DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZC3H3 and zc3h3

DIOPT Version :9

Sequence 1:	NP_648230.1	Gene:	ZC3H3 / 38968	FlyBaseID:	FBgn0035900	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_689680.3	Gene:	zc3h3 / 561182	ZFINID:	ZDB-GENE-030131-9399	Length:	929	Species:	Danio rerio

Alignment Length:	740	Identity:	189/740 - (25%)
Similarity:	277/740 - (37%)	Gaps:	229/740 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PHISADEAQPSMSRKVYINPNFQLQGQTAHQLPFQVPFQAFQAPLQPQPAIHINPHFLNRQRAMY 67
            ||:...    |.|.:..:.|:.:....||.... .:..||..:|.:||..:.     ..:..|..
Zfish   221 PHLPPS----SSSNRTVVIPSAKKDSTTASSAS-NLQSQATVSPAKPQVKLD-----STQTHAAS 275

  Fly    68 DQYQREQQEQLMMQQVSASHYRLDPTIHLLATPPP-----PPAKII----SKVSTCLVRKP---- 119
            ..::|.|...:..|:          |:::.:||.|     .|..|.    |..|..:.|||
Zfish   276 PCHKRSQFTWVKSQE----------TVNINSTPKPLTSGSSPGMIFTRRASSSSKRVSRKPNNSP 330

  Fly   120 ---------------SVVASG---PAVKL--------AASVPVPT-------VSSLVQPPLVSIS 151
                           |:..:|   |:|||        :...||.|       :....:...|:::
Zfish   331 GAPKTSKYTWVSSSCSLSTAGKANPSVKLPRKPLSPKSLKAPVRTFQGGMEGIKKEKKYTTVTVT 395

  Fly   152 KRKIVRQGAL-------------KAA--------------------------------------- 164
            ..|..|.||:             |||
Zfish   396 PLKKSRAGAVTTSHASHTSRYRWKAAGQNANASTSSSASRTTHKSTVYRWTANNNGQKGEKGSTL 460

  Fly   165 ----PAVAALHPPPPAKRTRYKLV-RSISLTCTPLVKKRRP-LREFVGQYAL-RRTN-------- 214
                ||.|||.......|:|.|:: ||.|..|  |.::..| ::....:|:| |||:
Zfish   461 SPNIPATAALSVGAFKLRSRTKIIRRSPSNPC--LERRHSPNVQTLKSRYSLWRRTHTQVKSPTS 523

  Fly   215 --EAQPN----------RKLSSKPQALKLGVNKS-LSMVSIHGVMYKKISKNKITKLDA------ 260
              .|||.          |:||.  .:..||.::| .|..|:......::.|.:. |:|.
Zfish   524 IKRAQPKVLVSFGRHKLRRLSL--TSTSLGTSRSGPSSSSVRSPASHRVIKTRY-KIDTRRAHAI 585

  Fly   261 ----SSSARVAKSESPRTL----QRTLSGRTLFVSGNKFILDPSGCRLTRVSTSSTGATQSSVNR 317
                :.|.||.:..|.|.|    .||.|.|.......::|    |..|.|||.:....||::
Zfish   586 HHNPALSYRVKRVHSARALLQNRMRTTSERQWRGRSMRWI----GGELYRVSANKLSRTQTT--- 643

  Fly   318 SILRRIDIGGLTYVASP-KALNVFVRTSNHVSRAHLI-----TAKQRSLTLL---NKSLVKTNVP 373
                      .|..:.| :..|.:|.:|.|..|....     .|.||||.::   .:...|....
Zfish   644 ----------CTPTSRPGEWYNPYVSSSGHQGRTSATQYVASRAVQRSLAIIRHAKQKKQKAKQY 698

  Fly   374 CAIFQKLGKCVAHSRGKCRKLHDKRQVAICVSFLRGECTKP--KCLLSHNVTLEKMPVCRYYLRG 436
            |..:.:.|||  :....|..:||..:||:|..||||.|.|.  .|..||.|..||||||.|:|:|
Zfish   699 CMYYNRFGKC--NHGNTCPYIHDPDKVAVCTRFLRGTCKKTDGTCPFSHKVAKEKMPVCSYFLKG 761

  Fly   437 VCVREDCPYLHKKLSSKTEICIDFVRGYCPLAAECNKRHEFSCPELERKGKCELPRCVFCKKSPS 501
            :|....|||.|..:|.|.|:|.||||||||...:|.|:|...||:....|.|  ||...||
Zfish   762 ICNNSSCPYSHVYVSRKAEVCEDFVRGYCPQGDKCKKKHTLVCPDFSSTGVC--PRGSKCK---- 820

  Fly   502 KRLAKVKSRPKLGSKPVAFTDTAKESSTADELPTSSRYFGSHKEPAEAILTRDDVEQKKPEAEDE 566
              |...:|:.:.||.  |....||::.|.|.|.:|                 |..:.:..|:...
Zfish   821 --LHHRQSKKRTGSN--ASYGAAKKACTRDVLRSS-----------------DAAQTQSSESTLA 864

  Fly   567 DQKEAGAPCPRRRPQLGTLPSFIPL 591
            |:   |:.|  .||:  .|||||.|
Zfish   865 DE---GSSC--SRPE--KLPSFISL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZC3H3	NP_648230.1	YTH1	329..519	CDD:227416	74/200 (37%)
ZC3H3	NP_648230.1	ZnF_C3H1	425..447	CDD:214632	13/21 (62%)
zc3h3	XP_689680.3	zf-CCCH	699..720	CDD:279036	6/22 (27%)
		ZnF_C3H1	749..774	CDD:214632	14/24 (58%)
		ZnF_C3H1	776..802	CDD:214632	15/25 (60%)
		zf-CCCH	801..823	CDD:279036	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006516
OrthoInspector	1	1.000	-	-		oto39662
orthoMCL	1	0.900	-	-		OOG6_104512
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5626
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.630