DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43163 and TTC28

DIOPT Version :10

Sequence 1:NP_648228.2 Gene:CG43163 / 38966 FlyBaseID:FBgn0262719 Length:2523 Species:Drosophila melanogaster
Sequence 2:NP_001138890.1 Gene:TTC28 / 23331 HGNCID:29179 Length:2481 Species:Homo sapiens


Alignment Length:2581 Identity:1107/2581 - (42%)
Similarity:1503/2581 - (58%) Gaps:362/2581 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 NAKIAIVGEQLLNKMSQRDFSENEPECTPELPAANRALFLEKVRQSNAACQSGDFATAVLLYTDA 91
            :|.|.:.|...:.:.|            |:.|..::|.|:|||||||.||..|||.||::||.:|
Human    32 SAPIPLFGADTIGQRS------------PDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEA 84

  Fly    92 LQLDPGNHILYSNRSAALLKQGQFTAALQDATQARDLCPQWPKAYFRQGVALQCLGRYGEALAAF 156
            |.:||.|.|||||||||.:|..|:..||.||.:||.|.|:|||||||||||||.|||:.:|||||
Human    85 LAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAF 149

  Fly   157 ASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSA 221
            ||||||:|.:.||:.|:|||::|||:|.:||||.|||:.|:|.:|||||.||||||||.|..:.|
Human   150 ASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGA 214

  Fly   222 AVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAKSLGDTAGECRAHGN 286
            :|.||||||:||:||||||||||||||||:|:|...:::.|||||||.|||:|||..||||||||
Human   215 SVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGN 279

  Fly   287 LGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAALTSLGHVYTASGDYPNALASHKQCVQLF 351
            ||||:||:|.::||||.||:|||||||.||.:||::||:||||||||.||||||||||||||.|.
Human   280 LGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLA 344

  Fly   352 KQLGDRLQEAREIGNVGAVYLALGECEAALDCHSQHLRLARKLHDQVEEARAYSNLGSAHHQRRQ 416
            ||..|.|.||||:||:||||:|:|:.|.|:.||.|||::|:.|.::.||||||||||||:|.||.
Human   345 KQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN 409

  Fly   417 FTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARCAGDASASKRFHERQLAMALAARDKLGEG 481
            |.:|.:.|..||.:||.|.::::|..|||||||||||..|...:|::||:||.:|...:|:..||
Human   410 FDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEG 474

  Fly   482 RACSNLGIVYQMLGSHDAALKLHQAHLGIARSLGDRTGMGKAYGNMARMAHMAGSYEAAVKYHKQ 546
            ||.|||||::||.|.:|.|||||:.||.||:.|.|....|:|||||....:..|.|:.|||||:|
Human   475 RASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQ 539

  Fly   547 ELAINQAMNDRSAEAATHGNLAVAYQALGAHDAALTHYRAHLATARSLKDTAGEACALLNLGNCL 611
            ||.|:..:|||:::|:||||||||||||||||.||.||:.||..||.|:|...||.||.||||..
Human   540 ELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFH 604

  Fly   612 SGRQEYEEAVPHYESYLMLAQELGDVAAEGKACHLLGYAHFSLGNYRAAVRYYDQDLALAKDAQH 676
            ..|.||.:|.|:||.||.||.:|.|:..|||.||.|||||:.||||:.||:||:||||||||...
Human   605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHD 669

  Fly   677 RPNMGRAYCNLGLAHLALGHTAAALECQQLFLAVAHATNQLPAKFRALGNIGDILIRTGSHEEAI 741
            :.:..:||||||||..||.:.:.|.|||:..|::|.:.|...||||||||:|||.|.......||
Human   670 KLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAI 734

  Fly   742 KLYQRQLALARAAGDRSMEAAACGALGLAHRLMRRWDKALGHHTQELTLRQELGDLSGECRAHGH 806
            |.|::||.||....||.:||:|..|||.|:|:::::|||||:|||||.:.|||.||.||||||||
Human   735 KFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGH 799

  Fly   807 LGAVHMALCSWTNAVKCYQEQLERAQEQRDAAVEAQAHGNLGIARLNMAHYEAAIGCLEAQLGTL 871
            |.||:|||..:|.|.|||:|||:..|:.:|.::|||.:||:||.::||...|.|||..|.||..|
Human   800 LAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864

  Fly   872 ERVSLPSTQADRARALGHLGDCYAALGDYEEALKCHDRQLQLALGLTSHRDQERAYRGLGQARRA 936
            :::|...:..||.||.|:|||||.||||||||:|.:::.|.:|..|...:||.:||||||...||
Human   865 QQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRA 929

  Fly   937 LGQLPAALVCLEKRLVVAHELHSPEIKALAYGDLGHVHAALGNHAQALNCLEHQRELAQGLQDRA 1001
            :|.|..||||.||||||||||.....||.|||:||.:|:.|||:.||::|||.|..:|:.::|||
Human   930 MGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRA 994

  Fly  1002 LESDAMCALGQVQQRMGQHAQALELHRQDLEICTELSAPALQARALSNLGSVHESLGQQAEALKC 1066
            |||||.|.||.|.|:||::..||:.|:.||:|..|.:.|..|.||..|||..:||||....|:..
Human   995 LESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVY 1059

  Fly  1067 YERQLELS---TDRLAKAMACLALGRVHHQLEQHNQAVDYLRQGLASAQTTGKSEEEAKIRHQLG 1128
            .|:.|.::   .|..||.::..:|||.||.|:.::|||.||::||..|:..|:.|:||||||.||
Human  1060 QEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLG 1124

  Fly  1129 LALRSSGDAEGAHIQLETAAQLLESVRHE-QRSPETRQALYDLQTTCYQLLQVLLVALNRNEDAL 1192
            |:|.:||:.|.|..||..|:.|.|::||| |.|.:.:.:|:||||:.||.||.:||:|..:::||
Human  1125 LSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEAL 1189

  Fly  1193 VAAERCKARGGADAV----SGEGSKVPLA--DSESIQETVDRGRTTVLYYSLAGDQLFTWLLEPH 1251
            ..|||.:.|..||.:    :|:....|.:  ..:.|.|.|:..|..|||||||...|::|||.|.
Human  1190 AVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPG 1254

  Fly  1252 VGIVRFHAAKIDAHSLQLPLSLSEEEEEEEDLEMERELKLNRDQNQDQSEDQGTSN-----KANR 1311
            .|||:||                             |..|..:..::.|:.|.:|:     ....
Human  1255 AGIVKFH-----------------------------EHYLGENTVENSSDFQASSSVTLPTATGS 1290

  Fly  1312 LLERYMSLVRDNLGV---------NSQSLLHEGDGSGWRASTEQLLEDLPGAGGS--GGGGFLRM 1365
            .||::::.||:.|||         :|::....||      ..:|..|::.....|  ...|||||
Human  1291 ALEQHIASVREALGVESHYSRACASSETESEAGD------IMDQQFEEMNNKLNSVTDPTGFLRM 1349

  Fly  1366 VSRNQLLNSSNYSLSSLFSVGSVGGSVASLQGSTRSVGSRSSRRAPGLPVWRGPSCLHILYNLLL 1430
            |.||.|.|.|..|::||||     .:|:..|..|.|:..|.|..|      :.|  |..||:||:
Human  1350 VRRNNLFNRSCQSMTSLFS-----NTVSPTQDGTSSLPRRQSSFA------KPP--LRALYDLLI 1401

  Fly  1431 APFDDLLPAGEADTNRQGRRELVLVLDSSLYLVPFAILRAAQEDGEYLCERCAILTAPSLQSM-- 1493
            ||.:..|........|  .|:|:|||:..|||:|||:|:.:..: |||.||..:|..||::|:  
Human  1402 APMEGGLMHSSGPVGR--HRQLILVLEGELYLIPFALLKGSSSN-EYLYERFGLLAVPSIRSLSV 1463

  Fly  1494 RSRPRIRRDRARPP-------KALVVGGPRIPSNLAELWGWAGAESPAALQEAAMVADMLQATAL 1551
            :|:..:|::   ||       .|.|:|.|::||.:.:.|.|  ...|:|.:||.||:::|....|
Human  1464 QSKSHLRKN---PPTYSSSTSMAAVIGNPKLPSAVMDRWLW--GPMPSAEEEAYMVSELLGCQPL 1523

  Fly  1552 AGSNATKESVLAELPSAECVHFAANISWQLGAVVLSP---GDVVTAEQ--------------QEQ 1599
            .||.||||.|::.|..|||||||.:|||:|.|:||:|   |:..:::.              |:.
Human  1524 VGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDD 1588

  Fly  1600 KEPHE-----PQMTDFTLAAGELRQLRLSARLVVL-SSYHSVEPITGDGVAQLAGGWLLAGAGVV 1658
            ....|     |.:.:..|.|.::..|:|..:|||| ||..|...:|.|||..|...:|.|||..|
Human  1589 ASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCV 1653

  Fly  1659 LISLWPVPETAAKILLRAFYSALLQGARAARALAEAMQTVQHTKHFAHPANWAGFLLVGSNIRLS 1723
            |:||||||..|:|:.:.||||:||.|.:|:.||.|||:.||.:|.|:||:|||||:|:||:::|:
Human  1654 LVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLN 1718

  Fly  1724 NKVAM-GHALCELLRTPERCRDALRVCLHLVEKSLQRIHRGQKNAMYTTQQSIENKAGPVAGWKD 1787
            :..:: |.||.|:|:.|||.||||||.|||||||||||..||:|||||:|||:|||.|.:.||:.
Human  1719 SPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQA 1783

  Fly  1788 LLMAVGFRVEPAANGIPASVFFPQADPEERLAQCSASLQALLALTPATLQALGKLVHVNSAEYAG 1852
            ||.|||||::|..:|:||:||||.:||.:||.|||::||:||.|....||||.||:   :|...|
Human  1784 LLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLI---TASETG 1845

  Fly  1853 D---------IIAVVRNILAQFPGSNPATGSSSTKSDAIAETCFIEMPLSVRLWRVAGCHELLAS 1908
            :         ::.::..:|.|..........:|..         |::.:||:|||:.||||.||:
Human  1846 EQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAP---------IQVSISVQLWRLPGCHEFLAA 1901

  Fly  1909 VGFDLTEVGADQVILRTGKQANRRQCQFVLQALLALFDTREAPKNLGLDRDSDHSSSCESLAEPE 1973
            :||||.|||.::|||:||||||||...|.||:||:|||:.|.||.|.|    |.|||.||||..:
Human  1902 LGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSL----DSSSSLESLASAQ 1962

  Fly  1974 MDVASIPPAASSTPSVNGGNKAPLPLHPRSAFISYVRRRGEPDGGRTDAIGGVGSGALDSSLANT 2038
             .|::..|.....|          |..|..|           |...:|||......::.||::  
Human  1963 -SVSNALPLGYQQP----------PFSPTGA-----------DSIASDAISVYSLSSIASSMS-- 2003

  Fly  2039 TDSEHSLSDGYVTQPGFGLSNPRLGYASMRAPVRVSRPGG-GGESDAAFTPSPPVTDPSLSLALA 2102
                      :|::|..|                 |..|| ||..|         .|.|.:..|.
Human  2004 ----------FVSKPEGG-----------------SEGGGPGGRQD---------HDRSKNAYLQ 2032

  Fly  2103 HQTRIRS-LYSQTSSA-----------AIV--PPVATTLNRR-----PDSSSSASSTTDWEGSGH 2148
            ..|..|| |..||..|           :|:  .|:||....|     ||.......|.   |...
Human  2033 RSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTA---GGMR 2094

  Fly  2149 ATVLRRG-VSTA-IPQQQPPLPPPRPP-------------------TFHNLSVGAGGRSKPKIKL 2192
            .:|..:| :||. .|.:...:|.|..|                   |..:.:|.:...|.||:. 
Human  2095 VSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLD- 2158

  Fly  2193 GSAQSSLAARVNKE---HALFMDRLSVRTELSAPGSGNAMTSGSAARKPLALPEEEDVSNVVFNP 2254
               ...||.::.:|   |.:.::||.        .||..::..:.....:..|.    |..||..
Human  2159 ---PQELAQKILEETQSHLIAVERLQ--------RSGGQVSKSNNPEDGVQAPS----STAVFRA 2208

  Fly  2255 SSLYFSQTDSDLLNEPKQEETP------PPTKSST---------------KSLQDSMMRHMNREL 2298
            |..  |.....:|:..|.:.:|      ||.:||:               .|::||..:|..|. 
Human  2209 SET--SAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRP- 2270

  Fly  2299 TPSISEMYHDRNVGLGLAPPLSKLLL-SPNYEEQEVVSITEACPQSGANLKTLVDAVSELELSGS 2362
            :|........      |..||.||.. |..|......|.....|.||.  ::...:.....||.|
Human  2271 SPGCDSQTSQ------LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGH--QSPAGSAPSPALSYS 2327

  Fly  2363 SSGATMPTVVGGGANEVEGTSGTSAEATCPICGEPADV--ICRCKAVTIQKK----SILKPWLSN 2421
            |:|                    ||.::      |||.  |.:.|...|.:|    ..||.:..:
Human  2328 SAG--------------------SARSS------PADAPDIDKLKMAAIDEKVQAVHNLKMFWQS 2366

  Fly  2422 VPDSSLVQASELTTADILERRLEIHTATSSELRSGAPYSVDLSRRD 2467
            .|.                     |:....::..|||.:: .|:||
Human  2367 TPQ---------------------HSTGPMKIFRGAPGTM-TSKRD 2390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43163NP_648228.2 PEP_TPR_lipo <78..751 CDD:274350 411/672 (61%)
TPR repeat 98..128 CDD:276809 18/29 (62%)
TPR repeat 133..161 CDD:276809 23/27 (85%)
TPR repeat 243..269 CDD:276809 16/25 (64%)
TPR repeat 281..311 CDD:276809 22/29 (76%)
TPR repeat 321..349 CDD:276809 23/27 (85%)
TPR repeat 354..390 CDD:276809 21/35 (60%)
TPR repeat 401..429 CDD:276809 17/27 (63%)
TPR repeat 441..469 CDD:276809 16/27 (59%)
TPR repeat 482..509 CDD:276809 17/26 (65%)
TPR repeat 522..549 CDD:276809 14/26 (54%)
TPR 523..781 CDD:440225 142/257 (55%)
TPR repeat 561..595 CDD:276809 25/33 (76%)
TPR repeat 600..630 CDD:276809 17/29 (59%)
TPR repeat 642..669 CDD:276809 18/26 (69%)
TPR repeat 680..716 CDD:276809 16/35 (46%)
TPR repeat 721..749 CDD:276809 15/27 (56%)
TPR_12 801..865 CDD:315987 35/63 (56%)
TPR repeat 801..829 CDD:276809 19/27 (70%)
Spy 841..>1073 CDD:443119 119/231 (52%)
TPR repeat 841..878 CDD:276809 17/36 (47%)
TPR repeat 883..913 CDD:276809 19/29 (66%)
TPR repeat 924..949 CDD:276809 14/24 (58%)
TPR repeat 964..998 CDD:276809 17/33 (52%)
COG4995 975..1718 CDD:444019 306/800 (38%)
TPR repeat 1004..1032 CDD:276809 14/27 (52%)
TPR repeat 1043..1073 CDD:276809 13/29 (45%)
TPR repeat 1081..1109 CDD:276809 12/27 (44%)
CHAT 1421..1718 CDD:432771 132/328 (40%)
TTC28NP_001138890.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 4/27 (15%)
PEP_TPR_lipo 47..937 CDD:274350 528/901 (59%)
TPR 1 58..91 21/32 (66%)
TPR repeat 91..121 CDD:276809 18/29 (62%)
TPR 2 93..125 19/31 (61%)
TPR 3 126..159 27/32 (84%)
TPR repeat 126..154 CDD:276809 23/27 (85%)
TPR repeat 160..188 CDD:276809 17/27 (63%)
TPR 4 196..229 22/32 (69%)
TPR 5 234..267 22/32 (69%)
TPR repeat 236..262 CDD:276809 16/25 (64%)
TPR 6 274..307 25/32 (78%)
TPR repeat 274..306 CDD:276809 24/31 (77%)
TPR 7 314..347 26/32 (81%)
TPR repeat 316..342 CDD:276809 23/25 (92%)
TPR 8 354..387 19/32 (59%)
TPR repeat 354..382 CDD:276809 17/27 (63%)
TPR repeat 393..423 CDD:276809 19/29 (66%)
TPR 9 394..427 20/32 (63%)
TPR repeat 428..459 CDD:276809 15/30 (50%)
TPR 10 434..467 18/32 (56%)
TPR 11 474..507 21/32 (66%)
TPR repeat 475..502 CDD:276809 17/26 (65%)
TPR 12 514..547 17/32 (53%)
TPR 515..774 CDD:440225 142/258 (55%)
TPR repeat 515..542 CDD:276809 14/26 (54%)
TPR 13 554..587 25/32 (78%)
TPR repeat 554..582 CDD:276809 22/27 (81%)
TPR 14 594..627 18/32 (56%)
TPR repeat 594..622 CDD:276809 15/27 (56%)
TPR repeat 633..663 CDD:276809 21/29 (72%)
TPR 15 634..667 24/32 (75%)
TPR 16 674..707 16/32 (50%)
TPR repeat 712..739 CDD:276809 16/26 (62%)
TPR 17 714..747 18/32 (56%)
TPR 18 754..787 18/32 (56%)
TPR repeat 754..782 CDD:276809 16/27 (59%)
TPR 19 794..827 21/32 (66%)
TPR repeat 794..822 CDD:276809 19/27 (70%)
TPR repeat 833..863 CDD:276809 16/29 (55%)
TPR 20 834..867 16/32 (50%)
TPR 21 877..910 19/32 (59%)
TPR repeat 878..905 CDD:276809 17/26 (65%)
TPR repeat 916..950 CDD:276809 23/33 (70%)
TPR 22 917..950 22/32 (69%)
COG4995 947..1713 CDD:444019 318/821 (39%)
TPR 23 957..990 17/32 (53%)
TPR repeat 957..982 CDD:276809 14/24 (58%)
TPR 24 997..1030 16/32 (50%)
TPR repeat 997..1025 CDD:276809 14/27 (52%)
TPR 25 1037..1070 12/32 (38%)
TPR repeat 1037..1065 CDD:276809 11/27 (41%)
TPR repeat 1075..1105 CDD:276809 14/29 (48%)
TPR 26 1077..1110 14/32 (44%)
TPR 27 1117..1150 18/32 (56%)
TPR repeat 1117..1143 CDD:276809 15/25 (60%)
TPR 28 1169..1202 14/32 (44%)
TPR repeat 1169..1194 CDD:276809 11/24 (46%)
CHAT 1390..1713 CDD:432771 133/332 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2004..2055 19/76 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2161 17/92 (18%)
Herpes_BLLF1 <2088..>2336 CDD:282904 60/303 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2339 43/211 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2420..2467
Blue background indicates that the domain is not in the aligned region.

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