Protein Alignment foi and slc39a4

DIOPT Version :10

• Sequence 1: NP_523974.3
• Gene: foi / 38976
• FlyBaseID: FBgn0024236
• Length: 706
• Species: Drosophila melanogaster
• Sequence 2: XP_031760368.1
• Gene: slc39a4 / 100485091
• XenbaseID: XB-GENE-6049378
• Length: 681
• Species: Xenopus tropicalis
• Alignment Length: 784
• Identity: 190/784 - (24%)
• Similarity: 287/784 - (36%)
• Gaps: 279/784 - (35%)

  Fly     6 MAVCVVCLLCAHRLHCQD-HIESLLGPARVTTHNSQDQLNARVYTNLSPSSETTDRRQQRSASG- 68
            ::..:.||  ..|:.|:. ..|..|.|        .|.|||   .||.|.| ..|.....:.||
 Frog    76 LSALIKCL--EERVQCESGPCEKCLSP--------MDLLNA---VNLPPGS-PLDAEGYMAVSGG 126

  Fly    69 ----------------------DDDTFNYSISPPSRREKR----------HAGHEH--------- 92
                                  ...||..|...||..|..          :.|.|.
 Frog   127 LLFYMSDPHTACSALRQGEWMNQSQTFIKSQVAPSALETAEHLIGAVQPLYRGGEQPCQRGENII 191

  Fly    93 GPTSE--SRVPQI-------------------TQYYLEKLMAQDELMNSSGFDGLLQQLSLHSLA 136
            ..|||  :..|:|                   .:|:|      ..:.|..|.||  ..|||.:|:
 Frog   192 NMTSEPDTVTPEIQGALLATVFEGKCLNVLPPPEYFL------GYIYNYLGSDG--TNLSLDALS 248

  Fly   137 SGASEGTCVPGSRLVHHVQPHDH----HHAHHHEEEDHSLQLNNCTLIQNGT--TSNVI--CPSL 193
                  ..:....||...:..||    |..|...:|......:...|.|:..  |.:.:  |.|
 Frog   249 ------LLMTNLSLVREEEHGDHDGEDHEGHGDAQEMPDPMAHRRRLAQDNAPHTRHWVETCFS- 306

  Fly   194 PN-----NNTHP-LGKEAKNFTLSDKDLLHLCPILLYELKAQSGGCIEPAILSDIDTTEELLEAE 252
            |.     :...| ||...:.|......|:.|....:.....:.||           ..|:|..||
 Frog   307 PRELFAIHGIDPDLGISPEQFPHVGTSLIQLQVSKVCARGQEPGG-----------NQEQLSIAE 360

  Fly   253 KDKDIFYVWIYAFISVFACGILGLVGVAIIPFMG-SRYYKYIIQYLVALAVGTMTGDALLHLLP- 315
            |       :||..|:.....:..|:|::|:.... :..|:||||:.|:||||::||||:|||:|
 Frog   361 K-------YIYGTIATLVVSLCALLGISILLCTSCTTAYQYIIQFFVSLAVGSLTGDAVLHLIPQ 418

  Fly   316 ------------HSLAGQDERGMIMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRA 368
                        ||...:::|..|.|.|..||||..|::||...:::
 Frog   419 LLGLHGHSDPQGHSHQEEEDRSHIWKLLAVLGGIYLFFLMEKLFSIL------------------ 465

  Fly   369 KVMRDPDSSVNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSVAELR 433
                        .::|:
 Frog   466 ------------MISGE------------------------------------------------ 470

  Fly   434 NGVGDHDGSNDMAAAAESLISPLHTNCVEMNH-----HNHNHKHNSHQQNHEGQDSNTIVTDLDG 493
                :.:|:|             |.:|   :|     :.|..|....:|..|.|......||::.
 Frog   471 ----EAEGAN-------------HGHC---DHGLSLQNYHQDKERRKEQKSESQADLVCATDVEF 515

  Fly   494 NAVYAVNKAKDKDSRNDHVTVILREHESSHHGHSHRHGHVHSPPETLSAVAWMIIMGDGLHNFTD 558
            .:  ...|||.::                                 |..:.:||.:||.:|||.|
 Frog   516 GS--GRQKAKSRE---------------------------------LQMIPYMITIGDAIHNFAD 545

  Fly   559 GMAIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFG 623
            |:||||||:.:...|.:|||||.||||||||||||.|:.||:.|:.|:..|..:.:.:|||:...
 Frog   546 GLAIGAAFSTSWKTGLATSLAVLCHELPHELGDFAALLHAGLRVRWALLLNFSSALTAFIGLYIS 610

  Fly   624 IAFGQSQDVAQWMFAVAAGLFIYIALVDMMPEIS--ASHKSLGQFLLQILGMLSGVGIMLLIALY 686
            ::....:.|.||:|.||.|||:|:||.||:|.:.  ..|:....|.|..||:|.|..|:|:::||
 Frog   611 LSISADEAVQQWIFTVATGLFLYVALADMLPAMMNVKLHRPWILFFLHNLGILLGWVILLILSLY 675

  Fly   687 EGDL 690
            |.::
 Frog   676 EDNI 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
foi	NP_523974.3	Zip	258..684	CDD:396884	120/446 (27%)
slc39a4	XP_031760368.1	ZIP4_domain	79..218	CDD:465698	31/152 (20%)
		Zip	363..672	CDD:396884	120/441 (27%)