DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6765 and br

DIOPT Version :9

Sequence 1:	NP_001261582.1	Gene:	CG6765 / 38971	FlyBaseID:	FBgn0035903	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	159/783 - (20%)
Similarity:	271/783 - (34%)	Gaps:	232/783 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ENYHLKWDSHLTYLNSSIATLYKNEKFADVVLYSSYNSSGIPSDIPTVGISAHKFILSASSQFFA 68
            :::.|:|:::.:.:.|:...|..:|.|.||.|.....|           |.||:.:|||.|.:|.
  Fly     5 QHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRS-----------IKAHRVVLSACSPYFR 58

  Fly    69 TMFETAPITNPNGVLYVVLPPDLSHRAIQILVQYMYSGEATVSNDILNEVLRGGEILKIRGLCRT 133
            .:.::.|..:|     |:|..|::...:..||:::|.||..|....|...|:..|:|::.||.:.
  Fly    59 ELLKSTPCKHP-----VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQ 118

  Fly   134 SS-------------SNGGGSGSVVTTTH---HPHSLAGHLH-PREASTMYMSNGTRTALPPPPP 181
            .:             :|.||...:.|.|.   |||.  |.|| ...:||::...|..:    |||
  Fly   119 QAEDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHH--GSLHDDGGSSTLFSRQGAGS----PPP 177

  Fly   182 PPQSTMSAQLQGDLYASKPGGSTRFALDHHHLSSHHSHLNHHNPQQQFRGLGASVMPKDSPVIIK 246
            ....::.:.:...|.       .|.|:.|...::..:....|    .|:.|..|    |:
  Fly   178 TAVPSLPSHINNQLL-------KRMAMMHRSSAAAAAEETSH----AFKRLRGS----DN----- 222

  Fly   247 SPKLAAHTGLLTVASSSKLGISVNKEVAIDPEDKCCFAAPGQL---------ESQSHPPP----- 297
                       ::..|..:|...|......|......|:|.|.         .:.::.||
  Fly   223 -----------SLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEK 276

  Fly   298 ---PTTTTTTVGGGGGSVGGSGAPPSQPISICTEVGCSSCPLTAGPGADQAETTLRRTEYEEQAL 359
               ||....:   |.|:..|:||.....|||..::|..:....|..|||..     ::|..:...
  Fly   277 RNGPTGNGNS---GNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDV-----KSEPMDMVC 333

  Fly   360 RERN----------EVGLVFERRLRRESACERSRDYYEAPHFEHVVSSRLAATPPPP-----PQQ 409
            ...|          ..|   |....|.|:.:..:....:.:.|. :...||:....|     |.:
  Fly   334 SNNNANANDEHSNDSTG---EHDANRSSSGDGGKGSLSSGNDEE-IGDGLASHHAAPQFIMSPAE 394

  Fly   410 APPSHPPTLRHPH-------NFLTIKQEPTDWSNNPPNASSASNNNNLEELPLASPKQPLDFKMS 467
            ....|......|:       ...|..|:..|.:.:|...|:.|                   .:|
  Fly   395 NKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGS-------------------LLS 440

  Fly   468 AVKLEVNRDRGTPSEESEEHTLRDYNNFKQLLVCEICQKSFEDTKMLVRHLGT-HAGDP------ 525
            .| :......||||..|..:...:.||.:|    ::.|:|.....:..:|..| |...|
  Fly   441 GV-IVPGGSGGTPSNSSSNNNNNNSNNQQQ----KVEQQSSPHQLLQQQHHSTPHTNSPQLKQEQ 500

  Fly   526 ---------------TGGTERNLLPSS-----ASGSTTSASSNLAL--RSVKTYVPKKRRRVSQQ 568
                           ..|:||:|..||     |.|.:.:.|...|.  |..:....::|.|..::
  Fly   501 PKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERERERERER 565

  Fly   569 ENNMDHDHVTLLCDLCSTSFDTPAEWVRHMNSQHTEIELAMFNSKKDGEQ---KGQQPPPPPATS 630
            |.::||:                                      :|.|:   .|..|||||:..
  Fly   566 ERSLDHE--------------------------------------RDLERPGGTGSPPPPPPSHH 592

  Fly   631 S-------SSTVSNSQMQPKYPSSTATRSTHSLMLHKMSNSDAVATTTSP----------GASTS 678
            |       |...|:.|:...:...:|..:.|:......:::.|:|...||          .||.|
  Fly   593 SHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRRASLS 657

  Fly   679 PNG 681
            |:|
  Fly   658 PSG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6765	NP_001261582.1	BTB	24..132	CDD:279045	32/107 (30%)
CG6765	NP_001261582.1	BTB	53..130	CDD:197585	23/76 (30%)
br	NP_001162638.2	BTB	22..118	CDD:279045	32/111 (29%)
		BTB	33..118	CDD:197585	29/100 (29%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010