAAQKAHEACGPMEIDSALNAVQTLKNELQDAKMAAS 1075

  Fly  1091 AGQLRPLPGQTVENTADELRKSAKNVGIALSQLLSSVLHNQRSYAGAAGRDTALALGDFTRSVHG 1155
            ..||:||||:|:|..|.:|..::|.||.:::|||:........|.|.|.|:||.||....::..|
 Frog  1076 DRQLKPLPGETLEKCAQDLGSTSKTVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARG 1140

  Fly  1156 VAATTQNPA----IIDCADDVVTSSARLIEQAQRTLQGASNPE---ALTQAGREVTGALSATVDC 1213
            |||:|.:|.    ::|.|.||:..||.||::|::.|....:.|   .|.|..:.|:.:|:..|:|
 Frog  1141 VAASTSDPQAASDMLDSARDVMEGSANLIQEAKQALVAPGDAEIQQRLAQVAKAVSHSLNNCVNC 1205

  Fly  1214 IPGQREVDVALRNVSELSEILSMSEFPPSSRPYATLQSELKQVAEQLSSAGGEIV-VSYSSPALL 1277
            :|||::||:||:::.|.|:.|.:...|||::.:...||||.|.||.|:.:.||:| .|......|
 Frog  1206 LPGQKDVDMALKSIGESSKKLLVDSLPPSTKSFQEAQSELNQAAEDLNQSAGEVVHASRGQSGEL 1270

  Fly  1278 AESSQNFAANYRDLLSVSMEMAGQTQEEEVRSHMIESLRHVSTQSCSLLSTAKSIAADPGQPNAK 1342
            |.:|..|:.::.:.|...:|||||||.::.:..:|.||:.:|..|..||..|||::.|.|.|:||
 Frog  1271 AAASGKFSQDFDEFLDAGIEMAGQTQNKDDQMQVIGSLKTISMASSKLLLAAKSLSVDSGAPSAK 1335

  Fly  1343 NLLHAAARGVTESINQLVDASIQSAPGQKECDNAMRNIEALRLMLDYPHEPINELGYFDCVEQAT 1407
            |||.||||.||||||||:....|.||||||||||:|.:|.::.||:.|:||.::|.||||:|...
 Frog  1336 NLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLENPNEPASDLSYFDCIESVM 1400

  Fly  1408 GKSRNLGYAISEMINNAKQSQHVEFSQSVNNVNDSIQGLIESSSQAAYLIGVSHPSSVAGRPGII 1472
            ..|:.||.:::.:..|||......|.:.|:..:.::.||.|::.|||||:|:|.|:|.||:.|::
 Frog  1401 ENSKVLGESMAGISQNAKTGDLPAFGECVSVASKALCGLTEAAVQAAYLVGISDPNSQAGQQGLV 1465

  Fly  1473 DQAQLTWAYQGIRQHCDIVSSQQSTKPQMISALTVIAKHTSYLCSICRQASMNTSNPVAKNEFIV 1537
            |..|...|.|.|:..|..:....|:..|::||.|::|||||.||:.||.||..|:|||||..|:.
 Frog  1466 DPIQFARANQAIQMACQNLVDPASSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKRHFVQ 1530

  Fly  1538 LAKQVATATSDLVQDIKAIEEQSAGGSRER---LVDPLLEAVKAVRQYASSSEFSSVPAKISAEG 1599
            .||:||.:|::||:.||.::...:..:|.:   ...||:.||:.:..:||:.||:|:||:||:||
 Frog  1531 SAKEVANSTANLVKTIKTLDGDFSEENRNKCSIATSPLISAVENLTAFASNPEFASIPAQISSEG 1595

  Fly  1600 RKAQEPVIQAGRGVIDGVVEMVKAAKSLALTPDNPPVWQQLSMHSTPVSESVKRLVDNIRDKAPG 1664
            .:||||::.:...:::....::|.|:|||:.|.:||.|..|:.||..||:|:|.|:.:|||||||
 Frog  1596 ARAQEPILVSAVTMLESSSSLIKTARSLAINPKDPPTWSSLAGHSRIVSDSIKSLITSIRDKAPG 1660

  Fly  1665 QAQCEQVLHTLGTCTRELDSCALAVNAQGLSQRRDNNLHGFSGQTMNSASELIDKLEPIRMAGKN 1729
            |.:|:|.:.::....|:::..:||..:|.|:.|.|.:|.....|..:...|:...::||..|.:.
 Frog  1661 QRECDQSIDSINRFIRDIEQASLASVSQDLAMRDDISLEALQEQLTSVVQEIGHLIDPITTAARG 1725

  Fly  1730 NAEQLGHAVGEISRYVVPMVNGAIGACTHIVHSQQQMSLIQQTRSVVESAITLVQSAKESAGNPR 1794
            .|.||||.|.:::||..|:|..|:|..:.::..||||:::.||:::.|||:.::.:|||..|||:
 Frog  1726 EAAQLGHKVTQLARYFEPLVLAAVGLVSKVLDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPK 1790

  Fly  1795 ATHAHPRLDDAIDGTREAIQELQQTVEKINAETGIVTGLMEQVNRSITRLTDKRQSLLNASYSDT 1859
            |.|.|..:.:|....:||:.:|..|:.:..:|.|:|.|:::.:..::::|.:...    ...:.|
 Frog  1791 AFHTHDAIAEAAQLMKEAVDDLMITLNEAASEVGMVGGMVDSIAEAMSKLDEGTP----PEPTGT 1851

  Fly  1860 FVDYQTRMVARAKEIASLANEMNAKSSVEPSALPQLAVDMTQNYQQLTQDSVGASTTTSSPDVAM 1924
            ||||||..|..:|.||..|.||..||...|..|..||..:|.:|..|......|:.|....:|..
 Frog  1852 FVDYQTTGVKYSKAIAVTAQEMMTKSVTNPEELGGLASQVTSDYGNLAVQGRMAAATAEPKEVGF 1916

  Fly  1925 RIRTTVIDLGRSVSSMIQSSAGGAR--PNDAGAQKEIARSAREVSEKVAQVLAALQAGSRGTQAC 1987
            :|::.:.|||.....::| .||..:  |.|:..::|:...||.|:|||:.||:|||||::|||||
 Frog  1917 QIKSRIQDLGHGCIFLVQ-KAGALQICPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQAC 1980

  Fly  1988 INAAHTVSGIIGDLDTTIMFATAGTLHSDGDGSFADHREHILQTAKALVEDTKVLVTGAAGTQDQ 2052
            |.|:..|||||.||||||||||||||:::...|||||||:||:||||||||||:||:|||.:|::
 Frog  1981 ITASSAVSGIIADLDTTIMFATAGTLNAENKESFADHRENILKTAKALVEDTKLLVSGAASSQEK 2045

  Fly  2053 LANAAQNAVSTITQLAEAVKRGACSLGSTQPDSQ------------------------VMVINAV 2093
            ||.|||::.:|||||||.||.||.||||..|::|                        |::|||:
 Frog  2046 LAQAAQSSANTITQLAEVVKLGAASLGSDDPETQLFIFLQIRRPGPETVFQMNTEQCGVVLINAI 2110

  Fly  2094 KDVASALGDLINCTKLASGKSINDPSMQDLKESARVMVLNVSSLLKTVKAVEDEHTRGTRAMEAT 2158
            ||||.||||||..||.|:||:.:||||..||.:|:|||.||:||||||||||||.||||||:|||
 Frog  2111 KDVAKALGDLIEATKCAAGKAADDPSMYQLKSAAKVMVTNVTSLLKTVKAVEDEATRGTRALEAT 2175

  Fly  2159 VEAISQEIRAMHSPPPVGNTQVGPEDLIRVTMNVTAATAKAVAAGTSNLQADIVSAANLGRRAIS 2223
            :|.|.||:....|......|. .||:.||:|..:|.|||||||||.|..|.|:::.|||.|:|:|
 Frog  2176 IEHIKQELTVFQSKDIPEKTS-SPEESIRMTKGITTATAKAVAAGNSCRQEDVIATANLSRKAVS 2239

  Fly  2224 EMLIVCRSVAWNCAETEELRSRTLEAGTAVGESYRDLLS---GILHNCSADDRMHL---SRRVAK 2282
            |||..|:...::.....:.|.|....||....:|.::|.   .||...|.:.:..|   |:|:|.
 Frog  2240 EMLTACKQAVYHPDVNADTRQRAFRYGTECTFAYLEMLEHVLSILQKPSLETKQQLSIFSKRIAA 2304

  Fly  2283 CVTDLVAMARLLKGSDWIDPEDPTVIAENELLGAAASIDAAAKKLASLRPR---RQADVKIELDE 2344
            .||:|:.....:||::|:||:|||||||.|||||||||:||||||..|:||   |||      ||
 Frog  2305 AVTELIQTTETMKGTEWVDPQDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPRQA------DE 2363

  Fly  2345 NMKFDEMILEAAKGIMGASAALVRAANAAQRELIDTGKVARRPLTSSDDGQWSEGLISAARLVAA 2409
            .:.|:|.||||||.|..|::|||::|:||||||:..|||......::||||||:|||||||:|||
 Frog  2364 TLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGAIAANAADDGQWSQGLISAARMVAA 2428

  Fly  2410 ATHSLVEAAQNLVRGVGTEEMLISTAKQVAASTAQLLIACKVKSNPNSEAGRRLQAAGNAVIKST 2474
            ||.:|.|:|...|:|..:||.|||:||||||||||||:|||||::.:|||.||||||||||.:::
 Frog  2429 ATSNLCESANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRAS 2493

  Fly  2475 DNLVHSAQQ-GLEAEEEHSLKINTSMVDGMAQEINARSAVLRKEKELEEARQLLKNVRHAQ 2534
            ||||.:||: .....||..:.:.|..|.|:||.|.|:..:|:||:||||||:.|..:|..|
 Frog  2494 DNLVRAAQKAAFSKAEEDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQ 2554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rhea	NP_648238.1	FERM_f0	4..85	CDD:465152	43/80 (54%)
		FERM_F1_TLN	88..205	CDD:340610	63/116 (54%)
		B41	89..322	CDD:214604	141/232 (61%)
		FERM_C_Talin	318..409	CDD:269973	71/90 (79%)
		Talin_middle	510..668	CDD:462691	60/160 (38%)
		ILWEQ	622..>768	CDD:214607	76/145 (52%)
		Vinculin	<874..>1035	CDD:460040	74/160 (46%)
		talin-RS	1661..1832	CDD:213393	58/170 (34%)
		VBS	1859..1982	CDD:430312	49/124 (40%)
		I_LWEQ	2392..2533	CDD:460265	84/141 (60%)
tln2	XP_012822328.1	FERM_F0_TLN2	4..87	CDD:340692	43/82 (52%)
		Ubl1_cv_Nsp3_N-like	88..199	CDD:475130	63/116 (54%)
		FERM_M	203..316	CDD:459788	76/112 (68%)
		FERM_C_Talin	312..403	CDD:269973	71/90 (79%)
		Talin_middle	495..656	CDD:462691	60/160 (38%)
		talin-RS	1046..>1175	CDD:213393	52/128 (41%)
		talin-RS	1207..1354	CDD:213393	67/146 (46%)
		talin-RS	1657..1828	CDD:213393	58/170 (34%)
		VBS	1851..1975	CDD:430312	49/124 (40%)
		ILWEQ	2362..2557	CDD:214607	110/193 (57%)