DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and slc39a6

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001001591.1	Gene:	slc39a6 / 324303	ZFINID:	ZDB-GENE-030131-3023	Length:	742	Species:	Danio rerio

Alignment Length:	718	Identity:	211/718 - (29%)
Similarity:	314/718 - (43%)	Gaps:	220/718 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 HNSQDQLNARVYTNL-SPSSETTDRRQQRSASGD--DDTFNYSISPPSRREKRHAGH-EHGPTSE 97
            ||...::|....|.| :||..|..||..|||..|  .|..::|.|.|:.....|..| |..||.:
Zfish   185 HNLYMKMNQESTTALTTPSYVTRSRRTNRSADYDFTQDHASFSPSQPNVTHSNHTHHDEDTPTHQ 249

  Fly    98 SRVPQITQYYLEKLMAQDELMNSSGFDGLLQQLSLHSLASGASEGTCVPGSRLVHHVQPHDHHHA 162
                                                                       ||.|..
Zfish   250 -----------------------------------------------------------HDDHDE 255

  Fly   163 HHHEEEDHSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELK 227
            |.|.......| |..|::|                ||.:.|||   :||.||...|||.||.::.
Zfish   256 HEHARASLGCQ-NASTILQ----------------THGMRKEA---SLSVKDFSFLCPALLMQID 300

  Fly   228 AQSGGCIEPAILSDIDTTEELL------------------------EAEKDKDIFYVWIYAFISV 268
            ::|  ||   :..|.|...:..                        ..:::..::..|:..|:|:
Zfish   301 SKS--CI---VHEDEDEHSDHSHHHKHHHHHHDHQHLQHPHNHTNGRGQRNTPVYIAWLGGFLSI 360

  Fly   269 FACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDALLHLLPHS------------LAGQ 321
            ....:|.||||.:||.|....:.:::.:||||||||::|||||||:|||            ...:
Zfish   361 TLISLLALVGVVLIPLMNRVCFNFLLSFLVALAVGTLSGDALLHLIPHSQGHHHHGHSEEHAEEE 425

  Fly   322 DERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDK 386
            |....:..||..|.|:...:::||.||:                  .|:.:|.:..|...|
Zfish   426 DSLRPVWTGLTALSGVYIMFLIEHFLTL------------------GKMYKDKNQKVQKRV---- 468

  Fly   387 ICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSVAE--LRNGVGDHDGSNDMAAAA 449
                          ::|....:||.:              ||:.|  ::....:.:|...:|...
Zfish   469 --------------DLTTEVLESEKL--------------PSLEENDVKIEAAETNGGRALAEEE 505

  Fly   450 ESLISPLHTNCVEMNHHNHNHKHN----SHQQNHEGQDSNTIVTDLDGNAVYAVNKAKDKDSRND 510
            |.::.....|.::..:..|:|.|:    |.:|:|.                           .:|
Zfish   506 EVMLGAELYNDIDCENKCHSHFHDTVGQSDEQHHH---------------------------HHD 543

  Fly   511 HVTVILREHESSHHGHSHRHGHVHSPPET------LSAVAWMIIMGDGLHNFTDGMAIGAAFAEN 569
            :..::...|..:||.|:|.|.|.||..:.      ::.:|||:|||||||||:||:||||||.|.
Zfish   544 YHHILHHHHSQNHHPHTHTHRHTHSYSQQHFEQAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEG 608

  Fly   570 IAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVA 633
            ::.|.|||:|||||||||||||||:|:||||||:.|:.||||:.::.::|||.||..|. :::||
Zfish   609 LSSGLSTSVAVFCHELPHELGDFAVLLKAGMSVRQAMLYNLLSALMGYLGMIIGILIGHYAENVA 673

  Fly   634 QWMFAVAAGLFIYIALVDMMPEI------SASHKSLGQFLLQILGMLSGVGIMLLIALYEGDLMS 692
            .|:||:.||||:|:|||||:||:      .|.....|.||||..|:|.|.||||:||::|..:..
Zfish   674 TWIFALTAGLFMYVALVDMVPEMLHNDASEAGFSHYGFFLLQNAGILLGFGIMLIIAVFEDRIQL 738

  Fly   693 AFG 695
            ..|
Zfish   739 DLG 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	156/456 (34%)
slc39a6	NP_001001591.1	Zip	351..730	CDD:280666	156/455 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2750
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26076
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	1	1.000	-	-		X2614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.960