DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43163 and sti-1

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	NP_001367444.1	Gene:	sti-1 / 178587	WormBaseID:	WBGene00019983	Length:	320	Species:	Caenorhabditis elegans

Alignment Length:	190	Identity:	52/190 - (27%)
Similarity:	91/190 - (47%)	Gaps:	17/190 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AGN---NENNAKIAIVG-EQLLNKMSQRDFSENEPECTPELPAANRALFL------EKVRQSNAA 75
            |||   .:|:..:|:.. .:.|::....:..:...|...:|.||.|..::      |:..:.|..
Worm    86 AGNAFQKQNDLSLAVQWFHRSLSEFRDPELVKKVKELEKQLKAAERLAYINPELAQEEKNKGNEY 150

  Fly    76 CQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQARDLCPQWPKAYFRQG 140
            .:.||:.||:..|.:|::.||.|.||||||:|.|.|..:|..||.|......|..::.|.|.|:.
Worm   151 FKKGDYPTAMRHYNEAVKRDPENAILYSNRAACLTKLMEFQRALDDCDTCIRLDSKFIKGYIRKA 215

  Fly   141 VALQCLGRYGEALAAFASGLAQEPSNKQLMAGL-------VEASLKSPLRAALEPTLQQL 193
            ..|..:..:.:|..|:...|..:|||::...|:       .|...|:..|:..:|.:|::
Worm   216 ACLVAMREWSKAQRAYEDALQVDPSNEEAREGVRNCLRSNDEDPEKAKERSLADPEVQEI 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150	24/59 (41%)
		TPR repeat	98..128	CDD:276809	14/29 (48%)
		TPR_11	101..164	CDD:290150	20/62 (32%)
		TPR repeat	133..161	CDD:276809	6/27 (22%)
		TPR repeat	243..269	CDD:276809
		TPR repeat	281..311	CDD:276809
		TPR_12	282..353	CDD:290160
		TPR_12	320..393	CDD:290160
		TPR repeat	321..349	CDD:276809
		TPR repeat	354..390	CDD:276809
		TPR_12	401..473	CDD:290160
		TPR repeat	401..429	CDD:276809
		TPR_7	403..438	CDD:289919
		TPR repeat	441..469	CDD:276809
		TPR	467..752	CDD:223533
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR_7	643..677	CDD:289919
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
sti-1	NP_001367444.1	3a0801s09	<5..>241	CDD:273380	44/154 (29%)
		TPR repeat	5..33	CDD:276809
		TPR repeat	38..68	CDD:276809
		TPR repeat	80..108	CDD:276809	5/21 (24%)
		TPR repeat	140..168	CDD:276809	8/27 (30%)
		TPR repeat	173..203	CDD:276809	14/29 (48%)
		TPR repeat	208..236	CDD:276809	6/27 (22%)
		STI1	259..311	CDD:407696	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810