DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZC3H3 and zc3h3

DIOPT Version :9

Sequence 1:	NP_648230.1	Gene:	ZC3H3 / 38968	FlyBaseID:	FBgn0035900	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_017950172.1	Gene:	zc3h3 / 733707	XenbaseID:	XB-GENE-995650	Length:	830	Species:	Xenopus tropicalis

Alignment Length:	578	Identity:	166/578 - (28%)
Similarity:	234/578 - (40%)	Gaps:	153/578 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QAPLQPQPAIHINPHFLNRQRAMYDQYQREQQEQLMMQQVSASHYRLDPTIHLL------ATPPP 102
            :.|:|..|  ..:||.|.:.:.      .....:|.::..:.|||::.....::      ::|..
Frog   343 EPPVQTTP--KASPHLLFKGQG------PPTAPKLPLRDSAHSHYKVKSRTKIIRRRSSSSSPTD 399

  Fly   103 PPAKIISKVST----CLVRKPSVVASGPAVKLAASVPVPTVSSLVQP-PLVSISKRKIVR----- 157
            ..|..::.||.    ||.|:     |.|.||      .|.|.....| .|:.|:|.|:.|
Frog   400 KKASPLAPVSVRSRYCLRRR-----SSPRVK------SPVVQRRSSPRGLIHITKHKLRRLPPSK 453

  Fly   158 -QGALKAAPAVAALHPPPPAK--RTRYKLVRSISLTCTPLVKKRRPLREFVGQYALR-RTNEAQP 218
             ....||.|...|:..||.::  :|||::|:.......|    ..|...|....:.| |......
Frog   454 QHDPTKAGPPTTAMRSPPSSRVIKTRYRIVKKNVSALHP----ASPFSPFSPSLSWRSRVLLVHQ 514

  Fly   219 NRKLSSK-----PQALKLGVNKSLSMVSIHGVMYKKISKNKITKLDASSSARVAKSESPRTLQRT 278
            .|:||..     ||...    ||..:..|.|||| ::|.||::|  .||...|:|. |||.....
Frog   515 IRQLSQSSRFPHPQQRW----KSRGIRCIGGVMY-RVSANKLSK--TSSPGPVSKL-SPRAGSLD 571

  Fly   279 LSGRTLFVSGNKFILDPSGCRLTRVSTSSTGATQSSVNRSILRRIDIGGLTYVASPKALNVFVRT 343
            ||..:           |.....:|.:|.|                     .|:||
Frog   572 LSSTS-----------PGSLYPSRTTTPS---------------------RYIAS---------- 594

  Fly   344 SNHVSRAHLITAKQRSLTLLNKSLVKTNVP--CAIFQKLGKCVAHSRGK-CRKLHDKRQVAICVS 405
                      .|.||||.::.::..|....  |..:.:.|||   :||: |..:||..:||:|..
Frog   595 ----------RAVQRSLAIIRQAKHKKEKKEYCMYYNRFGKC---NRGQNCPFIHDPEKVAVCTR 646

  Fly   406 FLRGECTKP--KCLLSHNVTLEKMPVCRYYLRGVCVREDCPYLHKKLSSKTEICIDFVRGYCPLA 468
            ||||.|.|.  .|..||.|:.:|||||.|:|:|:|...||||.|..:|.|.|||.||::|||||.
Frog   647 FLRGTCKKTDGTCPFSHKVSKDKMPVCSYFLKGICHNNDCPYSHVYVSRKAEICKDFLKGYCPLG 711

  Fly   469 AECNKRHEFSCPELERKGKCELPRCVFCKKSPSKRLAKVKSRPKLGSKPVAFTDTAKESSTADEL 533
            |:|.|:|...||:..|.|||  |....||....:|    |.||              |:....|.
Frog   712 AKCKKKHTLQCPDYARDGKC--PNGAKCKLQHRQR----KKRP--------------ENVAQSEW 756

  Fly   534 PTSSRYFGSHKEPAEAILTRDDVEQKKPEAEDEDQKEAGAPCPRRRPQLGTLPSFIPL 591
            |......| ....|.||.:.|       .|.|||         ..|.::.|||:||.|
Frog   757 PRPGGRQG-QSAGASAIGSTD-------TASDED---------LGRSRMQTLPAFISL 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZC3H3	NP_648230.1	YTH1	329..519	CDD:227416	74/194 (38%)
ZC3H3	NP_648230.1	ZnF_C3H1	425..447	CDD:214632	13/21 (62%)
zc3h3	XP_017950172.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006516
OrthoInspector	1	1.000	-	-		oto104576
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000