DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43163 and stip1

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	NP_001007767.1	Gene:	stip1 / 493606	ZFINID:	ZDB-GENE-041121-17	Length:	542	Species:	Danio rerio

Alignment Length:	507	Identity:	133/507 - (26%)
Similarity:	200/507 - (39%)	Gaps:	156/507 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LEKVR----QSNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQAR 126
            :|||.    |.|.|..:|:...|:..||:||.|||.||:|:||||||..|:|.:..||:||.|..
Zfish     1 MEKVSQLKDQGNKALSAGNLEEAIRCYTEALTLDPSNHVLFSNRSAAYAKKGDYDNALKDACQTI 65

  Fly   127 DLCPQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGL--VEASL----------- 178
            .:.|.|.|.|.|:..||:.|||..:|.|.:..||.|||||:||..||  :||.|
Zfish    66 KIKPDWGKGYSRKAAALEFLGRLEDAKATYQEGLRQEPSNQQLKEGLQNMEARLAEKKMMNPFSI 130

  Fly   179 ---------KSPLRAAL-EPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVL------- 226
                     .|..||.| :|:.::| ..||:..|    |.:|.: ||..:....::||
Zfish   131 PNLYEKLEGDSRTRALLSDPSYREL-LEQLRNKP----SELGTK-LQDPRVMTTLSVLLGLDLSG 189

  Fly   227 --------------------------------EAALR---IGSCSLKLRGSVFSALSSAHWALNQ 256
                                            ..||:   :|:.:.| :....:||.....|:..
Zfish   190 MDEEEEPTPPPPPKPKETAPPPPKEEDLPENKRMALKEKELGNAAYK-KKDFATALKHYEEAIKH 253

  Fly   257 LDQAIGYMQQDLAVAKSLGDTAGECR----------------------AHGNLGSAYFSQGAHKE 299
            ....:.|:....||....|| ..:||                      |:..:|::||.|..:||
Zfish   254 DPTNMTYLSNQAAVYFEKGD-FDKCRELCEKAIDVGRENREDYRQIAKAYARIGNSYFKQEKYKE 317

  Fly   300 A-------LTAHRYQLVLAMKCKDTQA--------------AAAALTSLGHVYTASGDYPNALAS 343
            |       ||.||...|| .||::.:.              .|....:.|:.....||||.|:..
Zfish   318 AVQFFNKSLTEHRTPDVL-KKCQEAEKILKEQEKVAYINPDLALEEKNKGNDAFQKGDYPLAMKH 381

  Fly   344 HKQCVQLFKQLGDRLQEAREIGNVGAVY-------LALGECEAALDCHSQHLRLARKLHDQVEEA 401
            :.:.::      ....:|:...|..|.|       |||.:||..::..|..:
Zfish   382 YSEAIK------RNPYDAKLFSNRAACYTKLLEFQLALKDCEECINLDSTFI------------- 427

  Fly   402 RAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARC 453
            :.|:..|:|....:.|::|...:::.|.    |...|.||.  .||   .||
Zfish   428 KGYTRKGAALEAMKDFSKAMDVYQKALE----LDSNSKEAT--EGL---QRC 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150	28/63 (44%)
		TPR repeat	98..128	CDD:276809	16/29 (55%)
		TPR_11	101..164	CDD:290150	29/62 (47%)
		TPR repeat	133..161	CDD:276809	11/27 (41%)
		TPR repeat	243..269	CDD:276809	4/25 (16%)
		TPR repeat	281..311	CDD:276809	15/58 (26%)
		TPR_12	282..353	CDD:290160	24/113 (21%)
		TPR_12	320..393	CDD:290160	17/79 (22%)
		TPR repeat	321..349	CDD:276809	7/27 (26%)
		TPR repeat	354..390	CDD:276809	10/42 (24%)
		TPR_12	401..473	CDD:290160	14/53 (26%)
		TPR repeat	401..429	CDD:276809	5/27 (19%)
		TPR_7	403..438	CDD:289919	7/34 (21%)
		TPR repeat	441..469	CDD:276809	5/13 (38%)
		TPR	467..752	CDD:223533
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR_7	643..677	CDD:289919
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
stip1	NP_001007767.1	TPR_11	7..69	CDD:290150	28/61 (46%)
		TPR	7..37	CDD:197478	12/29 (41%)
		TPR repeat	7..32	CDD:276809	8/24 (33%)
		TPR repeat	37..67	CDD:276809	16/29 (55%)
		TPR_11	40..103	CDD:290150	29/62 (47%)
		TPR repeat	72..100	CDD:276809	11/27 (41%)
		TPR_11	224..285	CDD:290150	14/62 (23%)
		TPR repeat	228..252	CDD:276809	5/24 (21%)
		TPR_1	230..257	CDD:278916	5/27 (19%)
		TPR_12	254..327	CDD:290160	15/73 (21%)
		TPR repeat	257..287	CDD:276809	7/30 (23%)
		TPR	299..327	CDD:197478	8/27 (30%)
		TPR repeat	299..326	CDD:276809	8/26 (31%)
		TPR_11	359..423	CDD:290150	16/69 (23%)
		TPR repeat	363..387	CDD:276809	6/23 (26%)
		TPR repeat	392..422	CDD:276809	9/29 (31%)
		TPR_1	427..459	CDD:278916	7/48 (15%)
		TPR repeat	427..455	CDD:276809	5/40 (13%)
		STI1	491..530	CDD:128966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810