Protein Alignment CG43163 and STIP1

DIOPT Version :10

• Sequence 1: NP_648228.2
• Gene: CG43163 / 38966
• FlyBaseID: FBgn0262719
• Length: 2523
• Species: Drosophila melanogaster
• Sequence 2: NP_001269581.1
• Gene: STIP1 / 10963
• HGNCID: 11387
• Length: 590
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 115/498 - (23%)
• Similarity: 181/498 - (36%)
• Gaps: 159/498 - (31%)

  Fly    67 EKVRQSNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQARDLCPQ 131
            |...:.|.|...|:...|:..|::|::|||.||:||||||||..|:|.:..|.:|..:..||.|.
Human    53 ELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 117

  Fly   132 WPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGL--VEASL---------------- 178
            |.|.|.|:..||:.|.|:.||...:..||..|.:|.||..||  :||.|
Human   118 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQ 182

  Fly   179 ---KSPLRAAL--EPTLQQLRTMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIGSCSL- 237
               ..|....|  :||.::| ..||:..|    |.:|.:|    |....:|.|...|.:...|:
Human   183 KLESDPRTRTLLSDPTYREL-IEQLRNKP----SDLGTKL----QDPRIMTTLSVLLGVDLGSMD 238

  Fly   238 -------------------------------------KLRGSVFSALSSAHWALNQLDQA----- 260
                                                 |..|:..........||...|:|
Human   239 EEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDP 303

  Fly   261 --IGYMQQDLAVAKSLGDTAGECR----------------------AHGNLGSAYFSQGAHKEAL 301
              :.|:....||....|| ..:||                      |:..:|::||.:..:|:|:
Human   304 TNMTYITNQAAVYFEKGD-YNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAI 367

  Fly   302 TAHRYQLVLA--------MKCKDTQAAAAALTSLGHVYT--------------ASGDYPNALASH 344
              |.|...||        .||:..:........|.::..              ..||||.|:..:
Human   368 --HFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHY 430

  Fly   345 KQCVQLFKQLGDRLQEAREIGNVGAVY-------LALGECEAALDCHSQHLRLARKLHDQVEEA- 401
            .:.::      ...::|:...|..|.|       |||.:||..:               |:|..
Human   431 TEAIK------RNPKDAKLYSNRAACYTKLLEFQLALKDCEECI---------------QLEPTF 474

  Fly   402 -RAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAA 443
             :.|:...:|....:.:|:|...:::.|.:     |.|.:.||
Human   475 IKGYTRKAAALEAMKDYTKAMDVYQKALDL-----DSSCKEAA 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_648228.2	PEP_TPR_lipo	<78..751	CDD:274350	112/487 (23%)
		TPR repeat	98..128	CDD:276809	14/29 (48%)
		TPR repeat	133..161	CDD:276809	10/27 (37%)
		TPR repeat	243..269	CDD:276809	5/32 (16%)
		TPR repeat	281..311	CDD:276809	10/51 (20%)
		TPR repeat	321..349	CDD:276809	6/41 (15%)
		TPR repeat	354..390	CDD:276809	9/42 (21%)
		TPR repeat	401..429	CDD:276809	4/29 (14%)
		TPR repeat	441..469	CDD:276809	2/3 (67%)
		TPR repeat	482..509	CDD:276809
		TPR repeat	522..549	CDD:276809
		TPR	523..781	CDD:440225
		TPR repeat	561..595	CDD:276809
		TPR repeat	600..630	CDD:276809
		TPR repeat	642..669	CDD:276809
		TPR repeat	680..716	CDD:276809
		TPR repeat	721..749	CDD:276809
		TPR_12	801..865	CDD:315987
		TPR repeat	801..829	CDD:276809
		Spy	841..>1073	CDD:443119
		TPR repeat	841..878	CDD:276809
		TPR repeat	883..913	CDD:276809
		TPR repeat	924..949	CDD:276809
		TPR repeat	964..998	CDD:276809
		COG4995	975..1718	CDD:444019
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:432771
STIP1	NP_001269581.1	3a0801s09	<54..579	CDD:273380	114/497 (23%)
		TPR repeat	54..79	CDD:276809	6/24 (25%)
		TPR repeat	84..114	CDD:276809	14/29 (48%)
		TPR repeat	119..147	CDD:276809	10/27 (37%)
		TPR repeat	276..300	CDD:276809	6/23 (26%)
		TPR repeat	305..335	CDD:276809	7/30 (23%)
		TPR repeat	347..375	CDD:276809	8/29 (28%)
		TPR repeat	411..435	CDD:276809	5/23 (22%)
		TPR repeat	440..470	CDD:276809	9/44 (20%)
		TPR repeat	475..503	CDD:276809	4/27 (15%)
		TPR repeat	509..538	CDD:276809	2/4 (50%)