DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43163 and Stip1

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	NP_620266.1	Gene:	Stip1 / 192277	RGDID:	621599	Length:	543	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	117/503 - (23%)
Similarity:	185/503 - (36%)	Gaps:	163/503 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LEKVRQ----SNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQAR 126
            :|:|.:    .|.|..:|:...|:..|::|::|||.||:||||||||..|:|.:..|.:|..:..
  Rat     1 MEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTV 65

  Fly   127 DLCPQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGL--VEASL----------- 178
            ||.|.|.|.|.|:..||:.|.|:.||...:..||..|.:|.||..||  :||.|
  Rat    66 DLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAERKFMNPFNL 130

  Fly   179 --------KSPLRAAL--EPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIG 233
                    ..|....|  :||.::| ..|||..|    |.:|.:|    |....:|.|...|.:.
  Rat   131 PNLYQKLENDPRTRTLLSDPTYREL-IEQLQNKP----SDLGTKL----QDPRVMTTLSVLLGVD 186

  Fly   234 SCSL--------------------------------------KLRGSVFSALSSAHWALNQLDQA 260
            ..|:                                      |..|:..........||...|:|
  Rat   187 LGSMDEEEEAATPPPPPPPKKEAKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDKALKHYDKA 251

  Fly   261 -------IGYMQQDLAVAKSLGDTAGECR----------------------AHGNLGSAYFSQGA 296
                   :.|:....||....|| ..:||                      |:..:|::||.:..
  Rat   252 KELDPTNMTYITNQAAVHFEKGD-YNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEER 315

  Fly   297 HKEALTAHRYQLVLA--------MKCKDTQAAAAALTSLGHVYT--------------ASGDYPN 339
            :|:|:  |.|...||        .||:..:........|.::..              ..||||.
  Rat   316 YKDAI--HFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQ 378

  Fly   340 ALASHKQCVQLFKQLGDRLQEAREIGNVGAVY-------LALGECEAALDCHSQHLRLARKLHDQ 397
            |:..:.:.::      ...::|:...|..|.|       |||.:||..:               |
  Rat   379 AMKHYTEAIK------RNPRDAKLYSNRAACYTKLLEFQLALKDCEECI---------------Q 422

  Fly   398 VEEA--RAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAA 443
            :|..  :.|:...:|....:.:|:|...:::.|.:     |.|.:.||
  Rat   423 LEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL-----DSSCKEAA 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150	25/63 (40%)
		TPR repeat	98..128	CDD:276809	14/29 (48%)
		TPR_11	101..164	CDD:290150	27/62 (44%)
		TPR repeat	133..161	CDD:276809	10/27 (37%)
		TPR repeat	243..269	CDD:276809	5/32 (16%)
		TPR repeat	281..311	CDD:276809	10/51 (20%)
		TPR_12	282..353	CDD:290160	19/114 (17%)
		TPR_12	320..393	CDD:290160	15/93 (16%)
		TPR repeat	321..349	CDD:276809	6/41 (15%)
		TPR repeat	354..390	CDD:276809	9/42 (21%)
		TPR_12	401..473	CDD:290160	9/45 (20%)
		TPR repeat	401..429	CDD:276809	4/29 (14%)
		TPR_7	403..438	CDD:289919	6/34 (18%)
		TPR repeat	441..469	CDD:276809	2/3 (67%)
		TPR	467..752	CDD:223533
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR_7	643..677	CDD:289919
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
Stip1	NP_620266.1	TPR 1	4..37		10/32 (31%)
		3a0801s09	<7..532	CDD:273380	115/497 (23%)
		TPR repeat	7..32	CDD:276809	6/24 (25%)
		TPR repeat	37..67	CDD:276809	14/29 (48%)
		TPR 2	39..71		15/31 (48%)
		TPR repeat	72..100	CDD:276809	10/27 (37%)
		TPR 3	73..105		12/31 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..233		1/41 (2%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	222..239		2/16 (13%)
		TPR 4	225..258		6/32 (19%)
		TPR repeat	229..253	CDD:276809	6/23 (26%)
		TPR repeat	258..288	CDD:276809	7/30 (23%)
		TPR 5	260..292		7/32 (22%)
		TPR 6	300..333		10/34 (29%)
		TPR repeat	300..328	CDD:276809	8/29 (28%)
		TPR 7	360..393		5/38 (13%)
		TPR repeat	364..388	CDD:276809	5/23 (22%)
		TPR repeat	393..423	CDD:276809	9/44 (20%)
		TPR 8	395..427		10/46 (22%)
		TPR 9	428..461		6/37 (16%)
		TPR repeat	428..456	CDD:276809	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810