DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43163 and gpsm2

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	XP_005171423.1	Gene:	gpsm2 / 393410	ZFINID:	ZDB-GENE-040426-1169	Length:	670	Species:	Danio rerio

Alignment Length:	563	Identity:	139/563 - (24%)
Similarity:	223/563 - (39%)	Gaps:	180/563 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LAAFASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTLQQLRTMQLQESPFVVSSVVGQELLQAT 217
            :|..::.::.:..|:..:...:|||.   |..|||                      .:.|.:..
Zfish     1 MAVSSAVVSMQNENRTFVHYRMEASC---LDLALE----------------------AERLCKVG 40

  Fly   218 QYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAKSLGDTAGECR 282
            .|||.|:..|||:::|:..|::..:|:|
Zfish    41 DYSAGVSYFEAAIQVGTEDLQVLSAVYS------------------------------------- 68

  Fly   283 AHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAALTSLGHVYTASGDYPNALASHKQC 347
               .||:|||                                    |::    ||..||..|...
Zfish    69 ---QLGNAYF------------------------------------HLH----DYSKALEFHHHD 90

  Fly   348 VQLFKQLGDRLQEAREIGNVGAVYLALGECEAALDCHSQHLRLARKLHDQVEEARAYSNLGSAHH 412
            :.|.:..||||.||:..||:|.....||..:.|:.|..:||.:||:|.|:|.:|||..|.|:.:|
Zfish    91 LTLTRTTGDRLGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIARELGDKVGQARALYNFGNVYH 155

  Fly   413 QRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARCAGDASASKRFHERQLAMALAARDK 477
            .:.:                                  :.|...|.......|...|:..||
Zfish   156 AKGK----------------------------------SVCWSGAEPGDFPEEIMTALRRAA--- 183

  Fly   478 LGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLGDRTGMGKAYGNMARMAHMAGSYEAAVK 542
                                    :.::|:|.|.:.||||...|:.|||:....::.|::..||.
Zfish   184 ------------------------EYYEANLCIVKELGDRAAQGRTYGNLGNTYYLLGNFRDAVA 224

  Fly   543 YHKQELAINQAMNDRSAEAATHGNLAVAYQALGAHDAALTHYRAHLATARSLKDTAGEACALLNL 607
            .|:|.|.|.:...|||||...:.||..|...||..:.|..|||..|..||.|||.|.||.|..:|
Zfish   225 SHEQRLLIAKEFGDRSAERRAYCNLGNACIFLGEFERAAEHYRRALQIARQLKDLAVEAQACYSL 289

  Fly   608 GNCLSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACHLLGYAHFSLGNYRAAVRYYDQDLALAK 672
            ||..:..|::|.|:.::..:|::||:|.|...||:||..||.||.:|||:..|:.:.::.|.::|
Zfish   290 GNTYTLMQDFERAIDYHLKHLIIAQDLNDRIGEGRACWSLGNAHTALGNHDQAMHFAEKHLEISK 354

  Fly   673 DAQHRPNMGRAYCNLGLAHLALGHTAAALECQQLFLAVAHATN 715
            :...|  .|.....:.::.|            |:.|.::::||
Zfish   355 ETGDR--SGELTARMNVSDL------------QMVLGISYSTN 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150
		TPR repeat	98..128	CDD:276809
		TPR_11	101..164	CDD:290150	1/10 (10%)
		TPR repeat	133..161	CDD:276809	1/7 (14%)
		TPR repeat	243..269	CDD:276809	2/25 (8%)
		TPR repeat	281..311	CDD:276809	5/29 (17%)
		TPR_12	282..353	CDD:290160	12/70 (17%)
		TPR_12	320..393	CDD:290160	23/72 (32%)
		TPR repeat	321..349	CDD:276809	6/27 (22%)
		TPR repeat	354..390	CDD:276809	15/35 (43%)
		TPR_12	401..473	CDD:290160	10/71 (14%)
		TPR repeat	401..429	CDD:276809	6/27 (22%)
		TPR_7	403..438	CDD:289919	4/34 (12%)
		TPR repeat	441..469	CDD:276809	3/27 (11%)
		TPR	467..752	CDD:223533	77/249 (31%)
		TPR repeat	482..509	CDD:276809	1/26 (4%)
		TPR repeat	522..549	CDD:276809	8/26 (31%)
		TPR repeat	561..595	CDD:276809	12/33 (36%)
		TPR repeat	600..630	CDD:276809	10/29 (34%)
		TPR repeat	642..669	CDD:276809	10/26 (38%)
		TPR_7	643..677	CDD:289919	12/33 (36%)
		TPR repeat	680..716	CDD:276809	6/36 (17%)
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
gpsm2	XP_005171423.1	TPR	20..320	CDD:223533	116/465 (25%)
		TPR repeat	29..54	CDD:276809	11/46 (24%)
		TPR repeat	66..92	CDD:276809	13/105 (12%)
		TPR repeat	103..133	CDD:276809	11/29 (38%)
		TPR repeat	144..184	CDD:276809	12/100 (12%)
		TPR repeat	204..231	CDD:276809	8/26 (31%)
		TPR repeat	236..272	CDD:276809	15/35 (43%)
		TPR repeat	283..310	CDD:276809	8/26 (31%)
		TPR_12	287..355	CDD:315987	24/67 (36%)
		TPR repeat	323..351	CDD:276809	11/27 (41%)
		GoLoco	494..513	CDD:308026
		GoLoco	611..632	CDD:308026
		GoLoco	645..666	CDD:308026
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920