DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and slc39a14

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001313628.1	Gene:	slc39a14 / 799782	ZFINID:	ZDB-GENE-060315-2	Length:	494	Species:	Danio rerio

Alignment Length:	541	Identity:	150/541 - (27%)
Similarity:	234/541 - (43%)	Gaps:	138/541 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EEEDHSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELKAQS 230
            :.|||.      :..|...|:...|.:......:.:.::::   :.::.|..:||.::.:|.:|:
Zfish    73 QSEDHD------SKTQPTRTNASKCLAADTLAVYGMSEQSR---IDERGLQQICPTMIQQLDSQA 128

  Fly   231 GGC-IEPAILSDIDTTEELLEAEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYII 294
              | .:|.  .:.:::....|||       ||.|..:.|....:..|||.:::|||...:||.::
Zfish   129 --CKTQPN--QESESSPRPTEAE-------VWGYGLLCVTVISLCSLVGASVVPFMRKTFYKRLL 182

  Fly   295 QYLVALAVGTMTGDALLHLLPHSLAGQD--ERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSV 357
            .|.:|||:||:..:||..|:|.:. |.|  |...:.|.....||...|:..|..|.||      :
Zfish   183 LYFIALAIGTLYSNALFQLIPEAF-GFDPMEDYYVPKSAVVFGGFYLFFFTEKILKMI------L 240

  Fly   358 EKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGA 422
            :.|:|.......                                          .|.|.:..|.:
Zfish   241 KPKDTGGHGHGH------------------------------------------SHFPAERYANS 263

  Fly   423 GGDAPSVAELRNGVGDHDGSNDMAAAAESLISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTI 487
            .||      |.:||            .|.|                        ||.|...:...
Zfish   264 NGD------LEDGV------------MEKL------------------------QNGEAGGAALP 286

  Fly   488 VTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHS----HRHGHVHSPPETLSAVAWMII 548
            ..:.||..|     .:|....:...||  ::.:||..|.:    ...|..:|...||   ||||.
Zfish   287 RAEADGRGV-----GEDDKMLSTGQTV--QDTQSSGGGGTGGCYWLKGRAYSDIGTL---AWMIT 341

  Fly   549 MGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTG 613
            :.||||||.||:||||:|..::..|.|||:|:.|.|.|||||||.||:.||||::.|:::|.|:.
Zfish   342 LSDGLHNFIDGLAIGASFTASVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSA 406

  Fly   614 VLSFIGMIFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMP---EISASHKSLG------QFLLQ 669
            ...::||.|||..|.:.. ..|:||:|.|:|:||||.||.|   |:|...:..|      .|.||
Zfish   407 CCCYLGMGFGILAGNNFS-PNWIFALAGGMFLYIALADMFPEMNEVSREEEEAGGSGFLLTFALQ 470

  Fly   670 ILGMLSGVGIMLLIALYEGDL 690
            ..|:|:|..|||::.:|.|.:
Zfish   471 NAGLLTGFAIMLVLTIYSGQI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	132/440 (30%)
slc39a14	NP_001313628.1	Zip	146..485	CDD:308248	134/447 (30%)
		HHHGHXHX-motif. /evidence=ECO:0000250\|UniProtKB:Q15043	248..255		0/48 (0%)
		XEXPHE-motif. /evidence=ECO:0000250\|UniProtKB:Q15043	376..381		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020