Protein Alignment foi and SLC39A12

DIOPT Version :9

• Sequence 1: NP_001261584.1
• Gene: foi / 38976
• FlyBaseID: FBgn0024236
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: NP_001138667.1
• Gene: SLC39A12 / 221074
• HGNCID: 20860
• Length: 691
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 148/657 - (22%)
• Similarity: 259/657 - (39%)
• Gaps: 230/657 - (35%)

  Fly    96 SESRVPQIT---------------------QYYLEKLMAQDELMNS---SGFDGLLQQLSLHSLA 136
            :||.:||:.                     .|:.|.:.:.....|:   |..|.||..|...|
Human   201 NESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRS-- 263

  Fly   137 SGASEGTCVPGSRLVHHVQ-------PHDHHHAH-----HHEEEDHSLQLN-NC--------TLI 180
                  ||:...: :|..|       .||..:::     ..|.||..:..: .|        ..:
Human   264 ------TCIKNEK-IHQFQRKQNNIITHDQDYSNFSSSMEKESEDGPVSWDQTCFSARQLVEIFL 321

  Fly   181 QNGTTSNVICPSLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTT 245
            |.|.:                       .:|.:|...:.|.::.:|.:.|  |..|.     |..
Human   322 QKGLS-----------------------LISKEDFKQMSPGIIQQLLSCS--CHLPK-----DQQ 356

  Fly   246 EELLEAEKDKDIFYVWIYAFISVFACGILGLVGVAIIPFMG-SRYYKYIIQYLVALAVGTMTGDA 309
            .:|.....:|     :.|:.::|....:..::|.|::.|.. ...|:.|:|..|.|||||::|||
Human   357 AKLPPTTLEK-----YGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDA 416

  Fly   310 LLHLLPHSLA-----------GQDERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETK 363
            ||||:|..|.           ..:.:|.|.|.:|.:|||..|:::|....::
Human   417 LLHLIPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILL------------- 468

  Fly   364 KPSRAKVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPS 428
                                                  ::.|:||.
Human   469 --------------------------------------VSPNDKQG------------------- 476

  Fly   429 VAELRNGVGDHDGSNDMAAAAESLISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTIVTDLDG 493
             ..|.||   |.|                        |:|:...||...:..|:          |
Human   477 -LSLVNG---HVG------------------------HSHHLALNSELSDQAGR----------G 503

  Fly   494 NAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSHRHGHV---HSPPETLSAVAWMIIMGDGLHN 555
            .:...:.....:||:...:.:                |.:   :...:.:|.:|.||::||.|||
Human   504 KSASTIQLKSPEDSQAAEMPI----------------GSMTASNRKCKAISLLAIMILVGDSLHN 552

  Fly   556 FTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGM 620
            |.||:||||||:.:...|.:|::|:.|||:|||:||||:|:.:|:|:|:|:..|.::.:.:|:|:
Human   553 FADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFMGL 617

  Fly   621 IFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEIS--ASHKSLGQFLLQILGMLSGVGIMLLI 683
            ..|::......|..|:|.|.||:|:|::||:|:||::  .:.:....||||..|::.|...:||:
Human   618 YIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLLQNFGLILGWLSLLLL 682

  Fly   684 ALYEGDL 690
            |:||.::
Human   683 AIYEQNI 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	110/442 (25%)
SLC39A12	NP_001138667.1	Zip	369..671	CDD:308248	106/425 (25%)
		XEXPHE-motif	580..585		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D657777at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12191
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920