DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43163 and Stip1

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	96/432 - (22%)
Similarity:	177/432 - (40%)	Gaps:	80/432 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LEKVRQ----SNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQAR 126
            ::||.:    .|.|..:..|..||..||:|:.||..||:||||||||..|.|:|..||:||.:..
  Fly     1 MDKVNELKEKGNQALSAEKFDEAVAAYTEAIALDDQNHVLYSNRSAAFAKAGKFQEALEDAEKTI 65

  Fly   127 DLCPQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGLVEASLKS----------- 180
            .|.|.|||.|.|:|.|...|..:.:|..|:..||..:|:|..|:.|.:|.:..:
  Fly    66 QLNPTWPKGYSRKGAAAAGLNDFMKAFEAYNEGLKYDPTNAILLQGRMETTASALSFMQSQGDIP 130

  Fly   181 -----------------PLRAA-----LEPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSAAV 223
                             |.:.|     .||.::.:...|..:........:|....:...:..|:
  Fly   131 MDVDPQQARSRRAPSPPPAKPAEPPKPAEPRVEDMTEEQKNKYFARKEKELGNAAYKKKDFETAL 195

  Fly   224 TVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAK-SLGDTAGECRAHGNL 287
            ....||:......:    :.::.:::.|:...:.::.|...::.:.|.: |..|.....::...:
  Fly   196 KHYHAAIEHDPTDI----TFYNNIAAVHFERKEYEECIKQCEKGIEVGRESRADFKLIAKSFARI 256

  Fly   288 GSAY-----FSQGA--HKEALTAHRYQLV------LAMKCKDTQ-------AAAAALTSLGHVYT 332
            |:.|     :.|..  :::|::.||...:      :..|.|:.:       ..|......|:::.
  Fly   257 GNTYRKLENYKQAKVYYEKAMSEHRTPEIKTSLSEVEAKIKEEERMAYINPEKAEEEKEQGNLFF 321

  Fly   333 ASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAAL-DCHSQHLRLARKLHD 396
            ..|||..|:   |...:..|:..|   :.:...|..|.|..|...:..| ||.: .::|..|.
  Fly   322 KKGDYSTAV---KHYTEAIKRNPD---DPKLYSNRAACYTKLAAFDLGLKDCDT-CIKLDEKF-- 377

  Fly   397 QVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRI----AQAL 434
                .:.|...|......:|.::|.|.:::.|.:    |:|:
  Fly   378 ----IKGYIRKGKILQGMQQQSKAQAAYQKALELDPNNAEAI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150	28/63 (44%)
		TPR repeat	98..128	CDD:276809	17/29 (59%)
		TPR_11	101..164	CDD:290150	29/62 (47%)
		TPR repeat	133..161	CDD:276809	10/27 (37%)
		TPR repeat	243..269	CDD:276809	2/25 (8%)
		TPR repeat	281..311	CDD:276809	6/42 (14%)
		TPR_12	282..353	CDD:290160	15/90 (17%)
		TPR_12	320..393	CDD:290160	17/73 (23%)
		TPR repeat	321..349	CDD:276809	7/27 (26%)
		TPR repeat	354..390	CDD:276809	8/36 (22%)
		TPR_12	401..473	CDD:290160	8/38 (21%)
		TPR repeat	401..429	CDD:276809	5/27 (19%)
		TPR_7	403..438	CDD:289919	8/36 (22%)
		TPR repeat	441..469	CDD:276809
		TPR	467..752	CDD:223533
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR_7	643..677	CDD:289919
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150	28/62 (45%)
		TPR repeat	7..32	CDD:276809	8/24 (33%)
		TPR repeat	37..67	CDD:276809	17/29 (59%)
		TPR_11	40..103	CDD:290150	29/62 (47%)
		TPR repeat	72..100	CDD:276809	10/27 (37%)
		TPR_11	175..237	CDD:290150	6/65 (9%)
		TPR repeat	175..203	CDD:276809	4/27 (15%)
		TPR_1	181..208	CDD:278916	4/26 (15%)
		TPR_12	205..278	CDD:290160	9/76 (12%)
		TPR repeat	208..238	CDD:276809	2/33 (6%)
		TPR repeat	250..278	CDD:276809	4/27 (15%)
		TPR_1	250..>276	CDD:278916	3/25 (12%)
		TPR_11	309..375	CDD:290150	17/72 (24%)
		TPR repeat	310..338	CDD:276809	7/30 (23%)
		TPR_1	<317..343	CDD:278916	8/31 (26%)
		TPR repeat	343..373	CDD:276809	7/30 (23%)
		TPR_1	378..411	CDD:278916	6/32 (19%)
		TPR repeat	378..406	CDD:276809	5/27 (19%)
		STI1	439..478	CDD:128966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810