DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foi and AgaP_AGAP005405

DIOPT Version :9

Sequence 1:	NP_001261584.1	Gene:	foi / 38976	FlyBaseID:	FBgn0024236	Length:	706	Species:	Drosophila melanogaster
Sequence 2:	XP_315414.4	Gene:	AgaP_AGAP005405 / 1276105	VectorBaseID:	AGAP005405	Length:	823	Species:	Anopheles gambiae

Alignment Length:	870	Identity:	309/870 - (35%)
Similarity:	436/870 - (50%)	Gaps:	225/870 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARHIMAVCVVCLLCAHRLHCQDHI-----ESLLGPARVTTHNSQDQLNARVYTNLSPSSETTDR 60
            ||||:|||||||||||..|.|:.|.     |.|:...|.|..|.:..|:.:.|..:..:.:...|
Mosquito     1 MARHLMAVCVVCLLCADHLPCKQHFSDDGTEKLVPGPRGTLRNVRSLLDQQQYEPVVAAYDAVHR 65

  Fly    61 RQQRSASGDDDTFNYSISPPSRREKRHA-GHEHGPTSESR-VPQITQYYLEKLMAQ-----DELM 118
            ..:|.|....:..::      ..|..|. |....||...| :....:..:.|:..:     ...|
Mosquito    66 IVRRHAHHHHEEEDH------EEEDVHTEGVSEAPTEFDRLIKGKMEQAMRKIFTEYGDPASMTM 124

  Fly   119 NSSGFDGLLQQLSLHSL------------ASGASEGT--------CVPGSRLVHHVQP------- 156
            :..||:.:::||.:..|            .|.|:|.|        |:..:..:..|.|
Mosquito   125 DVQGFERMVRQLGMIRLVQSGVAAPIDGSGSDATETTPQQVDSLKCISSNDFLRRVTPPKIRSQE 189

  Fly   157 -----HDHHHAHHHEEEDHSLQLNNCTLI-----------------------------------Q 181
                 .....::..|:|..:.|..:.|.:                                   .
Mosquito   190 WEDAAKSDTSSNEAEKEGSNSQPTDSTSVDGGDSVNQKSGAKLILTNDKIQNTSISNSSANSDSS 254

  Fly   182 NGTTSN-------------VICP------SLPNNNTHPLGKEAKNFTLSDKDLLHLCPILLYELK 227
            |..|||             |:.|      :..:|:|..|.:...:..|.|:||..:||:||..|.
Mosquito   255 NNNTSNNSSSSTEDPLLVRVLVPEEKQMNASSDNSTTILPRVESSVMLGDRDLYSVCPMLLGHLL 319

  Fly   228 A----QSGGC-----IEPAILSDIDTTEELLEAEKDKDIFY----------------VWIYAFIS 267
            :    :..||     |.|.::|      .||: :.|....:                ||||:|::
Mosquito   320 STVPLERSGCFDEDSIPPLLVS------SLLD-QNDPHHHHHHHHHHHHGDGGSEAAVWIYSFLT 377

  Fly   268 VFACGILGLVGVAIIPFMGSRYYKYIIQYLVALAVGTMTGDALLHLLPHSL--------AGQDER 324
            :....:.||:|||:||.|...:|.:::|:|||||:||:.||||||||||::        |..|
Mosquito   378 ILGVSLCGLLGVAVIPCMDKHFYHHVLQFLVALAIGTLCGDALLHLLPHAMLSSLGNAKAAHD-- 440

  Fly   325 GMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDS-SVNNSVAGDKIC 388
            .|:.|||..:.||:|||.||..||:|:||.|:.:||: |.|||.:|||||:| |::.:.||:|.|
Mosquito   441 AMMYKGLAAVLGIVFFYFMERFLTVIAEWCKTRQKKD-KPPSRVRVMRDPESTSLHAASAGEKQC 504

  Fly   389 KQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSVAELRNGVGDHDGSNDMAAAAESLI 453
            |.||||||||||||.|:.|.....|                   ..|.|.::..|...|
Mosquito   505 KHKYSSYPYCYDEIAMDTKDDHHEH-------------------NTGTGTNENHNSALA------ 544

  Fly   454 SPLHTNCVEMNHHNHN---------------HKHNSHQQ-NHEGQDSNTIVTDLDGNAVYAV--- 499
                 .|.  ||| ||               :.|::||. ..|..|:||:.|:||..::.:.
Mosquito   545 -----KCA--NHH-HNGELNADHGSSEYAGLNNHHAHQHAAQEANDNNTVSTNLDEGSIESEQLN 601

  Fly   500 -----------------NKAKDKDS---RNDHVTVILREHESSHHGHSHRHGHVHSPPETLSAVA 544
                             :|:.:..|   |.::.|:||||||:.||||||.||||||||.:|||||
Mosquito   602 NHHQTGAAGGGAGGRQGSKSSEPASGKLRPENYTIILREHETKHHGHSHTHGHVHSPPGSLSAVA 666

  Fly   545 WMIIMGDGLHNFTDGMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYN 609
            ||::||||||||||||.||||||.||||||||::|||||||||||||||:|:|||||.:.|||||
Mosquito   667 WMVVMGDGLHNFTDGMTIGAAFANNIAGGFSTAIAVFCHELPHELGDFAVLLKAGMSAREAVYYN 731

  Fly   610 LLTGVLSFIGMIFGIAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEISASHKS-----LGQFLLQ 669
            ||:.:||.:||:.||..|...:.:.|:||||||:|:|||||||:||:::||.:     ..:|:||
Mosquito   732 LLSSLLSLLGMVLGIIVGHQPEASSWVFAVAAGMFLYIALVDMIPELTSSHGAEERCKTSEFVLQ 796

  Fly   670 ILGMLSGVGIMLLIALYEGDLMSAF 694
            .||:..|..||::||:||.|||..|
Mosquito   797 FLGLTLGFSIMMVIAMYEHDLMLIF 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_001261584.1	Zip	258..684	CDD:280666	223/494 (45%)
AgaP_AGAP005405	XP_315414.4	Zip	370..811	CDD:280666	223/476 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	267	1.000	Domainoid score	I4441
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H106911
Inparanoid	1	1.050	491	1.000	Inparanoid score	I3125
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D461652at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto108115
Panther	1	1.100	-	-	LDO	PTHR12191
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2614
TreeFam	1	0.960	-	-
	11	10.930