Protein Alignment GstO2 and CLIC3

DIOPT Version :10

• Sequence 1: NP_729388.1
• Gene: GstO2 / 38974
• FlyBaseID: FBgn0035906
• Length: 251
• Species: Drosophila melanogaster
• Sequence 2: NP_004660.2
• Gene: CLIC3 / 9022
• HGNCID: 2064
• Length: 236
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 49/234 - (20%)
• Similarity: 89/234 - (38%)
• Gaps: 57/234 - (24%)

  Fly    13 TKPEL----PEDGVPRFFSMAFCPFSHRVRLMLAAKHIEHHKIYVDLIEKPEWYKDFSPLGKVPA 73
            ||.:|    .|||.    |:..||...|:.::|..|.:......||....|:..|||:|..::|.
Human     4 TKLQLFVKASEDGE----SVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPI 64

  Fly    74 LQLTGVKDQPTLVESLIIAEYLDQ------------QYPQTRLFPTDPLQK----------ALDK 116
            |    :.|.....::|.|.::|::            :|.::.....|...|          |.|:
Human    65 L----LYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDE 125

  Fly   117 ILIERFAPVVSAIYPVLTCNPNAPKDAIPNFENALDVFEVELGKRGTPYFAGQHIGIVDYMIWP- 180
            .|.::....::.:...|    .||      .|:.| ..|.:|.:....:..|..:.:.|..:.|
Human   126 ALYQQLLRALARLDSYL----RAP------LEHEL-AGEPQLRESRRRFLDGDRLTLADCSLLPK 179

  Fly   181 ---------WFERFP-SMKINTEQKYELDTKRFEKLLKW 209
                     .|.:.| ..::...::| ||:...||..|:
Human   180 LHIVDTVCAHFRQAPIPAELRGVRRY-LDSAMQEKEFKY 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstO2	NP_729388.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	5..96	CDD:469754	24/86 (28%)
		GST_C_Omega	110..235	CDD:198293	22/121 (18%)
CLIC3	NP_004660.2	Required for insertion into the membrane. /evidence=ECO:0000250	1..88		25/91 (27%)
		O-ClC	5..229	CDD:129941	48/233 (21%)
		G-site. /evidence=ECO:0000305|PubMed:28198360, ECO:0000305|PubMed:37759794	22..25		2/2 (100%)