DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment L1CAM and l1cam

DIOPT Version :10

Sequence 1:NP_000416.1 Gene:L1CAM / 3897 HGNCID:6470 Length:1257 Species:Homo sapiens
Sequence 2:XP_012823307.1 Gene:l1cam / 100124734 XenbaseID:XB-GENE-5914700 Length:1254 Species:Xenopus tropicalis


Alignment Length:1257 Identity:604/1257 - (48%)
Similarity:814/1257 - (64%) Gaps:30/1257 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    12 LLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHF 76
            ||||.....|:|:.|....:|.|||||||||.:.|::|.|||.|||||....:.::.|.:||..|
 Frog    17 LLCSHMEAFQLPKGYVMQEIMYPPVITEQSPEKYVLYPNDDIVLKCEAKRNAKAKYTWKKDGETF 81

Human    77 KPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKE 141
            :|..:..|:  :...||:..|:| |.|..:.|||.|||:|:|.||||:||||.::.|..|||.||
 Frog    82 QPDNDPRVS--RKKDSGTLNISG-NGNSMKDFQGKYRCYATNDLGTAISHEIHVITESTPKWQKE 143

Human   142 TVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 206
            .::|:::|||.|::||||||.||.|.|:.||||.:|||.|||||:||.||||||:||...|.|.|
 Frog   144 LIRPLDIEEGASLILPCNPPKSAVPPRVIWMNSNLLHITQDERVSMGVNGNLYFSNVQKQDEHPD 208

Human   207 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPT 271
            |||||.|.|.|||:|||.|.::|:.|||:..|||.::.|..|.|.::||:.|||.|||||||.||
 Frog   209 YICHAQFVGARTIVQKEAISIKVRPTNSVKFRKPEMMLPEGSMSTVLALRDQPLQLECIAEGLPT 273

Human   272 PTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWL 336
            |.|:|:...|....:|:.:.:..|||.:.||.:||||:|:|:|:|:.||:.|.:.|.||:||||:
 Frog   274 PEIEWIPLLGSTYNERIQFDDFKKTLHIDKVQDEDDGDYQCIAKNTQGSSSHTFTVVVESAPYWI 338

Human   337 HKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMV 401
            :||:..:|.|||...|.|:|.|:|:|:|||:|||..:::......:::..|:|:|:|:|.:||.|
 Frog   339 NKPEDGIYAPGEDIILHCEVGGKPKPKVTWKINGKSLKDSDLYHNWKLIDGSLVLNNMQLNDTSV 403

Human   402 TQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
            .||||||:||.|||||::|||:||.:|||.:::.|:.|:.:...:.|:|||.|.|::||..:...
 Frog   404 VQCEARNKHGNLLANAFVYVVELPPQILTRNDEQYIVVEKTNVSMDCRAFGTPFPTIQWESDLED 468

Human   467 TVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKK 531
            .:...::|..:.||||.|..:...|.|.|.|.|:|:|.||:|.|.|.|::||:|...|.....:|
 Frog   469 NLFALDQFSMHTNGTLTITGVAKEDEGIYRCTASNNQGNVSISAYLDVRNATKIITPPMEQHARK 533

Human   532 GSRVTFTCQASFDPSLQPS-ITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAST 595
            |.:..|.|:..|||.:... |.||.:|.:::|..|:|||||||..|.|.::..||.|.|:|.|.|
 Frog   534 GGKAIFQCKVEFDPKMSDKIIQWRKNGNEIKEDADNDKYFIEDYTLSISNVQESDHGMYTCAAHT 598

Human   596 ELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE 660
            |||.||..|:|:|:..|.....|.||:..   ::.:.::|:|..|:|:|||::.||:|:....|.
 Frog   599 ELDAVELTAELVVIDLPEAPFDLELSNAQ---ETSITLTWTPGNDNNSPIEEFIIEYEEDSFEPG 660

Human   661 KWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEG 725
            .|:.|.:|.|:..:..|.|||||:|.|||.|:|:.||...|..|:...||..||.|||.:|||||
 Frog   661 VWHELTRVDGDMFNVDLDLSPYVNYQFRVIAVNEVGPSNGSNPSDRYETPAFAPAKNPREVKGEG 725

Human   726 NETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQA 790
            .|..||.|:||||:.:|||.|..:|.|:||..| :..|:|.:...|.::||.||.|.||||.||:
 Frog   726 TEPQNMYISWKPLKGIDWNGPGFKYLVKWRQLG-KEEWKEVVADSPPVLVSGTSIFEPYEIIVQS 789

Human   791 VNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWRE 855
            ||..|:..||:..||:||||.|...||..|:|.:|.||:.|.|.||....:.|||:|:.|.|.| 
 Frog   790 VNDIGRATEPKPVIGHSGEDMPDITPENVGLEAMNESAIKVAWLPVQKNGLNGHLKGFMVYYTR- 853

Human   856 GSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEF-TFSTPEGVPG 919
                 |:..:.|...::|..|||..:::||:|||:|.:||...||:|.|..||. ...|.||||.
 Frog   854 -----HNGHNRHPGKLLVHGNTTHALITGLKPYSNYSVEVAIINGKGEGEHSESRMIRTDEGVPS 913

Human   920 HPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL---DEGGKGQLSFNLRDPELRTHNLT 981
            .|..|.||.||:|||.|.|.||.:.||:||||.: ||.:   ...|....|..:.||..:...|:
 Frog   914 PPSFLRLERQSDTSLTLIWGPPETPNGILTGYEI-YHQIVNKTHTGAKYFSETINDPTQQNWTLS 977

Human   982 DLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFR 1046
            ::|....|||.|.|||..|..||::.||.||....:....|:|...|:|...::|:..||..|..
 Frog   978 NISSKDTYRFYLYATTSVGQSEAVMVEGSTMQEIEVPPVLNVSIETGDNVVTLNWMQLEGPSNAE 1042

Human  1047 FHILFKALGEEKGGASLSPQYVSYN--QSSYTQWDLQPDTDYEIHLFKERMFRH----QMAVKTN 1105
            ..:..:    .|....|...|.|.|  .|::....|.|.|.|.|.|......:|    ...|:|:
 Frog  1043 IRVEIR----NKSSELLWRHYGSVNTTDSTFQLSGLLPGTFYFIRLMALNHTQHVEIWSDMVQTS 1103

Human  1106 GTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKD 1170
            ||. :.....||..|||||..::||::|||:||||||||||||||||||||||||.|||||||||
 Frog  1104 GTA-IPTKQGGFPNEGWFIALITAIVVLLLILLILCFIKRSKGGKYSVKDKEDTQGDSEARPMKD 1167

Human  1171 ETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEK 1235
            |||||||||||||:||.|.||||||||:||.||||||||||||||||||||||||||||||||||
 Frog  1168 ETFGEYRSLESDNDEKPFTSSQPSLNGEIKQLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEK 1232

Human  1236 EAAGGNDSSGATSPINPAVALE 1257
            |..|||:|||||||:||.||:|
 Frog  1233 EPTGGNESSGATSPVNPNVAVE 1254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
L1CAMNP_000416.1 Ig 35..130 CDD:472250 46/94 (49%)
Ig strand B 53..57 CDD:409353 2/3 (67%)
Ig strand C 66..70 CDD:409353 0/3 (0%)
Ig strand E 93..97 CDD:409353 1/3 (33%)
Ig strand F 111..116 CDD:409353 3/4 (75%)
Ig strand G 125..128 CDD:409353 2/2 (100%)
IgI_2_L1-CAM_like 140..230 CDD:409432 56/89 (63%)
Ig strand A 140..143 CDD:409432 2/2 (100%)
Ig strand A' 145..149 CDD:409432 1/3 (33%)
Ig strand B 152..160 CDD:409432 4/7 (57%)
Ig strand C 167..173 CDD:409432 2/5 (40%)
Ig strand C' 176..179 CDD:409432 1/2 (50%)
Ig strand D 185..189 CDD:409432 2/3 (67%)
Ig strand E 191..195 CDD:409432 3/3 (100%)
Ig strand F 206..214 CDD:409432 6/7 (86%)
Ig strand G 217..230 CDD:409432 7/12 (58%)
Ig3_L1-CAM 248..330 CDD:409460 38/81 (47%)
Ig strand B 260..264 CDD:409460 2/3 (67%)
Ig strand C 273..277 CDD:409460 1/3 (33%)
Ig strand E 295..299 CDD:409460 3/3 (100%)
Ig strand F 309..314 CDD:409460 2/4 (50%)
Ig strand G 322..325 CDD:409460 1/2 (50%)
Ig4_L1-CAM_like 334..422 CDD:409453 42/87 (48%)
Ig strand B 350..354 CDD:409453 1/3 (33%)
Ig strand C 363..367 CDD:409453 2/3 (67%)
Ig strand E 387..391 CDD:409453 2/3 (67%)
Ig strand F 401..406 CDD:409453 3/4 (75%)
Ig strand G 414..417 CDD:409453 2/2 (100%)
Ig 428..514 CDD:472250 31/85 (36%)
Ig strand B 444..448 CDD:409353 0/3 (0%)
Ig strand C 457..461 CDD:409353 1/3 (33%)
Ig strand E 480..484 CDD:409353 3/3 (100%)
Ig strand F 494..499 CDD:409353 2/4 (50%)
Ig strand G 507..510 CDD:409353 1/2 (50%)
Ig_3 519..594 CDD:464046 29/75 (39%)
Cell attachment site. /evidence=ECO:0000255 554..556 1/1 (100%)
FN3 612..709 CDD:238020 35/96 (36%)
FN3 <627..>837 CDD:442628 96/209 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 698..725 12/26 (46%)
fn3 824..907 CDD:394996 32/82 (39%)
FN3 918..1003 CDD:238020 36/87 (41%)
Bravo_FIGEY 1144..1233 CDD:464016 82/88 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1207 25/30 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1226..1257 25/30 (83%)
l1camXP_012823307.1 Ig 40..133 CDD:472250 46/95 (48%)
Ig strand B 58..62 CDD:409353 2/3 (67%)
Ig strand C 71..75 CDD:409353 0/3 (0%)
Ig strand E 96..100 CDD:409353 1/3 (33%)
Ig strand F 113..118 CDD:409353 3/4 (75%)
Ig strand G 127..130 CDD:409353 2/2 (100%)
IgI_2_L1-CAM_like 142..232 CDD:409432 56/89 (63%)
Ig strand A 142..145 CDD:409432 2/2 (100%)
Ig strand A' 147..151 CDD:409432 1/3 (33%)
Ig strand B 154..162 CDD:409432 4/7 (57%)
Ig strand C 169..175 CDD:409432 2/5 (40%)
Ig strand C' 178..181 CDD:409432 1/2 (50%)
Ig strand D 187..191 CDD:409432 2/3 (67%)
Ig strand E 193..197 CDD:409432 3/3 (100%)
Ig strand F 208..216 CDD:409432 6/7 (86%)
Ig strand G 219..232 CDD:409432 7/12 (58%)
Ig3_L1-CAM_like 250..332 CDD:409394 38/81 (47%)
Ig strand B 262..266 CDD:409394 2/3 (67%)
Ig strand C 275..279 CDD:409394 1/3 (33%)
Ig strand E 297..301 CDD:409394 3/3 (100%)
Ig strand F 311..316 CDD:409394 2/4 (50%)
Ig strand G 324..327 CDD:409394 1/2 (50%)
Ig 336..424 CDD:472250 42/87 (48%)
Ig strand B 352..356 CDD:409353 1/3 (33%)
Ig strand C 365..369 CDD:409353 2/3 (67%)
Ig strand E 389..393 CDD:409353 2/3 (67%)
Ig strand F 403..408 CDD:409353 3/4 (75%)
Ig strand G 416..419 CDD:409353 2/2 (100%)
Ig 430..516 CDD:472250 31/85 (36%)
Ig strand B 446..450 CDD:409353 0/3 (0%)
Ig strand C 459..463 CDD:409353 1/3 (33%)
Ig strand E 482..486 CDD:409353 3/3 (100%)
Ig strand F 496..501 CDD:409353 2/4 (50%)
Ig strand G 509..512 CDD:409353 1/2 (50%)
Ig 521..611 CDD:472250 38/89 (43%)
Ig strand B 537..541 CDD:409353 1/3 (33%)
Ig strand C 550..557 CDD:409353 1/6 (17%)
Ig strand E 577..581 CDD:409353 1/3 (33%)
Ig strand F 591..596 CDD:409353 2/4 (50%)
Ig strand G 604..607 CDD:409353 1/2 (50%)
FN3 615..704 CDD:238020 34/91 (37%)
FN3 717..795 CDD:238020 40/78 (51%)
FN3 815..907 CDD:238020 38/97 (39%)
FN3 <877..>1119 CDD:442628 88/247 (36%)
Bravo_FIGEY 1141..1230 CDD:464016 82/88 (93%)

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