DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43163 and gpsm2

DIOPT Version :9

Sequence 1:	NP_001246673.1	Gene:	CG43163 / 38966	FlyBaseID:	FBgn0262719	Length:	2523	Species:	Drosophila melanogaster
Sequence 2:	XP_002932195.2	Gene:	gpsm2 / 100380004	XenbaseID:	XB-GENE-949357	Length:	663	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	152/561 - (27%)
Similarity:	256/561 - (45%)	Gaps:	73/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 GQELLQATQYSAAVTVLEAALRIGSCSLKLRGSVFSALSSAHWALNQLDQAIGYMQQDLAVAKSL 274
            |:.|.:|....|.|:..|||:::|:..||...:::|.|.:|::.|::.::|:.|...||.:|:::
Frog    35 GERLCKAGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHEYNKALEYHHHDLTLARTI 99

  Fly   275 GDTAGECRAHGNLGSAYFSQGAHKEALTAHRYQLVLAMKCKDTQAAAAALTSLGHVY-------- 331
            ||..||.:|.||||:.....|..:||:......|.::.:..|....|.||.:||:||
Frog   100 GDRLGEAKASGNLGNTLKVLGNFEEAVLYCERHLEISRELYDKVGEARALYNLGNVYHSQGKSLA 164

  Fly   332 -TAS---GDYP-NALASHKQCVQLFK-------QLGDRLQEAREIGNVGAVYLALGECEAALDCH 384
             ||:   |::| :..|:.::.|..::       .||||..:.|..||:|..:..||....|:..|
Frog   165 CTATQDPGEFPEDVKAALQRAVDYYEANLLIVTDLGDRAAQGRAYGNLGNTHYLLGNFRRAVSSH 229

  Fly   385 SQHLRLARKLHDQVEEARAYSNLGSAHHQRRQFTQAAACHEQVLRIAQALGDRSMEAAAYAGLGH 449
            .|.|.:||:..|:..|.|||||||:|.....:|..||..:::.|::|:.|.||::||.:...||:
Frog   230 EQRLLIAREFGDRSAERRAYSNLGNAFIFLGEFEMAAEYYKKTLQLARQLKDRAVEAQSCYSLGN 294

  Fly   450 AARCAGDASASKRFHERQLAMALAARDKLGEGRACSNLGIVYQMLGSHDAALKLHQAHLGIARSL 514
            ......|...:..:|.:.||:|...||::||||||.:||..|..||:||.|:...:.||.|:|.|
Frog   295 TYTLLQDYEKAIEYHLKHLAIAQELRDRVGEGRACWSLGNAYTALGNHDEAVHFAEKHLDISREL 359

  Fly   515 GDRTG--------------MGKAYGNMARMAHMAGSYEAAVKYHKQELAINQAMNDRSAEAATHG 565
            |||.|              :|.:|...|.:.......:.:....:..|:...:|.:......|..
Frog   360 GDRNGELTAQLNLSDLQMVLGLSYSTNASVLSEIQDTDTSKNVARPRLSRRHSMENLELVKITPE 424

  Fly   566 NLAVA---YQALGAHDAALTHYRAHL--------------ATARSLKDTAGEACALLNLGNC--- 610
            ...|.   .:.|....|.|:...|.|              ::::.|:||:....|...|.|.
Frog   425 KFQVQNWNSEILAKQKALLSKPSAKLMFVNRLKGKKLKSSSSSKVLQDTSNSTDAYRKLSNSQRK 489

  Fly   611 -----LSGRQEYEEAVPHYESYLMLAQELGDVAAEGKACHLLGYAHFSLGNYRAAVR---YYDQD 667
                 ..|.:.:.:.:..::|..|..|...  ..:||..::......::....:|..   :.|:.
Frog   490 STSTDAIGEEGFFDLLSRFQSNRMDDQRCS--LQDGKRLNVPSTTPKTMKKSVSACAMSPHTDEF 552

  Fly   668 LALAKDAQHR---------PNMGRAYCNLGLAHLALGHTAA 699
            |.|...:|.|         .|:.....|...:|..|||..|
Frog   553 LDLIASSQGRRLDDQRASLSNLPGLRINQQQSHSVLGHLMA 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43163	NP_001246673.1	TPR_11	70..130	CDD:290150
		TPR repeat	98..128	CDD:276809
		TPR_11	101..164	CDD:290150
		TPR repeat	133..161	CDD:276809
		TPR repeat	243..269	CDD:276809	7/25 (28%)
		TPR repeat	281..311	CDD:276809	9/29 (31%)
		TPR_12	282..353	CDD:290160	23/90 (26%)
		TPR_12	320..393	CDD:290160	28/92 (30%)
		TPR repeat	321..349	CDD:276809	12/40 (30%)
		TPR repeat	354..390	CDD:276809	14/35 (40%)
		TPR_12	401..473	CDD:290160	25/71 (35%)
		TPR repeat	401..429	CDD:276809	11/27 (41%)
		TPR_7	403..438	CDD:289919	14/34 (41%)
		TPR repeat	441..469	CDD:276809	5/27 (19%)
		TPR	467..752	CDD:223533	65/284 (23%)
		TPR repeat	482..509	CDD:276809	12/26 (46%)
		TPR repeat	522..549	CDD:276809	2/26 (8%)
		TPR repeat	561..595	CDD:276809	7/50 (14%)
		TPR repeat	600..630	CDD:276809	5/37 (14%)
		TPR repeat	642..669	CDD:276809	3/29 (10%)
		TPR_7	643..677	CDD:289919	5/36 (14%)
		TPR repeat	680..716	CDD:276809	6/20 (30%)
		TPR repeat	721..749	CDD:276809
		TPR_7	723..758	CDD:289919
		TPR repeat	801..829	CDD:276809
		TPR_12	841..914	CDD:290160
		TPR repeat	841..878	CDD:276809
		TPR_12	882..949	CDD:290160
		TPR repeat	883..913	CDD:276809
		TPR	884..914	CDD:197478
		TPR repeat	924..949	CDD:276809
		TPR_12	964..1036	CDD:290160
		TPR repeat	964..998	CDD:276809
		TPR repeat	1004..1032	CDD:276809
		TPR repeat	1043..1073	CDD:276809
		TPR_12	1044..1112	CDD:290160
		TPR_7	1046..1078	CDD:289919
		TPR_12	1081..1153	CDD:290160
		TPR repeat	1081..1109	CDD:276809
		CHAT	1421..1718	CDD:289536
		Treacle	<1957..2287	CDD:281536
gpsm2	XP_002932195.2	TPR	<31..290	CDD:223533	83/254 (33%)
		TPR repeat	31..56	CDD:276809	8/20 (40%)
		TPR repeat	68..94	CDD:276809	7/25 (28%)
		TPR repeat	105..135	CDD:276809	10/29 (34%)
		TPR_12	207..278	CDD:315987	27/70 (39%)
		TPR repeat	207..234	CDD:276809	9/26 (35%)
		TPR_12	247..318	CDD:315987	25/70 (36%)
		TPR repeat	247..274	CDD:276809	11/26 (42%)
		TPR repeat	285..315	CDD:276809	7/29 (24%)
		TPR_12	290..358	CDD:315987	26/67 (39%)
		TPR repeat	326..354	CDD:276809	13/27 (48%)
		GoLoco	500..520	CDD:366965	3/21 (14%)
		GoLoco	551..571	CDD:366965	4/19 (21%)
		GoLoco	602..620	CDD:366965
		GoLoco	636..656	CDD:366965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321819at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010