DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and SLC39A10

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001120729.1	Gene:	SLC39A10 / 57181	HGNCID:	20861	Length:	831	Species:	Homo sapiens

Alignment Length:	767	Identity:	236/767 - (30%)
Similarity:	343/767 - (44%)	Gaps:	205/767 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HCQDHIESLLGPARVTTHNSQDQLNARVYTNLS------------PSSETTDRRQQRSASGDDDT 72
            |..||...|....|:  |:..|..|...:.|.|            ||:||...::|....
Human   170 HMHDHNHRLRHHHRL--HHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVK----- 227

  Fly    73 FNYSISPPSRREKRHAGHEHGPTSESRVP-------QITQYYLEKLMAQDELMNSSGFDGLLQQL 130
                 .|..:|:|:  |.:....||...|       |..||...::...|.:.|
Human   228 -----LPKGKRKKK--GRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHN----------- 274

  Fly   131 SLHSLASGASEGTCVPGSRLVH--HVQPHDHHHAHHHEEEDHSLQLNNCTLIQNGTTSNVICPSL 193
                           ||...||  ....||....|...:.|:..:|.:        |.....|.:
Human   275 ---------------PGHSHVHLPERNGHDPGRGHQDLDPDNEGELRH--------TRKREAPHV 316

  Fly   194 PNNNTHPLGKE----------------------AKNFTLSDKDLLHLCPILLYELKAQSGGCIE- 235
            .||....|.|:                      ..|..:|.....:|||.|||::.::.  |||
Human   317 KNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRL--CIEH 379

  Fly   236 --PAILSDIDTTEELLEAEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYIIQYLV 298
              ..::.||:..:.|:..::.......||...||:....:|.|:||.::|.:....:|:::.:||
Human   380 FDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLV 444

  Fly   299 ALAVGTMTGDALLHLLPHSLAGQD----------------------ERGMIMKGLGCLGGIIFFY 341
            |||||||:|||||||||||..|.|                      |...::|||..||||...:
Human   445 ALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLLF 509

  Fly   342 VMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNN 406
            ::||.:.|...:          |..|.|.......:...|..|.|:...|.::.|
Human   510 IIEHCIRMFKHY----------KQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTP---------- 554

  Fly   407 KQSEWMHL-PFDVAAGAGGDAPSVAELRNGVGDHDGSNDMAAAAESLISPLHTNCVE---MNHHN 467
             .|:|:.| |.     ||.|...|:|.|.   :.....|:....||  .|.:..|:|   :..|:
Human   555 -DSDWLQLKPL-----AGTDDSVVSEDRL---NETELTDLEGQQES--PPKNYLCIEEEKIIDHS 608

  Fly   468 HN------HKHNSH--QQNHEGQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESS-H 523
            |:      |:|:.|  ..||.|:                 ||            .:||:|... |
Human   609 HSDGLHTIHEHDLHAAAHNHHGE-----------------NK------------TVLRKHNHQWH 644

  Fly   524 HGHSHR-HGHVHSPPET----LSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCH 583
            |.|||. ||..||..:.    ::.:|||:|||||:|||:||:||||||:..:.||.|||:|||||
Human   645 HKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCH 709

  Fly   584 ELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVAQWMFAVAAGLFIYI 647
            ||||||||||:|:||||:||.|:.||||:.::::|||:.|.|.|| :.::..|:|||.||:|:|:
Human   710 ELPHELGDFAVLLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYV 774

  Fly   648 ALVDMMPEI------SASHK--SLGQFLLQILGMLSGVGIMLLIALYEGDLM 691
            |||||:||:      :..|.  .:|||:||.||:|.|..|||:|||||..::
Human   775 ALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIV 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	175/474 (37%)
SLC39A10	NP_001120729.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..318		38/195 (19%)
		Zip	404..819	CDD:280666	175/474 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..484		2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2474
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	1	1.000	-	-		FOG0009675
OrthoInspector	1	1.000	-	-		otm41192
orthoMCL	1	0.900	-	-		OOG6_106743
Panther	1	1.100	-	-	LDO	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	1	1.000	-	-		X2614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790