Protein Alignment CG43163 and TTC29

DIOPT Version :10

• Sequence 1: NP_648228.2
• Gene: CG43163 / 38966
• FlyBaseID: FBgn0262719
• Length: 2523
• Species: Drosophila melanogaster
• Sequence 2: NP_001287690.1
• Gene: TTC29 / 83894
• HGNCID: 29936
• Length: 501
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 90/412 - (21%)
• Similarity: 147/412 - (35%)
• Gaps: 93/412 - (22%)

  Fly   399 EEARAYSN----------LGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARC 453
            ||..||.|          |...:|  :.||:..|..|:                 :..|..|||.
Human    81 EEVAAYRNSYKKNICVDMLRDGYH--KSFTELFALMER-----------------WDALREAARV 126

  Fly   454 AGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLGDRT 518
            .......|...|:.        |||..        :.:.:..:.||..|         .|..|
Human   127 RSLFWLQKPLEEQP--------DKLDY--------LYHYLTRAEDAERK---------ESFED-- 164

  Fly   519 GMGKAYGNMARMA-HMAGSYEAAVKYHKQELAINQA----MNDRSAEAATHGNLAVAYQALGAHD 578
                .:.|:..:| :...|.:..|:.|..|.....|    ::....||..|.::.:.|:..|...
Human   165 ----VHNNLYALACYFNNSEDKWVRNHFYERCFKIAQLIKIDCGKKEAEAHMHMGLLYEEDGQLL 225

  Fly   579 AALTHYRA--HLATARSLKDTAGE-----AC-ALLNLGNCLSGR----QEYEEAVPHYESYLMLA 631
            .|..||.|  .|...|..||..|.     || :||.....||.:    :||::|:........:|
Human   226 EAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLENKEYKQAIKILIKASEIA 290

  Fly   632 QELGDVAAEGKACHLLGYAHFSLGNYRAAVRYYDQDLALAKDAQHRPNMGRAYCNLGLAHLALGH 696
            :|..|...|.:|.:.||.||.:...|..|:...|....::.|.....::||.|..:.....:.|.
Human   291 KEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGE 355

  Fly   697 TAAALECQQLFLAVAHATNQLPAKFRALGNIGDILIRTGSHEEAIKLYQRQLALARAAGDRSMEA 761
            ...|::..:.|:.:|....|.....||...:|||....|.:.:|.:.:|:       |.|.::|.
Human   356 MTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKASECFQQ-------AFDTTVEL 413

  Fly   762 AACG---------ALGLAHRLM 774
            .:..         .:..||::|
Human   414 MSMPLMDETKVHYGIAKAHQMM 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_648228.2	PEP_TPR_lipo	<78..751	CDD:274350	84/378 (22%)
		TPR repeat	98..128	CDD:276809
		TPR repeat	133..161	CDD:276809
		TPR repeat	243..269	CDD:276809
		TPR repeat	281..311	CDD:276809
		TPR repeat	321..349	CDD:276809
		TPR repeat	354..390	CDD:276809
		TPR repeat	401..429	CDD:276809	9/37 (24%)
		TPR repeat	441..469	CDD:276809	6/27 (22%)
		TPR repeat	482..509	CDD:276809	3/26 (12%)
		TPR repeat	522..549	CDD:276809	6/27 (22%)
		TPR	523..781	CDD:440225	65/278 (23%)
		TPR repeat	561..595	CDD:276809	10/35 (29%)
		TPR repeat	600..630	CDD:276809	9/39 (23%)
		TPR repeat	642..669	CDD:276809	8/26 (31%)
		TPR repeat	680..716	CDD:276809	7/35 (20%)
		TPR repeat	721..749	CDD:276809	8/27 (30%)
		TPR_12	801..865	CDD:315987
		TPR repeat	801..829	CDD:276809
		Spy	841..>1073	CDD:443119
		TPR repeat	841..878	CDD:276809
		TPR repeat	883..913	CDD:276809
		TPR repeat	924..949	CDD:276809
		TPR repeat	964..998	CDD:276809
		COG4995	975..1718	CDD:444019
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:432771
TTC29	NP_001287690.1	LapB	197..>408	CDD:442196	53/217 (24%)
		TPR repeat	208..252	CDD:276809	13/43 (30%)
		TPR repeat	259..289	CDD:276809	7/29 (24%)
		TPR repeat	300..328	CDD:276809	8/27 (30%)
		TPR repeat	333..369	CDD:276809	6/35 (17%)
		TPR repeat	380..408	CDD:276809	9/34 (26%)