DRSC/TRiP Functional Genomics Resources

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Protein Alignment L1CAM and l1camb

DIOPT Version :10

Sequence 1:NP_000416.1 Gene:L1CAM / 3897 HGNCID:6470 Length:1257 Species:Homo sapiens
Sequence 2:NP_571458.1 Gene:l1camb / 30656 ZFINID:ZDB-GENE-980526-512 Length:1269 Species:Danio rerio


Alignment Length:1247 Identity:503/1247 - (40%)
Similarity:701/1247 - (56%) Gaps:46/1247 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    20 IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGV 84
            ||||.:|..:.:.:.|..|.| |.....|..||::|.|||||.|...|||.:||..|      |.
Zfish    35 IQIPHDYTYNKLKQAPEFTTQ-PVPHTAFSLDDVNLACEASGDPSPSFRWVKDGKQF------GE 92

Human    85 TVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP---KWPKETVKPV 146
            .:     |.|.|:|.:.:.....:||.|||:|:|:||||:|:.:.|..|..|   |..|:..:..
Zfish    93 VL-----SESGTLTPHPTMDLHFYQGTYRCYAANELGTAVSNLVHLTTEPVPSLAKVKKQKRRAY 152

Human   147 EVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHA 211
            ||  |||.||.||||.|:...:|:||:.:..||..:||||:.::|||||||::.:|:..||.|:|
Zfish   153 EV--GESAVLRCNPPKSSVTPKIHWMDMQFHHIPLNERVTISRDGNLYFANLIANDSRDDYTCNA 215

Human   212 HFPGTRTIIQKEPIDLRVKATNSMI-DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIK 275
            |:.....|:.|||:.:.|..:||:: :|:.:|..|..:.|..:.|:||.|.||||.||.|||.:.
Zfish   216 HYINASIILPKEPMSIYVTPSNSVVKNRRAKLHHPAGARSSYLVLRGQTLTLECIPEGLPTPEVH 280

Human   276 WLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQ 340
            |.|....:..:|.....:|:.||:..|.|.|||||.|.|.||..|.:|.|.|||||||||..:|:
Zfish   281 WDRIDSALSPNRTKKLYNNRWLQIDNVLESDDGEYVCTARNSENSVKHHYTVTVEAAPYWTRRPE 345

Human   341 SHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCE 405
            .|||.||||.|||||..|.|.|.:||.|||:||.....|.:.|:..|.||||||:.|||.|.|||
Zfish   346 EHLYAPGETVRLDCQADGIPAPNITWSINGVPVSGTDVDPRRRVSSGKLILSNVEFSDTAVYQCE 410

Human   406 ARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ 470
            |.|:||.:|.|.:::||:|||:|||.|.:.|.|..|.|..|.|:.||:|:|.:.|...|....|.
Zfish   411 AVNKHGSILINTHVHVVELPAQILTPDERLYQATAGQTVMLDCRTFGSPLPKIHWEILDSIPALS 475

Human   471 DERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRV 535
            :.:.....||:|.|.::...|:.||.|..:  :.|.:|.|.|:|.:.|:|...|::....:||..
Zfish   476 NAKISQMTNGSLKISNVSEEDSNRYTCSVS--ETNKSISAELEVLNRTKIVGPPQNLHVIRGSDA 538

Human   536 TFTCQASFDPSLQ-PSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDV 599
            ...|:.:.|.:|: |::.|:.||..:.....:|||...:|.|.:..:...|.|.|||..||.||.
Zfish   539 ILHCKYTVDHNLKSPTVQWKKDGHKITASTSNDKYHEIEGSLKVLDVQMEDMGIYSCGVSTTLDS 603

Human   600 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE-KWY 663
            ..:...:.|...|.|...|.||:   ..:..|.:||.|:.::|:|:.:|.||..:.|...| :|.
Zfish   604 DTASGYITVQDKPDPPQSLKLSE---KMERSVTISWMPSVENNSPVTEYVIEMNEGETPDEGQWQ 665

Human   664 SLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNET 728
            ....|..:.....:.|.||..|.|::.|:|..|...||..|.:..||.|.|::||.:|.....:.
Zfish   666 KYRSVSQDIRQLEIHLQPYSKYHFQIRAVNSIGTSAPSESSLSYSTPAAKPDRNPENVMTLSTDP 730

Human   729 TNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP-WQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 792
            .:|:|:|:.:....:|.|..||:|.||.....|. |.|..||:|.|:|:||.|||.:||||||||
Zfish   731 KSMIISWQEMDRRQFNGPGFQYKVFWRRAADSGAHWTESSVSNPPLLVNNTGTFVSFEIKVQAVN 795

Human   793 SQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR--- 854
            ..|..|||...|||||||:|...|....:..|..::|:|:|.||....|:|||.||.: |.|   
Zfish   796 DLGAAPEPLTVIGYSGEDFPLEAPSALSVTELQKTSVMVRWSPVRPESVRGHLLGYKI-YLRMKG 859

Human   855 -EGSQRKHSKRHIHKDHVV-VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEG 916
             .|..|......:....|: |||:....|:|.|:.||.|.|.:.|||.:|.||.| |.:||||||
Zfish   860 PSGRLRAGRSPAVGNPTVIEVPADAAEKIVSDLQYYSDYTLTITAFNSKGEGPHSEESSFSTPEG 924

Human   917 VPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRD-PELRTHNL 980
            .||....|..:..|.:.:.|||:.|...||.:.||:|.|..:..|.:........| |.:....|
Zfish   925 APGPVLFLPFDSPSESEITLRWEAPHKPNGEIRGYLLQYQEVVIGSESPQHVESIDLPAVTEFTL 989

Human   981 TDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNF 1045
            .:|:|..||.|.|.|....|.|...::.|.|: |.| .....|:.||||....:||||.:...|.
Zfish   990 KNLNPESRYTFHLSARNSAGDGAPAIQSGATL-LDG-EPPSVINMTAGETSVNLSWVPGDRHRNV 1052

Human  1046 RFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRV 1110
            .|.  |:.|.:.:|......:.::..|:.|....|.....|.:.:..... .:....||..:...
Zfish  1053 GFS--FRYLKKIEGAEWEESEKINSTQAFYQLQGLDSGVIYHLQVLSGNT-SYDWDFKTIYSPEW 1114

Human  1111 RLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGE 1175
            ...|..|||||||||.:||::|||||||:||:||:||||||||||||:.|.|:..:.:||:.|||
Zfish  1115 HKSPRNFATEGWFIGLISALVLLLLVLLLLCYIKKSKGGKYSVKDKEEGQGDAANQKLKDDAFGE 1179

Human  1176 YRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGG 1240
            |||||||.|:.:.  ||||  |......|:|||||||.|||:||||||||||||||:::..   |
Zfish  1180 YRSLESDMEKCSI--SQPS--GCESKRSSNDSLADYGDSVDIQFNEDGSFIGQYSGRRDPR---G 1237

Human  1241 NDSSGATSPINP 1252
            :|||||.||:||
Zfish  1238 HDSSGAVSPVNP 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
L1CAMNP_000416.1 Ig 35..130 CDD:472250 37/94 (39%)
Ig strand B 53..57 CDD:409353 1/3 (33%)
Ig strand C 66..70 CDD:409353 2/3 (67%)
Ig strand E 93..97 CDD:409353 1/3 (33%)
Ig strand F 111..116 CDD:409353 3/4 (75%)
Ig strand G 125..128 CDD:409353 1/2 (50%)
IgI_2_L1-CAM_like 140..230 CDD:409432 39/89 (44%)
Ig strand A 140..143 CDD:409432 1/2 (50%)
Ig strand A' 145..149 CDD:409432 1/3 (33%)
Ig strand B 152..160 CDD:409432 5/7 (71%)
Ig strand C 167..173 CDD:409432 2/5 (40%)
Ig strand C' 176..179 CDD:409432 0/2 (0%)
Ig strand D 185..189 CDD:409432 2/3 (67%)
Ig strand E 191..195 CDD:409432 3/3 (100%)
Ig strand F 206..214 CDD:409432 5/7 (71%)
Ig strand G 217..230 CDD:409432 4/12 (33%)
Ig3_L1-CAM 248..330 CDD:409460 36/81 (44%)
Ig strand B 260..264 CDD:409460 2/3 (67%)
Ig strand C 273..277 CDD:409460 0/3 (0%)
Ig strand E 295..299 CDD:409460 1/3 (33%)
Ig strand F 309..314 CDD:409460 3/4 (75%)
Ig strand G 322..325 CDD:409460 1/2 (50%)
Ig4_L1-CAM_like 334..422 CDD:409453 47/87 (54%)
Ig strand B 350..354 CDD:409453 2/3 (67%)
Ig strand C 363..367 CDD:409453 1/3 (33%)
Ig strand E 387..391 CDD:409453 2/3 (67%)
Ig strand F 401..406 CDD:409453 3/4 (75%)
Ig strand G 414..417 CDD:409453 1/2 (50%)
Ig 428..514 CDD:472250 29/85 (34%)
Ig strand B 444..448 CDD:409353 1/3 (33%)
Ig strand C 457..461 CDD:409353 0/3 (0%)
Ig strand E 480..484 CDD:409353 2/3 (67%)
Ig strand F 494..499 CDD:409353 3/4 (75%)
Ig strand G 507..510 CDD:409353 1/2 (50%)
Ig_3 519..594 CDD:464046 21/75 (28%)
Cell attachment site. /evidence=ECO:0000255 554..556 0/1 (0%)
FN3 612..709 CDD:238020 29/97 (30%)
FN3 <627..>837 CDD:442628 80/211 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..725 10/26 (38%)
fn3 824..907 CDD:394996 33/87 (38%)
FN3 918..1003 CDD:238020 26/85 (31%)
Bravo_FIGEY 1144..1233 CDD:464016 58/88 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1207 14/30 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257 16/27 (59%)
l1cambNP_571458.1 Ig 50..133 CDD:472250 37/94 (39%)
Ig strand B 67..71 CDD:409353 1/3 (33%)
Ig strand C 80..84 CDD:409353 2/3 (67%)
Ig strand E 98..101 CDD:409353 1/2 (50%)
Ig strand F 114..119 CDD:409353 3/4 (75%)
Ig strand G 128..131 CDD:409353 1/2 (50%)
Ig 146..233 CDD:472250 39/88 (44%)
Ig strand B 158..162 CDD:409353 2/3 (67%)
Ig strand C 172..176 CDD:409353 1/3 (33%)
Ig strand E 195..199 CDD:409353 3/3 (100%)
Ig strand F 210..215 CDD:409353 3/4 (75%)
Ig strand G 226..229 CDD:409353 2/2 (100%)
Ig3_L1-CAM 253..335 CDD:409460 36/81 (44%)
Ig strand B 265..269 CDD:409460 2/3 (67%)
Ig strand C 278..282 CDD:409460 0/3 (0%)
Ig strand E 300..304 CDD:409460 1/3 (33%)
Ig strand F 314..319 CDD:409460 3/4 (75%)
Ig strand G 327..330 CDD:409460 1/2 (50%)
Ig 339..427 CDD:472250 47/87 (54%)
Ig strand B 355..359 CDD:409353 2/3 (67%)
Ig strand C 368..372 CDD:409353 1/3 (33%)
Ig strand E 392..396 CDD:409353 2/3 (67%)
Ig strand F 406..411 CDD:409353 3/4 (75%)
Ig strand G 419..422 CDD:409353 1/2 (50%)
IG_like 441..517 CDD:214653 25/77 (32%)
Ig strand B 449..453 CDD:409353 1/3 (33%)
Ig strand C 462..467 CDD:409353 1/4 (25%)
Ig strand E 485..489 CDD:409353 2/3 (67%)
Ig strand G 510..513 CDD:409353 1/2 (50%)
Ig 523..612 CDD:472250 25/88 (28%)
Ig strand B 538..542 CDD:409353 0/3 (0%)
Ig strand C 554..558 CDD:409353 0/3 (0%)
Ig strand E 578..582 CDD:409353 2/3 (67%)
Ig strand F 592..597 CDD:409353 3/4 (75%)
Ig strand G 605..608 CDD:409353 0/2 (0%)
FN3 616..706 CDD:238020 28/92 (30%)
FN3 719..798 CDD:214495 34/78 (44%)
FN3 817..921 CDD:238020 37/104 (36%)
FN3 926..1014 CDD:238020 27/87 (31%)
FN3 1025..>1095 CDD:238020 18/71 (25%)
Bravo_FIGEY 1148..1233 CDD:464016 58/88 (66%)

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