DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43163 and TTC12

DIOPT Version :10

Sequence 1:NP_648228.2 Gene:CG43163 / 38966 FlyBaseID:FBgn0262719 Length:2523 Species:Drosophila melanogaster
Sequence 2:NP_001305462.1 Gene:TTC12 / 54970 HGNCID:23700 Length:711 Species:Homo sapiens


Alignment Length:769 Identity:166/769 - (21%)
Similarity:248/769 - (32%) Gaps:224/769 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTNYENIINLPLNFNANNHAAGNNENNAKIAIVGEQLLNKMSQRDFSENEPECTPEL-------- 57
            :.|.:.|.||....|:::...     ..|..:..|:.|..|.:   .:.|.||...|        
Human    13 LKNVDEISNLIQEMNSDDPVV-----QQKAVLETEKRLLLMEE---DQEEDECRTTLNKTMISPP 69

  Fly    58 -------PAANRALFLEKV----------------------RQSNAACQSGDFATAVLLYTDALQ 93
                   ...|...||..|                      .:.|.|...|::.||:|.|::.|:
Human    70 QTAMKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLE 134

  Fly    94 LDPGNHILYSNRSAALLKQGQFTAALQDA---------TQARDLCPQWPKAYFRQGVALQCLGRY 149
            ......:||:||:.|.:|...:..||.|.         .|..:.|   .||||..|.|...|..|
Human   135 KLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSFSFMQCDEKC---TKAYFHMGKANLALKNY 196

  Fly   150 GEALAAFASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTLQQLRTMQLQESPFVVSSVVGQELL 214
            ..:...:...|...|..:..:.|.:.           :..||:...:|.:|:         .|||
Human   197 SVSRECYKKILEINPKLQTQVKGYLN-----------QVDLQEKADLQEKEA---------HELL 241

  Fly   215 QATQYSAAVT--VLEAALRIGSCSLKLRGSVFSALSSAHWALNQ-LDQAIGYMQ------QDLAV 270
            .:.:.:|..|  :||...:.....|...|.: ..|:.   .:|: .:|.:..|.      .|..|
Human   242 DSGKNTAVTTKNLLETLSKPDQIPLFYAGGI-EILTE---MINECTEQTLFRMHNGFSIISDNEV 302

  Fly   271 AKSLGDTAGE-------CRAHGNLGSAYFSQG-AHKEALTAH--RYQLVLAMKCKDT----QAAA 321
            .:....|||.       |.:...|..|..|:. .::..|..|  |.:|:.|:.....    |.:.
Human   303 IRRCFSTAGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHHDRARLLAALLSSKVLAIRQQSF 367

  Fly   322 AALTSLGHVYTASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGA---VYLALGE-----CE 378
            |.|..|..  |.||  .:.:.:|....:|.:.|...|..:.:..|...   ..|||.|     .:
Human   368 ALLLHLAQ--TESG--RSLIINHLDLTRLLEALVSFLDFSDKEANTAMGLFTDLALEERFQVWFQ 428

  Fly   379 AALDCHSQHLRLARKLHDQVEEARA-------YSNLGSAHHQRRQFTQAAACHEQVLRIAQALGD 436
            |.|......|....|...:|..:.|       ..||.:....||..   |||.|        .||
Human   429 ANLPGVLPALTGVLKTDPKVSSSSALCQCIAIMGNLSAEPTTRRHM---AACEE--------FGD 482

  Fly   437 RSMEAAAYAGLGHAARCAGDASASKRFHE-----RQLAMALAARD-------KLGEGRACSNLGI 489
                    ..|...|||..|...   |.|     ..|.|.|..:.       .:...|.|.:|  
Human   483 --------GCLSLLARCEEDVDL---FREVIYTLLGLMMNLCLQAPFVSEVWAVEVSRRCLSL-- 534

  Fly   490 VYQMLGSHDAALKLHQAHLGIARSLGD---------RTGMGKAYGNMARMAHMAGSYEAAVKYHK 545
                |.|.|..:....|.: ::|:|..         |.|:.|   .|.:.....|  |.|.:|..
Human   535 ----LNSQDGGILTRAAGV-LSRTLSSSLKIVEEALRAGVVK---KMMKFLKTGG--ETASRYAI 589

  Fly   546 QELAI--NQAMNDRSAEAATHGNLAVAYQALGAHDAALTHYRAHLATARSLKDTAGEACALLNLG 608
            :.|||  |.....|.........|:|..:.|.:.|..|                .|.|.  |.||
Human   590 KILAICTNSYHEAREEVIRLDKKLSVMMKLLSSEDEVL----------------VGNAA--LCLG 636

  Fly   609 NCLSGRQEYEEAVPHYESYLM---LAQELGDVA---------------AEGKAC 644
            ||:.        ||:..|.|:   |.|.|..:|               |.||.|
Human   637 NCME--------VPNVASSLLKTDLLQVLLKLAGSDTQKTAVQVNAGIALGKLC 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43163NP_648228.2 PEP_TPR_lipo <78..751 CDD:274350 147/655 (22%)
TPR repeat 98..128 CDD:276809 10/38 (26%)
TPR repeat 133..161 CDD:276809 8/27 (30%)
TPR repeat 243..269 CDD:276809 5/32 (16%)
TPR repeat 281..311 CDD:276809 8/32 (25%)
TPR repeat 321..349 CDD:276809 7/27 (26%)
TPR repeat 354..390 CDD:276809 10/43 (23%)
TPR repeat 401..429 CDD:276809 9/34 (26%)
TPR repeat 441..469 CDD:276809 7/32 (22%)
TPR repeat 482..509 CDD:276809 7/26 (27%)
TPR repeat 522..549 CDD:276809 6/26 (23%)
TPR 523..781 CDD:440225 34/142 (24%)
TPR repeat 561..595 CDD:276809 5/33 (15%)
TPR repeat 600..630 CDD:276809 10/32 (31%)
TPR repeat 642..669 CDD:276809 2/3 (67%)
TPR repeat 680..716 CDD:276809
TPR repeat 721..749 CDD:276809
TPR_12 801..865 CDD:315987
TPR repeat 801..829 CDD:276809
Spy 841..>1073 CDD:443119
TPR repeat 841..878 CDD:276809
TPR repeat 883..913 CDD:276809
TPR repeat 924..949 CDD:276809
TPR repeat 964..998 CDD:276809
COG4995 975..1718 CDD:444019
TPR repeat 1004..1032 CDD:276809
TPR repeat 1043..1073 CDD:276809
TPR repeat 1081..1109 CDD:276809
CHAT 1421..1718 CDD:432771
TTC12NP_001305462.1 TPR 105..>212 CDD:440225 28/109 (26%)
TPR 1 106..139 8/32 (25%)
TPR repeat 106..134 CDD:276809 7/27 (26%)
TPR repeat 139..175 CDD:276809 9/35 (26%)
TPR 3 180..213 10/32 (31%)
TPR repeat 180..208 CDD:276809 8/27 (30%)
TPR repeat 217..242 CDD:276809 7/44 (16%)
armadillo repeat 561..597 CDD:293788 11/40 (28%)
armadillo repeat 603..637 CDD:293788 10/51 (20%)
Blue background indicates that the domain is not in the aligned region.

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