DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and SLC39A6

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	NP_036451.4	Gene:	SLC39A6 / 25800	HGNCID:	18607	Length:	755	Species:	Homo sapiens

Alignment Length:	814	Identity:	225/814 - (27%)
Similarity:	340/814 - (41%)	Gaps:	277/814 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TFNYSISPPSRREKRHA----GHEHGPTSESRVP-----QITQYYLEKLM---AQDELMNSSGFD 124
            ||..|::.|....|..|    ..:..|..||.:.     ...||:|::|.   .::..::..||.
Human    12 TFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFR 76

  Fly   125 GLLQQLSLHSLASGASEGTCVPGSRL-VHHVQPHDHH--------------HAH-----HHEEED 169
            .|||.:.:..:            .|: :||  .||||              |.|     ||.:.|
Human    77 KLLQNIGIDKI------------KRIHIHH--DHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHD 127

  Fly   170 HSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAKNF-------------------------- 208
            |....|:....:|  ....:|   |::::...||:.:|.
Human   128 HHSHHNHAASGKN--KRKALC---PDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEV 187

  Fly   209 ------TLSD------------------KDLL--------------------------------- 216
                  |:|:                  ||:.
Human   188 TSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFM 252

  Fly   217 ------------------------------------HLCPILLYELKAQSGGCIEPAILSDIDTT 245
                                                :|||.::.::.|:|  |:       |.|:
Human   253 YSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARS--CL-------IHTS 308

  Fly   246 EELLE-AEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDA 309
            |:..| ..|...:...|:..||::.....|.|:||.::|.|...::|:::.:||||||||::|||
Human   309 EKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDA 373

  Fly   310 LLHLLPHSLA------GQDERGMIM------------------------KGLGCLGGIIFFYVME 344
            .|||||||.|      ..:|..|.|                        |||..|||:.|.:::|
Human   374 FLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVE 438

  Fly   345 HALTMISEWRKSVEKKETKKPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQS 409
            |.||:|.:: |..:||..|||.     .|.|..:...::       ||.|      :::.|.::.
Human   439 HVLTLIKQF-KDKKKKNQKKPE-----NDDDVEIKKQLS-------KYES------QLSTNEEKV 484

  Fly   410 EWMHLPFDVAAG---AGGDAPSVAELRNGVGDHDGSNDMAAAAES--LISPLHTNCVEMNHHNHN 469
            :    ..|...|   |....||          |..|...|...|.  :|:..|...|...:....
Human   485 D----TDDRTEGYLRADSQEPS----------HFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRG 535

  Fly   470 HKHNSHQQNHE--GQDSNTIVTDLDGNAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSH--RH 530
            .|:..|...|:  ||..:.|                  ...:|:..::...|..:||.|||  |:
Human   536 CKNKCHSHFHDTLGQSDDLI------------------HHHHDYHHILHHHHHQNHHPHSHSQRY 582

  Fly   531 GHVHSPPETLSAVAWMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAIL 595
            .........::.:|||:|||||||||:||:||||||.|.::.|.|||:|||||||||||||||:|
Human   583 SREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVL 647

  Fly   596 IKAGMSVKSAVYYNLLTGVLSFIGMIFGIAFGQ-SQDVAQWMFAVAAGLFIYIALVDMMPEI--- 656
            :||||:||.||.||.|:.:|:::||..||..|. :::|:.|:||:.||||:|:|||||:||:
Human   648 LKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHN 712

  Fly   657 -SASH--KSLGQFLLQILGMLSGVGIMLLIALYE 687
             ::.|  ...|.|.||..|||.|.||||||:::|
Human   713 DASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	170/471 (36%)
SLC39A6	NP_036451.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..186		17/95 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..246		2/43 (5%)
		Zip	323..742	CDD:308248	169/469 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3166
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2474
Isobase	1	0.950	-	0	Normalized mean entropy	S3931
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41192
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4006
SonicParanoid	1	1.000	-	-		X2614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.910