Protein Alignment GstO2 and CLIC6

DIOPT Version :10

• Sequence 1: NP_729388.1
• Gene: GstO2 / 38974
• FlyBaseID: FBgn0035906
• Length: 251
• Species: Drosophila melanogaster
• Sequence 2: NP_001303938.1
• Gene: CLIC6 / 54102
• HGNCID: 2065
• Length: 704
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 58/274 - (21%)
• Similarity: 98/274 - (35%)
• Gaps: 53/274 - (19%)

  Fly     2 ALPQKHFKRGSTKPELPEDGVPRFF------------SMAFCPFSHRVRLMLAAKHIEHHKIYVD 54
            ||.|:|......|.:|...|..|..            |:..||||.|:.::|..|.:..:...||
Human   446 ALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVD 510

  Fly    55 LIEKPEWYKDFSPLGKVPALQLTG-VKDQPTLVESLIIAEYLDQQYPQTRLFPTDPLQKALDKIL 118
            |..||...::.:|....|.:...| ||.....:|..:..:....:||  :|....|...:....:
Human   511 LKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYP--KLGTQHPESNSAGNDV 573

  Fly   119 IERFAPVVSAIYPVLTCNPNAPKDA--------------IPNFENA-----LDVFEVE-LGKRGT 163
            ..:|:..:.          |..|||              :.|:.|:     :|.:..| :...|.
Human   574 FAKFSAFIK----------NTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGR 628

  Fly   164 PYFAGQHIGIVDYMIWPWFERFPSMKINTEQKYELDTKRFEKLLKWRDL---MTQDEVVQKTALD 225
            .:..|..:.:.|..:.|   :...:|| ..:||.......|....||.|   ..:||.......|
Human   629 KFLDGDELTLADCNLLP---KLHIIKI-VAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPAD 689

  Fly   226 VQL-HAEFQKSKTL 238
            .:: ||....:|.:
Human   690 QEIEHAYSDVAKRM 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GstO2	NP_729388.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	5..96	CDD:469754	25/103 (24%)
		GST_C_Omega	110..235	CDD:198293	26/148 (18%)
CLIC6	NP_001303938.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..446		58/274 (21%)
		PRK07764	<9..382	CDD:236090
		13 X 10 AA tandem repeat of G-D-[SNG]-[VIM]-[DEQ]-A-[EAG]-[GDVE]-[PRG]-[LAVP]	157..282
		O-ClC	471..704	CDD:129941	50/249 (20%)
		G-site. /evidence=ECO:0000250|UniProtKB:Q9Y696	487..490		2/2 (100%)