DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43163 and Gpsm2

DIOPT Version :9

Sequence 1:NP_001246673.1 Gene:CG43163 / 38966 FlyBaseID:FBgn0262719 Length:2523 Species:Drosophila melanogaster
Sequence 2:NP_083798.2 Gene:Gpsm2 / 76123 MGIID:1923373 Length:679 Species:Mus musculus


Alignment Length:561 Identity:149/561 - (26%)
Similarity:255/561 - (45%) Gaps:76/561 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 GQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAKSL 274
            |:.|.::....|.|:..|||:::|:..||...:::|.|.:|::.|:...:|:.|...||.:|:::
Mouse    31 GERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTI 95

  Fly   275 GDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAALTSLGHVYTA------ 333
            ||..||.:|.||||:.....|...||:...:..|.::.:..|....|.||.:||:||.|      
Mouse    96 GDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG 160

  Fly   334 ------SGDYP----NALAS----HKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAALDCH 384
                  :|::|    |||.:    :::.:.|...||||..:.|..||:|..:..||....|:..|
Mouse   161 CPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAH 225

  Fly   385 SQHLRLARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGH 449
            .|.|.:|::..|:..|.|||||||:|:....:|..|:..:::.|.:|:.|.||::||.:...||:
Mouse   226 EQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGN 290

  Fly   450 AARCAGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSL 514
            ......|...:..:|.:.||:|...:|::||||||.:||..|..||:||.|:...:.||.|:|.:
Mouse   291 TYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREV 355

  Fly   515 GDRTGMGKAYGNMARMAHMAG-SYEAAVKYHKQELAINQAMNDRSAE-AATHG--NLAVA----- 570
            ||::|...|..|::.:..:.| ||........:.:.|:.:::...|: ...|.  ||.:.     
Mouse   356 GDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEIDGSLHGAGAKLGRRHSMENLELMKLTPE 420

  Fly   571 ------YQALGAHDAALTHYRAHLATARSLKD---TAGEACALLNLGNCLSGRQEYEEAVPHY-- 624
                  .:.|......:....|.|.....||.   .:|.||..:        .|:...:|.|.  
Mouse   421 KVPNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKSGSACTKV--------LQDASNSVDHRAP 477

  Fly   625 -------------ESYLMLAQELGDVAAEGKACHLLGYAHFSLGNYRAAVRYY------------ 664
                         |.:..|.:.......:.:.|||.|....:.....:|....            
Mouse   478 RSQKKISSDTIGDEGFFDLLRRFQSNRMDDQRCHLQGNCRTTSTAAASATPKLMKAPSVSVVSPN 542

  Fly   665 -DQDLALAKDAQHR--PNMGRAYCNLGLAHLALGHTAAALE 702
             |:.|.|...:|.|  .:...::.||....|..|::.:.||
Mouse   543 TDEFLDLLASSQSRRLDDQRASFSNLPGLRLTKGNSPSVLE 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43163NP_001246673.1 TPR_11 70..130 CDD:290150
TPR repeat 98..128 CDD:276809
TPR_11 101..164 CDD:290150
TPR repeat 133..161 CDD:276809
TPR repeat 243..269 CDD:276809 7/25 (28%)
TPR repeat 281..311 CDD:276809 9/29 (31%)
TPR_12 282..353 CDD:290160 24/90 (27%)
TPR_12 320..393 CDD:290160 29/92 (32%)
TPR repeat 321..349 CDD:276809 13/47 (28%)
TPR repeat 354..390 CDD:276809 14/35 (40%)
TPR_12 401..473 CDD:290160 24/71 (34%)
TPR repeat 401..429 CDD:276809 10/27 (37%)
TPR_7 403..438 CDD:289919 13/34 (38%)
TPR repeat 441..469 CDD:276809 5/27 (19%)
TPR 467..752 CDD:223533 64/284 (23%)
TPR repeat 482..509 CDD:276809 12/26 (46%)
TPR repeat 522..549 CDD:276809 5/27 (19%)
TPR repeat 561..595 CDD:276809 6/46 (13%)
TPR repeat 600..630 CDD:276809 6/44 (14%)
TPR repeat 642..669 CDD:276809 6/39 (15%)
TPR_7 643..677 CDD:289919 9/46 (20%)
TPR repeat 680..716 CDD:276809 6/23 (26%)
TPR repeat 721..749 CDD:276809
TPR_7 723..758 CDD:289919
TPR repeat 801..829 CDD:276809
TPR_12 841..914 CDD:290160
TPR repeat 841..878 CDD:276809
TPR_12 882..949 CDD:290160
TPR repeat 883..913 CDD:276809
TPR 884..914 CDD:197478
TPR repeat 924..949 CDD:276809
TPR_12 964..1036 CDD:290160
TPR repeat 964..998 CDD:276809
TPR repeat 1004..1032 CDD:276809
TPR repeat 1043..1073 CDD:276809
TPR_12 1044..1112 CDD:290160
TPR_7 1046..1078 CDD:289919
TPR_12 1081..1153 CDD:290160
TPR repeat 1081..1109 CDD:276809
CHAT 1421..1718 CDD:289536
Treacle <1957..2287 CDD:281536
Gpsm2NP_083798.2 Important for interaction with NUMA1, INSC and FRMPD1. /evidence=ECO:0000269|PubMed:21816348, ECO:0000269|PubMed:23318951 22..357 107/325 (33%)
TPR repeat 27..52 CDD:276809 7/20 (35%)
TPR_12 63..134 CDD:290160 22/70 (31%)
TPR repeat 64..90 CDD:276809 7/25 (28%)
TPR repeat 101..131 CDD:276809 10/29 (34%)
TPR_1 102..131 CDD:278916 9/28 (32%)
TPR_12 142..234 CDD:290160 29/91 (32%)
TPR repeat 203..230 CDD:276809 9/26 (35%)
TPR_12 243..314 CDD:290160 24/70 (34%)
TPR_1 243..274 CDD:278916 12/30 (40%)
TPR repeat 243..270 CDD:276809 10/26 (38%)
TPR repeat 281..311 CDD:276809 7/29 (24%)
TPR_12 282..354 CDD:290160 26/71 (37%)
TPR_7 284..318 CDD:289919 7/33 (21%)
TPR repeat 322..350 CDD:276809 13/27 (48%)
GoLoco 490..512 CDD:214645 3/21 (14%)
GoLoco 544..565 CDD:280368 5/20 (25%)
GoLoco 594..616 CDD:214645
GoLoco 629..650 CDD:280368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D321819at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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