DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43163 and Ttc28

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	XP_006249646.1	Gene:	Ttc28 / 304558	RGDID:	1594541	Length:	2451	Species:	Rattus norvegicus

Alignment Length:	2543	Identity:	1095/2543 - (43%)
Similarity:	1482/2543 - (58%)	Gaps:	350/2543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SQRDFSENEPEC----------------TPELPAANRALFLEKVRQSNAACQSGDFATAVLLYTD 90
            |.|.....|||.                :|:.||.::|.|:|||||||.||..|||.||:.||.:
  Rat    13 SARSRRRREPESPPAPIPLFGAKTIIQRSPDEPALSKAEFVEKVRQSNQACHDGDFHTAIALYNE 77

  Fly    91 ALQLDPGNHILYSNRSAALLKQGQFTAALQDATQARDLCPQWPKAYFRQGVALQCLGRYGEALAA 155
            ||.:||.|.|||||||||.:|..|:..||.||.:||.|.|:|||||||||||||.|||:.:||||
  Rat    78 ALAVDPQNCILYSNRSAAYMKTQQYHKALDDAVKARLLNPKWPKAYFRQGVALQYLGRHADALAA 142

  Fly   156 FASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTLQQLRTMQLQESPFVVSSVVGQELLQATQYS 220
            |||||||:|.:.||:.|:|||::|||:|..||||.|||:.|:|.:|||||.||||||||.|..:.
  Rat   143 FASGLAQDPKSLQLLVGMVEAAMKSPMRDTLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHG 207

  Fly   221 AAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAKSLGDTAGECRAHG 285
            |:|.||||||:||:||||||||||||||||||:|...:::.|||||||.|||:|||..|||||||
  Rat   208 ASVVVLEAALKIGTCSLKLRGSVFSALSSAHWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHG 272

  Fly   286 NLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAALTSLGHVYTASGDYPNALASHKQCVQL 350
            |||||:||:|.::||||.||:|||||||.||.:||::||:||||||||.||||||||||||||.|
  Rat   273 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLL 337

  Fly   351 FKQLGDRLQEAREIGNVGAVYLALGECEAALDCHSQHLRLARKLHDQVEEARAYSNLGSAHHQRR 415
            .||..|.|.||||:||:||||:|:|:.|.|:.||.||||:|:.|..:.||||||||||||:|.||
  Rat   338 AKQSKDDLSEARELGNMGAVYIAMGDFENAVQCHEQHLRIAKDLGSKREEARAYSNLGSAYHYRR 402

  Fly   416 QFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARCAGDASASKRFHERQLAMALAARDKLGE 480
            .|.:|.:.|..||.:||.|.::.:|..|||||||||||..|...::::||:||::|...:|:..|
  Rat   403 NFDKAMSYHNCVLELAQELTEKPIEMRAYAGLGHAARCMQDLERARQYHEQQLSIAEDLKDRAAE 467

  Fly   481 GRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLGDRTGMGKAYGNMARMAHMAGSYEAAVKYHK 545
            |||.|||||::||.|.:|.|||||:.||.||:.|.|....|:|||||....:..|.|:.|||||:
  Rat   468 GRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 532

  Fly   546 QELAINQAMNDRSAEAATHGNLAVAYQALGAHDAALTHYRAHLATARSLKDTAGEACALLNLGNC 610
            |||.|:..:|||:::|:||||||||||||||||.||.||:.||..||.|:|...||.||.||||.
  Rat   533 QELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNF 597

  Fly   611 LSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACHLLGYAHFSLGNYRAAVRYYDQDLALAKDAQ 675
            ...|.||.:|.|:||.||.||.:|.|:..|||.||.|||||:.||||:.||:||:||||||||..
  Rat   598 HCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLH 662

  Fly   676 HRPNMGRAYCNLGLAHLALGHTAAALECQQLFLAVAHATNQLPAKFRALGNIGDILIRTGSHEEA 740
            .:.:..:||||||||..||.:...|.|||:..|::|.:.:...||||||||:|||.:.......|
  Rat   663 DKLSQAKAYCNLGLAFKALLNFTKAEECQKYLLSLAQSLDNSQAKFRALGNLGDIFVCKKDVNGA 727

  Fly   741 IKLYQRQLALARAAGDRSMEAAACGALGLAHRLMRRWDKALGHHTQELTLRQELGDLSGECRAHG 805
            ||.|::||.|:....||.:||:|..|||.|:|:::::|||||:|||||.:.|||.||.|||||||
  Rat   728 IKFYEQQLGLSHHVKDRRLEASAYAALGTAYRMVQKYDKALGYHTQELEVYQELSDLPGECRAHG 792

  Fly   806 HLGAVHMALCSWTNAVKCYQEQLERAQEQRDAAVEAQAHGNLGIARLNMAHYEAAIGCLEAQLGT 870
            ||.||:|||..:|.|.||||||||..::.::.::|||.:||:||.::||...|.|||..|.||..
  Rat   793 HLAAVYMALGKYTMAFKCYQEQLELGRKLKEPSLEAQVYGNMGITKMNMNVVEDAIGYFEQQLAM 857

  Fly   871 LERVSLPSTQADRARALGHLGDCYAALGDYEEALKCHDRQLQLALGLTSHRDQERAYRGLGQARR 935
            |:::|...:..||.||.|:|||||.||||||||:|.:::.|.:|..|...:||.:||||||...|
  Rat   858 LQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 922

  Fly   936 ALGQLPAALVCLEKRLVVAHELHSPEIKALAYGDLGHVHAALGNHAQALNCLEHQRELAQGLQDR 1000
            |.|.|..||||.||||||||||.....||.|||:||.:|:.|||:.||::|||.|..:|:.::||
  Rat   923 ATGSLQQALVCFEKRLVVAHELGEASNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDR 987

  Fly  1001 ALESDAMCALGQVQQRMGQHAQALELHRQDLEICTELSAPALQARALSNLGSVHESLGQQAEALK 1065
            ||||||.|.||.|.|:||::..||:.|:.||:|..|...|..|.||..|||..:||||....|:.
  Rat   988 ALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETDNPTCQGRAYGNLGLTYESLGTFERAVV 1052

  Fly  1066 CYERQLELS---TDRLAKAMACLALGRVHHQLEQHNQAVDYLRQGLASAQTTGKSEEEAKIRHQL 1127
            ..|:.|.::   .|.:||.::..:|||.||.|:.::|||.||::||..|:..|:.|:||||||.|
  Rat  1053 YQEQHLSIAAQMNDLVAKTLSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGL 1117

  Fly  1128 GLALRSSGDAEGAHIQLETAAQLLESVRHE-QRSPETRQALYDLQTTCYQLLQVLLVALNRNEDA 1191
            ||:|.:||:.|.|..||..|:.|.|::||| |.|.:.:.:|:||||:.||.||.:||:|..:::|
  Rat  1118 GLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEA 1182

  Fly  1192 LVAAERCKARGGADAV----SGEGSKVPLA--DSESIQETVDRGRTTVLYYSLAGDQLFTWLLEP 1250
            |..|||.:.|..||.:    :|:....|.:  ..:.|.|.|:..|..|||||||...|::|||.|
  Rat  1183 LAVAERGRTRAFADLLVERQTGQQDSDPYSPITIDQILEMVNAQRGLVLYYSLAAGYLYSWLLAP 1247

  Fly  1251 HVGIVRFHAAKIDAHSLQLPLSLSEEEEEEEDLEMERELKLNRDQNQDQSEDQGTSNKA-----N 1310
            ..||::||                             |..|..:..:..|:.|..|:.|     :
  Rat  1248 GAGILKFH-----------------------------EHYLGDNSVESSSDFQAGSSAALPIATS 1283

  Fly  1311 RLLERYMSLVRDNLGV---------NSQSLLHEGDGSGWRASTEQLLEDLPGAGGS--GGGGFLR 1364
            ..||::::.||:.|||         :|::....||      ..||.||::.....|  ...||||
  Rat  1284 STLEQHIASVREALGVESYYSRACASSETESEAGD------IVEQQLEEMNKQLNSVTDPTGFLR 1342

  Fly  1365 MVSRNQLLNSSNYSLSSLFSVGSVGGSVASLQGSTRSVGSRSSRRAPGLPVWRGPSCLHILYNLL 1429
            ||..|.||:.|..|::||||     |:|:..:..|.|:..|.:..|      :.|  |..||:||
  Rat  1343 MVRHNNLLHRSCQSMTSLFS-----GTVSPSKDGTSSLPRRQNSLA------KPP--LRALYDLL 1394

  Fly  1430 LAPFDDLLPAGEADTNRQGRRELVLVLDSSLYLVPFAILRAAQEDGEYLCERCAILTAPSLQSM- 1493
            :||.:..|........|  .|:|||||:..|||||||:|:.:..: |||.||..::..|:::|:
  Rat  1395 IAPMEGGLMHSSGPVGR--HRQLVLVLEGELYLVPFALLKGSASN-EYLYERFTLIAVPAVRSLG 1456

  Fly  1494 -RSRPRIRRDRARPP-------KALVVGGPRIPSNLAELWGWAGAESPAALQEAAMVADMLQATA 1550
             .|:..:|:   .||       .|.|:|.|::||.:.:.|.|  ...|:|.:||.||:::|....
  Rat  1457 PHSKGHLRK---TPPTYSSSTAMAAVIGNPKLPSAVMDRWLW--GPMPSAEEEAYMVSELLGCQP 1516

  Fly  1551 LAGSNATKESVLAELPSAECVHFAANISWQLGAVVLSP---GDVVTAEQ--------------QE 1598
            |.||.||||.|::.|..|||:|||.::||:|.|:||:|   |:..:::.              |:
  Rat  1517 LVGSMATKERVMSALTQAECIHFATHVSWKLSALVLTPNTEGNPASSKSSFGHPYTIPESLRVQD 1581

  Fly  1599 QKEPHE-----PQMTDFTLAAGELRQLRLSARLVVLSSYHSVEP-ITGDGVAQLAGGWLLAGAGV 1657
            .....|     |.:.:..|.|.:|..||||.:||||||...... :|.||:..|...:|.|||..
  Rat  1582 DASDVESISDCPPLRELLLTAADLLDLRLSVKLVVLSSSQEANSRVTADGLVALTRAFLAAGAQC 1646

  Fly  1658 VLISLWPVPETAAKILLRAFYSALLQGARAARALAEAMQTVQHTKHFAHPANWAGFLLVGSNIRL 1722
            ||::|||||..|:|:.:.||||:||.|.:|:.:|.|||:.||.:|.|:||:|||||.|:|::|:|
  Rat  1647 VLVALWPVPVAASKMFVHAFYSSLLNGLKASASLGEAMKAVQSSKAFSHPSNWAGFTLIGNDIKL 1711

  Fly  1723 SNKVAM-GHALCELLRTPERCRDALRVCLHLVEKSLQRIHRGQKNAMYTTQQSIENKAGPVAGWK 1786
            ::..:: |.||.|:|:.|||.||||||.|||||||||||..||:|||||:|||:|||.|.:.||:
  Rat  1712 NSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQ 1776

  Fly  1787 DLLMAVGFRVEPAANGIPASVFFPQADPEERLAQCSASLQALLALTPATLQALGKLVHVNSAEYA 1851
            .||.|||||::|||:|:||:||||.:||.:||.|||::|||||.|....||||.||:   :|...
  Rat  1777 ALLTAVGFRLDPAASGLPAAVFFPTSDPGDRLQQCSSTLQALLGLPNPALQALCKLI---TASET 1838

  Fly  1852 GD---------IIAVVRNILAQFPGSNPATGSSSTKSDAIAETCFIEMPLSVRLWRVAGCHELLA 1907
            |:         ::.::..:|.|..........:|..         |.:.|||:|||:.||||.||
  Rat  1839 GEQLISRAVKNMVGMLHQVLVQLQACEKEQDFASAP---------IPVSLSVQLWRLPGCHEFLA 1894

  Fly  1908 SVGFDLTEVGADQVILRTGKQANRRQCQFVLQALLALFDTREAPKNLGLDRDSDHSSSCESLAEP 1972
            ::||||.|||.::|||:|||||:||...|.||:||:|||:.|.||.|.|    |.|||.||||..
  Rat  1895 ALGFDLCEVGQEEVILKTGKQASRRTTHFALQSLLSLFDSTELPKRLSL----DSSSSLESLASA 1955

  Fly  1973 EMDVASIP-----PAASSTPSVNGGNKAPLPLHPRSAFISYVRRRGEPDGGRTDAIGGVGSGALD 2032
            :....::|     |..|.|.:.:..:.| :.::..|:..|.:....:|:||..   ||...|..|
  Rat  1956 QSVSNTLPLGYQHPPFSPTGADSIASDA-ISVYSLSSIASSMSFVSKPEGGLE---GGAPRGRQD 2016

  Fly  2033 SSLANTT--------------------DSEHSLSDGY--------VTQPGFGLS--NPRLGYASM 2067
            ...:.:|                    ..|....:|:        .|..|.|.:  :|......:
  Rat  2017 YDRSKSTHPQRATLPRRQMSPQARRGVSKEEEEYEGFSIISMEPLATYQGEGKARFSPDPKQPCV 2081

  Fly  2068 RAP--VRVSRPGGG--------------------------------GESDAAFT----------P 2088
            :||  ||:|....|                                ||||.:.|          .
  Rat  2082 KAPGGVRLSVSSKGSVSTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEE 2146

  Fly  2089 SPPVTDPS------LSLALAHQTRIRSLYSQTSSAA------IVPPVATTLNR------------ 2129
            |.|..||.      |....:|...:..|......|:      :|.|.:||:.|
  Rat  2147 SSPKLDPQELAQRILEETKSHLLAVERLQRSGGPASPDREDGVVAPSSTTVFRASETSAFSKPIL 2211

  Fly  2130 --------------RPDSSSSA----SSTTDWEGSGHATVLRRGVSTAIPQQQPPLPPPRPPTFH 2176
                          :|.:.||:    ||....|.||...:...|.|...|.:..|:.|..||.|
  Rat  2212 SHQRSQLSPLTIKPQPPARSSSLPKVSSPATSEVSGKDGLSPPGSSHPSPGRDTPVSPADPPLF- 2275

  Fly  2177 NLSVGAGGRSKPKIKLGSAQSSLAARVNKEHALFMDRLSVRTELSAPGSGNAMTS-GSAARKPLA 2240
                          :|....|..:|.::|...      :.....|||....:.:| |||...|..
  Rat  2276 --------------RLKYPSSPYSAHISKSPR------NTSPACSAPSPALSYSSAGSARSSPAD 2320

  Fly  2241 LPEEEDVSNVVFNPSSLYFSQTDSDLLNEPKQEETPPPTKSSTKSLQDSMMRHMNRELTPSISEM 2305
            :|:|:  ...|.:...|:              :.||.|.:...|     :.|.....||..
  Rat  2321 VPDEK--VQAVHSLKMLW--------------QSTPQPPRGPRK-----ICRGAPGTLTSK---- 2360

  Fly  2306 YHDRNVGLGLAPPLSKLLLSPNYEEQE------------VVSITEACPQSGANLKTLVDAVSELE 2358
               |:|       ||.|.|||.:.::|            |....|..|:...|.....||.:...
  Rat  2361 ---RDV-------LSLLNLSPRHGKEEGEADRLELKELSVQRRDEVPPKVPTNGHWCSDAATLTT 2415

  Fly  2359 LSGSSSGA 2366
            .||.|:.|
  Rat  2416 ASGRSTTA 2423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150	36/59 (61%)
		TPR repeat	98..128	CDD:276809	18/29 (62%)
		TPR_11	101..164	CDD:290150	45/62 (73%)
		TPR repeat	133..161	CDD:276809	23/27 (85%)
		TPR repeat	243..269	CDD:276809	17/25 (68%)
		TPR repeat	281..311	CDD:276809	22/29 (76%)
		TPR_12	282..353	CDD:290160	54/70 (77%)
		TPR_12	320..393	CDD:290160	51/72 (71%)
		TPR repeat	321..349	CDD:276809	23/27 (85%)
		TPR repeat	354..390	CDD:276809	21/35 (60%)
		TPR_12	401..473	CDD:290160	39/71 (55%)
		TPR repeat	401..429	CDD:276809	17/27 (63%)
		TPR_7	403..438	CDD:289919	19/34 (56%)
		TPR repeat	441..469	CDD:276809	15/27 (56%)
		TPR	467..752	CDD:223533	156/284 (55%)
		TPR repeat	482..509	CDD:276809	17/26 (65%)
		TPR repeat	522..549	CDD:276809	14/26 (54%)
		TPR repeat	561..595	CDD:276809	25/33 (76%)
		TPR repeat	600..630	CDD:276809	17/29 (59%)
		TPR repeat	642..669	CDD:276809	18/26 (69%)
		TPR_7	643..677	CDD:289919	23/33 (70%)
		TPR repeat	680..716	CDD:276809	16/35 (46%)
		TPR repeat	721..749	CDD:276809	14/27 (52%)
		TPR_7	723..758	CDD:289919	15/34 (44%)
		TPR repeat	801..829	CDD:276809	20/27 (74%)
		TPR_12	841..914	CDD:290160	37/72 (51%)
		TPR repeat	841..878	CDD:276809	17/36 (47%)
		TPR_12	882..949	CDD:290160	38/66 (58%)
		TPR repeat	883..913	CDD:276809	19/29 (66%)
		TPR	884..914	CDD:197478	18/29 (62%)
		TPR repeat	924..949	CDD:276809	14/24 (58%)
		TPR_12	964..1036	CDD:290160	38/71 (54%)
		TPR repeat	964..998	CDD:276809	17/33 (52%)
		TPR repeat	1004..1032	CDD:276809	14/27 (52%)
		TPR repeat	1043..1073	CDD:276809	13/29 (45%)
		TPR_12	1044..1112	CDD:290160	28/70 (40%)
		TPR_7	1046..1078	CDD:289919	12/34 (35%)
		TPR_12	1081..1153	CDD:290160	34/71 (48%)
		TPR repeat	1081..1109	CDD:276809	12/27 (44%)
		CHAT	1421..1718	CDD:289536	129/328 (39%)
		Treacle	<1957..2287	CDD:281536	89/451 (20%)
Ttc28	XP_006249646.1	TPR_11	57..117	CDD:290150	36/59 (61%)
		TPR repeat	85..115	CDD:276809	18/29 (62%)
		TPR_11	88..151	CDD:290150	45/62 (73%)
		TPR repeat	120..148	CDD:276809	23/27 (85%)
		TPR repeat	154..182	CDD:276809	17/27 (63%)
		TPR repeat	230..256	CDD:276809	17/25 (68%)
		TPR repeat	268..300	CDD:276809	24/31 (77%)
		TPR_11	269..339	CDD:290150	54/69 (78%)
		TPR repeat	305..337	CDD:276809	26/31 (84%)
		TPR_12	309..380	CDD:290160	50/70 (71%)
		TPR repeat	348..376	CDD:276809	17/27 (63%)
		TPR_7	351..385	CDD:289919	18/33 (55%)
		TPR	373..687	CDD:223533	176/313 (56%)
		TPR repeat	387..417	CDD:276809	19/29 (66%)
		TPR	388..420	CDD:197478	19/31 (61%)
		TPR repeat	428..456	CDD:276809	15/27 (56%)
		TPR repeat	469..496	CDD:276809	17/26 (65%)
		TPR repeat	509..536	CDD:276809	14/26 (54%)
		TPR_7	510..545	CDD:289919	18/34 (53%)
		TPR repeat	548..576	CDD:276809	22/27 (81%)
		TPR repeat	588..616	CDD:276809	15/27 (56%)
		TPR_7	590..625	CDD:289919	19/34 (56%)
		TPR repeat	627..657	CDD:276809	21/29 (72%)
		TPR_7	630..664	CDD:289919	23/33 (70%)
		TPR	688..989	CDD:223533	158/300 (53%)
		TPR repeat	706..733	CDD:276809	15/26 (58%)
		TPR repeat	748..776	CDD:276809	16/27 (59%)
		TPR	788..817	CDD:197478	21/28 (75%)
		TPR repeat	788..816	CDD:276809	20/27 (74%)
		TPR repeat	827..857	CDD:276809	16/29 (55%)
		TPR repeat	872..899	CDD:276809	17/26 (65%)
		TPR_7	873..905	CDD:289919	18/31 (58%)
		TPR repeat	910..944	CDD:276809	23/33 (70%)
		TPR repeat	951..976	CDD:276809	14/24 (58%)
		TPR_7	953..988	CDD:289919	17/34 (50%)
		TPR repeat	991..1019	CDD:276809	14/27 (52%)
		TPR_12	993..1061	CDD:290160	29/67 (43%)
		TPR repeat	1031..1059	CDD:276809	11/27 (41%)
		TPR_12	1032..1103	CDD:290160	29/70 (41%)
		TPR repeat	1069..1099	CDD:276809	14/29 (48%)
		TPR_11	1072..1140	CDD:290150	33/67 (49%)
		TPR repeat	1111..1137	CDD:276809	15/25 (60%)
		TPR repeat	1163..1188	CDD:276809	11/24 (46%)
		CHAT	1384..1707	CDD:289536	130/332 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351951
Domainoid	1	1.000	215	1.000	Domainoid score	I2635
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41023
Inparanoid	1	1.050	1651	1.000	Inparanoid score	I72
OMA	1	1.010	-	-		QHG49865
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	1	1.000	-	-		FOG0007055
OrthoInspector	1	1.000	-	-		oto96188
orthoMCL	1	0.900	-	-		OOG6_106923
Panther	1	1.100	-	-	LDO	PTHR10098
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870