DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pus7 and Pus7l

DIOPT Version :9

Sequence 1:	NP_648231.1	Gene:	Pus7 / 38969	FlyBaseID:	FBgn0035901	Length:	734	Species:	Drosophila melanogaster
Sequence 2:	NP_766025.1	Gene:	Pus7l / 78895	MGIID:	1926145	Length:	702	Species:	Mus musculus

Alignment Length:	745	Identity:	184/745 - (24%)
Similarity:	303/745 - (40%)	Gaps:	197/745 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GFTGILKSRFSDFHVNEIDSNGKVLE-----------------LNDLSVPKVAIVAVA------- 105
            ||.|.:|:..|||.|.|||..|:::.                 .|.:..||:.|..|:
Mouse    22 GFQGSIKTSPSDFIVIEIDEQGQLVSKATDGSLYEISKIQSEPSNSVKKPKLNIQNVSLEHKNSE 86

  Fly   106 ---------------------------------ENELDNWRKELEAVIGPEVWQDIANLAKAKND 137
                                             |..:|..|..|:......:.|...::.:..|.
Mouse    87 GAADLPGCSDGDRSHQSDSEKENSVNSVTSKCEEESVDLLRSLLDEKTHTSLGQFACDIKRMWNS 151

  Fly   138 PA--IEQKVEIDV-TTLDKEQRTQVHQMIKQLYKGKLLSTTIGQQQAKP--KVQEEASLENKDAA 197
            ..  .|...|:.: ..|||.:|..:|..::|.:...:.....|:...||  :.:|...|.:::.|
Mouse   152 QTELTEPSPELSLGKILDKNRRAVLHSAVRQAFPFLITVGNQGEVVVKPNRECKELCRLVSEEEA 216

  Fly   198 EGETSTQKDSQVPAEEKKTIKVFKPKPGRGDKR----------------WSFP------------ 234
            .|..     ..:.|:::.:...|||.|.:..::                .|||
Mouse   217 LGFF-----KYLDAKKENSKFTFKPDPNKDHRKAVHHFLNKKFGNLVETKSFPGQHHSAGNPDSA 276

  Fly   235 -----------------------ADYVTFLVHKTNLVTSDVASTLAARLNLRPSQVNYSGIKDKR 276
                                   |.|..|.:.|.||.|.:....||.:|.:.||..:|:|:||||
Mouse   277 ITVRFREKARGKRSHPEGCERGKAVYTAFTLQKENLETFEAIGLLAVKLGVIPSDFSYAGLKDKR 341

  Fly   277 AKTTQKFSVKRRTPESI--LVAARSQRNVHIGNFGFESNTLKLGDLQGNRFRIALRHIAKEKR-- 337
            |.|.|...||:.|||.:  :.....::.:::.|.....:.|:||.|:||.|.|.:||:..:..
Mouse   342 AITYQSMVVKKVTPERLKSIKEEIEKKRMNVFNIRSVGDCLRLGQLKGNHFEIIIRHLRNQLNDS 406

  Fly   338 ----EEIEQALQSLKERGFINYYGLQRFGNSASVPTYEVGVALLKHDYKLACELILKPRDSDVEF 398
                |.|.:|::::|.:||:||||.||||....:.|.::|:||||::...|.:|.|.|.|.| :.
Mouse   407 ANLTERILEAIENVKNKGFVNYYGPQRFGKGQKIQTDQIGLALLKNEMVKAIKLFLTPEDVD-DP 470

  Fly   399 LRPIREEWWKNRDSAAAAAQIYGEKFIEKKLLDGLARFG--ESDYSSALRQIPRNMLMLYPHAYQ 461
            :...::.:.:..|:....:.:...:..|:.||:.|.|||  |.....|....|.:|.:.|.|||.
Mouse   471 VNKAKQYFLRTEDAKGTLSLMPEFRVRERALLESLHRFGVTEEGCVRAWFSFPHSMRIFYIHAYS 535

  Fly   462 SLIFNRIASRRIKEFGLKLIPGDLVYVEQDQSEASEEQAQQGEALEEQKEEEPNDEPLEVPEGDE 526
            |.|:|..||.|:..:|.|::.|||:        .|:|.|.:                 ..|..
Mouse   536 SRIWNEAASYRLAAYGPKVVEGDLI--------CSDEDADK-----------------HFPSS-- 573

  Fly   527 AIEEESIFKRKVRPLTAEDIASGKYKLCDVVLPLPGHDITYPSNECGAWYEEMLAEVGLSSDQLK 591
                      ||..:|.|:.::..|.|..||||:.|:::.||.|:.|.||:|.|:..||.:.:.:
Mouse   574 ----------KVHLVTKEEESAHTYALHQVVLPVLGYNVQYPENQVGRWYQEALSRDGLQACRFR 628

  Fly   592 HKEKTYALAGAYRKMIISSSDLKWSFRMYNTPEDTLIASDWELLKNIPVAPEPAEAEANY----- 651
            .......:.|.||.::....::  |.|:                    |.|:||..||..
Mouse   629 VPALKLNVPGCYRHIVKHPRNV--SHRL--------------------VHPDPATEEARVEGPHS 671

  Fly   652 ----MALLLEFSLPTAAYATMFLRELLKQD 677
                .:|.|.|.|..:.|||:.|||::|.|
Mouse   672 DDTASSLSLSFDLDASCYATVCLREMMKGD 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pus7	NP_648231.1	PseudoU_synth_ScPUS7	236..674	CDD:211341	135/456 (30%)
Pus7l	NP_766025.1	PseudoU_synth	22..>46	CDD:294089	12/23 (52%)
		FSIP1	50..>170	CDD:292191	14/119 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..116		0/31 (0%)
		PseudoU_synth_ScPUS7	302..698	CDD:211341	135/455 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D298799at33208
OrthoFinder	1	1.000	-	-		FOG0002144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2938
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810