DRSC/TRiP Functional Genomics Resources

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Protein Alignment L1CAM and lad-2

DIOPT Version :10

Sequence 1:NP_000416.1 Gene:L1CAM / 3897 HGNCID:6470 Length:1257 Species:Homo sapiens
Sequence 2:NP_001023496.1 Gene:lad-2 / 177078 WormBaseID:WBGene00002243 Length:1187 Species:Caenorhabditis elegans


Alignment Length:1238 Identity:351/1238 - (28%)
Similarity:549/1238 - (44%) Gaps:173/1238 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    34 PPVITEQSPRRLVVFPTDD-------ISLKCEASGKPEVQFRWTRDG---------VHFKPKEEL 82
            ||.:.|||... |.:..||       ::|:|||....: ::.|.:||         |.::.:.:.
 Worm    24 PPKLLEQSGEE-VWYHLDDEDLLKNRLTLRCEADENTD-RYSWLKDGEPFVIDSEDVLWEKESQS 86

Human    83 GVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE 147
            |..|:..||:.              .||.|:|||||..|||:|:::.|.......:||..||.:.
 Worm    87 GSIVFTKPHAS--------------HQGYYQCFASNIFGTALSNKMHLRLGSLEHFPKRDVKLLR 137

Human   148 VEEGESVVLPCNPPPSAEPLRIYWM-----NSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD- 206
            |:||||:.|.|.||......:|.|:     :|.::...:...:|:...|:|:|::|..||..:. 
 Worm   138 VKEGESLTLNCTPPRGTPDPKIVWLYRSLDDSSVIETIRSRHITVDNEGHLHFSSVELSDGKATL 202

Human   207 -YICHAHFP--------GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
             |.|.|..|        |.|..:..||...:......|          :.|.|.:....|..|.|
 Worm   203 VYECAATSPVLRGEYRSGDRIQLDIEPSQDKSHPVKKM----------SVSPSEVTVRAGGQLKL 257

Human   263 ECIAEGFPTPTIKWLRPSGPMPADRVT-----YQNHNKTLQLLKVGEEDDGEYRCLAENSLGSAR 322
            :||..|.|.|||.|.:..|.:|..|:.     ..:..::|.:..|..:|.|.|.|...:.:    
 Worm   258 QCIFGGRPLPTIFWSKIDGELPKSRIKDLTSHESDFGRSLIVENVHPDDAGAYECRGRHLV---- 318

Human   323 HAYYVTVEAAPYWLHKPQSHLYGPGE-TARLDCQVQGRPQPEVTWRINGIPVEELAKD-QKYRIQ 385
            |...|.|.|||:|...|...:..|.| |..|:|...|:|.|.:||.:||..:.|||:| ::..:.
 Worm   319 HTVNVRVMAAPFWEFDPPRDISLPEESTGELECLAGGQPTPIITWSMNGKFLHELAEDSRRVLLD 383

Human   386 RGALI-LSNVQPS-DTMVTQCEARNRHGLLLANAYIYV------VQLPAKILTADNQTYMAVQGS 442
            .|.:: :.|:... ||.|.||.|.|..|.:.|||:::|      .::||.      :.:..|..|
 Worm   384 HGRILRVRNLNHDLDTGVYQCNASNPLGYVFANAFVHVRAHAPFFRMPAA------RHWKVVLHS 442

Human   443 TAYLLCKAFGAPVPSVQWLDEDG---TTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQN 504
            |..|.|....||...|:|:|.|.   ..|....:.||  |.|..:.|:.:.|.|.|:|..:|...
 Worm   443 TVVLDCDVDAAPEAMVRWVDADDRPLQVVEGKNKLFP--NHTFMVYDVNSADEGLYYCNVSNKYG 505

Human   505 NVTIMANLKVKDATQITQ--GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSD 567
            .......|:|...|...:  .|:..|.:.|......|:|..||.|.....|..:|:.|.|   |.
 Worm   506 INRATNRLQVFKPTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGKVLTE---SQ 567

Human   568 KYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR 632
            .|.|...||...|:.....|...|.|.|::||..:..||:|...|.   ..|:...| .::.:..
 Worm   568 YYEILPDRLRFRSVRGRHSGIIDCAAITDVDVKLASMQLIVKDVPA---HPVVETAH-CSERKAT 628

Human   633 VSWSPAEDHNAPIEKYDIE-FEDKEMAPEKWYSLGK---VPGNQTSTTLKLSPYVHYTFRVTAIN 693
            |.|..|.||...|:||.:| |.|  ....:|..:.:   |........:.|:|:|:|||||.|:|
 Worm   629 VKWVAASDHGDSIKKYIVEMFTD--FKKNEWEVINEEVNVNKETFEVDITLTPWVNYTFRVVAVN 691

Human   694 KYG------PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRV 752
            .:|      .|:|.....|..|..:.|..||..|||||.|..|:||:||||....||||.:||.|
 Worm   692 SHGRSDMKIDGQPKEDWLTCQTRPSFPYTNPTGVKGEGTEPDNLVISWKPLDRYYWNAPNMQYLV 756

Human   753 QWRPQGTRGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQGKG-PEPQVTIGYSGEDYPQ 813
            :::.......|.|.:|.|.   |.::.:..||..|.|:||:|||.|.. .||::..|:||||.|.
 Worm   757 RYKLDEPIHGWTEFLVEDSLANFTIIRDQPTFRKYLIQVQSVNSVGPSIVEPEIHHGWSGEDVPD 821

Human   814 AIPELEGIEI-LNSSAVLVKWRPVDLAQVKGHLRGYNVTYWR-EGSQRKHSKRHIHKDHVVVPAN 876
            ..|....|:. :|.:.:...|.|||...|.||..||.:.||: |.:.||:|        :.:|||
 Worm   822 EAPRDFHIDTQINFTTINFTWNPVDANTVNGHFVGYEIEYWKAENTIRKYS--------IKIPAN 878

Human   877 TTSVILSGLRPYSSYHLEVQAFNGR-GSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQP 940
            :|..:::.....::|...::..|.| .|.|:...:|:.|||.||....|.:....:|::||:|..
 Worm   879 STYKVINSFHAVTNYSAHIRTRNKRLRSAPSDYVSFAMPEGPPGKVHNLRVYSVGSTAILLQWDA 943

Human   941 PLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAI 1005
            ||..||.:.||.:|:.  :|..:.:.::.:...:...|..::  |...|:..:.|.|:.|.|...
 Worm   944 PLQPNGRIRGYFISFQ--NEKNETEETYVIHRQKHYLHEKSE--PDTGYKVSVWAETRAGEGPVT 1004

Human  1006 VREGGTMAL----SGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQ 1066
            :|...|...    :.|....|||..:    .||.|.|..       |.::|     ..||:....
 Worm  1005 LRPVRTWPARIPDAPIFRVKNISLDS----FVVEWQPNN-------HSVWK-----MPGAAFFVN 1053

Human  1067 YVSYNQSSYTQWDL--QPDTDYEIHLFKERMFRHQMAVKTNGTGRV----------------RLP 1113
            |.:.:..::.|.::  .|.|:..|...||........:..:|..|.                ||.
 Worm  1054 YTAESSKTWFQSEIIYLPYTEITIRNLKEDQKYFMQGIAKDGPRRSESVFLPIKTLNRDYANRLK 1118

Human  1114 PAGFATEGWFIGFVSAI-ILLLLVLLILCFIKRSKGGKYSVKDKE---DTQVDSEARPMKDETFG 1174
            .....:..|||..:..: |.|..:.|..|...:::..|::|:.||   ..|.|:|    :::.|.
 Worm  1119 EDSLRSAAWFIAVLGVLGIGLFTICLTFCCGNKNRQEKFAVRRKEIEIGHQQDNE----EEKQFL 1179

Human  1175 EYR 1177
            ||:
 Worm  1180 EYQ 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
L1CAMNP_000416.1 Ig 35..130 CDD:472250 31/110 (28%)
Ig strand B 53..57 CDD:409353 1/3 (33%)
Ig strand C 66..70 CDD:409353 0/3 (0%)
Ig strand E 93..97 CDD:409353 0/3 (0%)
Ig strand F 111..116 CDD:409353 2/4 (50%)
Ig strand G 125..128 CDD:409353 1/2 (50%)
IgI_2_L1-CAM_like 140..230 CDD:409432 30/104 (29%)
Ig strand A 140..143 CDD:409432 1/2 (50%)
Ig strand A' 145..149 CDD:409432 0/3 (0%)
Ig strand B 152..160 CDD:409432 4/7 (57%)
Ig strand C 167..173 CDD:409432 2/10 (20%)
Ig strand C' 176..179 CDD:409432 0/2 (0%)
Ig strand D 185..189 CDD:409432 1/3 (33%)
Ig strand E 191..195 CDD:409432 2/3 (67%)
Ig strand F 206..214 CDD:409432 3/9 (33%)
Ig strand G 217..230 CDD:409432 3/12 (25%)
Ig3_L1-CAM 248..330 CDD:409460 24/86 (28%)
Ig strand B 260..264 CDD:409460 2/3 (67%)
Ig strand C 273..277 CDD:409460 2/3 (67%)
Ig strand E 295..299 CDD:409460 1/3 (33%)
Ig strand F 309..314 CDD:409460 2/4 (50%)
Ig strand G 322..325 CDD:409460 1/2 (50%)
Ig4_L1-CAM_like 334..422 CDD:409453 32/97 (33%)
Ig strand B 350..354 CDD:409453 1/3 (33%)
Ig strand C 363..367 CDD:409453 1/3 (33%)
Ig strand E 387..391 CDD:409453 1/4 (25%)
Ig strand F 401..406 CDD:409453 3/4 (75%)
Ig strand G 414..417 CDD:409453 1/2 (50%)
Ig 428..514 CDD:472250 23/88 (26%)
Ig strand B 444..448 CDD:409353 1/3 (33%)
Ig strand C 457..461 CDD:409353 1/3 (33%)
Ig strand E 480..484 CDD:409353 1/3 (33%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 0/2 (0%)
Ig_3 519..594 CDD:464046 20/76 (26%)
Cell attachment site. /evidence=ECO:0000255 554..556 0/1 (0%)
FN3 612..709 CDD:238020 30/106 (28%)
FN3 <627..>837 CDD:442628 79/224 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..725 10/26 (38%)
fn3 824..907 CDD:394996 25/84 (30%)
FN3 918..1003 CDD:238020 21/84 (25%)
Bravo_FIGEY 1144..1233 CDD:464016 10/37 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1207 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257
lad-2NP_001023496.1 Ig 25..121 CDD:472250 31/111 (28%)
Ig strand B 49..53 CDD:409353 1/3 (33%)
Ig strand C 61..65 CDD:409353 0/3 (0%)
Ig strand E 87..91 CDD:409353 1/3 (33%)
Ig strand F 101..106 CDD:409353 2/4 (50%)
Ig strand G 115..118 CDD:409353 1/2 (50%)
Ig 133..216 CDD:472250 25/82 (30%)
Ig strand B 144..148 CDD:409353 1/3 (33%)
Ig strand C 158..162 CDD:409353 1/3 (33%)
Ig strand E 186..190 CDD:409353 2/3 (67%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig 243..325 CDD:472250 24/85 (28%)
Ig strand B 255..259 CDD:409353 2/3 (67%)
Ig strand C 268..272 CDD:409353 2/3 (67%)
Ig strand E 295..299 CDD:409353 1/3 (33%)
Ig strand F 309..314 CDD:409353 2/4 (50%)
Ig4_L1-NrCAM_like 330..422 CDD:409367 31/91 (34%)
Ig strand B 347..351 CDD:409367 1/3 (33%)
Ig strand C 360..364 CDD:409367 1/3 (33%)
Ig strand E 386..390 CDD:409367 0/3 (0%)
Ig strand F 401..406 CDD:409367 3/4 (75%)
Ig strand G 414..417 CDD:409367 1/2 (50%)
IG_like 438..515 CDD:214653 23/78 (29%)
Ig strand B 444..448 CDD:409353 1/3 (33%)
Ig strand C 457..461 CDD:409353 1/3 (33%)
Ig strand E 482..485 CDD:409353 1/2 (50%)
Ig strand F 495..500 CDD:409353 2/4 (50%)
Ig strand G 508..511 CDD:409353 0/2 (0%)
Ig 527..593 CDD:472250 20/68 (29%)
Ig strand B 538..542 CDD:409353 0/3 (0%)
Ig strand C 551..557 CDD:409353 0/5 (0%)
Ig strand E 574..578 CDD:409353 2/3 (67%)
Ig strand F 588..593 CDD:409353 1/4 (25%)
FN3 610..697 CDD:238020 27/92 (29%)
FN3 <666..1095 CDD:442628 136/456 (30%)
fn3 823..909 CDD:394996 26/93 (28%)
FN3 921..1010 CDD:238020 23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

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