DRSC/TRiP Functional Genomics Resources

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Protein Alignment L1CAM and sdk

DIOPT Version :10

Sequence 1:NP_000416.1 Gene:L1CAM / 3897 HGNCID:6470 Length:1257 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:1299 Identity:304/1299 - (23%)
Similarity:491/1299 - (37%) Gaps:262/1299 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    11 LLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDIS------------LKCEASGKP 63
            |..|..|...     |...::.:...|.:|...:...|.|...|            |:|.|.|.|
  Fly    42 LCYCDSCFFC-----YADANLQQQNSIVQQQQLQAPRFTTHPSSSGSIVSEGSTKILQCHALGYP 101

Human    64 EVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEI 128
            :..:||.:|||   |..:...:.:...||           ..:...|.|:|.|.|..|:..|.:.
  Fly   102 QPTYRWLKDGV---PVGDFSSSQFYRFHS-----------TRREDAGSYQCIARNDAGSIFSEKS 152

Human   129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMN----------------SKIL 177
            .::......:...|...:.|..|...:....|..|.....:.|.:                ::::
  Fly   153 DVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDGPLNYDIKYAFTHANQLI 217

Human   178 HIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTI-----IQKEPIDLRVKATNSMID 237
            .:..||....|.....  .|.......|....|.:..|...|     |...|.|::||....:::
  Fly   218 ILSADENDRKGYRAKA--INTQLGKEESSAFVHLNVSGDPYIEVAPEIIVRPQDVKVKVGTGVVE 280

Human   238 RKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIK--WLRPSGPMPADRVTYQNH---NKTL 297
                                    |:|||...|...::  ||:....:....|.:..:   |:||
  Fly   281 ------------------------LQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTL 321

Human   298 QLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAA--------PYWLHKPQSHLYGP-GETARLD 353
            .||:......|||.|...     .|...|..|.|:        |.:....::..:|. |...:|.
  Fly   322 ALLQANSSHSGEYTCQVR-----LRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLT 381

Human   354 CQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANA 417
            |.|.|.|.|:|.|..|...|:...:..:|.:.. ..|::..:...|..:.||.|.|..|...|:.
  Fly   382 CDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSAST 446

Human   418 YIYVVQLPAK--------------------------------------------ILTADNQTYMA 438
            ::.|....||                                            |:....|...|
  Fly   447 WLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTA 511

Human   439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQ 503
            :.|..|.:.|:|.|:|.|::.|:..:...|....|.....:|.|.|.::::.|.|.|.|:.||:.
  Fly   512 LDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLISNIRSVDAGLYICVRANEA 576

Human   504 NNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDK 568
            .:|...|.|.|...|||.|.|..|....|...|..|:.|.|||:..:|.|..:|:....:.:|.:
  Fly   577 GSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQR 641

Human   569 YFIE-DGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR 632
            ..:: ||:|.|.::..||.|:|:||.::........|:|.|:..|.|...:.:..|....|..:.
  Fly   642 IGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSIN 706

Human   633 VSWSPAEDHNAPIEKYDIE-FEDKEMAPE-----KWYS-LGKVPGNQTSTTLK-LSPYVHYTFRV 689
            |||:|..|.|:||.|:.|: .|..|:.|.     .|.: |..|..:|....|: |.....|.|||
  Fly   707 VSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRV 771

Human   690 TAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQW 754
            :|:|:.|.|.||..|..|..|:.||...||...|.....:.::..|:|......|...:.|.:::
  Fly   772 SAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRY 836

Human   755 RPQGTRG-PWQEQIVSDP----FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQA 814
            |..|... ||..|.:::.    || :....|:..|.:::.|.|:.|.|...:.:...:.|..|:|
  Fly   837 RLFGYNNVPWSYQNITNEAQRNFL-IQELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEGVPEA 900

Human   815 IPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR----EGSQRKHSKR-HIHKDHVVVP 874
            .|....:|.:||:|...:|.|.:..|:.|..:||.:..|:    :|..|...:| ......::.|
  Fly   901 PPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDP 965

Human   875 ANTTSVILSGLRPYSSYHLEVQAFNGRGSGPA-SEFTFSTPEGVPGHPEALHLECQSNTSLLLRW 938
            ....:.||.||..::.|::.|..|...|.|.| |:....|.:.||.....||.:..|:.|:.:.|
  Fly   966 LAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLW 1030

Human   939 QPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR--DPELRTHNLTDLSPHLRYRFQLQATTKEG- 1000
            .||.:.||:||||.:.|...|.....: ||||.  |.|| |.|....:.|  |.|::.|.|:.| 
  Fly  1031 APPRASNGILTGYTVRYQVKDRPDTLK-SFNLTADDTEL-TVNQLQATTH--YWFEIVAWTRVGS 1091

Human  1001 --PGEAIVREG---------GTMALSGISDF-----------GNISAT----AGENYSVVSWV-- 1037
              |..|.::.|         ..:|||.|..|           ||.|.|    .|:....::|.  
  Fly  1092 GIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTI 1156

Human  1038 ------------------------------------PKEGQCNFR----------FHILFKALGE 1056
                                                |.|...:|:          |::..:|:..
  Fly  1157 CEINDPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSA 1221

Human  1057 EKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATE 1120
            ::    |..:::...|   |:|...| ..|.|        .::..|||.||  ::..|.....|
  Fly  1222 QQ----LRVRWIPLQQ---TEWYGNP-RGYNI--------SYKQLVKTPGT--IKYVPRSVVIE 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
L1CAMNP_000416.1 Ig 35..130 CDD:472250 25/106 (24%)
Ig strand B 53..57 CDD:409353 2/15 (13%)
Ig strand C 66..70 CDD:409353 1/3 (33%)
Ig strand E 93..97 CDD:409353 0/3 (0%)
Ig strand F 111..116 CDD:409353 2/4 (50%)
Ig strand G 125..128 CDD:409353 1/2 (50%)
IgI_2_L1-CAM_like 140..230 CDD:409432 17/110 (15%)
Ig strand A 140..143 CDD:409432 0/2 (0%)
Ig strand A' 145..149 CDD:409432 0/3 (0%)
Ig strand B 152..160 CDD:409432 0/7 (0%)
Ig strand C 167..173 CDD:409432 1/5 (20%)
Ig strand C' 176..179 CDD:409432 0/2 (0%)
Ig strand D 185..189 CDD:409432 0/3 (0%)
Ig strand E 191..195 CDD:409432 0/3 (0%)
Ig strand F 206..214 CDD:409432 1/7 (14%)
Ig strand G 217..230 CDD:409432 4/17 (24%)
Ig3_L1-CAM 248..330 CDD:409460 19/86 (22%)
Ig strand B 260..264 CDD:409460 1/3 (33%)
Ig strand C 273..277 CDD:409460 0/5 (0%)
Ig strand E 295..299 CDD:409460 2/3 (67%)
Ig strand F 309..314 CDD:409460 3/4 (75%)
Ig strand G 322..325 CDD:409460 1/2 (50%)
Ig4_L1-CAM_like 334..422 CDD:409453 21/89 (24%)
Ig strand B 350..354 CDD:409453 1/3 (33%)
Ig strand C 363..367 CDD:409453 1/3 (33%)
Ig strand E 387..391 CDD:409453 1/3 (33%)
Ig strand F 401..406 CDD:409453 2/4 (50%)
Ig strand G 414..417 CDD:409453 1/2 (50%)
Ig 428..514 CDD:472250 25/85 (29%)
Ig strand B 444..448 CDD:409353 1/3 (33%)
Ig strand C 457..461 CDD:409353 0/3 (0%)
Ig strand E 480..484 CDD:409353 2/3 (67%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 0/2 (0%)
Ig_3 519..594 CDD:464046 26/75 (35%)
Cell attachment site. /evidence=ECO:0000255 554..556 0/1 (0%)
FN3 612..709 CDD:238020 35/104 (34%)
FN3 <627..>837 CDD:442628 65/222 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..725 11/26 (42%)
fn3 824..907 CDD:394996 24/88 (27%)
FN3 918..1003 CDD:238020 32/89 (36%)
Bravo_FIGEY 1144..1233 CDD:464016
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1207
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257
sdkNP_001284756.1 Ig_3 72..142 CDD:464046 20/83 (24%)
Ig 280..344 CDD:409353 18/92 (20%)
Ig strand B 280..283 CDD:409353 1/26 (4%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 2/3 (67%)
Ig strand F 333..338 CDD:409353 3/4 (75%)
Ig 360..451 CDD:472250 22/90 (24%)
Ig strand B 378..382 CDD:409353 1/3 (33%)
Ig strand C 391..395 CDD:409353 1/3 (33%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 2/4 (50%)
Ig strand G 443..446 CDD:409353 1/2 (50%)
Ig 502..587 CDD:472250 24/84 (29%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 0/3 (0%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 28/89 (31%)
Ig strand B 608..612 CDD:409353 1/3 (33%)
Ig strand C 623..627 CDD:409353 1/3 (33%)
Ig strand E 648..652 CDD:409353 2/3 (67%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 34/102 (33%)
FN3 798..893 CDD:238020 20/95 (21%)
FN3 901..1005 CDD:238020 27/103 (26%)
FN3 <960..>1261 CDD:442628 76/322 (24%)
fn3 1317..1402 CDD:394996
FN3 1415..1507 CDD:238020
FN3 1513..1608 CDD:238020
FN3 1583..>2011 CDD:442628
Blue background indicates that the domain is not in the aligned region.

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