Protein Alignment CG43163 and LOC1273312

DIOPT Version :10

• Sequence 1: NP_648228.2
• Gene: CG43163 / 38966
• FlyBaseID: FBgn0262719
• Length: 2523
• Species: Drosophila melanogaster
• Sequence 2: XP_312278.6
• Gene: LOC1273312 / 1273312
• VectorBaseID: AGAMI1_001428
• Length: 2916
• Species: Anopheles gambiae
• Alignment Length: 2955
• Identity: 1685/2955 - (57%)
• Similarity: 1998/2955 - (67%)
• Gaps: 510/2955 - (17%)

  Fly    16 ANNHAAGNNEN----NAKIAIVGEQLLNKMSQRD----------------FSENEPECTPELPAA 60
            |.:|..|...:    .|..||...|...:..|:.                ...||||.|||||||
Mosquito    16 AGHHQTGVGSSGTVVTATAAISAHQQQQQQQQQQQPAIHPTVWEILSAELILSNEPEGTPELPAA 80

  Fly    61 NRALFLEKVRQSNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQA 125
            |||||||||||||.|||:|||:|||.||||||.|||||||||||||||.||||||..||||||:|
Mosquito    81 NRALFLEKVRQSNTACQNGDFSTAVQLYTDALGLDPGNHILYSNRSAARLKQGQFALALQDATRA 145

  Fly   126 RDLCPQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTL 190
            |:|||||||||||||||||||||||||||||::||||:|::|||:|||||||:|||||.|||||.
Mosquito   146 RELCPQWPKAYFRQGVALQCLGRYGEALAAFSAGLAQDPNSKQLLAGLVEASIKSPLRHALEPTF 210

  Fly   191 QQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALN 255
            |||:.|:|.:|||||.||||||||.|.||.|||||||:|||||||||||||||||||||||||||
Mosquito   211 QQLKAMKLDQSPFVVISVVGQELLGAGQYHAAVTVLESALRIGSCSLKLRGSVFSALSSAHWALN 275

  Fly   256 QLDQAIGYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAA 320
            |||:||.|||||||||||||||||||||||||||||||||::|||||:|||||||||||||||||
Mosquito   276 QLDKAIAYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGSYKEALTSHRYQLVLAMKCKDTQAA 340

  Fly   321 AAALTSLGHVYTASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAALDCHS 385
            |||||||||||||.||||||||||||||||.||:|||||||||||||||||||:||.::|:|||:
Mosquito   341 AAALTSLGHVYTAIGDYPNALASHKQCVQLVKQMGDRLQEAREIGNVGAVYLAMGEFDSAVDCHT 405

  Fly   386 QHLRLARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHA 450
            |||||||||.:|||||||||||||::|.:|.||||...||.||||||.||||::||.||||||||
Mosquito   406 QHLRLARKLGNQVEEARAYSNLGSSYHYKRNFTQAITYHESVLRIAQQLGDRAIEARAYAGLGHA 470

  Fly   451 ARCAGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLG 515
            |||..|...:||:||:||.||||||||:||||||||||||||:||.||||||||||||.|||.|.
Mosquito   471 ARCGHDFVQAKRWHEKQLEMALAARDKVGEGRACSNLGIVYQLLGEHDAALKLHQAHLTIARQLQ 535

  Fly   516 DRTGMGKAYGNMARMAHMAGSYEAAVKYHKQELAINQAMNDRSAEAATHGNLAVAYQALGAHDAA 580
            |:.|||:||||:......||.||:|:|||||||.|::.::||||||:||||||||||||||||.|
Mosquito   536 DKAGMGRAYGNIGNAYSAAGYYESAIKYHKQELIISKEVHDRSAEASTHGNLAVAYQALGAHDMA 600

  Fly   581 LTHYRAHLATARSLKDTAGEACALLNLGNCLSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACH 645
            |.||||||..||.|||||||||||||||||||.|||:.:|||:||.||||:||||||||||||||
Mosquito   601 LMHYRAHLNIARELKDTAGEACALLNLGNCLSSRQEFAQAVPYYEQYLMLSQELGDVAAEGKACH 665

  Fly   646 LLGYAHFSLGNYRAAVRYYDQDLALAKDAQHRPNMGRAYCNLGLAHLALGHTAAALECQQLFLAV 710
            .|||||:.:||||.||||||||||||||.|::.|||||||||||||||||:|..|||||:.|||:
Mosquito   666 FLGYAHYCIGNYREAVRYYDQDLALAKDLQNKMNMGRAYCNLGLAHLALGNTGGALECQKYFLAI 730

  Fly   711 AHATNQLPAKFRALGNIGDILIRTGSHEEAIKLYQRQLALARAAGDRSMEAAACGALGLAHRLMR 775
            ||.||.||.||||||||||:|||.|..:||||:|||||||||...:|.|||||||||||||||::
Mosquito   731 AHMTNHLPGKFRALGNIGDVLIRMGDVDEAIKMYQRQLALARQTRERGMEAAACGALGLAHRLLK 795

  Fly   776 RWDKALGHHTQELTLRQELGDLSGECRAHGHLGAVHMALCSWTNAVKCYQEQLERAQEQRDAAVE 840
            :.|||||:||||||||||:.||.||||||||||||||||.::|:||||||||||||||.:|:|||
Mosquito   796 KLDKALGYHTQELTLRQEMSDLPGECRAHGHLGAVHMALGNYTHAVKCYQEQLERAQELQDSAVE 860

  Fly   841 AQAHGNLGIARLNMAHYEAAIGCLEAQLGTLERVSLPSTQADRARALGHLGDCYAALGDYE-EAL 904
            |||.||||||||||.|||.|||.||.||||||:||.|:.|.|||||||||||||.|||||. ||:
Mosquito   861 AQAFGNLGIARLNMGHYEDAIGYLEQQLGTLEQVSSPTAQHDRARALGHLGDCYDALGDYHTEAI 925

  Fly   905 KCHDRQLQLALGLTSHRDQERAYRGLGQARRALGQLPAALVCLEKRLVVAHELHSPEIKALAYGD 969
            |||:|.||||:.|.|.|||||||||||...:::|.|..|||||||||||:|||.|.|.||.||||
Mosquito   926 KCHERHLQLAIALQSPRDQERAYRGLGNCYKSVGNLQEALVCLEKRLVVSHELGSAEAKAAAYGD 990

  Fly   970 LGHVHAALGNHAQALNCLEHQRELAQGLQDRALESDAMCALGQVQQRMGQHAQALELHRQDLEIC 1034
            ||.:|:||||:.||:|||||||::|:.|.||.|.|||:..||.|.|:||.:.::|.||:||||:.
Mosquito   991 LGSIHSALGNYEQAINCLEHQRDIARELGDRVLTSDAISGLGAVFQQMGDYDESLRLHKQDLELG 1055

  Fly  1035 TELSAPALQARALSNLGSVHESLGQQAEALKCYERQLELSTDRLAKAMACLALGRVHHQLEQHNQ 1099
            ..::...|||||..|||||:::|...||:.:.||:||.|:.||..||.||||||||:|.:||..|
Mosquito  1056 ESVNHATLQARASGNLGSVYDALRNYAESARYYEKQLTLTADRQTKAHACLALGRVYHAMEQVPQ 1120

  Fly  1100 AVDYLRQGLASAQTTGKSEEEAKIRHQLGLALRSSGDAEGAHIQLETAAQLLESVRHEQRSPETR 1164
            ||.:||||||.||:..|.|:|||:|::|||||.:||:.:.|..|:|:|||:|||:|.:|.:||.|
Mosquito  1121 AVGFLRQGLAIAQSLNKLEDEAKLRYRLGLALVASGEDDAARQQMESAAQILESIRSDQVTPEGR 1185

  Fly  1165 QALYDLQTTCYQLLQVLLVALNRNEDALVAAERCKARGGADA-VSGEGS----KVPLADSESIQE 1224
            ..||||||.|||.||.:||.|.|.|:||||||||::|.|||: .|.|.|    |..|..||.|.:
Mosquito  1186 TQLYDLQTACYQTLQRVLVGLGRTEEALVAAERCRSRLGADSNQSAENSLNNRKTLLTCSEYIFD 1250

  Fly  1225 TVDRGRTTVLYYSLAGDQLFTWLLEPHVGIVRFHAAKIDAHSLQL--------PLSLSEEEEEEE 1281
            ||:|.:|:::||||||..|:.|.|:|...||||||.|:|..:|.:        |...|....:.:
Mosquito  1251 TVNRSKTSIIYYSLAGADLYAWFLQPQKRIVRFHATKLDDQTLPMLKQKALAGPAGASTATLDTK 1315

  Fly  1282 -----DLEMERELKLNRDQNQDQSEDQGTSNKANRLLERYMSLVRDNLGVNSQSLLHEGDGSGWR 1341
                 .|.::          :....|.|:......||.||::.|||.|||||.|:|.|||||||:
Mosquito  1316 GGGGGKLVVQ----------EGAGGDDGSMGDEQSLLARYINYVRDCLGVNSGSVLQEGDGSGWK 1370

  Fly  1342 ASTEQLLEDLPGAGGSGGGGFLRMVSRNQLLNSSNYSLSSLFSVGSVGGSVASLQGSTRSV---- 1402
            :|:|.|::|..    :...||||||:||.||||||||||||||:||||||||||||||||:
Mosquito  1371 SSSENLIDDFT----NERAGFLRMVNRNHLLNSSNYSLSSLFSLGSVGGSVASLQGSTRSIGSLQ 1431

  Fly  1403 GSRSSRRAPGLPVWRGPSCLHILYNLLLAPFDDLLPAGEADTNRQGRRELVLVLDSSLYLVPFAI 1467
            ||..|||:..||.|:||||||:|||||||||:|||| ..:.|.|.|||||:|||:..||||||||
Mosquito  1432 GSTRSRRSNMLPPWQGPSCLHVLYNLLLAPFEDLLP-DISTTARIGRRELILVLEKELYLVPFAI 1495

  Fly  1468 LRAAQEDGEYLCERCAILTAPSLQSMRSRPRIRRDRARPP-----KALVVGGPRIPSNLAELWGW 1527
            ||:..||||||.|||::||.|||.::|.:.||   :.|.|     .|||:|||:|||:|::.|||
Mosquito  1496 LRSGDEDGEYLSERCSLLTVPSLHTLRQKSRI---KTREPAEGLNSALVIGGPKIPSSLSDTWGW 1557

  Fly  1528 AGAESPAALQEAAMVADMLQATALAGSNATKESVLAELPSAECVHFAANISWQLGAVVLSPGDVV 1592
              ::|||:|||||||:|||....|..::||||::::|||:|||||||||:||:|||||||||:|:
Mosquito  1558 --SDSPASLQEAAMVSDMLNTKPLVSTSATKEAIVSELPAAECVHFAANVSWKLGAVVLSPGEVL 1620

  Fly  1593 TAEQ----------------QEQKEPHE--------PQMTDFTLAAGELRQLRLSARLVVLSSYH 1633
            .:..                ...:||.:        |.::||.|:|.:|..:||:|:||||||||
Mosquito  1621 DSPSTGKRFYPSAAGELLGADNDEEPTDLSTTNMEIPPLSDFILSAADLLSMRLTAKLVVLSSYH 1685

  Fly  1634 SVEPITGDGVAQLAGGWLLAGAGVVLISLWPVPETAAKILLRAFYSALLQGARAARALAEAMQTV 1698
            |||||||.|||.||..||.||.|.||:||||||||||||||||||||||||.|||||||||||||
Mosquito  1686 SVEPITGSGVANLASSWLFAGTGAVLVSLWPVPETAAKILLRAFYSALLQGTRAARALAEAMQTV 1750

  Fly  1699 QHTKHFAHPANWAGFLLVGSNIRLSNKVAM-GHALCELLRTPERCRDALRVCLHLVEKSLQRIHR 1762
            |||||||||||||||:|:|.|:|||||||: |.|||||:|||::|||||||||||||||||||||
Mosquito  1751 QHTKHFAHPANWAGFILIGGNVRLSNKVALIGQALCELMRTPDKCRDALRVCLHLVEKSLQRIHR 1815

  Fly  1763 GQKNAMYTTQQSIENKAGPVAGWKDLLMAVGFRVEPAANGIPASVFFPQADPEERLAQCSASLQA 1827
            ||||||||||:||:||||||:||||||||||||.||||||||:||||||:|||:||:||||||||
Mosquito  1816 GQKNAMYTTQKSIDNKAGPVSGWKDLLMAVGFRFEPAANGIPSSVFFPQSDPEDRLSQCSASLQA 1880

  Fly  1828 LLALTPATLQALGKLVHVNSAEYAGDIIAVVRNILAQFPGSNPATGSSSTKSDAIAETCFIEMPL 1892
            ||.|:|.||.||.||||  .||.|.:||.|:||::||||  :.||.:.|.          |::||
Mosquito  1881 LLGLSPTTLHALSKLVH--GAEIADEIIGVMRNVVAQFP--SKATDNESA----------IDVPL 1931

  Fly  1893 SVRLWRVAGCHELLASVGFDLTEVGADQVILRTGKQANRRQCQFVLQALLALFDTREAPKNLGLD 1957
            |||||||:||||||||:||||.|||.|||.||||||||||.||||||||||||||:||||:||:
Mosquito  1932 SVRLWRVSGCHELLASLGFDLMEVGQDQVTLRTGKQANRRNCQFVLQALLALFDTQEAPKSLGI- 1995

  Fly  1958 RDSDHSSSCESL-AEPEMDVASIPPAASST----------------------------------- 1986
               :.|||.||| .|.|.|......|..||
Mosquito  1996 ---ESSSSSESLNEEDEQDEQGAAAAQQSTGQQSQQSQSQSAQQQQQQQQSSQQQVTQQQQQQQM 2057

  Fly  1987 -------PSVNGG---------------------NKAPLPLH------PRSAFISYVRRRGEPDG 2017
                   |:...|                     ::.||||.      .||||||||||||||||
Mosquito  2058 KVSSSVSPTPTSGDSQQRSISPAVTVKSQSSYNFSRPPLPLRRVPFLSTRSAFISYVRRRGEPDG 2122

  Fly  2018 GRTDA---IGGVGSGALDSSLANTTDSEHSLSDGYVTQPGFGLSN---PRLGYASMRAPVRVSRP 2076
            |:||:   .......|||:|||||||||  |||||.||.....|:   ..|||:|:|..::||||
Mosquito  2123 GQTDSAQTAPAANGPALDTSLANTTDSE--LSDGYTTQQILLKSDHLAKGLGYSSLRGTIKVSRP 2185

  Fly  2077 GGGGESDAAFTPSPPVT----DPSLSLALAHQTRIRSLYS----------------QT------- 2114
            |||||||||||||||||    |.::||||||||||::||:                ||
Mosquito  2186 GGGGESDAAFTPSPPVTIQTVDQNVSLALAHQTRIKNLYTNNGNGLLHGTMNGGHGQTAAPSGLA 2250

  Fly  2115 SSAAIVP------PVATTLNRRPDSSSSASSTTDWEGSGHATVLRRGVSTAIPQQQPPLPPPR-- 2171
            |..|.:|      |.....:|||||||||||.||||||||||||||..... ....|||||||
Mosquito  2251 SGYAGLPDGVHHHPNPVHHHRRPDSSSSASSATDWEGSGHATVLRRAAGHQ-GHHLPPLPPPRQT 2314

  Fly  2172 -------------PPTFHNL-------SVGA-------------------------------GG- 2184
                         .|.::|:       ||||                               ||
Mosquito  2315 LPMVESLRPLAPLAPVYNNINGAVGPSSVGAASGKSGGQKSLSVLESTSSDSEFERSFDLPPGGP 2379

  Fly  2185 ----------------------RSKPKIKLG----------------------------SAQSSL 2199
                                  |::.|:|:|                            ..|..|
Mosquito  2380 GPSNAASISSKLTSLAHSLQSMRTRNKLKMGPMPHIPTAAGQQHLQQHHQQQQQQHQQQQQQQQL 2444

  Fly  2200 AARVNKEHAL------------------FMDRLSVRTELSAPGSGNAMTSGSAA---RKPLA-LP 2242
            ..:....|.|                  |:||||.|||:|     :|.|.||.|   ||||: ||
Mosquito  2445 HQQQLHGHPLHSTTSTISRSKLPVDQFGFLDRLSCRTEIS-----SAATLGSLAAPPRKPLSTLP 2504

  Fly  2243 EEEDVSNVVFNPSSLYFSQTDSDLLNEPKQEETP------------------------------- 2276
            ::|...|:  |.:.||||.||:::|  |..|.:|
Mosquito  2505 DDERTLNL--NANKLYFSPTDAEML--PLAEASPADLGLGGKVAASHAASAHAPPLGGVGAGAPG 2565

  Fly  2277 ----------PPTKSSTKSLQDSMMRHMNRELTPSISEMYHDRNVGLGLAPPLSKLLLSPNYEEQ 2331
                      |..|||.|::|||::|||:||:||:|||:||:||:||||||.|||||||.||:|.
Mosquito  2566 PGAASSKDVQPGAKSSQKTIQDSILRHMSREMTPTISEVYHERNIGLGLAPSLSKLLLSKNYDES 2630

  Fly  2332 EVVSITEACPQSGANLKT--LVDAVSELELSGSSSGA----------TMPTVVGGGA---NEVEG 2381
                 .:....||:|...  ...|...|...|:||.|          :....||..|   ||:|.
Mosquito  2631 -----PDLGKGSGSNSSNGGGAGAGGALSAGGASSAAAAAASMLNKPSAALTVGNLAEAMNEIEM 2690

  Fly  2382 TSGTSA---EATCPICGEPADVICRCKAV----------------TIQKKSIL-KPWLSNVPDSS 2426
            .:.||:   |..|.||..|:|::|.|.|.                |:.|||.. ||||||| ..:
Mosquito  2691 NATTSSKLDEGACAICHSPSDLLCGCSATSTVAAVAAMTAALGASTMAKKSSSNKPWLSNV-SPN 2754

  Fly  2427 LVQASELTTADILERRLEIHTATSSEL-----------------RSGAPYSVDLSRRDEGDGRSV 2474
            :|:||:||||||||::.::.::.||.|                 |||:|:| |||||||||||||
Mosquito  2755 IVKASDLTTADILEQQKQLKSSVSSGLTSNLSSSTENSLSTVVKRSGSPFS-DLSRRDEGDGRSV 2818

  Fly  2475 ADSQCSSNYK------------------RVLASAS-------------------------GGALS 2496
            ||||||.:::                  ::::|:|                         ||
Mosquito  2819 ADSQCSGSFRTDITGSTVATSKSQQQQQQIVSSSSQQQQQQQQQKQQSTQQQQLQTQQSTGG--- 2880

  Fly  2497 LAGIGKGSEAEAQSASS-----GATCSSAR 2521
             .|...||.|..|.|||     |.|.:..|
Mosquito  2881 -GGDPNGSSAAQQMASSVTMPTGTTVTQQR 2909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_648228.2	PEP_TPR_lipo	<78..751	CDD:274350	544/672 (81%)
		TPR repeat	98..128	CDD:276809	25/29 (86%)
		TPR repeat	133..161	CDD:276809	25/27 (93%)
		TPR repeat	243..269	CDD:276809	23/25 (92%)
		TPR repeat	281..311	CDD:276809	26/29 (90%)
		TPR repeat	321..349	CDD:276809	26/27 (96%)
		TPR repeat	354..390	CDD:276809	28/35 (80%)
		TPR repeat	401..429	CDD:276809	18/27 (67%)
		TPR repeat	441..469	CDD:276809	18/27 (67%)
		TPR repeat	482..509	CDD:276809	24/26 (92%)
		TPR repeat	522..549	CDD:276809	15/26 (58%)
		TPR	523..781	CDD:440225	195/257 (76%)
		TPR repeat	561..595	CDD:276809	27/33 (82%)
		TPR repeat	600..630	CDD:276809	23/29 (79%)
		TPR repeat	642..669	CDD:276809	21/26 (81%)
		TPR repeat	680..716	CDD:276809	28/35 (80%)
		TPR repeat	721..749	CDD:276809	21/27 (78%)
		TPR_12	801..865	CDD:315987	52/63 (83%)
		TPR repeat	801..829	CDD:276809	23/27 (85%)
		Spy	841..>1073	CDD:443119	150/232 (65%)
		TPR repeat	841..878	CDD:276809	29/36 (81%)
		TPR repeat	883..913	CDD:276809	24/30 (80%)
		TPR repeat	924..949	CDD:276809	15/24 (63%)
		TPR repeat	964..998	CDD:276809	22/33 (67%)
		COG4995	975..1718	CDD:444019	444/793 (56%)
		TPR repeat	1004..1032	CDD:276809	14/27 (52%)
		TPR repeat	1043..1073	CDD:276809	16/29 (55%)
		TPR repeat	1081..1109	CDD:276809	19/27 (70%)
		CHAT	1421..1718	CDD:432771	201/325 (62%)
LOC1273312	XP_312278.6	None