DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and Slc39a6

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_001019916.1	Gene:	Slc39a6 / 291733	RGDID:	1304664	Length:	741	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	216/770 - (28%)
Similarity:	329/770 - (42%)	Gaps:	238/770 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 EKRHAGHEHGPTSESRVPQITQYYLEKLM---AQDELMNSSGFDGLLQQLSLHSLASGASEGTCV 145
            ||.::..|.|...:..| .:.:::|::|.   .:::.::..||..|||.:.:..:
  Rat    35 EKINSNWESGINVDVAV-TMQRHHLQQLFYRYGENDSLSVEGFRKLLQNIGIDKI---------- 88

  Fly   146 PGSRLVH-HVQPHDH-HHAHHHEEEDHSLQLNNCTLIQNGTTSNVICPSLPNNN----------- 197
               :.|| |   ||| .|:.|....||....:.........:....||.|.::|
  Rat    89 ---KRVHIH---HDHERHSDHERHSDHERHSHRGHAAAGKNSRKAFCPDLDSDNSGKNPNTSQGK 147

  Fly   198 -THPL--------GKEAKNF---------TLSD-----------------KDLLHLCPILLYE-- 225
             :.|.        |||:.:.         |:|:                 ||:....|..:.|
  Rat   148 GSRPAEHVNGRRNGKESASSSEVTSAVYNTVSEGTHFLETIETPKPGRRTKDINPSTPPSITEKS 212

  Fly   226 ------------------------------------------------------LKAQSGGCIEP 236
                                                                  |.|.....:.|
  Rat   213 RVGRLSRLARRKGNDSVSEPRKSFMYSRTSNDNIQECFNATKLLTSHGMSVQALLNATEFNYLCP 277

  Fly   237 AILSDIDTTEELLEAEKDK---------DIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKY 292
            ||::.||....|:....:|         .:...|:..||::.....|.|:||.::|.|...::|:
  Rat   278 AIINQIDARSCLIHTASEKKAEIPPKTYSLQIAWLGGFIAISIISFLSLLGVILVPLMNRVFFKF 342

  Fly   293 IIQYLVALAVGTMTGDALLHLLPHSLA------GQDERGMIM----------------------- 328
            ::.:||||||||::|||||||||||.|      ..:|..|.|
  Rat   343 LLSFLVALAVGTLSGDALLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSAQNLEESSYFDST 407

  Fly   329 -KGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQ-- 390
             |||..|||:.|.:::||.||:|.:: |..:||..|||       :.|..|.:.       ||
  Rat   408 WKGLTALGGLYFMFLVEHVLTLIKQF-KDKKKKNQKKP-------ENDEDVESK-------KQLS 457

  Fly   391 KYSSYPYCYDE-ITMNNKQSEWMHL------PFDVAAGAGGDAPSVAELRNGVGDHDGSNDMAAA 448
            ||.|.....:| :....:...::..      |||      ...|::.|                .
  Rat   458 KYESQLSTNEEKVDTGERPESYLQADSQEPSPFD------SQQPTLLE----------------E 500

  Fly   449 AESLISPLHTNCVEMNHHNHNHKHNSHQQNHE--GQDSNTIVTDLDGNAVYAVNKAKDKDSRNDH 511
            .|.:|:..|...|...:.....|:..|...|:  ||..:.|                  ...:|:
  Rat   501 EEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLI------------------HHHHDY 547

  Fly   512 VTVILREHESSHHGHSH--RHGHVHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGF 574
            ..::...|..:||.|||  |:.........::.:|||:|||||||||:||:||||||.|.::.|.
  Rat   548 HHILHHHHHQNHHPHSHSQRYSREELKDAGIATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGL 612

  Fly   575 STSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVAQWMFA 638
            |||:|||||||||||||||:|:||||:||.||.||.|:.:|:::||..||..|. :::|:.|:||
  Rat   613 STSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFA 677

  Fly   639 VAAGLFIYIALVDMMPEI----SASH--KSLGQFLLQILGMLSGVGIMLLIALYE 687
            :.||||:|:|||||:||:    ::.|  ...|.|.||..|:|.|.||||||:::|
  Rat   678 LTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGILLGFGIMLLISIFE 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	169/475 (36%)
Slc39a6	NP_001019916.1	TroA-like	<77..>123	CDD:294188	13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..172		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..213		4/23 (17%)
		Zip	309..728	CDD:280666	168/473 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..494		17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2663
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45329
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2614
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930