DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6765 and ZBTB9

DIOPT Version :9

Sequence 1:	NP_001261582.1	Gene:	CG6765 / 38971	FlyBaseID:	FBgn0035903	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_689948.1	Gene:	ZBTB9 / 221504	HGNCID:	28323	Length:	473	Species:	Homo sapiens

Alignment Length:	486	Identity:	104/486 - (21%)
Similarity:	149/486 - (30%)	Gaps:	187/486 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 TRTALPPPPPPPQSTMSAQLQGDLYASKPGGSTRFALDHHHLSSHHSHLNHHNPQQQF------- 229
            |.|.|||.|..|             ...|...|.......|.||....||.|..:.:|
Human     3 TPTPLPPVPASP-------------TCNPAPRTIQIEFPQHSSSLLESLNRHRLEGKFCDVSLLV 54

  Fly   230 --RGLGA--SVMPKDSP------VIIKSPKLA--------AHTGLLTVASSSKLGISVNKEVA-- 274
              |.|.|  :|:...||      ::..:|:|.        |..|||.:..|.:|.:.::...|
Human    55 QGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHL 119

  Fly   275 -----------IDPEDKCCFAAPGQLESQSHPPPPTTTTTTVGGG----GG-----------SVG 313
                       :|.    |.....:||             |.|||    ||           |.|
Human   120 LVASGLQMWQVVDQ----CSEILRELE-------------TSGGGISARGGNSYHALLSTTSSTG 167

  Fly   314 G---SGAPPSQPI--SICTEVGCSSCPLTAGPGADQAETTLRRTEYEEQALRERN--EVGLVFER 371
            |   ..:|...|:  |..||...|:.....|.|::..|....:.|.||:...:.:  :.|   ..
Human   168 GWCIRSSPFQTPVQSSASTESPASTESPVGGEGSELGEVLQIQVEEEEEEEEDDDDEDQG---SA 229

  Fly   372 RLRRESACERSRDYYEAPHFEHVVSSRLAATPPPPPQ--------QAPPSHPPTLRHPHNFLTIK 428
            .|.:....:|....:..||..|.:.  :.|||...|:        .|||:.||.:.:      ||
Human   230 TLSQTPQPQRVSGVFPRPHGPHPLP--MTATPRKLPEGESAPLELPAPPALPPKIFY------IK 286

  Fly   429 QEPTD------WSNNPPNAS-------SASNNNNLEELPLASPK-------------QPLDFK-- 465
            |||.:      .|...|..:       |..:.....||....|.             :|:|..
Human   287 QEPFEPKEEISGSGTQPGGAKEETKVFSGGDTEGNGELGFLLPSGPGPTSGGGGPSWKPVDLHGN 351

  Fly   466 ----------------MSAVKLEVNRDRGTPSEES-----------------EEH-----TLRDY 492
                            ...|||     .|||..:.                 :.|     :||.:
Human   352 EILSGGGGPGGAGQAVHGPVKL-----GGTPPADGKRFGCLCGKRFAVKPKRDRHIMLTFSLRPF 411

  Fly   493 NNFKQLLVCEICQKSFEDTKMLVRHLGTHAG 523
            .       |.||.|.|:....|..|:.||||
Human   412 G-------CGICNKRFKLKHHLTEHMKTHAG 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6765	NP_001261582.1	BTB	24..132	CDD:279045
CG6765	NP_001261582.1	BTB	53..130	CDD:197585
ZBTB9	NP_689948.1	BTB	38..140	CDD:306997	21/105 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..279		24/106 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..376		11/87 (13%)
		C2H2 Zn finger	388..405	CDD:275368	1/16 (6%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-C2H2	413..433	CDD:306579	7/19 (37%)
		C2H2 Zn finger	440..457	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910