DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43163 and ttc28

DIOPT Version :10

Sequence 1:NP_648228.2 Gene:CG43163 / 38966 FlyBaseID:FBgn0262719 Length:2523 Species:Drosophila melanogaster
Sequence 2:XP_002932145.3 Gene:ttc28 / 100485210 XenbaseID:XB-GENE-998938 Length:2442 Species:Xenopus tropicalis


Alignment Length:2582 Identity:1097/2582 - (42%)
Similarity:1516/2582 - (58%) Gaps:341/2582 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 FLEKVRQSNAACQSGDFATAVLLYTDALQLDPGNHILYSNRSAALLKQGQFTAALQDATQARDLC 129
            |:||||.||.||::|||..|:.|||:.|.:||.|.|||||||||.||..|:..:|.||.:||.|.
 Frog    35 FIEKVRHSNEACKNGDFQLAIDLYTETLLVDPQNCILYSNRSAAFLKVQQYEKSLDDAIKARLLN 99

  Fly   130 PQWPKAYFRQGVALQCLGRYGEALAAFASGLAQEPSNKQLMAGLVEASLKSPLRAALEPTLQQLR 194
            |:|||||||||||||.|||:.:|||||||||||:|.:.||:.|:|||::|||:|.:||||.|||:
 Frog   100 PKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLLGMVEAAMKSPMRESLEPTYQQLQ 164

  Fly   195 TMQLQESPFVVSSVVGQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQ 259
            .|:|.:|||||.||:|||||.|..:.|:|.||||||:||:||||||||||||||||:|:|...::
 Frog   165 KMKLDKSPFVVVSVIGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEK 229

  Fly   260 AIGYMQQDLAVAKSLGDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAAL 324
            :.|||||||.|||:|||..|||||:||||||:||:|..:||||.||:|||||||.|:.:||::||
 Frog   230 STGYMQQDLDVAKTLGDQTGECRAYGNLGSAFFSKGNFREALTNHRHQLVLAMKLKEREAASSAL 294

  Fly   325 TSLGHVYTASGDYPNALASHKQCVQLFKQLGDRLQEAREIGNVGAVYLALGECEAALDCHSQHLR 389
            :||||||||.||||||||||||||.|.||..|.|.||||:||:||||:|:|:.|.|:.||.|||:
 Frog   295 SSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVHCHEQHLK 359

  Fly   390 LARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGHAARCA 454
            :|:.|.::.||||||||||||.|.||.|.:|.:.|..||.:||.|.|:::|..|||||||||||.
 Frog   360 IAKDLGNKREEARAYSNLGSAFHYRRNFDKAMSYHNHVLELAQELPDKAIEMRAYAGLGHAARCM 424

  Fly   455 GDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSLGDRTG 519
            .|...:|::||:||::|.:.:|:..||||.|||||::||.|..|.|||||:.||.||:.|.|...
 Frog   425 QDLERAKQYHEQQLSIAESLKDRAAEGRASSNLGIIHQMKGEFDTALKLHKTHLSIAQELNDYAA 489

  Fly   520 MGKAYGNMARMAHMAGSYEAAVKYHKQELAINQAMNDRSAEAATHGNLAVAYQALGAHDAALTHY 584
            .|:|||||....:..|.|:.|||||:|||.|:..:|||:::|:||||||||||||||||.||.||
 Frog   490 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHY 554

  Fly   585 RAHLATARSLKDTAGEACALLNLGNCLSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACHLLGY 649
            :.||..||.|:|...||.||.||||....|.||.:|||.||.||.::.||.|:..|||.||.|||
 Frog   555 QNHLNIARELRDIQSEARALSNLGNFHCSRGEYMQAVPFYEQYLRISPELQDMEGEGKVCHNLGY 619

  Fly   650 AHFSLGNYRAAVRYYDQDLALAKDAQHRPNMGRAYCNLGLAHLALGHTAAALECQQLFLAVAHAT 714
            ||:.||||:.||:||:||||||||...:.:..:||||||||..||.:...|.:||:..|::|.:.
 Frog   620 AHYCLGNYQDAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALMNYNKAEDCQKYLLSLAQSL 684

  Fly   715 NQLPAKFRALGNIGDILIRTGSHEEAIKLYQRQLALARAAGDRSMEAAACGALGLAHRLMRRWDK 779
            |...||||||||:|||.:.......|||.|::||:||....||.:||:|..|||.|:|:::::||
 Frog   685 NNSQAKFRALGNLGDIFVAKKDINGAIKFYEQQLSLAHQVKDRRLEASAYAALGSAYRMIQKYDK 749

  Fly   780 ALGHHTQELTLRQELGDLSGECRAHGHLGAVHMALCSWTNAVKCYQEQLERAQEQRDAAVEAQAH 844
            |||:|||||.:.|||.||.|||:|||||.||:|:|..:|.|.|||:||||..|:.:|.::|||.:
 Frog   750 ALGYHTQELEVFQELNDLPGECKAHGHLAAVYMSLEKYTMAFKCYEEQLELGQKLKDPSIEAQVY 814

  Fly   845 GNLGIARLNMAHYEAAIGCLEAQLGTLERVSLPSTQADRARALGHLGDCYAALGDYEEALKCHDR 909
            ||:||.::||...|.|||..|.||..|::::...:..||.||.|:|||||.||||||||:|.:::
 Frog   815 GNMGITKMNMNVMEEAIGYFEQQLAMLQQLNGNDSMLDRGRAYGNLGDCYDALGDYEEAIKYYEQ 879

  Fly   910 QLQLALGLTSHRDQERAYRGLGQARRALGQLPAALVCLEKRLVVAHELHSPEIKALAYGDLGHVH 974
            .|.:|..|...:||.:||||||...|:||.|..:|||.||||||||||.....||.|||:||::|
 Frog   880 YLSVAQSLNRLQDQSKAYRGLGNGHRSLGNLQQSLVCFEKRLVVAHELGETSNKAQAYGELGNLH 944

  Fly   975 AALGNHAQALNCLEHQRELAQGLQDRALESDAMCALGQVQQRMGQHAQALELHRQDLEICTELSA 1039
            :.|||:.||::|||.|..:|:.::|:.|||||.|.||.|.|:||:...|||.|:.||:|..|.:.
 Frog   945 SQLGNYEQAISCLERQLNIAREMKDQILESDAACGLGGVHQQMGEFETALEFHQLDLQIAEETNN 1009

  Fly  1040 PALQARALSNLGSVHESLGQQAEALKCYERQLELS---TDRLAKAMACLALGRVHHQLEQHNQAV 1101
            |:.||||..|||..:||||....|:...|:.|.::   .|..||.:|..:|||.||.|:.::|||
 Frog  1010 PSCQARAYGNLGLTYESLGNFERAVVFQEQHLSIAAEMNDLAAKTIAYSSLGRTHHALQNYSQAV 1074

  Fly  1102 DYLRQGLASAQTTGKSEEEAKIRHQLGLALRSSGDAEGAHIQLETAAQLLESVRHE-QRSPETRQ 1165
            .||::||..|:...:.|:||||||:|||:|.:||:.|.|..||..|:.|.|::||| |.|.:.:.
 Frog  1075 MYLQEGLRLAEQLARREDEAKIRHRLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKL 1139

  Fly  1166 ALYDLQTTCYQLLQVLLVALNRNEDALVAAERCKARGGADAV----SGEGSKVPLA--DSESIQE 1224
            :|:||||:.||.||.:|::|..:::||..|||.:.|..||.:    :|:....|.:  ..:.|.|
 Frog  1140 SLFDLQTSSYQALQRVLISLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILE 1204

  Fly  1225 TVDRGRTTVLYYSLAGDQLFTWLLEPHVGIVRFHAAKIDAHSLQLPLSLSEEEEEEEDLEMEREL 1289
            |::..|..|||:|||...|::|||.|..||::||                  |....::.:|...
 Frog  1205 TINSQRGLVLYFSLAAGYLYSWLLAPGSGILKFH------------------EHYLGEISVENTS 1251

  Fly  1290 KLNRDQNQDQSEDQGTSNKANRLLERYMSLVRDNLGV---------NSQSLLHEGDGSGWRASTE 1345
            :.|...:.   ..||:||.   :||:|::.||:.|||         :|::....||      ..:
 Frog  1252 EFNESGSM---SFQGSSNS---VLEQYIANVRETLGVDSYYTRTCASSETESEAGD------YMD 1304

  Fly  1346 QLLEDLPGAGGS--GGGGFLRMVSRNQLLNSSNYSLSSLFSVGSVGGSVASLQGSTRSVGSRSS- 1407
            |..:||.....|  ...|||||||||...|.|..|::||||     .:::.::.:|.|:..:.| 
 Frog  1305 QQYDDLNNKINSVTDPTGFLRMVSRNNTFNRSCQSMTSLFS-----NNMSPVKDNTSSLPRKQSS 1364

  Fly  1408 -RRAPGLPVWRGPSCLHILYNLLLAPFDDLLPAGEADTNRQGRRELVLVLDSSLYLVPFAILRAA 1471
             .:.|          |..||:|||||.:..|........|  .|:|||||:..|||:|||:|:.:
 Frog  1365 FSKPP----------LRALYDLLLAPMEGSLMHSSGPVGR--HRQLVLVLEGELYLIPFALLKGS 1417

  Fly  1472 QEDGEYLCERCAILTAPSLQSM--RSRPRIRRDRA----RPPKALVVGGPRIPSNLAELWGWAGA 1530
            ..: |||.||..:::.||::|:  .|:...|::..    ....|.|||.|::|..:.:.|.|  .
 Frog  1418 SSN-EYLYERFNLISVPSIRSLSINSKSHFRKNAPIYSNSTSMAAVVGNPKLPPPVMDRWLW--G 1479

  Fly  1531 ESPAALQEAAMVADMLQATALAGSNATKESVLAELPSAECVHFAANISWQLGAVVLSP------- 1588
            ..|:|.:||.|||::|....|.|:.||||.|::.|..|||||||.:|||:|.|::|:|       
 Frog  1480 PMPSAEEEAYMVAELLGCQPLVGNLATKEKVMSALSQAECVHFATHISWKLAAIILTPNSEGGSG 1544

  Fly  1589 -----GDVVTAEQQEQKEPHE----------PQMTDFTLAAGELRQLRLSARLVVLSSY-HSVEP 1637
                 |:..|..:..|. |.:          |.:.:|.|.|.::..|||..:||||.|| .|...
 Frog  1545 TTKTFGNTYTIPESLQM-PDDASDVESISDCPPLQEFLLTAADVLDLRLPVKLVVLGSYQESSNK 1608

  Fly  1638 ITGDGVAQLAGGWLLAGAGVVLISLWPVPETAAKILLRAFYSALLQGARAARALAEAMQTVQHTK 1702
            :|.|||..|...:|.|||..||:||||||..|:|:.:.||||:||.|.:|:.:|:|||:|||.:|
 Frog  1609 VTADGVIGLTRAFLAAGAQCVLVSLWPVPVAASKMFVHAFYSSLLNGMKASASLSEAMKTVQSSK 1673

  Fly  1703 HFAHPANWAGFLLVGSNIRLSNKVAM-GHALCELLRTPERCRDALRVCLHLVEKSLQRIHRGQKN 1766
            .::||:|||||:|:||:::|::..:: |.||.|:|:.|:|.||||||.|||||||||||..||:|
 Frog  1674 QYSHPSNWAGFMLIGSDVKLNSPSSLIGQALSEILQNPDRARDALRVLLHLVEKSLQRIQNGQRN 1738

  Fly  1767 AMYTTQQSIENKAGPVAGWKDLLMAVGFRVEPAANGIPASVFFPQADPEERLAQCSASLQALLAL 1831
            :|||:|||:|||.|.|.||:.||.|||||::|.::|:||:||||.:||.:||.|||.::|:||.|
 Frog  1739 SMYTSQQSVENKVGGVQGWQSLLTAVGFRLDPPSSGLPAAVFFPTSDPGDRLQQCSTTIQSLLGL 1803

  Fly  1832 TPATLQALGKLVHVNSAEYAGD---------IIAVVRNILAQFPGSNPATGSSSTKSDAIAETCF 1887
            ..:.||||.||:   :|...|:         ::.::..:|.|....:.....||..         
 Frog  1804 PHSALQALCKLI---TASETGEQLINRAVKNMVGMLHQVLVQLQAGDKEHDFSSAP--------- 1856

  Fly  1888 IEMPLSVRLWRVAGCHELLASVGFDLTEVGADQVILRTGKQANRRQCQFVLQALLALFDTREAPK 1952
            |::.:||:|||:.||||.||::||||.|||.::|||:||||||:|..||.||:||||||:.|.||
 Frog  1857 IQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANKRTMQFALQSLLALFDSTELPK 1921

  Fly  1953 NLGLDRDSDHSSSCESLAEPEMDVASIPPAASSTPSVNGGNKAPLPLHPRSAFISYVRRRGEPDG 2017
            .|.|    |.|||.||||..:         :.|.|...|     .|.||.|...        |||
 Frog  1922 RLSL----DSSSSLESLASAQ---------SVSNPMPQG-----YPGHPFSPPC--------PDG 1960

  Fly  2018 GRTDAIGGVGSGALDSSLA----------------------------------NTTDSEHSLSDG 2048
            ..:|||......::.||::                                  :.:..:.::|.|
 Frog  1961 MASDAISVYSLSSIASSMSFVSKPECLIEGDQKMRHDHDRPKHIYSLRTSASRSQSSPQSNISLG 2025

  Fly  2049 YVTQ---PGFGL--SNPRLGYAS----------MRAPVRVS-RPGGGGESDAAFTPSPPVTDPSL 2097
            ...|   .||.:  :.|.|.|..          |:..:.|| .|.|     :..||:.||   .|
 Frog  2026 KEEQEEYDGFSIISNEPLLTYTENTDSGIKQDCMQESIHVSVNPKG-----SISTPNSPV---KL 2082

  Fly  2098 SLALAHQTRIRSLYSQTSSAAIVPPVATTLNRRPDSSSSASSTTDWEGSGHATVLRRGVSTAIPQ 2162
            :|..:..:..:.:....||               |:..|..|:|:.:            ||...|
 Frog  2083 ALIPSPNSPFQKVGKLVSS---------------DTGESDQSSTETD------------STVKSQ 2120

  Fly  2163 QQPPLPPPRPPTFHNLSVGAGGRSKPKIKLGSAQSSLAA--RVNKEHALFMDRLSVRTELSAPGS 2225
            ::.....|.             ....|| |...||.|.|  |:.:..:..:.|.|.....|.|..
 Frog  2121 EENQKLNPE-------------ELAQKI-LEETQSHLIAVERLQRSGSQVIKRTSSSDGASTPNG 2171

  Fly  2226 GNAMTSG--SAARKPL--ALPEEEDVSNVVFNP------SSLYFSQTDSDLLNEPKQEET----- 2275
            |::..|.  ||..:|:  .:|     |.|...|      |||   |..|...|.|...||     
 Frog  2172 GSSFRSSETSAFSRPVQKGMP-----SPVTVKPKPPTRSSSL---QKISSGYNSPANSETSLKEG 2228

  Fly  2276 -------PPPTKSS-------TKSLQDSMMRHMNRELTPSISEMYHDRNVGLGLAPPLSKLLL-- 2324
                   |.|:..|       ..|...|.:....|.::||..   |....|...:|.||....  
 Frog  2229 IGIHSGQPSPSSDSPHFRLKYPSSPYSSHISRSPRNISPSSG---HQSPAGSTSSPALSYSSAGS 2290

  Fly  2325 -------SPNYEEQEVVSITEACPQSGANLKTLVDAVSELELSGSSSGATMPTVVGGGANEVEGT 2382
                   :|:.::.::.:|.|.           |.|:..|::..:|:    |....|....:.|.
 Frog  2291 ARSSPADAPDIDKLKLAAIDEK-----------VKAIHNLKMFWTST----PQQTSGPIKILRGA 2340

  Fly  2383 SG--TSAEATCPICG---------EPADVICRCKAVTIQKKSI-LKPWLSNVPDSSLVQASELTT 2435
            .|  ||.:....:..         |.||.: ..|.:::|:|:| ..|   .:|.:...|...:..
 Frog  2341 PGTMTSKKDVLSLLNLSPRHSKKEEAADNL-ELKELSVQQKNIDAAP---QIPPNGHKQTENINV 2401

  Fly  2436 ADILERRLEIH---TATSSELRSGAPYSVDLSRRDEGDGRSVADSQC 2479
            |::.:....|:   |..|.:|.||..|.. ||     .||....|:|
 Frog  2402 ANVTQSSPSINLPGTLRSIKLTSGNGYKF-LS-----PGRFFPSSKC 2442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43163NP_648228.2 PEP_TPR_lipo <78..751 CDD:274350 406/672 (60%)
TPR repeat 98..128 CDD:276809 18/29 (62%)
TPR repeat 133..161 CDD:276809 23/27 (85%)
TPR repeat 243..269 CDD:276809 16/25 (64%)
TPR repeat 281..311 CDD:276809 21/29 (72%)
TPR repeat 321..349 CDD:276809 23/27 (85%)
TPR repeat 354..390 CDD:276809 21/35 (60%)
TPR repeat 401..429 CDD:276809 17/27 (63%)
TPR repeat 441..469 CDD:276809 16/27 (59%)
TPR repeat 482..509 CDD:276809 17/26 (65%)
TPR repeat 522..549 CDD:276809 14/26 (54%)
TPR 523..781 CDD:440225 140/257 (54%)
TPR repeat 561..595 CDD:276809 25/33 (76%)
TPR repeat 600..630 CDD:276809 18/29 (62%)
TPR repeat 642..669 CDD:276809 18/26 (69%)
TPR repeat 680..716 CDD:276809 15/35 (43%)
TPR repeat 721..749 CDD:276809 14/27 (52%)
TPR_12 801..865 CDD:315987 34/63 (54%)
TPR repeat 801..829 CDD:276809 17/27 (63%)
Spy 841..>1073 CDD:443119 117/231 (51%)
TPR repeat 841..878 CDD:276809 16/36 (44%)
TPR repeat 883..913 CDD:276809 19/29 (66%)
TPR repeat 924..949 CDD:276809 13/24 (54%)
TPR repeat 964..998 CDD:276809 17/33 (52%)
COG4995 975..1718 CDD:444019 303/794 (38%)
TPR repeat 1004..1032 CDD:276809 15/27 (56%)
TPR repeat 1043..1073 CDD:276809 14/29 (48%)
TPR repeat 1081..1109 CDD:276809 13/27 (48%)
CHAT 1421..1718 CDD:432771 132/325 (41%)
ttc28XP_002932145.3 PEP_TPR_lipo 2..803 CDD:274350 463/767 (60%)
TPR repeat 68..98 CDD:276809 18/29 (62%)
TPR repeat 103..131 CDD:276809 23/27 (85%)
TPR repeat 137..165 CDD:276809 17/27 (63%)
TPR repeat 251..283 CDD:276809 23/31 (74%)
TPR repeat 288..320 CDD:276809 26/31 (84%)
TPR repeat 331..359 CDD:276809 17/27 (63%)
TPR repeat 370..400 CDD:276809 19/29 (66%)
TPR repeat 405..439 CDD:276809 18/33 (55%)
TPR repeat 452..479 CDD:276809 17/26 (65%)
TPR 492..751 CDD:440225 140/258 (54%)
TPR repeat 492..519 CDD:276809 14/26 (54%)
TPR repeat 531..559 CDD:276809 22/27 (81%)
TPR repeat 571..599 CDD:276809 16/27 (59%)
TPR repeat 610..640 CDD:276809 21/29 (72%)
TPR repeat 689..719 CDD:276809 16/29 (55%)
TPR repeat 730..760 CDD:276809 18/29 (62%)
TPR 768..>977 CDD:440225 110/208 (53%)
TPR repeat 771..799 CDD:276809 17/27 (63%)
TPR repeat 810..844 CDD:276809 17/33 (52%)
TPR repeat 849..882 CDD:276809 19/32 (59%)
TPR repeat 894..919 CDD:276809 13/24 (54%)
COG4995 924..1689 CDD:444019 315/815 (39%)
TPR repeat 933..963 CDD:276809 17/29 (59%)
TPR repeat 974..1002 CDD:276809 15/27 (56%)
TPR repeat 1013..1047 CDD:276809 14/33 (42%)
TPR repeat 1052..1082 CDD:276809 15/29 (52%)
TPR repeat 1094..1120 CDD:276809 15/25 (60%)
TPR repeat 1146..1171 CDD:276809 10/24 (42%)
CHAT 1367..1689 CDD:432771 133/337 (39%)
DUF5585 2066..>2296 CDD:465521 62/289 (21%)

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