Protein Alignment se and CLIC2

DIOPT Version :10

• Sequence 1: NP_648235.1
• Gene: se / 38973
• FlyBaseID: FBgn0086348
• Length: 243
• Species: Drosophila melanogaster
• Sequence 2: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 46/185 - (24%)
• Similarity: 79/185 - (42%)
• Gaps: 32/185 - (17%)

  Fly    30 CPFAQRVHLVLDAKQIPYHSIYINLTDKPEWLLEKNPQGKVPALEIVREPGPPVLTESLLICEYL 94
            |||.||:.::|..|.:.::...:::|.|||.|.:..|....|.|...:|    :.|:.:.|.|:|
Human    30 CPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKE----LKTDFIKIEEFL 90

  Fly    95 DE-----QYP-LRPLYPRD-------------PLKKVQDKLLIERFRAVLGAFFKASDGGDLEPF 140
            ::     :|| |.|.|...             .:|..| |...:.|...|...||..|.....|.
Human    91 EQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQ-KEANKNFEKSLLKEFKRLDDYLNTPL 154

  Fly   141 WSGLD---IYERELARRGTEFFGGEQTGILDYMIWPWCERLELLKLQRGEDYNYD 192
            ...:|   ..|..::||  .|..|:|..:.|..:.|   :|.::|:...:..::|
Human   155 LDEIDPDSAEEPPVSRR--LFLDGDQLTLADCSLLP---KLNIIKVAAKKYRDFD 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
se	NP_648235.1	GST_N_Omega	3..95	CDD:239353	19/64 (30%)
		GST_C_Omega	109..229	CDD:198293	21/87 (24%)
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		20/69 (29%)
		N-terminal	1..94		20/67 (30%)
		O-ClC	12..245	CDD:129941	46/185 (25%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		2/2 (100%)
		Joint loop	95..106		4/10 (40%)
		C-terminal	107..247		21/104 (20%)
		Foot loop	151..171		3/19 (16%)