DRSC/TRiP Functional Genomics Resources

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Protein Alignment L1CAM and l1cama

DIOPT Version :10

Sequence 1:NP_000416.1 Gene:L1CAM / 3897 HGNCID:6470 Length:1257 Species:Homo sapiens
Sequence 2:NP_571436.3 Gene:l1cama / 30634 ZFINID:ZDB-GENE-990415-10 Length:1271 Species:Danio rerio


Alignment Length:1263 Identity:531/1263 - (42%)
Similarity:748/1263 - (59%) Gaps:42/1263 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    10 PLLLCSPCL-----LIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRW 69
            ||||.:..|     .|.||..|:...:..|||||.| |:.:..|..|||:|.|:|:|.|...|||
Zfish    22 PLLLLAVALKPGNTTINIPSRYKIRDLKSPPVITAQ-PKSVTTFSADDITLTCDATGNPPPTFRW 85

Human    70 TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEG 134
            .:|||.|.|.::..::|  |..||:|::|..:....| :||.|.|:|||:||||:|:|.|::.|.
Zfish    86 VKDGVEFDPSKDPDLSV--SRDSGTFSLTAKDGPIHQ-YQGRYNCYASNELGTAVSNEARIVTEN 147

Human   135 APKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVL 199
            .|...||.:...:||||||||||||||.......|:||:.|:.||:|:|||..|::|||||::..
Zfish   148 TPTLQKEKIITKKVEEGESVVLPCNPPNGTVAPVIHWMDKKLRHIQQNERVIQGRDGNLYFSHAT 212

Human   200 TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMI-DRKPRLLFPTNSSSHLVALQGQPLVLE 263
            .:|:..||.|:..||..|.|..||||.|.|.::||:: :|:|:::.||..||..:.|.||.|.||
Zfish   213 VADSRDDYTCNIQFPSARVIKLKEPIKLTVFSSNSVVRNRRPQMMRPTGPSSSYLVLSGQNLELE 277

Human   264 CIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVT 328
            ||.:|.|:|:|:|:|..|.:...|.|..::::.|:...:.|.|.|||:|.|.|..|.:.|.|.||
Zfish   278 CIVQGLPSPSIQWIRKDGVLSESRTTKDSNDRVLRFQNISETDGGEYQCTATNPQGMSTHTYRVT 342

Human   329 VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSN 393
            |||||||:.:|:|.||.||||.:|:|:..|.|:|||||.||||.:.::..|.:..::.|.|.|.|
Zfish   343 VEAAPYWIKEPKSQLYAPGETVKLECKADGIPKPEVTWSINGILLSDIDPDPRRSVKHGVLTLKN 407

Human   394 VQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSV 458
            |:.|||.|.||:|.::||.:|.|||:||::||.:|||.|...|...:|.|..|.|:.||:|.|:|
Zfish   408 VELSDTAVFQCKAASKHGSVLINAYVYVIELPPQILTEDGLMYSVAEGQTTELACETFGSPRPNV 472

Human   459 QWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG 523
            .|..|....::.::|....::|:|.|.:...||:|:|.|...|  :.:||.|.|.|.:.|.|.:.
Zfish   473 TWEGESWGALVANQRMIQLSDGSLQISNASLNDSGQYTCTVNN--SKITITAELDVLNKTVIVKP 535

Human   524 PRSTIEKKGSRVTFTCQASFDPSLQ--PSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586
            |.:...::|...|.||:...| |.|  |.:.||.:.:.|.|..|||||.|::..|:|..::..|:
Zfish   536 PLALRIQRGKPATLTCEYQVD-SRQDLPQVQWRKNTQKLTESSDSDKYMIDESTLIIPEVEEEDE 599

Human   587 GNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651
            |.|:|...|.||:.::...:.:|..|.| |.|:  .:....:.:|.:||:|..|||:|:.:|.||
Zfish   600 GTYTCEVITTLDMAKASGSITIVDRPDP-PSLI--QMTEPKERRVTLSWTPGADHNSPVLEYLIE 661

Human   652 FEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 716
            ||:.....::|..|.:|.|:....||.|.|::.|.|||.|||:.|..:||.|:|...||.|.|:.
Zfish   662 FEETGSDRKEWEELSRVSGSSQRATLPLKPFISYHFRVIAINEIGKSDPSMVTEAYSTPAAPPDS 726

Human   717 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGP-WQEQIVSDPFLVVSNTST 780
            ||..|:.:.:|...:|||||.:....:|.|...|:|.||.....|| |..:.::.|..||::...
Zfish   727 NPEGVRSDSDEPGTLVITWKEMDRRSFNGPDFHYKVMWRKVLGSGPSWHTKDITSPPFVVTDVGN 791

Human   781 FVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHL 845
            |..::|||||||..|:||||:..|||||||||...|...|:.::||:|:.|.|..|:...|:|.|
Zfish   792 FSAFDIKVQAVNEMGEGPEPKSIIGYSGEDYPLEAPLDVGLILINSTAIKVTWAAVNRETVRGRL 856

Human   846 RGYNVTYWREGSQRKHSKRHIHKDHVV-VPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE- 908
            :||.:.....|.:.:|.:|......|| ..:|....:|..|:|:|.|:|.|..||.:|.||.|| 
Zfish   857 QGYKIYLTYLGPKGQHLRREPKTTFVVTTDSNEEKKVLGDLQPFSHYNLAVSVFNYKGEGPQSES 921

Human   909 FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDP 973
            ..|.|||||||.|.:|.|:..|.|.:.:.|.||...||.|.||:|.:..||..........:.||
Zfish   922 ILFFTPEGVPGPPSSLMLDSPSETEMTVHWTPPNQPNGNLIGYILQHQQLDNDASLMQVVKISDP 986

Human   974 ELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVP 1038
             ..:|....|.||.||||.|:..|..|.|..|:::|.| .|..:.. .:||.:.||....::||.
Zfish   987 -TASHYKLKLDPHSRYRFYLRGYTAIGEGLPIIKDGAT-TLDPVPP-SDISISTGETSVNLTWVS 1048

Human  1039 KEGQCNFRF--HILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHL-FKERMFRHQM 1100
            ||.|.|..|  |.|.|. |.:|...|   :.|:..||.||...|||.:.|.:.: |....:..: 
Zfish  1049 KERQRNVEFFIHYLRKD-GPDKWEKS---EKVNSTQSFYTLHGLQPGSQYRLKIDFNNTKWEQE- 1108

Human  1101 AVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEA 1165
             ::|.| .||....:||.||.||||.:||::|||||||||||||||||||||||:||:.|:||||
Zfish  1109 -IQTAG-ARVMEVKSGFVTESWFIGLISALVLLLLVLLILCFIKRSKGGKYSVKEKEEGQIDSEA 1171

Human  1166 RPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFN--EDGSFIGQ 1228
            |||.:|.||||||||||||||. .:|||||..|.| |.:||.|.||..|..||..  .|.|...|
Zfish  1172 RPMNNEAFGEYRSLESDNEEKR-TASQPSLCEDSK-LCTDDGLDDYANSNSVQTEVIMDESLASQ 1234

Human  1229 YSGKKEKEAAGGNDSSGATSPINPAVAL 1256
            .||.::...|...:|    ||:|||.|:
Zfish  1235 SSGVRDVPDAETQES----SPLNPATAI 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
L1CAMNP_000416.1 Ig 35..130 CDD:472250 43/94 (46%)
Ig strand B 53..57 CDD:409353 2/3 (67%)
Ig strand C 66..70 CDD:409353 2/3 (67%)
Ig strand E 93..97 CDD:409353 2/3 (67%)
Ig strand F 111..116 CDD:409353 2/4 (50%)
Ig strand G 125..128 CDD:409353 1/2 (50%)
IgI_2_L1-CAM_like 140..230 CDD:409432 45/89 (51%)
Ig strand A 140..143 CDD:409432 2/2 (100%)
Ig strand A' 145..149 CDD:409432 0/3 (0%)
Ig strand B 152..160 CDD:409432 7/7 (100%)
Ig strand C 167..173 CDD:409432 2/5 (40%)
Ig strand C' 176..179 CDD:409432 0/2 (0%)
Ig strand D 185..189 CDD:409432 1/3 (33%)
Ig strand E 191..195 CDD:409432 3/3 (100%)
Ig strand F 206..214 CDD:409432 3/7 (43%)
Ig strand G 217..230 CDD:409432 7/12 (58%)
Ig3_L1-CAM 248..330 CDD:409460 33/81 (41%)
Ig strand B 260..264 CDD:409460 2/3 (67%)
Ig strand C 273..277 CDD:409460 1/3 (33%)
Ig strand E 295..299 CDD:409460 1/3 (33%)
Ig strand F 309..314 CDD:409460 3/4 (75%)
Ig strand G 322..325 CDD:409460 1/2 (50%)
Ig4_L1-CAM_like 334..422 CDD:409453 43/87 (49%)
Ig strand B 350..354 CDD:409453 1/3 (33%)
Ig strand C 363..367 CDD:409453 3/3 (100%)
Ig strand E 387..391 CDD:409453 2/3 (67%)
Ig strand F 401..406 CDD:409453 3/4 (75%)
Ig strand G 414..417 CDD:409453 1/2 (50%)
Ig 428..514 CDD:472250 30/85 (35%)
Ig strand B 444..448 CDD:409353 1/3 (33%)
Ig strand C 457..461 CDD:409353 1/3 (33%)
Ig strand E 480..484 CDD:409353 2/3 (67%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 2/2 (100%)
Ig_3 519..594 CDD:464046 26/76 (34%)
Cell attachment site. /evidence=ECO:0000255 554..556 1/1 (100%)
FN3 612..709 CDD:238020 37/96 (39%)
FN3 <627..>837 CDD:442628 87/210 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..725 11/26 (42%)
fn3 824..907 CDD:394996 29/83 (35%)
FN3 918..1003 CDD:238020 31/84 (37%)
Bravo_FIGEY 1144..1233 CDD:464016 57/90 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1207 20/30 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257 11/31 (35%)
l1camaNP_571436.3 None

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