DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43163 and gpsm2l

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	XP_021325463.1	Gene:	gpsm2l / 449665	ZFINID:	ZDB-GENE-041010-223	Length:	679	Species:	Danio rerio

Alignment Length:	604	Identity:	138/604 - (22%)
Similarity:	232/604 - (38%)	Gaps:	179/604 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 QQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALN 255
            |........|:..:..::.|:.|.:...|.|.|:..|:|:::|:..|::..:::|.|.:|::.|:
Zfish    10 QAFHVRSRMEASCLELALEGERLCKVGDYRAGVSFFESAIQVGTEDLQILSAIYSQLGNAYFHLH 74

  Fly   256 QLDQAIGYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAA 320
            ..::|:.|.:.||.:.:::||..||.:|.||||
Zfish    75 DYNKALEYHRHDLTLTRTIGDQLGEAKASGNLG-------------------------------- 107

  Fly   321 AAALTSLGHVYTASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAALDCHS 385
                              |.|.                              .||..:.|..|..
Zfish   108 ------------------NTLK------------------------------VLGRYDEAAVCCQ 124

  Fly   386 QHLRLARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHA 450
            :||.:||.|||:|.:|||..|.|:.:|.:.:    ..|..            .|:...:....|.
Zfish   125 RHLDIARTLHDKVGQARALYNYGNVYHAKGK----NICWS------------GMDPGEFPEEAHI 173

  Fly   451 ARCAGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLG 515
            |.                                             ..|.:|::|:|.|.:.||
Zfish   174 AL---------------------------------------------KKATELYEANLAIVKELG 193

  Fly   516 DRTGMGKAYGNMARMAHMAGSYEAAVKYHKQELAINQAMNDRSAEAATHGNLAVAYQALGAHDAA 580
            ||...|:.|||:....::.|:::.||..|:|.|.|.:...||:||...:.||..||..||..:.|
Zfish   194 DRAAQGRTYGNLGNSHYLLGNFQDAVLAHEQRLLIAKEFGDRAAERRAYCNLGNAYIFLGKFEVA 258

  Fly   581 LTHYRAHLATARSLKDTAGEACALLNLGNCLSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACH 645
            ..||:..|..||.|||.|.||.|..:|||..:..|:||.|:.::..:|::||:|.|...||:||.
Zfish   259 AEHYKRTLQLARQLKDRAVEAQACYSLGNTYTLLQDYERAIDYHLKHLIIAQDLKDRIGEGRACW 323

  Fly   646 LLGYAHFSLGNYRAAVRYYDQDLALAKDAQHRPNMGRAYCNLGLAHLALGHTAAALECQQLFLAV 710
            .||.|:.:|||:..|:.:.::.|.::|:...|.....|..|:....|.||..
Zfish   324 SLGNAYTALGNHEQAMSFAEKHLEISKEIGDRSGELTARMNVSDLQLVLGLV------------- 375

  Fly   711 AHATNQLPAKFRALGN-IGDILIRTGSHEEAIKLYQRQLALARAAGDRSMEAAACGALGLAHRLM 774
              ..|..|.....:|: ..|..:..|....:.:|....:.|.:...:::|
Zfish   376 --QNNSNPNSSVLIGSPAADSSLTDGRSRGSRRLSMENMELMKLTSEKNM--------------- 423

  Fly   775 RRWDKALGHHTQELTLRQE 793
                   |..::|.|..|:
Zfish   424 -------GQSSEETTTPQQ 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150
		TPR repeat	98..128	CDD:276809
		TPR_11	101..164	CDD:290150
		TPR repeat	133..161	CDD:276809
		TPR repeat	243..269	CDD:276809	7/25 (28%)
		TPR repeat	281..311	CDD:276809	5/29 (17%)
		TPR_12	282..353	CDD:290160	7/70 (10%)
		TPR_12	320..393	CDD:290160	9/72 (13%)
		TPR repeat	321..349	CDD:276809	2/27 (7%)
		TPR repeat	354..390	CDD:276809	6/35 (17%)
		TPR_12	401..473	CDD:290160	10/71 (14%)
		TPR repeat	401..429	CDD:276809	7/27 (26%)
		TPR_7	403..438	CDD:289919	5/34 (15%)
		TPR repeat	441..469	CDD:276809	2/27 (7%)
		TPR	467..752	CDD:223533	81/285 (28%)
		TPR repeat	482..509	CDD:276809	3/26 (12%)
		TPR repeat	522..549	CDD:276809	8/26 (31%)
		TPR repeat	561..595	CDD:276809	12/33 (36%)
		TPR repeat	600..630	CDD:276809	11/29 (38%)
		TPR repeat	642..669	CDD:276809	9/26 (35%)
		TPR_7	643..677	CDD:289919	11/33 (33%)
		TPR repeat	680..716	CDD:276809	5/35 (14%)
		TPR repeat	721..749	CDD:276809	4/28 (14%)
		TPR_7	723..758	CDD:289919	5/35 (14%)
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
gpsm2l	XP_021325463.1	TPR repeat	25..50	CDD:276809	7/24 (29%)
		TPR repeat	62..88	CDD:276809	7/25 (28%)
		TPR	<63..316	CDD:223533	96/393 (24%)
		TPR repeat	99..129	CDD:276809	14/109 (13%)
		TPR repeat	140..180	CDD:276809	11/100 (11%)
		TPR repeat	200..227	CDD:276809	8/26 (31%)
		TPR repeat	240..267	CDD:276809	9/26 (35%)
		TPR repeat	278..308	CDD:276809	11/29 (38%)
		TPR_12	283..351	CDD:315987	24/67 (36%)
		TPR repeat	319..347	CDD:276809	10/27 (37%)
		GoLoco	502..523	CDD:308026
		GoLoco	561..580	CDD:308026
		GoLoco	612..631	CDD:308026
		GoLoco	646..667	CDD:308026
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920