Protein Alignment CG43163 and STI1

DIOPT Version :10

• Sequence 1: NP_648228.2
• Gene: CG43163 / 38966
• FlyBaseID: FBgn0262719
• Length: 2523
• Species: Drosophila melanogaster
• Sequence 2: NP_014670.1
• Gene: STI1 / 854192
• SGDID: S000005553
• Length: 589
• Species: Saccharomyces cerevisiae
• Alignment Length: 467
• Identity: 94/467 - (20%)
• Similarity: 169/467 - (36%)
• Gaps: 122/467 - (26%)

  Fly    67 EKVRQSNAACQSGDFATAVLLYTDALQL-DPGNHILYSNRSAALLKQGQFTAALQDATQARDLCP 130
            |..:|.|||..:.|:..|:.|:|.|::: :..||:|||||||......:|:.||.||.:...:.|
Yeast     7 EYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINP 71

  Fly   131 QWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGLVEASLKSPLRAA---------- 185
            .|.|.|.|.|.|...||...||.:.:...|..:.|||....||.:.......|.|
Yeast    72 SWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLF 136

  Fly   186 LEPTL-----QQLRTMQLQESPFVVSSV---------VGQELL---------------------- 214
            .:|.|     :..:|.::.:.|.:|:.:         :||:|.
Yeast   137 ADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDI 201

  Fly   215 --------------------QATQYSAAVTVLEAA--------------LRIGSCSLKLRGSVFS 245
                                .|...|.:.|..|.:              :.:.....|:......
Yeast   202 NQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEK 266

  Fly   246 ALSSAHWALNQLDQAIGYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVL 310
            |..:..:...|.|:||.:..:...:.|.:       ....|..:|.:.:|.::.|::.....:..
Yeast   267 AEGNKFYKARQFDEAIEHYNKAWELHKDI-------TYLNNRAAAEYEKGEYETAISTLNDAVEQ 324

  Fly   311 AMKCK-DTQAAAAALTSLGHVYTASGD-------YPNALASHKQCVQLFKQLG------------ 355
            ..:.: |.:..:.:...:|:.|...||       |..:|..|:....|.|...
Yeast   325 GREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEA 389

  Fly   356 ----DRLQEAREIGNVGAVYLALGECEAALDCHSQHLRLARKLHDQVEEARAYSNLGSAHHQRRQ 416
                ::.:|||   ..|..|....:...|:..:::.::.|      .|:||.|||..:|..:...
Yeast   390 YVNPEKAEEAR---LEGKEYFTKSDWPNAVKAYTEMIKRA------PEDARGYSNRAAALAKLMS 445

  Fly   417 FTQAAA-CHEQV 427
            |.:|.| |::.:
Yeast   446 FPEAIADCNKAI 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_648228.2	PEP_TPR_lipo	<78..751	CDD:274350	89/456 (20%)
		TPR repeat	98..128	CDD:276809	14/29 (48%)
		TPR repeat	133..161	CDD:276809	9/27 (33%)
		TPR repeat	243..269	CDD:276809	5/25 (20%)
		TPR repeat	281..311	CDD:276809	4/29 (14%)
		TPR repeat	321..349	CDD:276809	7/34 (21%)
		TPR repeat	354..390	CDD:276809	6/51 (12%)
		TPR repeat	401..429	CDD:276809	10/28 (36%)
		TPR repeat	441..469	CDD:276809
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR	523..781	CDD:440225
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_12	801..865	CDD:315987
		TPR repeat	801..829	CDD:276809
		Spy	841..>1073	CDD:443119
		TPR repeat	841..878	CDD:276809
		TPR repeat	883..913	CDD:276809
		TPR repeat	924..949	CDD:276809
		TPR repeat	964..998	CDD:276809
		COG4995	975..1718	CDD:444019
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:432771
STI1	NP_014670.1	Spy	5..>110	CDD:443119	39/102 (38%)
		TPR repeat	5..33	CDD:276809	10/25 (40%)
		TPR repeat	39..69	CDD:276809	14/29 (48%)
		TPR repeat	74..102	CDD:276809	9/27 (33%)
		STI1	138..193	CDD:436075	8/54 (15%)
		TPR repeat	262..290	CDD:276809	5/27 (19%)
		LapB	267..515	CDD:442196	38/207 (18%)
		TPR repeat	294..324	CDD:276809	4/36 (11%)
		TPR repeat	336..363	CDD:276809	5/26 (19%)
		TPR repeat	396..424	CDD:276809	6/30 (20%)
		TPR repeat	429..459	CDD:276809	10/29 (34%)
		TPR repeat	464..490	CDD:276809
		STI1	527..581	CDD:436075