DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and Slc39a4

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_082340.1	Gene:	Slc39a4 / 72027	MGIID:	1919277	Length:	660	Species:	Mus musculus

Alignment Length:	773	Identity:	186/773 - (24%)
Similarity:	296/773 - (38%)	Gaps:	267/773 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RLHCQD-------HIESLLG--------PARVTTHNSQD----QLNARVYTNLSPSSETTDRRQQ 63
            |:||.|       .:|::|.        ||..:...|:.    ...|.:|.| :|.....|.:..
Mouse    53 RVHCTDGPCEKCLSVENVLALGKPDKPQPAPESVLESRHIIYLSAAAALYLN-NPEKTCKDIQAG 116

  Fly    64 RSASGDDDTFNYSISPPS---------RREKRHAGHEHGPTSESR---VPQITQYYLEKLMAQ-- 114
            ..||..||......||.:         ::.:.||..:  ||.|..   :||:    ||:..|.
Mouse   117 LLASHVDDYLATLESPEAMTLGLSQLLQKIEAHAASQ--PTGEKTCVDLPQL----LEEAEAAGV 175

  Fly   115 ------------DELMNSSGFDGLLQ-----------------QLSLHSLASGASEGTCVPGSRL 150
                        |.::|.|.|.||..                 .::||.|            ..|
Mouse   176 SKSAGLVLTALLDHVINGSCFQGLPSPQYFVDFVFRLHSSDPPNITLHEL------------ENL 228

  Fly   151 VHHV-------QPHDHH--HA-HHHEEEDHSLQLNNCTLIQNGTTS--NVICPSLPN-NNTHPLG 202
            :||:       ..||.|  || |.|.:...|.|.:......|..:|  :.:|.|..: ...:.|.
Mouse   229 MHHLGVGGEDHSDHDDHGDHADHSHPDRKASHQDSELHTPHNSNSSVWDTLCLSAKDIMAVYGLS 293

  Fly   203 KEAKNFTLSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTTEELLEAEKDKDIFYVWIY---A 264
            :||   .:|.:....|.|.|:.:   |..|...|  ...|...::|.:.|:       ::|   |
Mouse   294 EEA---GVSPQAWAQLTPALVQQ---QLSGACSP--YPTIRIQDQLSQTER-------YLYGSLA 343

  Fly   265 FISVFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDALLHLLP-----HSLAG---- 320
            .:.:..|.:.||:.:.......:.:  ||:|..::||||.:||||||||:|     |:..|
Mouse   344 TLLICLCAVFGLLLLTCAKCSTATH--YIMQTFLSLAVGALTGDALLHLIPKVLGLHTHGGEGHT 406

  Fly   321 -QDERGM----IMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNN 380
             ::|.|:    ..:.|..|||...|::.|....::                   :.||.||.
Mouse   407 HEEEVGVGGQATWRLLAVLGGFYIFFLFESFFNLL-------------------LPRDQDSE--- 449

  Fly   381 SVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSVAELRNGVGDHDGSNDM 445
                                                                ::|...|.|
Mouse   450 ----------------------------------------------------KDGPCSHGG---- 458

  Fly   446 AAAAESLISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTIVTDLDGNAVYAVNKAKDKDSRND 510
                       |::.:.:.....|.:.:  :|.||...|:.:.                     :
Mouse   459 -----------HSHGISLQLAPSNLRQS--KQTHESSRSDLVA---------------------E 489

  Fly   511 HVTVILREHESSHHGHSHRHGHVHSPPET------LSAVAWMIIMGDGLHNFTDGMAIGAAFAEN 569
            ....:|.                   |||      |..:.::|.:||.:|||.||:|:||||:.:
Mouse   490 ETPELLN-------------------PETRRLRAELRLLPYLITLGDAVHNFADGLAVGAAFSSS 535

  Fly   570 IAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQSQDVAQ 634
            ...|.:||||||||||||||||||.|:.||:|||.|:..||.:.:.:|.|:...:|.|..::...
Mouse   536 WKTGLATSLAVFCHELPHELGDFAALLHAGLSVKRALLLNLASALTAFAGLYVALAVGVGEEGEA 600

  Fly   635 WMFAVAAGLFIYIALVDMMPEIS--ASHKSLGQFLLQILGMLSGVGIMLLIALYEGDL 690
            |:.|||.|||:|:||.||:|.:.  ...:....|||..:|:|.|..::||::|||.::
Mouse   601 WILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTVLLLLSLYEDNI 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	115/450 (26%)
Slc39a4	NP_082340.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..273		10/39 (26%)
Slc39a4	NP_082340.1	Zip	338..651	CDD:280666	114/445 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.980